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Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface
Open accessAbstract
In addition to its effect on high density lipoprotein (HDL) cholesteryl ester (CE) uptake, scavenger receptor BI (SR-BI) was recently reported to stimulate free cholesterol (FC) flux from Chinese hamster ovary (CHO) cells stably expressing mouse SR-BI, a novel function of SR-BI that may play a role in cholesterol removal from the vessel wall where the receptor can be found. It is possible that SR-BI stimulates flux simply by tethering acceptor HDL particles in close apposition to the cell surface thereby facilitating the movement of cholesterol between the plasma membrane and HDL. To test this, we used transiently transfected cells and compared the closely related class B scavenger receptors mouse SR-BI and rat CD36 for their ability to stimulate cholesterol efflux as both receptors bind HDL with high affinity. The results showed that, although acceptor binding to SR-BI may contribute to efflux to a modest extent, the major stimulation of FC efflux occurs independently of acceptor binding to cell surface receptors. Instead our data indicate that SR-BI mediates alterations to membrane FC domains which provoke enhanced bidirectional FC flux between cells and extracellular acceptors. —de la Llera-Moya, M., G. H. Rothblat, M. A. Connelly, G. Kellner-Weibel, S. W. Sakr, M. C. Phillips, and D. L. Williams. Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface. J. Lipid Res. 1999. 40: 575–580.
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Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
Cited by
Kontush, A., & Chapman, M. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.1 · Cited by 647
High Density Lipoprotein Structure–Function and Role in Reverse Cholesterol Transport
Lund-Katz, S., & Phillips, M. C. (2010) · Subcellular Biochemistry · doi:10.1007/978-90-481-8622-8_7 · Cited by 262
Self-citationShen, W.-J., Asthana, S., Kraemer, F. B., & Azhar, S. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r083121 · Cited by 148
Pagler, T. A., Rhode, S., Neuhofer, A., Laggner, H., Strobl, W., Hinterndorfer, C., Volf, I., Pavelka, M., Eckhardt, E. R. M., van der Westhuyzen, D. R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510261200 · Cited by 119
Caveolae and intracellular trafficking of cholesterol
Fielding, C. J., & Fielding, P. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00140-5 · Cited by 116
Metadata
- Authors
- de la Llera-Moya, M., Rothblat, G. H., Connelly, M. A., Kellner-Weibel, G., Sakr, S. W., Phillips, M. C., & Williams, D. L.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1999-03
- Volume
- 40
- Issue
- 3
- Pages
- 575-580
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2170417134
- Cited by
- 234
- References
- 1
- FWCI
- 19.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- de la Llera-Moya, M., Rothblat, G. H., Connelly, M. A., Kellner-Weibel, G., Sakr, S. W., Phillips, M. C., & Williams, D. L. (1999). Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)32462-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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