The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
Open accessAbstract
Vesicles are released during the in vitro culture of sheep reticulocytes which can be harvested by centrifugation at 100,000 X g for 90 min. These vesicles contain a number of activities, characteristic of the reticulocyte plasma membrane, which are known to diminish or disappear upon reticulocyte maturation. The activities include acetylcholinesterase, cytochalasin B binding (glucose transporter) nucleoside binding (i.e. nucleoside transporter), Na+-independent amino acid transport, and the transferrin receptor. Enzymes of cytosolic origin are not detectable or are present at low activity in the vesicles. Cultures of whole blood, mature red cells, or white cells do not yield comparable levels of these activities, supporting the conclusion that the activities arise from the reticulocytes. In addition, the lipid composition of the vesicles shows the high sphingomyelin content characteristic of sheep red cell plasma membranes, but not white cell or platelet membranes, also consistent with the conclusion that the vesicles are of reticulocyte origin. It is suggested that vesicle externalization may be a mechanism for shedding of specific membrane functions which are known to diminish during maturation of reticulocytes to erythrocytes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Exosomes range between 30–100 nm in diameter, have a bilayered membrane (Johnstone et al., 1987) and express surface marker such as CD63 (Christianson et al., 2013).”
From Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism (2016) · cites this paper as Johnstone et al., 1987
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
A new and rapid colorimetric determination of acetylcholinesterase activity
Ellman, G. L., Courtney, K. D., Andres, V., & Featherstone, R. M. (1961) · Biochemical Pharmacology · doi:10.1016/0006-2952(61)90145-9 · Cited by 27,221
The preparation and chemical characteristics of hemoglobin-free ghosts of human erythrocytes
Dodge, J. T., Mitchell, C. D., & Hanahan, D. J. (1963) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(63)90042-0 · Cited by 4,419
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042
Self-citationHarding, C., Heuser, J., & Stahl, P. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.2.329 · Cited by 1,775
Pan, B., Teng, K., Wu, C., Adam, M., & Johnstone, R. M. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.101.3.942 · Cited by 1,242
Self-citationForm and function of phospholipids
ANSELL, G. B., Hawthorne, J. N., & DAWSON, R. M. C. (1973) · Medical Entomology and Zoology · Cited by 1,069
Post, R. L., Merritt, C. R., Kinsolving, C. R., & Albright, C. D. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76884-7 · Cited by 1,060
Research works printed but not linked: 4
- Sanchez, 1986, Biochim. Biophys. Acta, 856, 113
- Firkin, 1963, Aust. Ann. Med., 12, 26
- Harding, 1984, Eur. J. Cell. Biol., 35, 256
- Zweig, 1981, J. Supramol. Struct., 17, 163
Cited by
Sorted by citations
Items 701–800 of 1,010
Dong, G., Filho, A. L., & Olivier, M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00100 · Cited by 79
Exosomes in the Diseased Brain: First Insights from In vivo Studies
Levy, E. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00142 · Cited by 79
Exosomes: Biogenesis, Composition, Functions, and Their Role in Pre-metastatic Niche Formation
Patil, A. A., & Rhee, W. J. (2019) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-019-0170-y · Cited by 75
Chan, M., Chang, Z.-X., Huang, C. F., Lee, L. J., Liu, R., & Hsiao, M. (2022) · Nanoscale Horizons · doi:10.1039/d1nh00637a · Cited by 76
The Therapeutic Potential of Exosomes in Soft Tissue Repair and Regeneration
Wan, R., Hussain, A., Behfar, A., Moran, S. L., & Zhao, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073869 · Cited by 74
“, these particles were later termed “exosomes” [22].”
