The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.
Open accessAbstract
Cholesteryl ester-rich beta-very low density lipoproteins (beta-VLDL) are beta-migrating lipoproteins that accumulate in the d < 1.006 g/ml fraction of plasma from cholesterol-fed animals and from patients with Type III hyperlipoproteinemia. They can be separated from pre-beta-migrating very low density lipoproteins in the d 1.006 g/ml fraction by Geon-Pevikon block electrophoresis. The beta-VLDL have a general property of stimulating cholesteryl ester synthesis and accumulation in macrophages. In the present study, we demonstrated that beta-VLDL obtained from cholesterol-fed dogs fasted for 16 hr were heterogeneous and that two subpopulations of particles, referred to as Fractions I and II, could be isolated from the whole beta-VLDL fraction using gel filtration chromatography. These fractions of beta-VLDL were similar in that both were cholesteryl ester rich, had beta-electrophoretic mobility on Geon-Pevikon electrophoresis, and possessed the B and E apoproteins as major constituents. However, Fractions I and II differed in size, shape, electrophoretic mobility, chemical composition, and apoprotein B type. (Fraction I vs. Fraction II: size: 90 to 300 nm vs. 20 to 70 nm; shape: irregular with redundant surface vs. spherical; electrophoretic mobility on paper: origin vs. beta; chemical composition: rich in phospholipid and poor in protein vs. rich in protein and poor in triglycerides; apoprotein B types: equal amounts of the high and low molecular weight forms vs. predominant…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This defective binding causes impaired clearance of chylomicron and very low density lipoprotein remnants (β-VLDL) (5, 6), which accumulate in the plasma and cause both hypercholesterolemia and hypertriglyceridemia.”
From Apolipoprotein E3-Leiden contains a seven-amino acid insertion that is a tandem repeat of residues 121–127 (1989) · cites this paper as [5]
Citations
Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688
Phosphorus Assay in Column Chromatography
Bartlett, G. R. (1959) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70226-3 · Cited by 12,802
Goldstein, J. L., Ho, Y. K., Basu, S. K., & Brown, M. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.333 · Cited by 2,447
Bilheimer, D. W., Eisenberg, S., & Levy, R. I. (1972) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(72)90034-3 · Cited by 1,815
Weisgraber, K. H., Rall, S. C., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52510-8 · Cited by 777
Self-citationBrown, M. S., Ho, Y. K., & Goldstein, J. L. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70568-7 · Cited by 722
Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.
Kane, J. P., Hardman, D. A., & Paulus, H. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2465 · Cited by 581
Discoidal bilayer structure of nascent high density lipoproteins from perfused rat liver.
Hamilton, R. L., Williams, M. C., Fielding, C. J., & Havel, R. J. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108513 · Cited by 538
Self-citationDisturbances in Lipid and Lipoprotein Metabolism
Bouchier, I. A. D. (1978) · Gut · doi:10.1136/gut.19.11.1088 · Cited by 495
Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.
Hui, D. Y., Innerarity, T. L., & Mahley, R. W. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69254-9 · Cited by 383
Self-citationGoldstein, J. L., Ho, Y. K., Brown, M. S., Innerarity, T. L., & Mahley, R. W. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85958-6 · Cited by 376
Self-citationSata, T., Havel, R. J., & Jones, A. L. (1972) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39346-9 · Cited by 359
Mjøs, O. D., Færgeman, O., Hamilton, R. L., & Havel, R. J. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108130 · Cited by 322
Self-citationMahley, R. W., Innerarity, T. L., Brown, M. S., Ho, Y. K., & Goldstein, J. L. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34757-x · Cited by 276
Self-citationMahley, R. W. (1982) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31426-2 · Cited by 274
Self-citationStructure of human serum lipoproteins inferred from compositional analysis.
Shen, B. W., Scanu, A. M., & Kézdy, F. J. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.3.837 · Cited by 270
Canine Lipoproteins and Atherosclerosis
Mahley, R. W., Weisgraber, K. H., & Innerarity, T. L. (1974) · Circulation Research · doi:10.1161/01.res.35.5.722 · Cited by 257
Self-citationHavel, R. J., & Kane, J. P. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.7.2015 · Cited by 231
Canine Lipoproteins and Atherosclerosis
Mahley, R. W., & Weisgraber, K. H. (1974) · Circulation Research · doi:10.1161/01.res.35.5.713 · Cited by 201
Self-citationApolipoprotein B variant derived from rat intestine.
