Is rectal pain sensitivity a biological marker for irritable bowel syndrome: psychological influences on pain perception.
Open accessAbstract
Background & aims Rectal pain sensitivity has been called a biological marker for irritable bowel syndrome, but this conclusion may be premature. This article is a critical review of the evidence for psychological influences on perception.Methods The world literature accessible through Index Medicus from 1973 to 1997 was systematically reviewed.Results Evidence favoring a biological basis for pain sensitivity is that two thirds of patients report pain at abnormally low thresholds of rectal distention despite normal somatic pain thresholds. Pain thresholds are not correlated with anxiety or depression. Evidence favoring psychological influences on perception is that patients with the irritable bowel syndrome rate even sham distentions as more painful, and when perception tests that minimize psychological influences are used, they have normal sensory thresholds. Also, stress alters sensory thresholds. Sensitization by repeated distention has been cited as evidence of a biological basis for hyperalgesia, but it is not unique to patients with irritable bowel. Brain imaging shows that different regions are activated by painful distention in patients with irritable bowel syndrome, but this is consistent with psychological influences on perception.Conclusions Psychological factors influence pain thresholds in patients with the irritable bowel syndrome. Two cognitive traits, selective attention to gastrointestinal sensations and disease attribution, may account for increased pain sensitivity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent investigations have found that mindfulness meditation induces changes in neural circuits implicated in interoception and emotion regulation, while improving attentional control.
“Recent investigations have found that mindfulness meditation induces changes in the activation of neural circuits implicated in interoception (awareness of stimuli originating inside the body (21)) and emotion regulation (22,23), while improving attentional control (24–27).”
From Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial (2011) · cites this paper as [25]
Citation (21) is attached to the definition of interoception, not to the findings about mindfulness meditation. The paper’s “Selective Attention and Disease Attribution” section discusses becoming aware of gastrointestinal sensations, which supports awareness of internal sensations in that specific context. It does not define interoception or address awareness of stimuli originating throughout the body; no page number is available in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
(1966) · Medical Entomology and Zoology · Cited by 10,293 · see citing works
Signal detection theory and psychophysics
Ingleby, D. (1967) · Journal of Sound and Vibration · doi:10.1016/0022-460x(67)90197-6 · Cited by 8,616 · see citing works
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440 · see citing works
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404 · see citing works
Altered rectal perception is a biological marker of patients with irritable bowel syndrome
Mertz, H., Naliboff, B. D., Munakata, J., Niazi, N., & Mayer, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90267-8 · Cited by 976 · see citing works
Basic and clinical aspects of visceral hyperalgesia
Mayer, E. A., & Gebhart, G. F. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90086-8 · Cited by 920 · see citing works
A Primer of Signal Detection Theory
McNicol, D. (2005) · Psychology Press eBooks · doi:10.4324/9781410611949 · Cited by 862 · see citing works
Pain from distension of the pelvic colon by inflating a balloon in the irritable colon syndrome
Ritchie, J. (1973) · Gut · doi:10.1136/gut.14.2.125 · Cited by 832 · see citing works
A Primer of Signal Detection Theory.
Hawkes, A. G., & McNicol, D. (1973) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2345017 · Cited by 654 · see citing works
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592 · see citing works
Self-citationRegional cerebral activity in normal and pathological perception of visceral pain
Silverman, D. H. S., Munakata, J., Ennes, H. S., Mandelkern, M. A., Hoh, C. K., & Mayer, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70220-8 · Cited by 546 · see citing works
CONTROLLED TRIAL OF HYPNOTHERAPY IN THE TREATMENT OF SEVERE REFRACTORY IRRITABLE-BOWEL SYNDROME
Whorwell, P. J., Prior, A., & Faragher, E. B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92793-4 · Cited by 537 · see citing works
Sexual abuse trauma among professional women: Validating the Trauma Symptom Checklist-40 (TSC-40)
Elliott, D. M., & Briere, J. (1992) · Child Abuse & Neglect · doi:10.1016/0145-2134(92)90048-v · Cited by 491 · see citing works
Whitehead, W. E., Engel, B. T., & Schuster, M. M. (1980) · Digestive Diseases and Sciences · doi:10.1007/bf01395503 · Cited by 462 · see citing works
Self-citationA controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461 · see citing works
The functional gastrointestinal disorders
Olden, K. W. (1997) · General Hospital Psychiatry · doi:10.1016/s0163-8343(96)00109-0 · Cited by 439 · see citing works
Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M. (1992) · Gut · doi:10.1136/gut.33.6.825 · Cited by 432 · see citing works
Self-citationBrodman, K. (1949) · JAMA · doi:10.1001/jama.1949.02900410026007 · Cited by 409 · see citing works
Whitehead, W. E., & Delvaux, M. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018885028501 · Cited by 387 · see citing works
Self-citationSymptoms of irritable bowel syndrome in a British urban community: Consulters and nonconsulters
Heaton, K. W., O'Donnell, L. J. D., Braddon, F., Mountford, R. A., Hughes, A., & Cripps, P. J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90320-x · Cited by 382 · see citing works
Repetitive sigmoid stimulation induces rectal hyperalgesia in patients with irritable bowel syndrome