BackgroundStem cell–based therapies for the newborn lung and brain: Possibilities and challenges
Mitsialis, S. A., & Kourembanas, S. (2016) · Seminars in Perinatology · doi:10.1053/j.semperi.2015.12.002 · Cited by 74
A safe ride in extracellular vesicles – small RNA trafficking between plant hosts and pathogens
Cai, Q., He, B., & Jin, H. (2019) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2019.09.001 · Cited by 75
Cardiac Fibroblasts and Cardiac Fibrosis: Precise Role of Exosomes
Ranjan, P., Kumari, R., & Verma, S. K. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00318 · Cited by 76
Multiplexed strategies toward clinical translation of extracellular vesicles
Song, J., Song, B., Yuan, L., & Yang, G. (2022) · Theranostics · doi:10.7150/thno.75899 · Cited by 81
“However, the vesicles were not given the name “exosome” until 1987 by scientists from McGill University [22], depicting its structure vividly as “though tiny,”
BackgroundZeng, Z., & Xie, H. (2022) · PubMed Central · doi:10.12336/biomatertransl.2022.03.002 · Cited by 74
Peng, Y., Yang, Y., Li, Y., Shi, T., Luan, Y., & Yin, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154217 · Cited by 76
“Until 1987, this vesicle was named exosome, which provided a selective pathway for membrane protein loss for erythrocyte maturation (13).”
BackgroundQin, X., He, J., Wang, X., Wang, J., Yang, R., & Chen, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1256687 · Cited by 80
Qiu, J., Yang, G., Feng, M., Zheng, S., Cao, Z., You, L., Zheng, L., Zhang, T., & Zhao, Y. (2018) · Molecular Cancer · doi:10.1186/s12943-017-0755-z · Cited by 77
Exosomes and autophagy: rekindling the vesicular waste hypothesis
Gudbergsson, J. M., & Johnsen, K. B. (2019) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-019-00524-8 · Cited by 75
Inducible Polarized Secretion of Exosomes in T and B Lymphocytes
Calvo, V., & Izquierdo, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072631 · Cited by 73
Sakai‐Kato, K., Yoshida, K., Takechi‐Haraya, Y., & Izutsu, K. (2020) · Langmuir · doi:10.1021/acs.langmuir.0c02491 · Cited by 74
Breitwieser, K., Koch, L. F., Tertel, T., Proestler, E., Burgers, L. D., Lipps, C., Adjaye, J., Fürst, R., Giebel, B., & Saul, M. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158544 · Cited by 74
“Initially, sEV were considered as vehicles for cellular waste disposal [4].”
BackgroundExosome-mediated microenvironment dysregulation in leukemia
Kumar, B., García, M., Murakami, J. L., & Chen, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.09.017 · Cited by 75
Surface Engineering of Extracellular Vesicles through Chemical and Biological Strategies
Richardson, J. J., & Ejima, H. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.9b00050 · Cited by 73
Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression
Conigliaro, A., & Cicchini, C. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm8010026 · Cited by 74
A dual signal amplification method for exosome detection based on DNA dendrimer self-assembly
Gao, M.-L., He, F., Yin, B., & Ye, B. (2019) · The Analyst · doi:10.1039/c8an02383b · Cited by 72
Extracellular vesicles: new players in regulating vascular barrier function
Chatterjee, V., Yang, X., Ma, Y., Wu, M. H., & Yuan, S. Y. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00579.2020 · Cited by 74
Delivery of siRNA based on engineered exosomes for glioblastoma therapy by targeting STAT3
Liang, S., Zuo, F.-F., Yin, B., & Ye, B. (2022) · Biomaterials Science · doi:10.1039/d1bm01723c · Cited by 75
Zhou, M., He, X., Mei, C., & Ou, C. (2023) · Biomarker Research · doi:10.1186/s40364-023-00538-w · Cited by 74
“Exosomes were discovered by Trams et al. in 1981 [6].”
BackgroundBasics and applications of tumor-derived extracellular vesicles
Tai, Y.-L., Chu, P.-Y., Lee, B., Chen, K., Yang, C., Kuo, W., & Shen, T. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0533-x · Cited by 72
Therapeutic application of exosomes in ischaemic stroke
Li, Y.-F., Tang, Y., & Yang, G. (2021) · Stroke and Vascular Neurology · doi:10.1136/svn-2020-000419 · Cited by 75
Exosomes: Advances, development and potential therapeutic strategies in diabetic nephropathy
Chen, J., Zhang, Q. H., Liu, D., & Liu, Z. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154834 · Cited by 73
Biological Functions Driven by mRNAs Carried by Extracellular Vesicles in Cancer
Prieto‐Vila, M., Yoshioka, Y., & Ochiya, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.620498 · Cited by 77
Saad, M. H., Badierah, R., Redwan, E. M. M. M., & El‐Fakharany, E. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091405 · Cited by 70
“Rose Johnstone gave the term “exosomes” to these small vesicles [24,25].”
