Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189

A new and rapid colorimetric determination of acetylcholinesterase activity

Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221

The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes

Dodge, J. T., Mitchell, C. D., & Hanahan, D. J. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90042-0 · Cited by 4,419

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes

Harding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775

Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes.

Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242

Form and function of phospholipids

ANSELL, G. B., Hawthorne, J. N., & DAWSON, R. M. C. (1973) · Medical Entomology and Zoology · Cited by 1,069

Membrane Adenosine Triphosphatase as a Participant in the Active Transport of Sodium and Potassium in the Human Erythrocyte

Post, R. L., Merritt, C. R., Kinsolving, C. R., & Albright, C. D. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76884-7 · Cited by 1,060

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926

Exosomes: composition, biogenesis and function

Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature reviews. Immunology · doi:10.1038/nri855 · Cited by 5,355

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathieu, M., Jaular, L. M., Lavieu, G., & Théry, C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0250-9 · Cited by 3,863

Current knowledge on exosome biogenesis and release

Hessvik, N. P., & Llorente, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2595-9 · Cited by 2,362

Exosomes: biogenesis, biologic function and clinical potential

Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Vlassov, A. V., Magdaleno, S. M., Setterquist, R. A., & Conrad, R. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.03.017 · Cited by 1,979

The exosome journey: from biogenesis to uptake and intracellular signalling

Gurung, S., Perocheau, D. P. B., Touramanidou, L., & Baruteau, J. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00730-1 · Cited by 1,912

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781

Classification, Functions, and Clinical Relevance of Extracellular Vesicles

van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,806

New Technologies for Analysis of Extracellular Vesicles

Shao, H., Im, H., Castro, C. M., Breakefield, X. O., Weissleder, R., & Lee, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00534 · Cited by 1,697

Engineering exosomes for targeted drug delivery

Liang, Y., Duan, L., Lu, J., & Xia, J. (2021) · Theranostics · doi:10.7150/thno.52570 · Cited by 1,547

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

Akers, J. C., Gonda, D., Kim, R., Carter, B. S., & Chen, C. C. (2013) · Journal of Neuro-Oncology · doi:10.1007/s11060-013-1084-8 · Cited by 1,423

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.

Montecalvo, A., Larregina, A. T., Shufesky, W. J., Beer Stolz, D., Sullivan, M. L. G., Karlsson, J. M., Baty, C. J., Gibson, G. A., Erdos, G., Wang, Z., et al. (2012) · Blood · doi:10.1182/blood-2011-02-338004 · Cited by 1,429

Extracellular vesicles as tools and targets in therapy for diseases

Kumar, M. A., Baba, S. K., Sadida, H. Q., Al-Marzooqi, S. K., Jerobin, J., Altemani, F. H., Algehainy, N. A., Alanazi, M. A., Abou‐Samra, A., Kumar, R., et al. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01735-1 · Cited by 1,545

Exosomal-like vesicles are present in human blood plasma

Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

Ha, D., Yang, N., & Nadithe, V. (2016) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.02.001 · Cited by 1,346

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435

Exosome Theranostics: Biology and Translational Medicine

He, C., Zheng, S., Luo, Y., & Wang, B. (2017) · Theranostics · doi:10.7150/thno.21945 · Cited by 1,271

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Hoshino, A., Kim, H. S., Bojmar, L., Gyan, K. E., Cioffi, M., Hernandez, J. M., Zambirinis, C. P., Rodrigues, G., Molina, H., Heissel, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.009 · Cited by 1,275

Exosomes: key players in cancer and potential therapeutic strategy

Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186

Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes

Tauro, B. J., Greening, D. W., Mathias, R. A., Ji, H. L., Mathivanan, S., Scott, A. M., & Simpson, R. J. (2012) · Methods · doi:10.1016/j.ymeth.2012.01.002 · Cited by 1,214

