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Cited by 286Exercise and Physiological ResponsesAntioxidant Activity and Oxidative StressPhysical Activity and Health

Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women

Elosua, R, Molina, L, Fito, M, Arquer, A, Sanchez-Quesada, J.L, Covas, M.I, Ordoñez-Llanos, J, Marrugat, J·2003·Atherosclerosis
DOI 10.1016/s0021-9150(03)00018-2
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Abstract

Physical activity (PA) is associated with a reduced risk of coronary heart disease, and may favorably modify the antioxidant-prooxidant balance. This study assessed the effects of aerobic PA training on antioxidant enzyme activity, oxidized LDL concentration, and LDL resistance to oxidation, as well as the effect of acute PA on antioxidant enzyme activity before and after the training period. Seventeen sedentary healthy young men and women were recruited for 16 weeks of training. The activity of superoxide dismutase in erythrocytes (E-SOD), glutathione peroxidase in whole blood (GSH-Px), and glutathione reductase in plasma (P-GR), and the oxidized LDL concentration and LDL composition, diameter, and resistance to oxidation were determined before and after training. Shortly before and after this training period they also performed a bout of aerobic PA for 30 min. The antioxidant enzyme activity was also determined at 0 min, 30 min, 60 min, 120 min, and 24 h after both bouts of PA. Training induces an increase in GSH-Px (27.7%), P-GR (17.6%), and LDL resistance to oxidation, and a decrease in oxidized LDL (-15.9%). After the bout of PA, an increase in E-SOD and GSH-Px was observed at 0 min, with a posterior decrease in enzyme activity until 30-60 min, and a tendency to recover the basal values at 120 min and 24 h. Training did not modify this global response pattern. Regular PA increases endogenous antioxidant activity and LDL resistance to oxidation, and decreases oxidized LDL concentration; 30 min of aerobic PA decreases P-GR and B-GSH-Px activity in the first 30-60 min with a posterior recovery.

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  • Varady et al. found that LDL particle volume decreased in patients with hypercholesterolemia after aerobic exercise.

    “Varady et al. [40] found that the LDL particle volume decreased in patients with hypercholesterolemia after aerobic exercise.”

    From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [40]

  • Elosua et al. suggested that aerobic exercise had no effect on LDL particle diameter.

    “Elosua et al. [40] suggested that aerobic exercise had no effect on LDL particle diameter.”

    From Effects of aerobic exercise on lipids and lipoproteins (2017) · cites this paper as [40]

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Authors
Elosua, R., Molina, L., Fito, M., Arquer, A., Sanchez-Quesada, J. L., Covas, M. I., Ordoñez-Llanos, J., & Marrugat, J.
ORCID
Marrugat, J
Venue
Atherosclerosis
Publisher
Elsevier BV
Published
2003-04
Volume
167
Issue
2
Pages
327-334
ISSN
0021-9150 (ISSN-L)
DOI
10.1016/s0021-9150(03)00018-2
OpenAlex
W2103973623
Cited by
286
References
37
Citations by year
2026: 2 · 2025: 5 · 2024: 13 · 2023: 16 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 8 · 2016: 15 · 2015: 16 · 2014: 18 · 2013: 13 · 2012: 18
FWCI
10.57
Type
journal article
Language
en
Update notices
erratum (2008-04-01)
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Atherosclerosis (publishedVersion)
  • PubMed (publishedVersion)
Funders
Eli Lilly and Company
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
aerobic physical activity, oxidative stress, antioxidant enzymes, superoxide dismutase, glutathione peroxidase, glutathione reductase, oxidized LDL, LDL oxidation resistance, acute exercise, sedentary young adults, erythrocytes, coronary heart disease risk
MeSH terms
Adult, Female, Glutathione Peroxidase, Humans, Lipoproteins, LDL, Male, Oxidation-Reduction, Particle Size, Physical Education and Training, Physical Fitness, Probability, Reference Values, Sensitivity and Specificity, Superoxide Dismutase, Time Factors, Lipid Peroxidation, Cohort Studies, Biomarkers, Exercise, Linear Models, Oxidative Stress

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