Munakata, J., Naliboff, B. D., Harraf, F., Kodner, A., Lembo, T., Chang, L., Silverman, D. H. S., & Mayer, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70219-1 · Cited by 380 · see citing works
Evidence for two distinct perceptual alterations in irritable bowel syndrome
Naliboff, B. D., Munakata, J., Fullerton, S. C., Gracely, R. H., Kodner, A., Harraf, F., & Mayer, E. A. (1997) · Gut · doi:10.1136/gut.41.4.505 · Cited by 364 · see citing works
Symptom complaints and health care seeking behavior in subjects with bowel dysfunction
Sandler, R. S., Drossman, D. A., Nathan, H. P., & McKee, D. C. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90706-6 · Cited by 326 · see citing works
Learned illness behavior in patients with irritable bowel syndrome and peptic ulcer
Whitehead, W. E., Winget, C. N., Fedoravicius, A. S., Wooley, S. C., & Blackwell, B. (1982) · Digestive Diseases and Sciences · doi:10.1007/bf01296915 · Cited by 302 · see citing works
Self-citationRole of visceral afferent mechanisms in functional bowel disorders
Mayer, E. A., & Raybould, H. E. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90475-g · Cited by 298 · see citing works
Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome
Lembo, T., Munakata, J., Mertz, H., Niazi, N., Kodner, A., Nikas, V., & Mayer, E. A. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90809-5 · Cited by 290 · see citing works
Selective dysfunction of mechanosensitive intestinal afferents in irritable bowel syndrome
Accarino, A. M., Azpiroz, F., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90434-4 · Cited by 282 · see citing works
Heightened visceral sensation in functional gastrointestinal disease is not site-specific
Trimble, K. C., Farouk, R., Pryde, A., Douglas, S., & Heading, R. C. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02212678 · Cited by 243 · see citing works
Dysmotility of the small intestine in irritable bowel syndrome.
Kellow, J. E., Phillips, S. F., Miller, L. J., & Zinsmeister, A. R. (1988) · Gut · doi:10.1136/gut.29.9.1236 · Cited by 237 · see citing works
Patients with irritable bowel syndrome have greater pain tolerance than normal subjects
Cook, I. J., van Eeden, A., & Collins, S. M. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)90434-3 · Cited by 233 · see citing works
(2012) · SpringerReference · doi:10.1007/springerreference_115828 · Cited by 231 · see citing works
Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome
Welgan, P. R., Meshkinpour, H., & Beeler, M. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90006-6 · Cited by 227 · see citing works
A psychophysiological study in humans using phasic colonic distension as a noxious visceral stimulus
Ness, T. J., Metcalf, A., & Gebhart, G. F. (1990) · Pain · doi:10.1016/0304-3959(90)90035-c · Cited by 224 · see citing works
Prior, A., Maxton, D. G., & Whorwell, P. J. (1990) · Gut · doi:10.1136/gut.31.4.458 · Cited by 221 · see citing works
Illness representations and matching labels with symptoms.
Baumann, L. J., Cameron, L. D., Zimmerman, R. S., & Leventhal, H. (1989) · Health Psychology · doi:10.1037//0278-6133.8.4.449 · Cited by 187 · see citing works
Rectal afferent function in patients with inflammatory and functional intestinal disorders
Bernstein, C. N., Niazi, N., Robert, M. E., Mertz, H., Kodner, A., Munakata, J., Naliboff, B. D., & Mayer, E. A. (1996) · Pain · doi:10.1016/0304-3959(96)03062-x · Cited by 179 · see citing works
SITE OF PAIN FROM THE IRRITABLE BOWEL
Swarbrick, E. T., Bat, L., Hegarty, J. E., Williams, C. B., & Dawson, A. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91885-1 · Cited by 175 · see citing works
Gastric tone determines the sensitivity of the stomach to distention
Notivol, R., Coffin, B., Azpiroz, F., Mearin, F., Serra, J., & Malagelada, J. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90057-8 · Cited by 175 · see citing works
Psychosensory modulation of colonic sensation in the human transverse and sigmoid colon
Ford, M. J., Camilleri, M., Zinsmeister, A. R., & Hanson, R. B. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90743-2 · Cited by 167 · see citing works
Drossman, D. A., Li, Z., Toner, B. B., Diamant, N. E., Creed, F. H., Thompson, D. G., Read, N. W., Babbs, C., Barreiro, M. A., Bank, L., et al. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064187 · Cited by 165 · see citing works
Self-citationChanges in rectal sensitivity after hypnotherapy in patients with irritable bowel syndrome.
Prior, A., Colgan, S. M., & Whorwell, P. J. (1990) · Gut · doi:10.1136/gut.31.8.896 · Cited by 162 · see citing works
Irritable bowel syndrome defined by factor analysis gender and race comparisons
Taub, E., Cuevas, J. L., Cook, E. W., Crowell, M. D., & Whitehead, W. E. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02220455 · Cited by 158 · see citing works
Self-citationVisceral perception in irritable bowel syndrome
Zighelboim, J., Talley, N. J., Phillips, S. F., Harmsen, W. S., & Zinsmeister, A. R. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02064986 · Cited by 152 · see citing works
Evaluation of colonic sensory thresholds in IBS patients using a barostat
Bradette, M., Delvaux, M. M., Staumont, G., Fioramonti, J., Bueno, L. P., & Frexinos, J. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02088327 · Cited by 150 · see citing works
Two controlled evaluations of multicomponent psychological treatment of irritable bowel syndrome
Blanchard, E. B., Schwarz, S. P., Suls, J. M., Gerardi, M. A., Scharff, L., Greene, B., Taylor, A. E., Berreman, C. F., & Malamood, H. S. (1992) · Behaviour Research and Therapy · doi:10.1016/0005-7967(92)90141-3 · Cited by 148 · see citing works
Tp, A., & Tulin, M. (1947) · PubMed · Cited by 146 · see citing works
Relaxation training as a treatment for irritable bowel syndrome
Blanchard, E. B., Greene, B., Scharff, L., & Schwarz, S. P. (1993) · Applied Psychophysiology and Biofeedback · doi:10.1007/bf00999789 · Cited by 142 · see citing works
Illness representations and matching labels with symptoms.
