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Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
Open accessAbstract
Vesicles are released during the in vitro culture of sheep reticulocytes which can be harvested by centrifugation at 100,000 X g for 90 min. These vesicles contain a number of activities, characteristic of the reticulocyte plasma membrane, which are known to diminish or disappear upon reticulocyte maturation. The activities include acetylcholinesterase, cytochalasin B binding (glucose transporter) nucleoside binding (i.e. nucleoside transporter), Na+-independent amino acid transport, and the transferrin receptor. Enzymes of cytosolic origin are not detectable or are present at low activity in the vesicles. Cultures of whole blood, mature red cells, or white cells do not yield comparable levels of these activities, supporting the conclusion that the activities arise from the reticulocytes. In addition, the lipid composition of the vesicles shows the high sphingomyelin content characteristic of sheep red cell plasma membranes, but not white cell or platelet membranes, also consistent with the conclusion that the vesicles are of reticulocyte origin. It is suggested that vesicle externalization may be a mechanism for shedding of specific membrane functions which are known to diminish during maturation of reticulocytes to erythrocytes.
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“Exosomes range between 30–100 nm in diameter, have a bilayered membrane (Johnstone et al., 1987) and express surface marker such as CD63 (Christianson et al., 2013).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Johnstone et al., 1987
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes
Dodge, J. T., Mitchell, C. D., & Hanahan, D. J. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90042-0 · Cited by 4,419
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042
Self-citationHarding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775
Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242
Self-citationForm and function of phospholipids
ANSELL, G. B., Hawthorne, J. N., & DAWSON, R. M. C. (1973) · Medical Entomology and Zoology · Cited by 1,069
Post, R. L., Merritt, C. R., Kinsolving, C. R., & Albright, C. D. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76884-7 · Cited by 1,060
Research works printed but not linked: 4
- Sanchez, 1986, Biochim. Biophys. Acta, 856, 113
- Firkin, 1963, Aust. Ann. Med., 12, 26
- Harding, 1984, Eur. J. Cell. Biol., 35, 256
- Zweig, 1981, J. Supramol. Struct., 17, 163
Cited by
Sorted by citations
Items 401–500 of 1,010
Taverna, S., Giallombardo, M., Pucci, M., Flugy, A. M., Manno, M., Raccosta, S., Rolfo, C. D., Leo, G. D., & Alessandro, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4204 · Cited by 139
The emerging role of exosomes in Alzheimer’s disease
Zhang, T., Ma, S., Lv, J., Wang, X., Afewerky, H. K., Li, H. R., & Lu, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101321 · Cited by 141
New therapeutic approaches of mesenchymal stem cells-derived exosomes
Janočková, J., Slovinská, L., Harvanová, D., Špaková, T., & Rosocha, J. (2021) · Journal of Biomedical Science · doi:10.1186/s12929-021-00736-4 · Cited by 140
Extracellular Vesicles in Cancer Drug Resistance: Roles, Mechanisms, and Implications
Yang, Q., Xu, J. B., Gu, J., Shi, H., Zhang, J., Zhang, J., Chen, Z., Fang, X., Zhu, T., & Zhang, X. (2022) · Advanced Science · doi:10.1002/advs.202201609 · Cited by 148
The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise
Vechetti, I. J., Valentino, T., Mobley, C. B., & McCarthy, J. J. (2021) · The Journal of Physiology · doi:10.1113/jp278929 · Cited by 141
Zhao, D., Yu, Z., Li, Y., Wang, Y., Li, Q., & Han, D. (2020) · Journal of Molecular Histology · doi:10.1007/s10735-020-09877-6 · Cited by 139
Intercellular communication by exosomes in placenta: A possible role in cell fusion?
