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Cited by 557

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The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase.

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Bennetzen, J L, Hall, B D·1982·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)81067-0
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Abstract

The DNA sequence of the gene for the fermentative yeast alcohol dehydrogenase has been determined. The structural gene contains no introns. The amino acid sequence of the protein as determined from the nucleotide sequence disagrees with the published alcohol dehydrogenase isozyme I (ADH-I) sequence for 5 of the 347 amino acid residues. At least one, and perhaps as many as four, of these differences is probably due to ADH-I protein heterogeneity in different yeast strains and not to sequencing errors. S1 nuclease was used to map the 5' and 3' ends of the ADH-I mRNA. There are two discrete, mature 5' ends of the mRNA, mapping 27 and 37 nucleotides upstream of the translation initiating ATG. These two equally prevalent termini are 101 and 91 nucleotides, respectively, downstream from a TATAAA sequence. Analysis of the 3' end of ADH-I mRNA disclosed two minor ends upstream of the major poly(A) addition site. These three ends map 24, 67, and 83 nucleotides, respectively, downstream from the translation-terminating TAA triplet. The sequence AA-TAAG is found 28 to 34 nucleotides upstream of each ADH-I mRNA poly(A) addition site. Sequence comparisons of these three 3' ends with those for four other yeast mRNAs yielded a 13-nucleotide consensus sequence to which TAAATAAGA is central. All of the known yeast poly(A) addition sites map at or near the A residue of a CTA site 25 to 40 nucleotides downstream from this consensus octamer.

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Research works printed but not linked: 37

  1. Ebisuzaki, 1957, Arch. Biochem. Biophys., 69, 555, 10.1016/0003-9861(57)90520-9 · doi:10.1016/0003-9861(57)90520-9
  2. Lutstorf, 1968, Arch. Biochem. Biophys., 126, 933, 10.1016/0003-9861(68)90487-6 · DOI · Paper page
  3. Ciriacy, 1975, Mutat. Res., 29, 315, 10.1016/0027-5107(75)90053-6 · doi:10.1016/0027-5107(75)90053-6
  4. Ciriacy, 1975, Mol. Gen. Genet., 138, 157, 10.1007/BF02428119 · doi:10.1007/bf02428119
  5. Ciriacy, 1976, Mol. Gen. Genet., 145, 327, 10.1007/BF00325831 · doi:10.1007/bf00325831
  6. Wills, 1979, Eur. J. Biochem., 99, 323, 10.1111/j.1432-1033.1979.tb13260.x · doi:10.1111/j.1432-1033.1979.tb13260.x
  7. Wills, 1976, Nature, 261, 26, 10.1038/261026a0 · DOI
  8. Heick, 1969, Biochim. Biophys. Acta, 191, 493, 10.1016/0005-2744(69)90342-8 · doi:10.1016/0005-2744(69)90342-8
  9. Fowler, 1972, Can. J. Biochem., 50, 35, 10.1139/o72-007 · DOI
  10. Williamson, 1980, Nature, 283, 214, 10.1038/283214a0 · DOI
  11. Elwell, 1975, Infect. Immunol., 12, 404, 10.1128/iai.12.2.404-410.1975 · DOI · Paper page
  12. Bennetzen, J. (1980) Ph.D. dissertation, University of Washington
  13. Richardson, 1965, Proc. Natl. Acad. Sci. U. S. A., 54, 158, 10.1073/pnas.54.1.158 · DOI · Paper page
  14. Smith, 1976, Nucleic Acids Res., 3, 2387, 10.1093/nar/3.9.2387 · DOI · Paper page
  15. Maxam, 1977, Proc. Natl. Acad. Sci. U. S. A., 74, 560, 10.1073/pnas.74.2.560 · DOI · Paper page
  16. Berk, 1978, Proc. Natl. Acad. Sci. U. S. A., 75, 1274, 10.1073/pnas.75.3.1274 · DOI · Paper page
  17. Bennetzen, 1982, J. Biol. Chem., 257, 3026, 10.1016/S0021-9258(19)81068-2 · DOI · Paper page
  18. Benoist, 1980, Nucleic Acids Res., 8, 127, 10.1093/nar/8.1.127 · DOI · Paper page
  19. Proudfoot, 1976, Progr. Nucleic Acid Res. Mol. Biol., 19, 123, 10.1016/S0079-6603(08)60914-9 · DOI
  20. Bogenhagen, 1980, Cell, 19, 27, 10.1016/0092-8674(80)90385-2 · DOI
  21. Koski, 1980, Cell, 22, 415, 10.1016/0092-8674(80)90352-9 · doi:10.1016/0092-8674(80)90352-9
  22. Eklund, 1976, J. Mol. Biol., 102, 61, 10.1016/0022-2836(76)90073-5 · doi:10.1016/0022-2836(76)90073-5
  23. Jörnvall, 1977, Eur. J. Biochem., 72, 425, 10.1111/j.1432-1033.1977.tb11267.x · DOI
  24. Holland, 1979, J. Biol. Chem., 254, 9839, 10.1016/S0021-9258(19)83593-7 · doi:10.1016/s0021-9258(19)83593-7
  25. Holland, 1980, J. Biol. Chem., 255, 2596, 10.1016/S0021-9258(19)85934-3 · doi:10.1016/s0021-9258(19)85934-3
  26. Smith, 1979, Cell, 16, 753, 10.1016/0092-8674(79)90091-6 · DOI · Paper page
  27. Montgomery, 1980, Proc. Natl. Acad. Sci. U. S. A., 77, 541, 10.1073/pnas.77.1.541 · DOI
  28. Gallwitz, 1980, Proc. Natl. Acad. Sci. U. S. A., 77, 2546, 10.1073/pnas.77.5.2546 · DOI · Paper page
  29. Faye, 1981, Proc. Natl. Acad. Sci. U. S. A., 78, 2258, 10.1073/pnas.78.4.2258 · DOI · Paper page
  30. Grosschedl, 1980, Proc. Natl. Acad. Sci. U. S. A., 77, 1432, 10.1073/pnas.77.3.1432 · DOI · Paper page
  31. Ziff, 1978, Cell, 15, 1463, 10.1016/0092-8674(78)90070-3 · DOI · Paper page
  32. Kozak, 1978, Cell, 15, 1109, 10.1016/0092-8674(78)90039-9 · DOI · Paper page
  33. Fitzgerald, 1981, Cell, 24, 251, 10.1016/0092-8674(81)90521-3 · DOI · Paper page
  34. Nasmyth, 1981, Nature, 289, 244, 10.1038/289244a0 · DOI · Paper page
  35. Fraser, 1980, Virology, 103, 514, 10.1016/0042-6822(80)90210-X · doi:10.1016/0042-6822(80)90210-x
  36. Nevins, 1980, J. Mol. Biol., 144, 377, 10.1016/0022-2836(80)90096-0 · doi:10.1016/0022-2836(80)90096-0
  37. Nasmyth, 1981, Cold Spring Harbor Symp. Quant. Biol., 45, 961, 10.1101/SQB.1981.045.01.113 · doi:10.1101/sqb.1981.045.01.113

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Metadata

Authors
Bennetzen, J. L., & Hall, B. D.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1982-03
Volume
257
Issue
6
Pages
3018-3025
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)81067-0
OpenAlex
W1481736392
Cited by
557
References
0
FWCI
20.13
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase. https://app.cochat.ai/papers/10.1016/s0021-9258(19)81067-0
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Bennetzen, J. L., & Hall, B. D. (1982). The primary structure of the Saccharomyces cerevisiae gene for alcohol dehydrogenase. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)81067-0

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