Baumann, L. J., Cameron, L. D., Zimmerman, R. S., et al. (1989) · Health Psychology · doi:10.1037/0278-6133.8.4.449 · Cited by 142 · see citing works
Whitehead, W. E., Crowell, M. D., Bosmajian, L. S., Zonderman, A. B., Costa, P. T., Benjamin, C., Robinson, J. C., Heller, B., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90822-i · Cited by 134 · see citing works
Self-citationMechanic, D. (1983) · Journal of Human Stress · doi:10.1080/0097840x.1983.9936119 · Cited by 133 · see citing works
Traub, R. J., Pechman, P. S., Iadarola, M. J., & Gebhart, G. F. (1992) · Pain · doi:10.1016/0304-3959(92)90247-9 · Cited by 132 · see citing works
Modeling and reinforcement of the sick role during childhood predicts adult illness behavior.
Whitehead, W. E., Crowell, M. D., Heller, B., Robinson, J. C., Schuster, M., & Horn, S. R. G.-V. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199411000-00010 · Cited by 128 · see citing works
Self-citationBasic and Clinical Aspects of Chronic Abdominal Pain
Mayer, E. A., & Raybould, H. E. (1993) · Medical Entomology and Zoology · Cited by 128 · see citing works
Functional abdominal pain: further evidence that whole gut is affected.
Moriarty, K. J., & Dawson, A. M. (1982) · BMJ · doi:10.1136/bmj.284.6330.1670 · Cited by 123 · see citing works
Attention and distraction: Effects on gut perception
Accarino, A., Azpiroz, F., & Malagelada, J. R. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9247458 · Cited by 121 · see citing works
Pain from Rectal Distension in Women with Irritable Bowel Syndrome (Relationship to Sexual Abuse)
Whitehead, W. E., Crowell, M. D., Davidoff, A. L., Palsson, O. S., & Schuster, M. M. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018820315549 · Cited by 110 · see citing works
Self-citationBradette, M., Delvaux, M. M., Staumont, G., Fioramonti, J., Bueno, L. P., & Frexinos, J. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02093780 · Cited by 106 · see citing works
Towards positive diagnosis of the irritable bowel
Manning, A. P., Thompson, W. G., & Heaton, K. W. (1978) · BMJ · doi:10.1136/bmj.2.6150.1496-c · Cited by 105 · see citing works
Ranking of symptoms by patients with the irritable bowel syndrome.
Maxton, D. G., Morris, J. A., & Whorwell, P. J. (1989) · BMJ · doi:10.1136/bmj.299.6708.1138 · Cited by 101 · see citing works
Altered esophageal pain threshold in irritable bowel syndrome
Costantini, M., Sturniolo, G. C., Zaninotto, G., D'Inc�, R., Polo, R., Naccarato, R., & Ancona, E. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01307536 · Cited by 99 · see citing works
Hammer, J., Phillips, S. F., Talley, N. J., & Camilleri, M. (1993) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1993.tb00131.x · Cited by 87 · see citing works
Jejunal sensorimotor dysfunction in irritable bowel syndrome: Clinical and psychosocial features
Evans, P., Bennett, E., Bak, Y., Tennant, C., & Kellow, J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566585 · Cited by 82 · see citing works
Prior, A., Serial, E., Sun, W., & Read, N. W. (1993) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199305000-00008 · Cited by 77 · see citing works
Social learning influences on menstrual symptoms and illness behavior.
Whitehead, W. E., Busch, C. M., Heller, B., & Costa, P. T. (1986) · Health Psychology · doi:10.1037/0278-6133.5.1.13 · Cited by 74 · see citing works
Self-citationThe Illness Behavior Questionnaire as an aid to clinical assessment
Pilowsky, I., Spence, N. D., Cobb, J. A., & Katsikitis, M. (1984) · General Hospital Psychiatry · doi:10.1016/0163-8343(84)90070-7 · Cited by 72 · see citing works
Reflex changes in intestinal tone: relationship to perception
Rouillon, J.-M., Azpiroz, F., & Malagelada, J. ‐. (1991) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1991.261.2.g280 · Cited by 71 · see citing works
Introspectiveness and Adolescent Symptom Reporting
Hansell, S., & Mechanic, D. (1985) · Journal of Human Stress · doi:10.1080/0097840x.1985.9936755 · Cited by 68 · see citing works
Response to intraluminal gas in irritable bowel syndrome
Galati, J., McKee, D. P., & Quigley, E. M. M. (1995) · Digestive Diseases and Sciences · doi:10.1007/bf02065555 · Cited by 61 · see citing works
Symptom duration in patients with irritable bowel syndrome.