Record, M. (2014) · Placenta · doi:10.1016/j.placenta.2014.02.009 · Cited by 140
Diabetic Nephropathy: Perspective on Extracellular Vesicles
Lu, Y., Liu, D., Feng, Q., & Liu, Z. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00943 · Cited by 141
Circulating biomarkers to monitor cancer progression and treatment
Rapisuwon, S., Vietsch, E. E., & Wellstein, A. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.05.004 · Cited by 143
Beaudoin, A. R., & Grondin, G. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(91)90014-n · Cited by 139
Singh, P., LeMaire, C., Tan, J. C., Zeng, E., & Schorey, J. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018564 · Cited by 138
Exosome-mediated communication in the ovarian follicle
Pietro, C. D. (2016) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-016-0657-9 · Cited by 136
Emerging roles of extracellular vesicles in neurodegenerative disorders
You, Y., & Ikezu, T. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104512 · Cited by 138
Mignatti, P., & Rifkin, D. B. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470303 · Cited by 136
The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein
Hasegawa, T., Konno, M., Baba, T., Sugeno, N., Kikuchi, A., Kobayashi, M., Miura, E., Tanaka, N., Tamai, K., Furukawa, K., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029460 · Cited by 138
Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells
Kanlikilicer, P., Rashed, M. H., Bayraktar, R., Mitra, R., Ivan, C., Aslan, B., Zhang, X., Filant, J., da Silva, A. M., Rodriguez‐Aguayo, C., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0714 · Cited by 136
Chong, S. Y., Lee, C. K., Huang, C., Ou, Y. H., Charles, C. J., Richards, M., Neupane, Y. R., Pavón, M. V., Zharkova, O., Pastorin, G., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133272 · Cited by 138
Xia, X., Wang, S., Ni, B., Xing, S., Cao, H., Zhang, Z., Yu, F., Zhao, E., & Zhao, G. (2020) · Oncogene · doi:10.1038/s41388-020-01425-6 · Cited by 140
Exosomal ncRNAs: Novel therapeutic target and biomarker for diabetic complications
Xu, Y., Pu, S., Li, X., Yu, Z.-W., Zhang, Y., Tong, X., Shan, Y., & Gao, X. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106135 · Cited by 137
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Fan, Y., Chen, Z., & Zhang, M. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03493-6 · Cited by 134
“These vesicles were then named as "exosome" by Johnstone in 1987 [11].”
BackgroundThe potential of tumor-derived exosomes for noninvasive cancer monitoring
Whiteside, T. L. (2015) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2015.1071666 · Cited by 135
Exosomal RNA from Mycobacterium tuberculosis‐Infected Cells Is Functional in Recipient Macrophages
Singh, P., Li, L., & Schorey, J. S. (2015) · Traffic · doi:10.1111/tra.12278 · Cited by 136
The Role of Exosomes in Breast Cancer
Lowry, M. C., Gallagher, W. M., & O’Driscoll, L. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2015.240028 · Cited by 137
Physiological and pathological impact of exosomes of adipose tissue
Zhang, Y., Yu, M., & Tian, W. (2016) · Cell Proliferation · doi:10.1111/cpr.12233 · Cited by 133
Exosome: Function and Role in Cancer Metastasis and Drug Resistance
Zhang, C., Ji, Q., Yang, Y., Li, Q., & Wang, Z. (2018) · Technology in Cancer Research & Treatment · doi:10.1177/1533033818763450 · Cited by 138
Thakur, A., Ke, X., Chen, Y., Motallebnejad, P., Zhang, K., Lian, Q., & Chen, H. J. (2021) · Protein & Cell · doi:10.1007/s13238-021-00863-6 · Cited by 138
“The biogenesis of exosomes takes place via an endosomal pathway in which the introversion of early endosomes leads to the formation of MVBs carrying intraluminal vesicles, followed by the fusion of MVBs with the plasma membrane, resulting in the excretion of exosomes in the extracellular milieu (Johnstone et al., 1987…”
BackgroundExtracellular vesicles: Emerging frontiers in wound healing
Hade, M. D., Suire, C. N., Mossell, J., & Suo, Z. (2022) · Medicinal Research Reviews · doi:10.1002/med.21918 · Cited by 138
Exosomes bearing HLA-G are released by melanoma cells
Riteau, B., Faure, F., Menier, C., Viel, S., Carosella, E. D., Amigorena, S., & Rouas‐Freiss, N. (2003) · Human Immunology · doi:10.1016/j.humimm.2003.08.344 · Cited by 134
Extracellular Vesicles in Prostate Cancer Carcinogenesis, Diagnosis, and Management
Vlaeminck‐Guillem, V. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00222 · Cited by 136
Exosomes in hepatocellular carcinoma: a new horizon
Chen, R., Xu, X., Tao, Y., Qian, Z., & Yu, Y. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-018-0315-1 · Cited by 139
Novel leukocyte agonists are released by endothelial cells exposed to peroxide.