Cell-produced α-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

Emmanouilidou, E., Melachroinou, K., Roumeliotis, T., Garbis, S. D., Ntzouni, M., Margaritis, L. H., Stefanis, L., & Vekrellis, K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5699-09.2010 · Cited by 1,115

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Bobrie, A., Colombo, M., Raposo, G., & Théry, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01225.x · Cited by 1,148

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

Denzer, K., Kleijmeer, M. J., Heijnen, H. F. G., Stoorvogel, W., & Geuze, H. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.19.3365 · Cited by 1,067

Molecular Characterization of Dendritic Cell-Derived Exosomes

Théry, C., Régnault, A., Garin, J., Wolfers, J., Zitvogel, L., Ricciardi‐Castagnoli, P., Raposo, G., & Amigorena, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.599 · Cited by 1,065

Exosomes: Therapy delivery tools and biomarkers of diseases

Barile, L., & Vassalli, G. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.020 · Cited by 1,053

Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics

Yang, D., Zhang, W., Zhang, H., Zhang, F., Chen, L., Ma, L., Larcher, L. M., Chen, S., Liu, N., Zhao, Q., et al. (2020) · Theranostics · doi:10.7150/thno.41580 · Cited by 1,079

Exosomes: endosomal-derived vesicles shipping extracellular messages

Février, B., & Raposo, G. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.06.003 · Cited by 881

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Willms, E., Cabañas, C., Mäger, I., Wood, M. J. A., & Vader, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00738 · Cited by 1,030

Cellular Internalization of Exosomes Occurs Through Phagocytosis

Feng, D., Zhao, W.-L., Ye, Y.-Y., Bai, X., Liu, R.-Q., Chang, L.-F., Zhou, Q., & Sui, S. (2010) · Traffic · doi:10.1111/j.1600-0854.2010.01041.x · Cited by 1,035

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927

Exosomes and microvesicles: extracellular vesicles for genetic information transfer and gene therapy

Lee, Y., Andaloussi, S. E., & Wood, M. J. A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds317 · Cited by 958

Mechanisms of mesenchymal stem/stromal cell function

Spees, J. L., Lee, R. H., & Gregory, C. A. (2016) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0363-7 · Cited by 912

Exosomes as a new frontier of cancer liquid biopsy

Yu, D., Li, Y., Wang, M., Gu, J., Xu, W., Cai, H., Fang, X., & Zhang, X. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01509-9 · Cited by 855

Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes

Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

Ju, S., Mu, J., Dokland, T., Zhuang, X., Wang, Q., Jiang, H., Xiang, X., Deng, Z., Wang, B., Zhang, L., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2013.64 · Cited by 889

As we wait: coping with an imperfect nomenclature for extracellular vesicles

Gould, S. J., & Raposo, G. (2013) · Journal of Extracellular Vesicles · doi:10.3402/jev.v2i0.20389 · Cited by 864

Proteomic profiling of exosomes: Current perspectives

Simpson, R. J., Jensen, S. S., & Lim, J. W. E. (2008) · PROTEOMICS · doi:10.1002/pmic.200800109 · Cited by 872

Exosomes as new vesicular lipid transporters involved in cell–cell communication and various pathophysiologies

Record, M., Carayon, K., Poirot, M., & Silvente‐Poirot, S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.10.004 · Cited by 893

The Biogenesis and Functions of Exosomes

Stoorvogel, W., Kleijmeer, M. J., Geuze, H. J., & Raposo, G. (2002) · Traffic · doi:10.1034/j.1600-0854.2002.30502.x · Cited by 848

Exosomes Derived from Mesenchymal Stem Cells

Yu, B., Zhang, X., & Li, X. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15034142 · Cited by 788

Exosomes: secreted vesicles and intercellular communications

Théry, C. (2011) · F1000 Biology Reports · doi:10.3410/b3-15 · Cited by 989

Exosomes: Vehicles of Intercellular Signaling, Biomarkers, and Vectors of Cell Therapy