Lembo, T., Fullerton, S. C., Diehl, D. L., Raeen, H., Munakata, J., Naliboff, B. D., & Mayer, E. A. (1996) · PubMed · Cited by 52 · see citing works
Functional Gastrointestinal Disorders: A Behavioral Medicine Approach
Latimer, P. R. (1983) · Medical Entomology and Zoology · Cited by 40 · see citing works
Self-schema in irritable bowel syndrome and depression.
Toner, B. B., Garfinkel, P. E., Jeejeebhoy, K. N., Scher, H., Shulhan, D. L., & Gasbarro, I. D. (1990) · Psychosomatic Medicine · doi:10.1097/00006842-199003000-00003 · Cited by 39 · see citing works
Irritable bowel syndrome: A test of the colonic hyperalgesia hypothesis
Latimer, P. R., Campbell, D., Latimer, M., Sarna, S. K., Daniel, E. E., & Waterfall, W. E. (1979) · Journal of Behavioral Medicine · doi:10.1007/bf00844925 · Cited by 38 · see citing works
Cognitive-behavioral treatment of functional somatic syndromes: Integrating gender issues
Toner, B. B. (1994) · Cognitive and Behavioral Practice · doi:10.1016/s1077-7229(05)80091-4 · Cited by 36 · see citing works
Visceral nociception: consequences, modulation and the future.
Gf, G. (1995) · PubMed · Cited by 33 · see citing works
Nutrient ingestion increases rectal sensitivity in humans
Musial, F., Crowell, M. D., Kalveram, K. T., & Enck, P. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90085-x · Cited by 24 · see citing works
Rectal distensibility in the irritable bowel syndrome.
Kullmann, G., & Jf, F. (1981) · PubMed · Cited by 23 · see citing works
Sensational developments in the irritable bowel.
Naliboff, B. D., & Mayer, E. A. (1996) · Gut · doi:10.1136/gut.39.5.770 · Cited by 15 · see citing works
Bradette, M., Delvaux, M. M., Staumont, G., Fioramonti, J., Bueno, L. P., & Frexinos, J. (1994) · HAL · Cited by 15 · see citing works
Whttehead, W., Diamant, N., Meyer, K., Mikula, K., Hu, J., Jia, H., Bangdiwala, S. I., Toner, B. B., & Drossman, D. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)83500-2 · Cited by 14 · see citing works
Functional Gastrointestinal Disorders: A Behavioral Medicine Approach
Whitehead, W. W. (1984) · Psychosomatics · doi:10.1016/s0033-3182(84)73002-7 · Cited by 14 · see citing works
Self-citationFunctional abdominal pain: further evidence that whole gut is affected
&NA;, &. (1983) · Pain · doi:10.1016/0304-3959(83)90047-7 · Cited by 12 · see citing works
Introspection and illness behavior.
Mechanic, D., & Hansell, S. (1987) · PubMed · Cited by 10 · see citing works
Irritable bowel syndrome: a study to investigate the mechanism(s) of visceral hypersensitivity.
Greenwood, B., Rodriguez, S., Decktor, D. L., Maton, P. N., & Robinson, M. (1996) · PubMed · Cited by 7 · see citing works
The Colonic Air Insufflation Test Indicates a Colonic Cause of Abdominal Pain
Kang, J.-Y., Gwee, K., & Yap, I. (1994) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199401000-00006 · Cited by 6 · see citing works
Flagged first, then by citations
1 of the 85 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Metivier S, Delvaux D, Louvel D, Lagier E, Fioramonti J, Bueno L, Frexinos J. Influence of stress on sensory thresholds to rectal distension in healthy volunteers (abstr). Gastroenterology 1996; 110:A717.
- Palsson OS, McCommons JJ, Burnett CK, Bradley LA, Whitehead WE. Relationship between bowel sensations: pain, urge to defecate and rectal fullness in iritable bowel syndrome (IBS) patients and healthy subjects (abstr). Gastroenterology 1995;108: A663.
- Bradley L, Richter J, Scarinci IC, Haile JE, Schan CA. Mechanisms of altered pain perception in non-cardiac chest pain patients (abstr). Gastroenterology 1993;104:A482.
- Mertz H, Fass R, Hirsh T, Yan-Go F, Mayer EA. Amitryptiline for functional dyspepsia: effect on symptoms, gastic sensitivity and sleep (abstr). Gastroenterology 1995;108:A649.
- Bell AM, Pemberton JH, Camilleri M, Hanson RB, Zinsmeister AR. The effect of acute stress on rectal tone and anal sphincter pressure (abstr). Gastroenterology 1989;96:A38.
- Crowell M, Musial F, Kollmannsperger P, Mueller J, Orr WC. Association of rectal tone during stress with sensitivity to disten- sion in the irritable bowel syndrome (abstr). Am J Gastroenterol 1993;88:1572.
Cited by
Sorted by citations
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
Self-citationWhitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Self-citationFunctional anorectal disorders.