Krishnaiah, K. V., Walker, L., Borensztajn, J., Schonfeld, G., & Getz, G. S. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.7.3806 · Cited by 169
Mahley, R. W., Innerarity, T. L., Weisgraber, K. H., & Fry, D. L. (1977) · PubMed Central · Cited by 159
Self-citationWu, A. L., & Windmueller, H. G. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)69493-7 · Cited by 119
Secretion of Cholesterol-Rich Lipoproteins by Perfused Livers of Hypercholesterolemic Rats
Noël, S. P., Wong, L., Dolphin, P. J., Dory, L., & Rubinstein, D. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109508 · Cited by 108
Isolation and characterization of hepatic Golgi lipoproteins from hypercholesterolemic rats.
Swift, L. L., Manowitz, N., Dunn, G. D., & LeQuire, V. S. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109871 · Cited by 68
Chylomicron metabolism during dietary-induced hypercholesterolemia in dogs.
Melchior, G. W., Mahley, R. W., & Buckhold, D. K. (1981) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37370-3 · Cited by 66
Self-citationPhysical studies of d less than 1.006 g/ml lymph lipoproteins from rats fed palmitate-rich diets.
Clark, S. B., Atkinson, D., Hamilton, J. A., Forte, T. M., Russell, B. S., FELDMAN, E. B., & SMALL, D. M. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38171-2 · Cited by 38
Comparative Pathogenetic Patterns in Atherosclerosis
Wissler, R. W., & Vesselinovitch, D. (1968) · Advances in lipid research · doi:10.1016/b978-1-4831-9942-9.50011-5 · Cited by 32
An investigation of the defect in type III hyperlepoproteinemia using agarose column chromatography
Packard, C. J., Morgan, H., Third, J. L. H. C., & Shepherd, J. (1978) · Clinica Chimica Acta · doi:10.1016/0009-8981(78)90473-4 · Cited by 2
Research works printed but not linked: 2
- Mahley, 1979, Dietary fat, cholesterol, and accelerated atherosclerosis, Atheroscler. Rev., 5, 1
- Bersot, 1981, Stimulation of macrophage cholesteryl ester formation by ß-VLDL from cholesterol-fed and hyperlipidemic subjects, Clin. Res., 29, 536A
Cited by
Sorted by citations
Plasma lipoproteins: apolipoprotein structure and function.
Mahley, R. W., Innerarity, T. L., Rall, S. C., & Weisgraber, K. H. (1984) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34443-6 · Cited by 1,155
Self-citationLipoprotein receptors and cholesterol homeostasis
Mahley, R. W., & Innerarity, T. L. (1983) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(83)90001-1 · Cited by 756
Self-citationAstrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins
Pitas, R. E., Boyles, J. K., Lee, S. H., Foss, D., & Mahley, R. W. (1987) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(87)90295-5 · Cited by 693
Self-citationKowal, R. C., Herz, J., Goldstein, J. L., Esser, V., & Brown, M. S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5810 · Cited by 595
Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease.
Groot, P. H. E., van Stiphout, W. A. H. J., Krauss, X. H., Jansen, H., van Tol, A., van Ramshorst, E., Chin-On, S., Albert Hofman, D., Cresswell, S. R., & Havekes, L. M. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.3.653 · Cited by 528
Metadata
- Authors
- Fainaru, M., Mahley, R. W., Hamilton, R. L., & Innerarity, T. L.
- Affiliations
- Gladstone Institutes (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1982-07
- Volume
- 23
- Issue
- 5
- Pages
- 702-714
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2336112818
- Cited by
- 156
- References
- 29
- Citations by year
- 2023: 1 · 2020: 1
- FWCI
- 34.22
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- beta-VLDL, chylomicron remnants, type III hyperlipoproteinemia, apolipoprotein B, lipoprotein heterogeneity, cholesteryl ester synthesis, macrophages, retinol transport, lipoprotein clearance, fasting, lipoprotein metabolism, size exclusion chromatography
- MeSH terms
- Animals, Cells, Cultured, Cholesterol, Dietary, Chromatography, Gel, Dogs, Electrophoresis, Polyacrylamide Gel, Fasting, Female, Humans, Hyperlipoproteinemia Type III, Lipoproteins, VLDL, Male, Microscopy, Electron, Vitamin A, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
