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Cited by 171Physical Activity and HealthExercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Association between physical activity, physical performance, and inflammatory biomarkers in an elderly population: the InCHIANTI study

Elosua, R., Bartali, B., Ordovas, J. M., Corsi, A. M., Lauretani, F., Ferrucci, L., on Behalf of the InCHIANTI Investigators·2005·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
DOI 10.1093/gerona/60.6.760
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Abstract

BACKGROUND: Our aim was to determine the association between physical activity and physical performance, and inflammatory biomarkers in elderly persons. METHODS: One thousand four persons aged 65 years or more, participants in a cross-sectional population-based study, were included. Interviewers collected information on self-reported physical activity during the previous year. Moreover, 841 participants performed a 400-meter walking test to assess physical performance. Plasma concentrations of inflammatory biomarkers were determined. RESULTS: Compared to sedentary men, men practicing light and moderate-high physical activity had a significantly lower erythrocyte sedimentation rate (-0.33 and -0.40 mm/h; p =.023 and p =.006, respectively), fibrinogen level (-43 and -39 mg/dL; p =.001 and p =.004, respectively), and logarithm of C-reactive protein (CRP) (-0.43 and -0.73 mg/L; p =.025 and p <.001, respectively), whereas only those men practicing moderate-high physical activity had a significantly lower uric acid level (-0.57 mg/dL; p =.023), log(interleukin 6) levels (-0.33 pg/mL; p =.014), and log(tumor necrosis factor-alpha) (-0.31 pg/mL; p =.030). In women, those practicing light and moderate-high physical activity had significantly lower uric acid (-0.45 and -0.34 mg/dL; p =.001 and p =.039, respectively) and log(interleukin 6) levels (-0.18 and -0.30 pg/mL; p =.043 and p =.004, respectively); only those women practicing moderate-high physical activity had significantly lower log(CRP) (-0.31 mg/L; p =.020). In women, when the analysis was adjusted for body mass index, the association between physical activity and CRP was no longer significant. Similar findings were observed when we carried these analyses according to physical performance. CONCLUSIONS: Current physical activity practice and performance are associated with inflammatory biomarkers. A significant beneficial association is already observed with light physical activity practice and intermediate performance.

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Crossref · 10.1093/gerona/60.6.760

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  • Most intervention studies with vitamin D have failed to identify a reduction in markers of low-grade inflammation.

    “Most intervention studies with vitamin D have failed to identify a reduction in markers of low-grade inflammation (744,749,750) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [750]

  • In vitro, vitamin E exerts a range of anti-inflammatory actions on pro-inflammatory cytokine and eicosanoid production and on adhesive interactions of monocytes with endothelial cells.

    “In vitro, vitamin E exerts a range of anti-inflammatory actions with regard to the production of pro-inflammatory cytokines and eicosanoids and adhesive interactions of monocytes with endothelial cells (750,759 -761) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [750]

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Authors
Elosua, R., Bartali, B., Ordovas, J. M., Corsi, A. M., Lauretani, F., Ferrucci, L., & on Behalf of the InCHIANTI Investigators
Affiliations
  • Tufts University (US)
  • National Institutes of Health (US)
ORCID
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Publisher
Oxford University Press (OUP)
Published
2005-06-01
Volume
60
Issue
6
Pages
760-767
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
DOI
10.1093/gerona/60.6.760
OpenAlex
W2151579767
Cited by
171
References
43
Citations by year
2026: 3 · 2025: 7 · 2024: 3 · 2023: 11 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 10 · 2018: 9 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 6
FWCI
4.99
Type
journal article
Language
en
Open access
closed
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture (HL54776, 58-1950-9-001, 53‐K06‐5‐10)
  • Ministero della Salute
  • National Institutes of Health (58-1950-9-001)
  • National Institute on Aging (HL54776, 58-1950-9-001, 53-K06-5-10)
  • National Heart, Lung, and Blood Institute (HL54776, 58-1950-9-001, R01HL054776, 53-K06-5-10)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
physical activity, physical performance, inflammatory markers, older adults, C-reactive protein, fibrinogen, erythrocyte sedimentation rate, uric acid, interleukin-6, TNF-α, sex differences, sedentary behavior, body mass index
MeSH terms
Aged, Aged, 80 and over, Blood Sedimentation, C-Reactive Protein, Cross-Sectional Studies, Female, Fibrinogen, Humans, Inflammation, Interleukins, Interviews as Topic, Male, Motor Activity, Uric Acid, Biomarkers, Walking

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