Bharucha, A., Wald, A., Enck, P., & Rao, S. S. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.064 · Cited by 770 · see citing works
Mertz, H., Morgan, V. L., Tanner, G., Pickens, D. R., Price, R. R., Shyr, Y., & KESSLER, R. M. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70170-3 · Cited by 585 · see citing works
Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification
Maixner, W., Fillingim, R. B., Williams, D. A., Smith, S. B., & Slade, G. D. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2016.06.002 · Cited by 558 · see citing works
Rao, S. S. C., Bharucha, A., Chiarioni, G., Felt-Bersma, R., Knowles, C., Malcolm, A., & Wald, A. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.009 · Cited by 364 · see citing works
Bouin, M., Plourde, V., Boivin, M., Riberdy, M., Lupien, F., Laganière, M., Verrier, P., & Poitras, P. (2002) · Gastroenterology · doi:10.1053/gast.2002.33601 · Cited by 470 · see citing works
Müller-Lissner, S. A., Fumagalli, I. A. L., Bardhan, K. D., Pace, F., Pecher, E., Nault, B., & Rüegg, P. C. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01094.x · Cited by 462 · see citing works
Mechanisms of hypersensitivity in IBS and functional disorders
Azpiroz, F., Bouin, M., Camilleri, M., Mayer, E. A., Poitras, P., Serra, J., & Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00875.x · Cited by 353 · see citing works
Naliboff, B. D., Derbyshire, S. W. G., Munakata, J., Berman, S. M., Mandelkern, M. A., Chang, L., & Mayer, E. A. (2001) · Psychosomatic Medicine · doi:10.1097/00006842-200105000-00006 · Cited by 324 · see citing works
Gaylord, S. A., Palsson, O. S., Garland, E. L., Faurot, K. R., Coble, R. S., Mann, D. J., Frey, W., Leniek, K., & Whitehead, W. E. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.184 · Cited by 281 · see citing works
“Hence, we theorized that mindfulness training may be uniquely suited to treat the psychological factors associated with IBS, including a heightened perception of pain from intestinal distention (”
BackgroundSelf-citationSimrén, M., Törnblom, H., Palsson, O. S., van Tilburg, M. A. L., Van Oudenhove, L., Tack, J., & Whitehead, W. E. (2018) · Gut · doi:10.1136/gutjnl-2016-312361 · Cited by 254 · see citing works
Self-citationBurke, W. J., & McArthur-Miller, D. A. (2001) · PubMed · Cited by 255 · see citing works
Elsenbruch, S., Rosenberger, C., Enck, P., Forsting, M., Schedlowski, M., & Gizewski, E. R. (2010) · Gut · doi:10.1136/gut.2008.175000 · Cited by 242 · see citing works
Berman, S. M., Naliboff, B. D., Suyenobu, B. Y., Labus, J. S., Stains, J., Ohning, G., Kilpatrick, L. A., Bueller, J. A., Ruby, K., Jarcho, J. M., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2500-07.2008 · Cited by 233 · see citing works
Layer, P., Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S., Claßen, M., Enck, P., Frieling, T., Haag, S., Holtmann, G., et al. (2011) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0029-1245976 · Cited by 231 · see citing works
Visceral hyperalgesia in children with functional abdominal pain
Lorenzo, C. D., Youssef, N. N., Sigurðsson, L., Scharff, L., Griffiths, J., & Wald, A. M. (2001) · The Journal of Pediatrics · doi:10.1067/mpd.2001.118883 · Cited by 223 · see citing works
Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity
Posserud, I., Syrous, A., Lindström, L., Tack, J., Abrahamsson, H., & Simrén, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.024 · Cited by 248 · see citing works
van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works
Ki Cha, B., Mun Jung, S., Hwan Choi, C., Song, I.-D., Woong Lee, H., Joon Kim, H., Hyuk, J., Kyung Chang, S., Kim, K., Chung, W.-S., et al. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823712b1 · Cited by 216 · see citing works
Coelho, A.-M., Vergnolle, N., Guiard, B. P., Fioramonti, J., & Bueno, L. P. (2002) · Gastroenterology · doi:10.1053/gast.2002.32387 · Cited by 212 · see citing works
PTSD and stress sensitisation: A tale of brain and body
Stam, R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.11.010 · Cited by 211 · see citing works
Houghton, L. A., Fell, C., Whorwell, P. J., Jones, I., Sudworth, D. P., & Gale, J. D. (2007) · Gut · doi:10.1136/gut.2006.110858 · Cited by 204 · see citing works
Robinson, D. R., McNaughton, P. A., Evans, M. L., & Hicks, G. A. (2004) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00456.x · Cited by 204 · see citing works
Visceral hypersensitivity: facts, speculations, and challenges
Camilleri, M., COULIE, B., & Tack, J. F. (2001) · Gut · doi:10.1136/gut.48.1.125 · Cited by 204 · see citing works
Naliboff, B. D., Berman, S. M., Suyenobu, B. Y., Labus, J. S., Chang, L., Stains, J., Mandelkern, M. A., & Mayer, E. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.014 · Cited by 195 · see citing works
Palsson, O. S., Turner, M. J., Johnson, D. A., Burnett, C. K., & Whitehead, W. E. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020545017390 · Cited by 195 · see citing works
Self-citationGut memories: Towards a cognitive neurobiology of irritable bowel syndrome
Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.001 · Cited by 193 · see citing works
