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Cited by 53Ovarian function and disordersReproductive Biology and FertilityHypothalamic control of reproductive hormones

Regulation of the 24-hour rhythm of body temperature in menstrual cycles with spontaneous and gonadotropin-induced ovulation

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Cagnacci, Angelo, Volpe, Annibale, Paoletti, Anna Maria, Melis, Gian Benedetto·1997·Fertility and Sterility
DOI 10.1016/s0015-0282(97)00242-2
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Abstract

Objective To investigate the relation between gonadal steroids and the 24-hour body temperature rhythm.Patient(s) Nineteen normally cycling women.Design Controlled clinical study in volunteer women.Setting Clinical hospital.Intervention(s) Eleven women were studied in the early follicular and luteal menstrual phases of cycles with spontaneous ovulation, and 8 women were studied in the early follicular, preovulatory, and luteal phases of cycles with multiple follicular development.Main outcome measure(s) Starting at 5:00 P.M., intravaginal body temperature was monitored continuously for 24 hours and its values were related to E2 and P levels.Result(s) Twenty-four-hour body temperature rhythm parameters were related to the P:E2 ratio. Very low P:E2 ratios in the preovulatory phase were associated with a reduced 24-hour mean and an elevated body temperature rhythm amplitude. The progressive increase in the P:E2 ratio in the early follicular and luteal phases was associated with an increase in the 24-hour mean body temperature and a decrease in the rhythm amplitude. Body temperature differences between the luteal and early follicular phases were less pronounced in cycles with multiple follicular development.Conclusion(s) A woman's body temperature is related to her P:E2 ratio. Even in the presence of elevated P values, alterations of this ratio may influence negatively the postovulatory rise in body temperature.

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Crossref · 10.1016/s0015-0282(97)00242-2

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25 of 25 references verified0 citation errors · 0 not checkable

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  • The balance of progesterone and estrogen is critical for modulating core body temperature.

    “suggesting that the balance of these two hormones is critical for modulating core body temperature”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [67]

  • Most studies that confirmed ovulatory cycles found that the nocturnal decline in core body temperature is blunted, reducing the amplitude of the daily temperature rhythm in the luteal phase compared with the follicular phase.

    “the nocturnal decline in core body temperature is blunted, reducing the amplitude of the daily temperature rhythm in the luteal phase compared with the follicular phase (Figure 2; 35,65-75).”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [67]

  • Cagnacci and colleagues found that the progesterone:estrogen ratio, rather than progesterone levels alone, correlated with high 24-h mean core body temperature and reduced core body temperature amplitude.

    “Cagnacci and colleagues [67] found that the progesterone:estrogen ratio, rather than progesterone levels alone, correlated with the high 24-h mean core body temperature and the reduced core body temperature amplitude”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [67]

  • Most studies that confirmed ovulatory cycles found that mean or mesor core body temperature is increased in the luteal phase compared with the follicular phase.

    “Most studies that confirmed the presence of ovulatory cycles found that the mean or mesor core body temperature is increased”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [67]

  • After controlling for many masking effects by restricting subjects to 24-h bedrest and regulating sleep period, environmental temperature, and food intake, Cagnacci and colleagues found a significant phase delay in the luteal phase.

    “After controlling for many of the masking effects, by restricting subjects to 24-h bedrest and regulating the sleep period, environmental temperature, and food intake, Cagnacci, and colleagues [67,68] found a significant phase delay in the luteal phase.”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [67]

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Authors
Cagnacci, A., Volpe, A., Paoletti, A. M., & Melis, G. B.
Affiliations
University of Modena and Reggio Emilia (IT)
ORCID
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1997-09
Volume
68
Issue
3
Pages
421-425
ISSN
0015-0282 (ISSN-L)
DOI
10.1016/s0015-0282(97)00242-2
OpenAlex
W1999443717
Cited by
53
References
25
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 4
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
body temperature rhythm, menstrual cycle, gonadotropin-induced ovulation, progesterone, estradiol, luteal phase, follicular phase, preovulatory phase
MeSH terms
Adult, Body Temperature, Circadian Rhythm, Estradiol, Female, Follicle Stimulating Hormone, Humans, Menstrual Cycle, Ovulation, Ovulation Induction, Progesterone

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