Patel, K. D., Zimmerman, G. A., Prescott, S. M., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42161-8 · Cited by 133
Ung, T. H., Madsen, H. J., Hellwinkel, J. E., Lencioni, A., & Graner, M. W. (2014) · Cancer Science · doi:10.1111/cas.12534 · Cited by 135
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Yang, C., Guo, W., Zhang, W. ‐., Bian, J., Yang, J. ‐., Zhou, Q., Chen, M., Peng, W., Qi, T., Wang, C., et al. (2017) · Andrology · doi:10.1111/andr.12412 · Cited by 136
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Liu, J., Jiang, F., Jiang, Y., Wang, Y., Li, Z., Shi, X., Zhu, Y., Wang, H., & Zhang, Z. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s277190 · Cited by 131
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Almeria, C., Kreß, S., Weber, V., Egger, D., & Kasper, C. (2022) · Cell & Bioscience · doi:10.1186/s13578-022-00786-7 · Cited by 143
“Exosomes represent the most extensively studied EV species, and their secretion was originally described as a process that can complement and supplement lysosomal and proteasomal degradation for the removal of obsolete membrane and cytosolic materials [3].”
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Exosomal RNA as biomarkers and the therapeutic potential of exosome vectors
Lässer, C. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.680018 · Cited by 131
Chaudhuri, A. D., Dastgheyb, R. M., Devine, L. R., Bi, H., Cole, R. N., & Haughey, N. J. (2019) · Glia · doi:10.1002/glia.23708 · Cited by 130
Ramirez-Garrastacho, M., Bajo-Santos, C., Line, A., Martens-Uzunova, E. S., de la Fuente, J. M., Moros, M., Soekmadji, C., Tasken, K. A., & Llorente, A. (2022) · British Journal of Cancer · doi:10.1038/s41416-021-01610-8 · Cited by 130
“Although initially considered to be a waste-disposal mechanism [42], it is now clear that both EVs generated by living or apoptotic cells can be taken up by recipient cells and are important mediators of intercellular communication [37, 43].”
BackgroundRonquist, G. K. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02487.x · Cited by 129
Wieckowski, E. U., & Whiteside, T. L. (2006) · Immunologic Research · doi:10.1385/ir:36:1:247 · Cited by 129
Liu, H., Chen, L., Liu, J., Meng, H., Zhang, R., Ma, L., Wu, L., Yu, S., Shi, F., Li, Y., et al. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.09.022 · Cited by 129
Exosomes: Isolation, Analysis, and Applications in Cancer Detection and Therapy
Bu, H., He, D., He, X., & Wang, K. (2018) · ChemBioChem · doi:10.1002/cbic.201800470 · Cited by 129
Exosomes—the enigmatic regulators of bone homeostasis
Gao, M., Gao, W., Papadimitriou, J. M., Zhang, C., Gao, J., & Zheng, M. (2018) · Bone Research · doi:10.1038/s41413-018-0039-2 · Cited by 131
Miceli, R. T., Chen, T.-Y., Nose, Y., Tichkule, S., Brown, B., Fullard, J. F., Saulsbury, M. D., Heyliger, S. O., Gnjatic, S., Kyprianou, N., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70005 · Cited by 135
Immune Response Against Dying Tumor Cells
Zitvogel, L., Casares, N., Péquignot, M. O., Chaput, N., Albert, M. L., & Kroemer, G. (2004) · Advances in immunology · doi:10.1016/s0065-2776(04)84004-5 · Cited by 137
Li, J., Chen, X., Yi, J., Liu, Y., Li, D., Wang, J., Hou, D., Jiang, X., Zhang, J., Wang, J., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163043 · Cited by 133
Luo, P., Jiang, C., Ji, P., Wang, M., & Xu, J. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1341-7 · Cited by 129
Jiang, X., You, L., Zhang, Z., Cui, X., Zhong, H. P., Sun, X., Ji, C., & Chi, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.693534 · Cited by 129
“(3) high stability: Compared with exogenous synthetic miRNAs, milk EV miRNAs are more resistant to harsh conditions, including repeated freeze–thaw cycles, RNA enzyme, and high temperature (Zhou et al., 2012; Liao et al., 2017; Kahn et al., 2018).”