Kourembanas, S. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071641 · Cited by 761

Exosome Function: From Tumor Immunology to Pathogen Biology

Schorey, J. S., & Bhatnagar, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00734.x · Cited by 766

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

Hoen, E. N. M. N., Buermans, H. P. J., Waasdorp, M., Stoorvogel, W., Wauben, M. H. M., & Hoen, P. A. C. ’. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks658 · Cited by 772

Therapeutically harnessing extracellular vesicles

Cheng, L., & Hill, A. F. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00410-w · Cited by 737

Liquid biopsy in cancer: current status, challenges and future prospects

Ma, L., Guo, H., Zhao, Y., Liu, Z., Wang, C., Bu, J., Sun, T., & Wei, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02021-w · Cited by 820

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

Ma, L., Li, Y., Peng, J., Wu, D., Zhao, X., Cui, Y., Chen, L., Yan, X., Du, Y., & Yu, L. (2014) · Cell Research · doi:10.1038/cr.2014.135 · Cited by 737

Exosomes and other extracellular vesicles in host–pathogen interactions

Schorey, J. S., Cheng, Y., Singh, P., & Smith, V. L. (2014) · EMBO Reports · doi:10.15252/embr.201439363 · Cited by 752

A comprehensive overview of exosomes as drug delivery vehicles — Endogenous nanocarriers for targeted cancer therapy

Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704

Production and characterization of clinical grade exosomes derived from dendritic cells

Lamparski, H., Mehta-Damani, A., Yao, J.-Y., Patel, S., Hsu, D., Ruegg, C. L., & Pecq, J. L. (2002) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00330-7 · Cited by 701

Intestinal epithelial cells secrete exosome–like vesicles

van Niel, G., Raposo, G., Candalh, C., Boussac, M., Hershberg, R. M., Cerf–Bensussan, N., & Heyman, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.26263 · Cited by 698

Application of exosomes as liquid biopsy in clinical diagnosis

Zhou, B., Xu, K., Zheng, X., Chen, T., Wang, J., Song, Y., Shao, Y., & Zheng, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00258-9 · Cited by 685

Emerging role of extracellular vesicles in inflammatory diseases

Buzás, E. I., György, B., Nagy, G., Falus, A., & Gay, S. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.19 · Cited by 684

Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer

Han, Q.-F., Li, W.-J., Hu, K.-S., Gao, J., Zhai, W.-L., Yang, J.-H., & Zhang, S.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01671-0 · Cited by 678

Lipid raft-associated protein sorting in exosomes

Gassart, A. D., Géminard, C., Février, B., Raposo, G., & Vidal, M. (2003) · Blood · doi:10.1182/blood-2003-03-0871 · Cited by 675

The role of extracellular vesicles in cancer

Kalluri, R., & McAndrews, K. M. (2023) · Cell · doi:10.1016/j.cell.2023.03.010 · Cited by 695

Exosome-Based Cell-Cell Communication in the Tumor Microenvironment

Maia, J., Caja, S., Moraes, M. C. S., Couto, N., & Costa‐Silva, B. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00018 · Cited by 685

Interaction and uptake of exosomes by ovarian cancer cells

Escrevente, C., Keller, S., Altevogt, P., & Costa, J. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-108 · Cited by 666

The Trojan exosome hypothesis

Gould, S. J., Booth, A. M., & Hildreth, J. E. K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831413100 · Cited by 638

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

Taylor, D. D., & Shah, S. (2015) · Methods · doi:10.1016/j.ymeth.2015.02.019 · Cited by 659

Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Kou, M., Huang, L., Yang, J., Chiang, Z., Chen, S., Liu, J., Guo, L., Zhang, X., Zhou, X., Xu, X., et al. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05034-x · Cited by 640

Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies

Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 660

Emerging Roles of Exosomes in Normal and Pathological Conditions: New Insights for Diagnosis and Therapeutic Applications