BackgroundAdvances of exosomes in periodontitis treatment
Lin, H., Chen, H., Zhao, X., Ding, T., Wang, Y., Chen, Z. B., Tian, Y., Zhang, P., & Shen, Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03487-4 · Cited by 74
“Exos were discovered in 1987 and have been shown to be important in cell communication [6].”
BackgroundGu, C., Li, Y., Liu, J., Liu, S., Long, J., Zhang, Q., Duan, W., Feng, T., Huang, J., Qiu, Y., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114547 · Cited by 72
O’Malley, G., Heijltjes, M. T., Houston, A. M., Rani, S., Ritter, T., Egan, L. J., & Ryan, A. E. (2016) · Oncotarget · doi:10.18632/oncotarget.11354 · Cited by 72
The role of extracellular vesicles in malaria biology and pathogenesis
Sampaio, N. G., Cheng, L., & Eriksson, E. M. (2017) · Malaria Journal · doi:10.1186/s12936-017-1891-z · Cited by 76
Cheng, Y., Dai, X., Yang, T., et al. (2019) · Journal of Oncology · doi:10.1155/2019/2476175 · Cited by 71
Role of Extracellular Vesicles in Cellular Cross Talk in Malaria
Babatunde, K. A., Subramanian, B. Y., Ahouidi, A. D., Murillo, P. M., Walch, M., & Mantel, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00022 · Cited by 72
Extracellular vesicles: translational challenges and opportunities
Clemmens, H., & Lambert, D. W. (2018) · Biochemical Society Transactions · doi:10.1042/bst20180112 · Cited by 70
Converting extracellular vesicles into nanomedicine: loading and unloading of cargo
Joshi, B. S., Ortíz-Rios, D., & Zuhorn, I. S. (2021) · Materials Today Nano · doi:10.1016/j.mtnano.2021.100148 · Cited by 71
Exosomal Long Non-coding RNAs: Emerging Players in the Tumor Microenvironment
Pathania, A. S., & Challagundla, K. B. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.09.039 · Cited by 71
Circulating transferrin receptors and assessment of iron status
Baynes, R. (1994) · The Journal of Nutritional Biochemistry · doi:10.1016/0955-2863(94)90061-2 · Cited by 70
Yang, L., Patel, K. D., Rathnam, C., Thangam, R., Hou, Y., Kang, H., & Lee, K. (2022) · Small · doi:10.1002/smll.202104783 · Cited by 81
Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo
Tao, H., Xu, H., Zuo, L., Li, C., Qiao, G., Guo, M., Zheng, L., Leitgeb, M., & Lin, X. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.052 · Cited by 69
Tan, Q., Xia, D., & Ying, X. (2020) · International Journal of Stem Cells · doi:10.15283/ijsc20049 · Cited by 69
Fanini, F., & Fabbri, M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.004 · Cited by 70
Extracellular Vesicles in Glioma: From Diagnosis to Therapy
Basu, B., & Ghosh, M. K. (2019) · BioEssays · doi:10.1002/bies.201800245 · Cited by 71
Cicero, A. L., Majkowska, I., Nagase, H., Liegro, I. D., & Troeberg, L. (2012) · Matrix Biology · doi:10.1016/j.matbio.2012.02.005 · Cited by 71
Cardiomyocyte-Derived Exosomes: Biological Functions and Potential Therapeutic Implications
Yu, H., & Wang, Z. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01049 · Cited by 68
Xing, Z., Zhao, C. F., Liu, H., & Fan, Y. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000255 · Cited by 68
Exosomes: A Source for New and Old Biomarkers in Cancer
Logozzi, M., Mizzoni, D., Raimo, R. D., & Fais, S. (2020) · Cancers · doi:10.3390/cancers12092566 · Cited by 69
Exosomes and Their Role in Cancer Progression
Liu, Y., Shi, K., Chen, Y., Wu, X.-R., Chen, Z., Cao, K., Tao, Y.-G., Chen, X., Liao, J., & Zhou, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.639159 · Cited by 37
Exosomes Regulate the Epithelial–Mesenchymal Transition in Cancer
Jiang, J., Li, J., Zhou, X., Zhao, X., Huang, B., & Qin, Y. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.864980 · Cited by 66
“(19) first isolated these extracellular vesicles from an in vitro culture of sheep reticulocytes and named them “exosomes”.”