Talley, N. J., Dennis, E. H., Schettler-Duncan, V. A., Lacy, B. E., Olden, K. W., & Crowell, M. D. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07699.x · Cited by 239 · see citing works
Dorn, S. D., Palsson, O. S., Thiwan, S., Kanazawa, M., Clark, W. C., van Tilburg, M. A. L., Drossman, D. A., Scarlett, Y. V., Levy, R. L., Ringel, Y., et al. (2007) · Gut · doi:10.1136/gut.2006.117390 · Cited by 191 · see citing works
Self-citationPeripheral and central mechanisms of visceral sensitization in man
Anand, P., Aziz, Q., Willert, R. P., & Oudenhove, L. V. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00873.x · Cited by 183 · see citing works
Bharucha, A. E. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00329-9 · Cited by 180 · see citing works
Lea, R., Houghton, L. A., Calvert, E. L., Larder, S., Gonsalkorale, W. M., Whelan, V., Randles, J., Cooper, P., Cruickshanks, P., Miller, V., et al. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01486.x · Cited by 172 · see citing works
Familial aggregation of irritable bowel syndrome: a prospective study
Kalantar, J. S., Locke, G. R., Zinsmeister, A. R., Beighley, C. M., & Talley, N. J. (2003) · Gut · doi:10.1136/gut.52.12.1703 · Cited by 168 · see citing works
Larsson, M., Tillisch, K., Craig, A. D., Engström, M., Labus, J. S., Naliboff, B. D., Lundberg, P., Ström, M., Mayer, E. A., & Walter, S. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.022 · Cited by 169 · see citing works
Alterations in rectal sensitivity and motility in childhood irritable bowel syndrome
van Ginkel, R., Voskuijl, W. P., Benninga, M. A., Taminiau, J. A. J. M., & Boeckxstaens, G. E. (2001) · Gastroenterology · doi:10.1053/gast.2001.20898 · Cited by 166 · see citing works
Functional GI disorders: from animal models to drug development
Mayer, E. A., Bradesi, S., Chang, L., Spiegel, B. M. R., Bueller, J. A., & Naliboff, B. D. (2007) · Gut · doi:10.1136/gut.2006.101675 · Cited by 162 · see citing works
Central neural mechanisms mediating human visceral hypersensitivity
Sarkar, S., Hobson, A. R., Furlong, P. L., Woolf, C. J., Thompson, D. G., & Aziz, Q. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.5.g1196 · Cited by 159 · see citing works
Pace, F., Molteni, P., Bollani, S., Sarzi‐Puttini, P., Stockbrügger, R., Porro, G. B., & Drossman, D. A. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310004524 · Cited by 157 · see citing works
What determines severity among patients with painful functional bowel disorders?
Drossman, D. A., Whitehead, W. E., Toner, B. B., Diamant, N. E., Hu, Y., Bangdiwala, S. I., & Jia, H. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01936.x · Cited by 152 · see citing works
Self-citationUpdate of Tests of Colon and Rectal Structure and Function
Bharucha, A. E. (2005) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000196190.42296.a9 · Cited by 148 · see citing works
Choi, C. H., Jo, S. Y., Park, H. J., Chang, S. K., Byeon, J.-S., & Myung, S.-J. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318204593e · Cited by 144 · see citing works
Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome
Barbara, G., Cremon, C., GIORGIO, R. D., Dothel, G., Zecchi, L., Bellacosa, L., Carini, G., Stanghellini, V., & Corinaldesi, R. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0195-7 · Cited by 144 · see citing works
Principles of applied neurogastroenterology: physiology/motility–sensation
Kellow, J. E., Delvaux, M. M., Azpiroz, F., Camilleri, M., Quigley, E. M. M., & Thompson, D. G. (1999) · Gut · doi:10.1136/gut.45.2008.ii17 · Cited by 140 · see citing works
van der Veek, P. P. J., van Rood, Y. R., & Masclee, A. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.12.005 · Cited by 119 · see citing works
Plasticity in the enteric nervous system
Giaroni, C., De Ponti, F., Cosentino, M., Lecchini, S., & Frigo, G. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70295-7 · Cited by 119 · see citing works
Piché, M., Arsenault, M., Poitras, P., Rainville, P., & Bouin, M. (2009) · Pain · doi:10.1016/j.pain.2009.10.005 · Cited by 120 · see citing works
Applied Principles of Neurogastroenterology: Physiology/Motility Sensation
Kellow, J. E., Azpiroz, F., Delvaux, M. M., Gebhart, G. F., Mertz, H. R., Quigley, E. M. M., & Smout, A. J. P. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.08.061 · Cited by 117 · see citing works
Chan, C. L., Lunniss, P. J., Wang, D., Williams, N. S., & Scott, S. M. (2005) · Gut · doi:10.1136/gut.2005.071613 · Cited by 113 · see citing works
Guthrie, E., Creed, F. H., Fernandes, L., Ratcliffe, J., der Jagt, J. V., Martin, J., Howlett, S., Read, N., Barlow, J. D., Thompson, D., et al. (2003) · Gut · doi:10.1136/gut.52.11.1616 · Cited by 112 · see citing works
Bouin, M., Meunier, P., Riberdy, M., & Poitras, P. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1012356827026 · Cited by 111 · see citing works
Brain imaging of visceral functions in healthy volunteers and IBS patients
Rapps, N., Oudenhove, L. V., Enck, P., & Aziz, Q. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.02.018 · Cited by 105 · see citing works
Kilkens, T. O. C., Honig, A., van Nieuwenhoven, M. A., Riedel, W. J., & Brummer, R. J. (2004) · Gut · doi:10.1136/gut.2004.041657 · Cited by 103 · see citing works
Inflammation in irritable bowel syndrome: Myth or new treatment target?