BackgroundTumor-derived exosomes in oncogenic reprogramming and cancer progression
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Extracellular vesicles as a platform for ‘liquid biopsy’ in glioblastoma patients
Santiago-Dieppa, D. R., Steinberg, J. D., Gonda, D. D., Cheung, V. J., Carter, B. S., & Chen, C. C. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.943193 · Cited by 133
Chahar, H. S., Corsello, T., Kudlicki, A. S., Komaravelli, N., & Casola, A. (2018) · Scientific Reports · doi:10.1038/s41598-017-18672-5 · Cited by 130
Beatty, W. L., Ullrich, H., & Russell, D. G. (2001) · European Journal of Cell Biology · doi:10.1078/0171-9335-00131 · Cited by 128
Lässer, C. (2014) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.977250 · Cited by 128
Fleming, A., Sampey, G. C., Chung, M. J., Bailey, C., van Hoek, M. L., Kashanchi, F., & Hakami, R. M. (2014) · Pathogens and Disease · doi:10.1111/2049-632x.12135 · Cited by 128
Exosomal miRNAs as potential biomarkers of cardiovascular risk in children
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Huang, K., Fang, C., Yi, K., Liu, X., Qi, H., Tan, Y., Zhou, J., Li, Y., Liu, M., Zhang, Y., et al. (2018) · Theranostics · doi:10.7150/thno.22952 · Cited by 126
Yu, H., Sun, T., An, J., Wen, L., Liu, F., Bu, Z., Cui, Y., & Feng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00086 · Cited by 130
Tumor exosomes: a double-edged sword in cancer therapy
Sun, W., Luo, J., Jiang, H., & Duan, D. D. (2018) · Acta Pharmacologica Sinica · doi:10.1038/aps.2018.17 · Cited by 126
Exosomes: An emerging factor in stress-induced immunomodulation
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Signaling by Extracellular Vesicles Advances Cancer Hallmarks
Kanada, M., Bachmann, M. H., & Contag, C. H. (2016) · Trends in cancer · doi:10.1016/j.trecan.2015.12.005 · Cited by 130
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Crețoiu, D., Xu, J., Xiao, J., & Creţoiu, S. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081322 · Cited by 124
Salomón, C., Das, S., Erdbrügger, U., Kalluri, R., Lim, S. K., Olefsky, J. M., Rice, G. E., Sahoo, S., Tao, W. A., Vader, P., et al. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac009 · Cited by 129
“Exosomes 30-150 nm Originate in the endosomal pathway in the multi-vesicular bodies (MVBs) and are released upon fusion of MVBs with the plasma membrane Proteins of the endosomal pathway and endosomal sorting complexes required for transport complex (Alix, TSG101, HSP70) and members of tetraspanin family (CD62, CD9, C…”
BackgroundExosomes and their role in the micro-/macro-environment: a comprehensive review
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“However, the generic term “exosome” was not proposed until 1987 (Johnstone et al., 1987).”
