Extracellular vesicles as a source of prostate cancer biomarkers in liquid biopsies: a decade of research
Open accessAbstract
Prostate cancer is a global cancer burden and considerable effort has been made through the years to identify biomarkers for the disease. Approximately a decade ago, the potential of analysing extracellular vesicles in liquid biopsies started to be envisaged. This was the beginning of a new exciting area of research investigating the rich molecular treasure found in extracellular vesicles to identify biomarkers for a variety of diseases. Vesicles released from prostate cancer cells and cells of the tumour microenvironment carry molecular information about the disease that can be analysed in several biological fluids. Numerous studies document the interest of researchers in this field of research. However, methodological issues such as the isolation of vesicles have been challenging. Remarkably, novel technologies, including those based on nanotechnology, show promise for the further development and clinical use of extracellular vesicles as liquid biomarkers. Development of biomarkers is a long and complicated process, and there are still not many biomarkers based on extracellular vesicles in clinical use. However, the knowledge acquired during the last decade constitutes a solid basis for the future development of liquid biopsy tests for prostate cancer. These are urgently needed to bring prostate cancer treatment to the next level in precision medicine.
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The challenge of isolating EVs by biogenesis arises from the shared biomarkers and overlaps in size among the various EV subtypes.
“The challenge arises from the shared biomarkers and overlaps in size among the various EV subtypes [124].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [124]
The Background section (“Extracellular vesicles”; page unavailable) says EV subtypes have overlapping size ranges and that current isolation methods cannot accurately separate them. The methodological section describes EV-surface markers used for isolation, but does not establish that shared biomarkers among subtypes cause this difficulty. (LLM, conf=0.84)
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Extracellular vesicles from biological fluids as potential biomarkers for prostate cancerPreprint
Choi, W. Y., Sánchez, C., Li, J. J., Dinarvand, M., Adomat, H. H., Ghaffari, M., Khoja, L., Vafaee, F., Joshua, A. M., Chi, K. N., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1948091/v1
- Authors
- Ramirez-Garrastacho, M., Bajo-Santos, C., Line, A., Martens-Uzunova, E. S., de la Fuente, J. M., Moros, M., Soekmadji, C., Tasken, K. A., & Llorente, A.
- Affiliations
- Latvian Biomedical Research and Study Centre (LV)
- The University of Queensland (AU)
- Oslo University Hospital (NO)
- Corresponding author
- Llorente, Alicia
- Venue
- British Journal of Cancer
- Published
- 2021-11-22
- Volume
- 126
- Issue
- 3
- Pages
- 331-350
- ISSN
- 0007-0920 (ISSN-L)
- 1532-1827
- PMC
- PMC8810769
- OpenAlex
- W3217233110
- Cited by
- 130
- References
- 243
- Citations by year
- 2026: 27 · 2025: 25 · 2024: 36 · 2023: 29 · 2022: 13
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal of Cancer (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Zaguan (Universidad de Zaragoza) (submittedVersion, cc-by)
- Funders
- Latvijas Zinātnes Padome
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
- Keywords
- extracellular vesicles, prostate cancer, liquid biopsy, tumor markers, vesicle isolation, tumor microenvironment, precision medicine
- MeSH terms
- Extracellular Vesicles, Cell-Free Nucleic Acids, Liquid Biopsy, Animals, Humans, Male, Neoplastic Cells, Circulating, Prostatic Neoplasms, Biomarkers, Tumor, Early Detection of Cancer, Precision Medicine
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