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Cited by 521

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone

Open access
Robinson, John A., Chatterjee-Kishore, Moitreyee, Yaworsky, Paul J., Cullen, Diane M., Zhao, Weiguang, Li, Christine, Kharode, Yogendra, Sauter, Linda, Babij, Philip, Brown, Eugene L., Hill, Andrew A., Akhter, Mohammed P., Johnson, Mark L., Recker, Robert R., Komm, Barry S., Bex, Frederick J.·2006·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)84086-3
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Abstract

A preliminary expression profiling analysis of osteoblasts derived from tibia explants of the high bone mass LRP5 G171V transgenic mice demonstrated increased expression of canonical Wnt pathway and Wnt/beta-catenin target genes compared with non-transgenic explant derived osteoblasts. Therefore, expression of Wnt/beta-catenin target genes were monitored after in vivo loading of the tibia of LRP5 G171V transgenic mice compared with non-transgenic mice. Loading resulted in the increased expression of Wnt pathway and Wnt/beta-catenin target genes including Wnt10B, SFRP1, cyclin D1, FzD2, WISP2, and connexin 43 in both genotypes; however, there was a further increased in transcriptional response with the LRP5 G171V transgenic mice. Similar increases in the expression of these genes (except cyclin D1) were observed when non-transgenic mice were pharmacologically treated with a canonical Wnt pathway activator, glycogen synthase kinase 3beta inhibitor and then subjected to load. These in vivo results were further corroborated by in vitro mechanical loading experiments in which MC3T3-E1 osteoblastic cells were subjected to 3400 microstrain alone for 5 h, which increased the expression of Wnt10B, SFRP1, cyclin D1, FzD2, WISP2, and connexin 43. Furthermore, when MC3T3-E1 cells were treated with either glycogen synthase kinase 3beta inhibitor or Wnt3A to activate Wnt signaling and then subjected to load, a synergistic up-regulation of these genes was observed compared with vehicle-treated cells. Collectively, the in vivo and in vitro mechanical loading results support that Wnt/beta-catenin signaling is a normal physiological response to load and that activation of the Wnt/beta-catenin pathway enhances the sensitivity of osteoblasts/osteocytes to mechanical loading.

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Metadata

Authors
Robinson, J. A., Chatterjee-Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y., Sauter, L., Babij, P., Brown, E. L., Hill, A. A., Akhter, M. P., Johnson, M. L., Recker, R. R., Komm, B. S., & Bex, F. J.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2006-10
Volume
281
Issue
42
Pages
31720-31728
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)84086-3
OpenAlex
W2073907573
Cited by
521
References
50
FWCI
10.19
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone. https://app.cochat.ai/papers/10.1016/s0021-9258(19)84086-3
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Robinson, J. A., Chatterjee-Kishore, M., Yaworsky, P. J., Cullen, D. M., Zhao, W., Li, C., Kharode, Y., Sauter, L., Babij, P., Brown, E. L., Hill, A. A., Akhter, M. P., Johnson, M. L., Recker, R. R., Komm, B. S., & Bex, F. J. (2006). Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)84086-3

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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