BackgroundExtracellular vesicles in cancer therapy
Wang, S. E. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.06.001 · Cited by 70
The Multifaceted Functions of Exosomes in Health and Disease: An Overview
Arenaccio, C., & Federico, M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-4397-0_1 · Cited by 66
The Shape Shifting Story of Reticulocyte Maturation
Ovchynnikova, E., Aglialoro, F., Lindern, M. V., & van den Akker, E. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00829 · Cited by 72
Exosomes: natural nanoparticles as bio shuttles for RNAi delivery
Darband, S. G., Mirza‐Aghazadeh‐Attari, M., Kaviani, M., Mihanfar, A., Sadighparvar, S., Yousefi, B., & Majidinia, M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.001 · Cited by 69
Tumor-derived extracellular vesicles in breast cancer: From bench to bedside
Wang, H., & Gires, O. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.06.012 · Cited by 67
Jiang, R., Rong, C., Ke, R., Meng, S., Yan, X., Ke, H., & Wu, S. (2019) · Medicine · doi:10.1097/md.0000000000017478 · Cited by 68
Wen, S., Dooner, M. S., Papa, E. F., Tatto, M. D., Pereira, M. G., Borgovan, T., Cheng, Y., Goldberg, L. R., Liang, O. D., Camussi, G., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215468 · Cited by 67
The plasticity of multivesicular bodies and the regulation of antigen presentation
Murk, J., Stoorvogel, W., Kleijmeer, M. J., & Geuze, H. J. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084952102000605 · Cited by 68
Exosomes in HIV infection: A review and critical look
Ellwanger, J. H., Veit, T. D., & Chies, J. A. B. (2017) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2017.05.021 · Cited by 70
Acetylcholinesterase is not a generic marker of extracellular vesicles
Liao, Z., Jaular, L. M., Soueidi, E., Jouve, M. J., Muth, D. C., Schøyen, T. H., Seale, T. S., Haughey, N. J., Ostrowski, M., Théry, C., et al. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1628592 · Cited by 67
González, M. F., Díaz, P., Sandoval, A., Herrera, D., & Quest, A. F. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094823 · Cited by 66
Extracellular vesicles in the treatment of neurological disorders
Reed, S. L., & Escayg, A. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105445 · Cited by 71
“Early research on EVs documented their role in shuttling unneeded or excess proteins out of cells as a mechanism to eliminate cellular waste (Johnstone et al., 1987; Pan et al., 1985).”
BackgroundPanda, B., Sharma, Y., Gupta, S., & Mohanty, S. (2021) · Life · doi:10.3390/life11080784 · Cited by 66
“[34] to infer that vesicle shedding was an intermediate process during maturation to erythrocytes.”
BackgroundTumor-Derived Extracellular Vesicles Regulate Cancer Progression in the Tumor Microenvironment
Bao, Q., Huang, Q., Chen, Y., Wang, Q., Sang, R., Wang, L., Xie, Y., & Chen, W. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.796385 · Cited by 68
“Exosomes are secreted by inward invagination of the plasma membrane (Wolf, 1967; Johnstone et al., 1987).”
BackgroundExtracellular Vesicles in Tissue Engineering: Biology and Engineered Strategy
Pan, Z., Sun, W., Chen, Y., Tang, H., Lin, W., Chen, J., & Chen, C. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201384 · Cited by 69
Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics
Roerig, J., & Schulz‐Siegmund, M. (2023) · Small · doi:10.1002/smll.202301763 · Cited by 67
Cosme, J., Guo, H., Hadipour‐Lakmehsari, S., Emili, A., & Gramolini, A. O. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00144 · Cited by 71
Géminard, C., Nault, F., Johnstone, R. M., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009641200 · Cited by 67
Self-citationAgeta, H., & Tsuchida, K. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03246-7 · Cited by 67
A study of differential circRNA and lncRNA expressions in COVID-19-infected peripheral blood
Wu, Y., Zhao, T., Deng, R., Xia, X., Li, B., & Wang, X. (2021) · Scientific Reports · doi:10.1038/s41598-021-86134-0 · Cited by 67
Mishra, A., Singh, P., Qayoom, I., Prasad, A., & Kumar, A. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01088c · Cited by 70
The activity of alkaline phosphatase in breast cancer exosomes simplifies the biosensing design
Moura, S. L., Pallarès-Rusiñol, A., Sappia, L. D., et al. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113826 · Cited by 66
Role of exosomes in the pathogenesis of inflammation in Parkinson’s disease
Yang, X., Li, K., Huang, H., & Ren, H. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.335143 · Cited by 68
“Exosomes refer to a special subtype of nanoscale EVs that were first discovered during the culturing and differentiation of sheep reticulocytes in the late 1980s (Johnstone et al., 1987) and were first detected in the blood of healthy people in 2005 (Ren et al., 2011).”