BackgroundExosomes in melanoma: a role in tumor progression, metastasis and impaired immune system activity
Tucci, M., Mannavola, F., Passarelli, A. M., Stucci, L. S., Cives, M., & Silvestris, F. (2018) · Oncotarget · doi:10.18632/oncotarget.24846 · Cited by 121
Lee, H., Zhang, D., Laskin, D. L., & Jin, Y. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800264 · Cited by 119
Zhang, B., Shen, L., Shi, H., Pan, Z., Wu, L., Yan, Y., Zhang, X., Mao, F., Qian, H., & Xu, W. (2016) · Stem Cells International · doi:10.1155/2016/1929536 · Cited by 120
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Engineering therapeutical extracellular vesicles for clinical translation
Ma, Y., Dong, S., Grippin, A., Teng, L., Lee, A. S., Kim, B. Y. S., & Jiang, W. (2024) · Trends in biotechnology · doi:10.1016/j.tibtech.2024.08.007 · Cited by 136
Lyamzaev, K. G., Nepryakhina, O. K., Saprunova, V. B., Bakeeva, L. E., Pletjushkina, O. Y., Chernyak, B. V., & Skulachev, V. P. (2008) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2008.03.027 · Cited by 120
Xu, J., & Ikezu, T. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9136-0 · Cited by 120
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Gutkin, A., Uziel, O., Beery, E., Nordenberg, J., Pinchasi, M., Goldvaser, H., Henick, S. M., Goldberg, M., & Lahav, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10384 · Cited by 116
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“Several years later, Johnstone et al. [24] fi rst observed exosomes during the maturation of sheep reticulocytes in vitro and studied their relationship with plasma membrane activity in the 1980s.”
BackgroundPotential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s Disease
Vingtdeux, V., Sergeant, N., & Buée, L. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00229 · Cited by 116
Physical characterization and profiling of airway epithelial derived exosomes using light scattering
Kesımer, M., & Gupta, R. (2015) · Methods · doi:10.1016/j.ymeth.2015.03.013 · Cited by 116
Jurj, A. M., Zănoagă, O., Braicu, C., Lazar, V., Tomuleasa, C., Irimie, A., & Berindan‐Neagoe, I. (2020) · Cancers · doi:10.3390/cancers12020298 · Cited by 119
Nanomedicine to target multidrug resistant tumors
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Wang, L., Li, Z., Shen, J., Liu, Z., Liang, J., Wu, X., Sun, X., & Wu, Z. (2015) · Parasitology Research · doi:10.1007/s00436-015-4373-7 · Cited by 124
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Pinheiro, A., da Silva, A. M., Teixeira, J. H., Gonçalves, R. M., Almeida, M. I., Barbosa, M. A., & Santos, S. G. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.09.019 · Cited by 120
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Su, X., Wang, H., Li, Q., & Chen, Z. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s502591 · Cited by 126
Bütikofer, P., Kuypers, F. A., Xu, C., Chiu, D., & Lubin, B. H. (1989) · Blood · doi:10.1182/blood.v74.5.1481.1481 · Cited by 113
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Hogan, M. C., Johnson, K. L., Zenka, R. M., Charlesworth, M. C., Madden, B. J., Mahoney, D. W., Oberg, A. L., Huang, B. Q., Leontovich, A. A., Nesbitt, L. L., et al. (2013) · Kidney International · doi:10.1038/ki.2013.422 · Cited by 115
Metadata
- Authors
- Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C.
- Affiliations
- McGill University (CA)
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 262
- Issue
- 19
- Pages
- 9412-9420
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1915536483
- Semantic Scholar
- 9e8f5a8482d60e384e3dcd94080a64e9f387e3ae
- Cited by
- 2,931
- References
- 51
- Citations by year
- 2026: 132 · 2025: 231 · 2024: 281 · 2023: 285 · 2022: 291 · 2021: 296 · 2020: 276 · 2019: 197 · 2018: 157 · 2017: 134 · 2016: 131 · 2015: 79 · 2014: 76 · 2013: 46 · 2012: 53
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- reticulocyte maturation, exosomes, vesicle formation, membrane shedding, acetylcholinesterase, glucose transporters, nucleoside transporters, amino acid transport, transferrin receptor, sphingomyelin, sheep red blood cells, membrane lipid composition
- MeSH terms
- Acetylcholinesterase, Amino Acids, Animals, Carrier Proteins, Cell Membrane, Cells, Cultured, Cytochalasin B, Glyceraldehyde-3-Phosphate Dehydrogenases, Leucine, Membrane Proteins, Monosaccharide Transport Proteins, Receptors, Transferrin, Reticulocytes, Sheep, Sodium, Thioinosine, Nucleoside Transport Proteins
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