Toro, J. D., Herschlik, L., Waldner, C., & Mongini, C. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00203 · Cited by 632

Exosome Processing and Characterization Approaches for Research and Technology Development

Lai, J. J., Chau, Z. L., Chen, S., Hill, J. J., Korpany, K. V., Liang, N., Lin, L., Lin, Y., Liu, J. K., Liu, Y., et al. (2022) · Advanced Science · doi:10.1002/advs.202103222 · Cited by 623

Mesenchymal Stem Cell-Derived Exosomes: Applications in Regenerative Medicine

Hade, M. D., Suire, C. N., & Suo, Z. (2021) · Cells · doi:10.3390/cells10081959 · Cited by 642

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 636

TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex

Blanchard, N., Lankar, D., Faure, F., Regnault, A., Dumont, C., Raposo, G., & Hivroz, C. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3235 · Cited by 660

Exosomes in bodily fluids are a highly stable resource of disease biomarkers

Boukouris, S., & Mathivanan, S. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400114 · Cited by 598

Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation

Bobrie, A., Colombo, M., Krumeich, S., Raposo, G., & Théry, C. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18397 · Cited by 581

A brief history of nearly EV‐erything – The rise and rise of extracellular vesicles

Couch, Y., Buzás, E. I., Vizio, D. D., Gho, Y. S., Harrison, P., Hill, A. F., Lötvall, J. O., Raposo, G., Stahl, P. D., Théry, C., et al. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12144 · Cited by 602

Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles.

Regev-Rudzki, N., Wilson, D. W., Carvalho, T. G., Sisquella, X., Coleman, B. M., Rug, M., Bursac, D., Angrisano, F., Gee, M., Hill, A. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.029 · Cited by 545

The biology, function, and applications of exosomes in cancer

Liu, J., Ren, L., Li, S., Li, W., Zheng, X., Yang, Y., Fu, W., Yi, J., Wang, J., & Du, G. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.01.001 · Cited by 569

Circulating microRNAs as novel biomarkers for diabetes mellitus

Guay, C., & Regazzi, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.86 · Cited by 563

Exosomes: immune properties and potential clinical implementations

Chaput, N., & Théry, C. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0233-9 · Cited by 590

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

Fader, C. M., Sánchez, D. G., Mestre, M. B., & Colombo, M. I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.011 · Cited by 544

Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature

Witwer, K. W., & Théry, C. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1648167 · Cited by 546

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

Ha, D. H., Kim, H.-K., Lee, J., Kwon, H. H., Park, G., Yang, S. H., Jung, J. Y., Choi, H., Lee, J. H., Sung, S., et al. (2020) · Cells · doi:10.3390/cells9051157 · Cited by 556

Exosomes as intercellular signalosomes and pharmacological effectors

Record, M., Subra, C., Silvente‐Poirot, S., & Poirot, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.011 · Cited by 550

Exosomes: Small vesicles participating in intercellular communication

Ludwig, A., & Giebel, B. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.10.005 · Cited by 544

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

Kapustin, A. N., Chatrou, M. L. L., Drozdov, I., Zheng, Y., Davidson, S. M., Soong, D., Furmanik, M., Sanchis, P., De Rosales, R. T. M., Alvarez-Hernandez, D., et al. (2015) · Circulation Research · doi:10.1161/circresaha.116.305012 · Cited by 525

Exosomes: From Garbage Bins to Promising Therapeutic Targets

Rashed, M. H., Bayraktar, E., Helal, G. K., Abd‐Ellah, M. F., Amero, P., Chávez‐Reyes, A., & Rodriguez‐Aguayo, C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030538 · Cited by 533

Review on Strategies and Technologies for Exosome Isolation and Purification

Chen, J., Li, P., Zhang, T., Xu, Z., Huang, X., Wang, R., & Du, L. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.811971 · Cited by 585

Extracellular vesicles: masters of intercellular communication and potential clinical interventions