Sinagra, E., Pompei, G., Tomasello, G., Cappello, F., Morreale, G. C., Amvrosiadis, G., Rossi, F., Monte, A. I. L., Rizzo, A. G., & Raimondo, D. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2242 · Cited by 102 · see citing works
Neurophysiologic Assessment of Esophageal Sensory Processing in Noncardiac Chest Pain
Hobson, A. R., Furlong, P. L., Sarkar, S., Matthews, P., Willert, R. P., Worthen, S. F., Unsworth, B. J., & Aziz, Q. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.10.016 · Cited by 101 · see citing works
Subjective and Objective Sleep Quality in Irritable Bowel Syndrome
Elsenbruch, S., HARNISH, M., & Orr, W. C. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01374.x · Cited by 101 · see citing works
Chan, C. L. H., Scott, S. M., Williams, N. S., & Lunniss, P. J. (2004) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0774-x · Cited by 100 · see citing works
Outcome measures for fecal incontinence: anorectal structure and function
Bharucha, A. E. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.10.014 · Cited by 99 · see citing works
Is irritable bowel syndrome an organic disorder?
El‐Salhy, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i2.384 · Cited by 95 · see citing works
Negative Mood Affects Brain Processing of Visceral Sensation
Coen, S. J., Yágüez, L., Aziz, Q., Mitterschiffthaler, M. T., Brammer, M. J., Williams, S., & Gregory, L. J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.052 · Cited by 90 · see citing works
Brain imaging and functional gastrointestinal disorders: has it helped our understanding?
Hobson, A. R. (2004) · Gut · doi:10.1136/gut.2003.035642 · Cited by 91 · see citing works
Faure, C. C., & Wieckowska, A. (2006) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2006.08.072 · Cited by 90 · see citing works
Mertz, H. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01447.x · Cited by 90 · see citing works
Talley, N. J. (2006) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2006.01217.x · Cited by 86 · see citing works
Evolution of Visceral Sensitivity in Patients with Irritable Bowel Syndrome
Poitras, P., Riberdy, M., Plourde, V., Boivin, M., & Verrier, P. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1014729125428 · Cited by 85 · see citing works
Ringel, Y., Drossman, D. A., Turkington, T. G., Bradshaw, B. H., Hawk, T. C., Bangdiwala, S. I., Coleman, R. E., & Whitehead, W. E. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1025455330704 · Cited by 84 · see citing works
Self-citationReal-time imaging of human cortical activity evoked by painful esophageal stimulation
Hobson, A. R., Furlong, P. L., Worthen, S. F., Hillebrand, A., Barnes, G. R., Singh, K. D., & Aziz, Q. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.033 · Cited by 84 · see citing works
Functional findings in irritable bowel syndrome
Posserud, I. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i18.2830 · Cited by 83 · see citing works
Simrén, M., Abrahamsson, H., & Björnsson, E. S. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.09.032 · Cited by 83 · see citing works
Heymen, S., Maixner, W., Whitehead, W. E., Klatzkin, R. R., Mechlin, B., & Light, K. C. (2010) · The Clinical Journal of Pain · doi:10.1097/ajp.0b013e3181bff800 · Cited by 82 · see citing works
Self-citationBasic Pathophysiologic Mechanisms in Irritable Bowel Syndrome
Mayer, E. A., Naliboff, B. D., & Chang, L. (2001) · Digestive Diseases · doi:10.1159/000050682 · Cited by 81 · see citing works
Reproducibility of Gastric Barostat Studies in Healthy Controls and in Dyspeptic Patients
Sarnelli, G., Vos, R. D., Cuomo, R., Janssens, J., & Tack, J. F. (2001) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03520.x · Cited by 80 · see citing works
Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome
Barkhordari, E., Rezaei, N., Ansaripour, B., Larki, P., Alighardashi, M., Ahmadi-Ashtiani, H. R., Mahmoudi, M., Keramati, M.-R., Habibollahi, P., Bashashati, M., et al. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9342-4 · Cited by 78 · see citing works
Layer, P., Andresen, V., Allescher, H. ‐., Bischoff, S. C., Claßen, M., Elsenbruch, S., Freitag, M., Frieling, T., Gebhard, M., Goebel‐Stengel, M., et al. (2021) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1591-4794 · Cited by 78 · see citing works
Drossman, D. A. (2005) · Gut · doi:10.1136/gut.2004.058446 · Cited by 76 · see citing works
Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission
Vannucchi, M. G., & Evangelista, S. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7010004 · Cited by 75 · see citing works
Guthrie, E., Barlow, J., Fernandes, L., Ratcliffe, J., Read, N., Thompson, D. G., Tomenson, B., & Creed, F. H. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000128899.22514.c0 · Cited by 74 · see citing works
Cremonini, F., & Talley, N. (2004) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2004.02184.x · Cited by 80 · see citing works
Ringel, Y., Whitehead, W. E., Toner, B. B., Diamant, N. E., Hu, Y., Jia, H., Bangdiwala, S. I., & Drossman, D. A. (2004) · Gut · doi:10.1136/gut.2003.021725 · Cited by 72 · see citing works