BackgroundPan, W., Chen, H., Wang, A., Wang, F., & Zhang, X. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121524 · Cited by 69
Mesenchymal Stem Cell Exosomes: The Future MSC-Based Therapy?
Lai, R. C., Yeo, R. W. Y., Tan, S. S., Zhang, B., Yin, Y., Sze, N. S. K., Choo, A. B. H., & Lim, S. K. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-200-1_3 · Cited by 67
Saá, P., Yakovleva, O., de Castro, J., Vasilyeva, I. A., Paoli, S. H. D., Šimák, J., & Červen̆áková, L. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.589564 · Cited by 66
Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire
Kalamvoki, M., & Deschamps, T. (2016) · Virology Journal · doi:10.1186/s12985-016-0518-2 · Cited by 68
Rashed, M. H., Kanlikilicer, P., Rodriguez‐Aguayo, C., Pichler, M., Bayraktar, R., Bayraktar, E., Ivan, C., Filant, J., da Silva, A. M., Aslan, B., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15525 · Cited by 63
Wu, T., Chen, Y., Du, Y., Jin, T., Li, W., Zhou, Z., & Yang, Z. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.10.52 · Cited by 67
Extracellular Vesicles and MetastasisPreprint
Wang, S. E. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a037275 · Cited by 67
Mills, J., Capece, M., Cocucci, E., Tessari, A., & Palmieri, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246109 · Cited by 68
Composition, isolation, identification and function of adipose tissue-derived exosomes
Zhao, R., Zhao, T., He, Z., Cai, R., & Pang, W. (2021) · Adipocyte · doi:10.1080/21623945.2021.1983242 · Cited by 64
Recent advances in liquid biopsy technologies for cancer biomarker detection
Soda, N., Clack, K., & Shiddiky, M. J. A. (2022) · Sensors & Diagnostics · doi:10.1039/d2sd00010e · Cited by 66
Role of MSC‐derived small extracellular vesicles in tissue repair and regeneration
Koga, B. A. A., Fernandes, L. A., Fratini, P., Sogayar, M. C., & Carreira, A. C. O. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1047094 · Cited by 68
“of reticulocytes, as a consequence of multi-vesicular endosome fusion to the plasma membrane (Johnstone et al., 1987).”
BackgroundWang, J., Faict, S., Maes, K., Bruyne, E. D., Valckenborgh, E. V., Schots, R., Vanderkerken, K., & Menu, E. (2016) · Oncotarget · doi:10.18632/oncotarget.7792 · Cited by 67
Exosomal tetraspanins mediate cancer metastasis by altering host microenvironment
Lü, J., Li, J., Liu, S., Wang, T., Ianni, A., Bober, E., Braun, T. W., Xiang, R., & Yue, S. (2017) · Oncotarget · doi:10.18632/oncotarget.19119 · Cited by 67
Tumor-derived exosomes in colorectal cancer progression and their clinical applications
Zhou, J., Li, X., Chen, Z., & Chng, W. J. (2017) · Oncotarget · doi:10.18632/oncotarget.20117 · Cited by 67
Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis
Campos, A. V., Burgos-Ravanal, R., González, M. F., Huilcamán, R., Lobos‐González, L., & Quest, A. F. G. (2019) · Biomolecules · doi:10.3390/biom9080314 · Cited by 65
Li, Q., Fu, X., Kou, Y., & Han, N. (2023) · Theranostics · doi:10.7150/thno.84971 · Cited by 63
“first described extracellular “exosomes” as a mechanism for shedding of specific membrane functions [13].”