Pitt, J. M., Kroemer, G., & Zitvogel, L. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87316 · Cited by 534

Proteomics, transcriptomics and lipidomics of exosomes and ectosomes

Choi, D., Kim, D., Kim, Y., & Gho, Y. S. (2013) · PROTEOMICS · doi:10.1002/pmic.201200329 · Cited by 528

Rab11 Promotes Docking and Fusion of Multivesicular Bodies in a Calcium‐Dependent Manner

Savina, A., Fader, C. M., Damiani, M. T., & Colombo, M. I. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00257.x · Cited by 536

Exosomes: New players in cell–cell communication

Bang, C., & Thum, T. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.08.007 · Cited by 517

Extracellular membrane vesicles in the three domains of life and beyond

Gill, S., Catchpole, R. J., & Forterre, P. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy042 · Cited by 523

The significance of exosomes in the development and treatment of hepatocellular carcinoma

Li, X., Li, C., Zhang, L., Wu, M., Cao, K., Jiang, F., Chen, D., Li, N., & Li, W. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1085-0 · Cited by 395

Biological Functions and Current Advances in Isolation and Detection Strategies for Exosome Nanovesicles

Boriachek, K., Islam, M. N., Möller, A., Salomón, C., Nguyen, N., Hossain, M. S. A., Yamauchi, Y., & Shiddiky, M. J. A. (2017) · Small · doi:10.1002/smll.201702153 · Cited by 506

Nucleoside and nucleobase transport systems of mammalian cells

Griffith, D. A., & Jarvis, S. M. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/s0304-4157(96)00008-1 · Cited by 493

Biogenesis and function of ESCRT-dependent extracellular vesicles

Juan, T., & Fürthauer, M. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.022 · Cited by 479

Exosomes Communicate Protective Messages during Oxidative Stress; Possible Role of Exosomal Shuttle RNA

Eldh, M., Ekström, K. M., Valadi, H., Sjöstrand, M., Olsson, B., Jernås, M., & Lötvall, J. O. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015353 · Cited by 470

Evidence for export of a muscle lectin from cytosol to extracellular matrix and for a novel secretory mechanism.

Cooper, D. N., & Barondes, S. H. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.5.1681 · Cited by 462

Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator

Cheruvanky, A., Zhou, H., Pisitkun, T., Kopp, J. B., Knepper, M. A., Yuen, P. S. T., & Star, R. A. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00434.2006 · Cited by 481

RNA in extracellular vesicles

Kim, K. M., Abdelmohsen, K., Mustapić, M., Kapogiannis, D., & Gorospe, M. (2017) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1413 · Cited by 471

Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway

Möbius, W., van Donselaar, E. G., Ohno‐Iwashita, Y., Shimada, Y., Heijnen, H. F. G., Slot, J. W., & Geuze, H. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00072.x · Cited by 453

The Role of Nucleoside Transport in the Antineoplastic Activity of Purine Nucleoside Chemotherapeutic Agents

Cass, C. E., & King, K. M. (2008) · Current Cancer Therapy Reviews · doi:10.2174/157339408783565501 · Cited by 2

Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney

Mangravite, L. M., Badagnani, I., & Giacomini, K. M. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.076 · Cited by 84

Nucleoside Transporters: CNTs and ENTs

Li, X., Zhou, M., & Wang, J. (2006) · doi:10.1002/9780470140505.ch8 · Cited by 1

(Section A: Molecular, Structural, and Cellular Biology of Drug Transporters) Mammalian Nucleoside Transporters

Kong, W., Engel, K., & Wang, J. (2004) · Current Drug Metabolism · doi:10.2174/1389200043489162 · Cited by 244

48 PARTIAL PURIFICATION OF THE NUCLEOSIDE TRANSPORTER FROM HUMAN ERYTHROCYTES

Hanson, S., & Ullman, B. (1988) · Pediatric Research · doi:10.1203/00006450-198807000-00072