Self-citationRana, S., Sharma, S., Sk, S., Parsad, K., Malik, A., & Singh, K. (2012) · Tropical Gastroenterology · doi:10.7869/tg.2012.66 · Cited by 71 · see citing works
Labus, J. S., Naliboff, B. D., Berman, S. M., Suyenobu, B. Y., Vianna, E., Tillisch, K., & Mayer, E. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.078 · Cited by 71 · see citing works
Zhang, X., Li, Z., Leung, W.-M., Liu, L., Xu, H., & Bian, Z. (2008) · Journal of Pain · doi:10.1016/j.jpain.2007.12.009 · Cited by 71 · see citing works
Xu, X., Zhang, Y. L., Liu, L., Pan, L., & Yao, S. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13848 · Cited by 71 · see citing works
Development, plasticity and modulation of visceral afferents
Christianson, J. A., Bielefeldt, K., Altier, C., Cenac, N., Davis, B. M., Gebhart, G. F., High, K. W., Kollarik, M., Randich, A., Undem, B., et al. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.004 · Cited by 80 · see citing works
Day‐to‐day reproducibility of anorectal sensorimotor assessments in healthy subjects
Bharucha, A. E., Seide, B. M., Fox, J. C., & Zinsmeister, A. R. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00499.x · Cited by 68 · see citing works
Nutrient‐dependent enhancement of rectal sensitivity in irritable bowel syndrome (IBS)
Simrén, M., Agerforz, P., Björnsson, E. S., & Abrahamsson, H. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00849.x · Cited by 65 · see citing works
Drewes, A. M., Petersen, P., Rössel, P., Gao, C., Hansen, J. B., & Arendt‐Nielsen, L. (2001) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655201750313351 · Cited by 65 · see citing works
Systematic review: instruments to assess abdominal pain in irritable bowel syndrome
Mujagic, Z., Keszthelyi, D., Aziz, Q., Reinisch, W., Quetglas, E. G., Leonardis, F. D., Segerdahl, M., & Masclee, A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13378 · Cited by 64 · see citing works
Psychosocial aspects of functional gastrointestinal disorders
Budavari, A. I., & Olden, K. W. (2003) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(03)00030-x · Cited by 63 · see citing works
Testing the sensitivity hypothesis in practice: tools and methods, assumptions and pitfalls
Camilleri, M. (2002) · Gut · doi:10.1136/gut.51.suppl_1.i34 · Cited by 62 · see citing works
Hubbard, C. S., Hong, J., Jiang, Z., Ebrat, B., Suyenobu, B. Y., Smith, S. E., Heendeniya, N., Naliboff, B. D., Tillisch, K., Mayer, E. A., et al. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12622 · Cited by 61 · see citing works
Viscoelastic properties of the human colon
Bharucha, A. E., Hubmayr, R. D., Ferber, I. J., & Zinsmeister, A. R. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.2.g459 · Cited by 60 · see citing works
Gale, J. D., & Houghton, L. A. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00028 · Cited by 58 · see citing works
Gregory, L. J., Yágüez, L., Williams, S., Altmann, C., Coen, S. J., Ng, V., Brammer, M. J., Thompson, D., & Aziz, Q. (2003) · Gut · doi:10.1136/gut.52.12.1671 · Cited by 58 · see citing works
Brain-gut axis as an example of the bio-psycho-social model: Figure 1
Wilhelmsen, I. (2000) · Gut · doi:10.1136/gut.47.suppl_4.iv5 · Cited by 65 · see citing works
Chest Pain in Patients With Cardiac and Noncardiac Disease
Sheps, D. S., Creed, F. H., & Clouse, R. E. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000146330.80895.77 · Cited by 56 · see citing works
Peripheral factors in the pathophysiology of irritable bowel syndrome
Gunnarsson, J., & Simrén, M. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.07.006 · Cited by 57 · see citing works
Bacteria and irritable bowel syndrome: The evidence for small intestinal bacterial overgrowth
Lee, H.-R., & Pimentel, M. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0051-3 · Cited by 57 · see citing works
Andresen, V., Bach, D. R., Poellinger, A., Tsrouya, C., Stroh, A., Förschler, A., Georgiewa, P., Zimmer, C., & Mönnikes, H. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00720.x · Cited by 57 · see citing works
Hypervigilance in irritable bowel syndrome compared with organic gastrointestinal disease
Posserud, I., Svedlund, J., Wallin, J., & Simrén, M. (2009) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2008.09.020 · Cited by 56 · see citing works
- Authors
- WHITEHEAD, W., & PALSSON, O.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Eastern Virginia Medical School (US)
- ORCID
- PALSSON, O
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 115
- Issue
- 5
- Pages
- 1263-1271
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2150287168
- Cited by
- 314
- References
- 85
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 12 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (2k05mh000133-17)
- National Institute of Mental Health (KO5 MH00133)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK031369, R01 DK31369)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Keywords
- irritable bowel syndrome, pain threshold, rectal distension, hyperalgesia, anxiety, depression, stress, sensitization, neuroimaging, selective attention, disease attribution, biomarkers
- MeSH terms
- Colonic Diseases, Functional, Humans, Pain, Rectum, Biomarkers, Pain Threshold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
