Oral contraceptives suppress cell proliferation and enhance apoptosis of eutopic endometrial tissue from patients with endometriosis
Open accessAbstract
Objective To evaluate the effects of administering combination oral contraceptives (COCs) to patients with endometriosis on the regulation of cell growth in the eutopic endometrium.Design Prospective study.Setting Research institute and clinical fertility center.Patient(s) Thirteen women with untreated endometriosis and 13 controls.Intervention(s) Biopsy specimens of the eutopic endometrium were obtained from all subjects. Apoptosis, cell proliferation, and Bcl-2 and Bax expression were examined at the epithelial and stromal levels in the eutopic endometrium from patients with endometriosis before and after 30 days of daily exposure to COCs and from controls.Main outcome measure(s) Apoptotic cells were detected by using the dUTP nick-end labeling assay; Ki-67, Bcl-2, and Bax expressions were assessed by using immunohistochemical techniques.Result(s) After exposure to COCs, apoptosis was significantly increased in the eutopic endometrium compared with before COC administration, both at epithelial and stromal levels. Cell proliferation was significantly lowered by COCs.Conclusion(s) COCs showed a positive effect on patients with endometriosis by down-regulating cell proliferation and enhancing apoptosis in the eutopic endometrium.
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COCs reduce menstrual flow, cause decidualization of endometriotic implants, and decrease cell proliferation.
“COCs reduce menstrual flow, cause decidualisation of endometriotic implants and decrease cell proliferation [243].”
From Hormonal treatments for endometriosis: The endocrine background (2022) · cites this paper as [243]
The Ki-67 Expression in the Eutopic Endometrium section (page not specified) reports significantly reduced cell proliferation after COC administration in patients with endometriosis. The study examines eutopic endometrial tissue, not endometriotic implants; our copy does not report that COCs reduce menstrual flow or cause decidualisation of implants. (LLM, conf=0.88)
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- Authors
- Meresman, G. F., Augé, L., Barañao, R. I., Lombardi, E., Tesone, M., & Sueldo, C.
- Affiliations
- Experimental Medicine and Biology Institute (AR)
- Corresponding author
- Meresman, Gabriela F.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 77
- Issue
- 6
- Pages
- 1141-1147
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2166744769
- Cited by
- 130
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 6
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agencia Nacional de Promoción Científica y Tecnológica (PICT 6384 BID 1201 OC-AR)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometriosis, combined oral contraceptives, eutopic endometrium, apoptosis, cell proliferation, Bcl-2, Bax, Ki-67, endometrial stroma, endometrial epithelium
- MeSH terms
- Cell Division, Contraceptives, Oral, Endometriosis, Endometrium, Epithelial Cells, Female, Humans, Proto-Oncogene Proteins, Reference Values, Stromal Cells, Apoptosis, Proto-Oncogene Proteins c-bcl-2, Ki-67 Antigen, bcl-2-Associated X Protein
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