NANOmetric BIO-Banked MSC-Derived Exosome (NANOBIOME) as a Novel Approach to Regenerative Medicine
Codispoti, B., Marrelli, M., Paduano, F., & Tatullo, M. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100357 · Cited by 64
Zhu, X., Wang, X., Wang, Y., & Zhao, Y. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.11.009 · Cited by 65
The Role of Bone-Derived Exosomes in Regulating Skeletal Metabolism and Extraosseous Diseases
Lyu, H., Xiao, Y., Guo, Q., Huang, Y., & Luo, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00089 · Cited by 66
Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies
Martín-Gracia, B., Martín‐Barreiro, A., Cuestas-Ayllón, C., Grazú, V., Linē, A., Llorente, A., de la Fuente, J. M., & Moros, M. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00861c · Cited by 67
Extracellular vesicles in cardiovascular disease
Huang, C., Neupane, Y. R., Lim, X. C., Shekhani, R., Czarny, B., Wacker, M. G., Pastorin, G., & Wang, J. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.08.006 · Cited by 66
Extracellular vesicles: A dive into their role in the tumor microenvironment and cancer progression
Lopez, K., Lai, S. W. T., Gonzalez, E. D. J. L., Dávila, R. G., & Shuck, S. C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1154576 · Cited by 67
“Johnstone coined the term exosome to describe EVs of endosomal origin and although it is widely accepted, it is being replaced by small extracellular vesicles (sEVs) due to difficulties in separating the heterogenous population of EVs (Johnstone et al., 1987; Willms et al., 2018).”
BackgroundAdvances in development of exosomes for ophthalmic therapeutics
Tian, Y., Zhang, T., Li, J., & Tao, Y. K. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114899 · Cited by 65
Blanc, L., Liu, J., Vidal, M., Chasis, J. A., An, X., & Mohandas, N. (2009) · Blood · doi:10.1182/blood-2009-06-230086 · Cited by 63
ATL-derived exosomes modulate mesenchymal stem cells: potential role in leukemia progression
Saghir, J. E., Nassar, F. J., Tawil, N., et al. (2016) · Retrovirology · doi:10.1186/s12977-016-0307-4 · Cited by 64
Liu, H., Chen, W., Zhi, X., Chen, E., Wei, T., Zhang, J., Shen, J., Hu, L., Zhao, B., Feng, X., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0309-x · Cited by 65
Exosomes in triple negative breast cancer: Garbage disposals or Trojan horses?
Goh, C. Y., Wyse, C. A., Ho, M., O’Beirne, E., Howard, J., Lindsay, S., Kelly, P., Higgins, M. J., & McCann, A. H. (2020) · Cancer Letters · doi:10.1016/j.canlet.2019.12.046 · Cited by 64
Metadata
- Authors
- Johnstone, R. M., Adam, M., Hammond, J. R., Orr, L., & Turbide, C.
- Affiliations
- McGill University (CA)
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 262
- Issue
- 19
- Pages
- 9412-9420
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1915536483
- Semantic Scholar
- 9e8f5a8482d60e384e3dcd94080a64e9f387e3ae
- Cited by
- 2,931
- References
- 51
- Citations by year
- 2026: 132 · 2025: 231 · 2024: 281 · 2023: 285 · 2022: 291 · 2021: 296 · 2020: 276 · 2019: 197 · 2018: 157 · 2017: 134 · 2016: 131 · 2015: 79 · 2014: 76 · 2013: 46 · 2012: 53
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- reticulocyte maturation, exosomes, vesicle formation, membrane shedding, acetylcholinesterase, glucose transporters, nucleoside transporters, amino acid transport, transferrin receptor, sphingomyelin, sheep red blood cells, membrane lipid composition
- MeSH terms
- Acetylcholinesterase, Amino Acids, Animals, Carrier Proteins, Cell Membrane, Cells, Cultured, Cytochalasin B, Glyceraldehyde-3-Phosphate Dehydrogenases, Leucine, Membrane Proteins, Monosaccharide Transport Proteins, Receptors, Transferrin, Reticulocytes, Sheep, Sodium, Thioinosine, Nucleoside Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
