Metabolism of L-ascorbic acid-1-C14 in man
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
About 20% of urinary excretion accounted for unmetabolized ascorbic acid, 20% for 2,3-diketo-1-gulonic acid, 2% for dehydroascorbic acid, and on average 44% for oxalate.
“About 20% of urinary excretion accounted for unmetabolized ascorbic acid, the other 20% for 2,3-diketo-1-gulonic acid, only 2% for dehydroascorbic acid, while, on average, 44% was eliminated in the form of oxalate [79].”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [79]
Radioactive labelled vitamin C administered to three humans showed that most is eliminated by the kidney; less than 1% by feces and virtually none as carbon dioxide.
“Radioactive labelled vitamin C administered to three humans showed that most of the amount is eliminated by the kidney. Only less than 1% was eliminated by the feces and virtually no vitamin C was breathed out as carbon dioxide.”
From Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination (2021) · cites this paper as [79]
Cites
Roe, J. H., & Kuether, C. A. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)72395-8 · Cited by 1,799 · see citing works
299. The constitution of ascorbic acid
Herbert, R. W., Hirst, E. L., Percival, E. G. V., et al. (1933) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9330001270 · Cited by 173 · see citing works
Urinary Oxalate Excretion by Man Following Ascorbic Acid Ingestion.
Lamden, M. P., & CHRYSTOWSKI, G. A. (1954) · Experimental Biology and Medicine · doi:10.3181/00379727-85-20827 · Cited by 93 · see citing works
THE FATE OF HYDROCORTISONE-4-C14 IN MAN 1
HELLMAN, L., Bradlow, H. L., Adesman, J., Fukushima, D. K., Kulp, J. L., & Gallagher, T. F. (1954) · Journal of Clinical Investigation · doi:10.1172/jci102984 · Cited by 92 · see citing works
Self-citationTHE METABOLISM OF ASCORBIC ACID-1-C14 AND OXALIC ACID-C14 IN THE RAT
Curtin, C. O., & KING, C. G. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81411-4 · Cited by 88 · see citing works
THE SYNTHESIS OF l-ASCORBIC ACID IN THE RAT FROM d-GLUCURONOLACTONE AND l-GULONOLACTONE
Burns, J. J., & Evans, C. D. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65088-4 · Cited by 88 · see citing works
Self-citationTHE METABOLISM OF 1-C14-l-ASCORBIC ACID IN GUINEA PIGS
Burns, J. J., Burch, H. B., & KING, C. G. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)55954-8 · Cited by 83 · see citing works
Self-citationASCORBIC ACID SYNTHESIS IN NORMAL AND DRUG-TREATED RATS, STUDIED WITH l-ASCORBIC-1-C14 ACID
Burns, J. J., Mosbach, E. H., & Schulenberg, S. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65685-6 · Cited by 82 · see citing works
Self-citationSynthesis of L-Ascorbic-1-C14 Acid from D-Sorbitol1
Salomon, L. L., Burns, J. J., & KING, C. G. (1952) · Journal of the American Chemical Society · doi:10.1021/ja01140a051 · Cited by 51 · see citing works
Self-citationPractical Aspects of Oxalate Metabolism
Jeghers, H. J., & Murphy, R. (1945) · New England Journal of Medicine · doi:10.1056/nejm194508162330704 · Cited by 51 · see citing works
Practical Aspects of Oxalate Metabolism
Jeghers, H. J., & Murphy, R. (1945) · New England Journal of Medicine · doi:10.1056/nejm194508232330804 · Cited by 50 · see citing works
FURTHER OBSERVATIONS ON THE METABOLISM OF l-ASCORBIC ACID IN GUINEA PIGS
Burns, J. J., Dayton, P. G., & Schulenberg, S. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65866-1 · Cited by 39 · see citing works
Self-citationHexuronic Acid as the Antiscorbutic Factor
Cox, E. G., Hirst, E. L., & Reynolds, R. J. W. (1932) · Nature · doi:10.1038/130888a0 · Cited by 31 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Vitamin C in Human Health and Disease Is Still a Mystery? An Overview
Naidu, K. A. (2003) · Nutrition Journal · doi:10.1186/1475-2891-2-7 · Cited by 810 · see citing works
Vitamin C. Biosynthesis, recycling and degradation in mammals
Linster, C. L., & Van Schaftingen, E. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05607.x · Cited by 757 · see citing works
Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination
Doseděl, M., Jirkovský, E., Macáková, K., Krčmová, L., Javorská, L., Pourová, J., Mercolini, L., Remião, F., Nováková, L., Mladěnka, P., et al. (2021) · Nutrients · doi:10.3390/nu13020615 · Cited by 553 · see citing works
Effect of vitamin C supplements on urinary oxalate and pH in calcium stone-forming patients
Baxmann, A. C., de O.G. Mendonça, C., & Heilberg, I. P. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00815.x · Cited by 176 · see citing works
Scientific Opinion on Dietary Reference Values for vitamin C
EFSA Panel on Dietetic Products, N. A. A. (. (2013) · EFSA Journal · doi:10.2903/j.efsa.2013.3418 · Cited by 173 · see citing works
Oxalic acid excretion after intravenous ascorbic acid administration
Robitaille, L., Mamer, O. A., Miller, W. H., Levine, M., Assouline, S., Melnychuk, D., Rousseau, C., & Hoffer, L. J. (2009) · Metabolism · doi:10.1016/j.metabol.2008.09.023 · Cited by 67 · see citing works
- Authors
- Hellman, L., & Burns, J. J.
- Affiliations
- National Institutes of Health (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1958-02
- Volume
- 230
- Issue
- 2
- Pages
- 923-930
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1501148509
- Cited by
- 150
- References
- 13
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Keywords
- vitamin C, carbon-14, metabolic fate, human metabolism, vitamin C metabolism
- MeSH terms
- Ascorbic Acid, Humans, Male, Carbohydrate Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
