Cited by 157Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.

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Fainaru, M, Mahley, R W, Hamilton, R L, Innerarity, T L·1982·Journal of Lipid Research

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Abstract

Cholesteryl ester-rich beta-very low density lipoproteins (beta-VLDL) are beta-migrating lipoproteins that accumulate in the d < 1.006 g/ml fraction of plasma from cholesterol-fed animals and from patients with Type III hyperlipoproteinemia. They can be separated from pre-beta-migrating very low density lipoproteins in the d 1.006 g/ml fraction by Geon-Pevikon block electrophoresis. The beta-VLDL have a general property of stimulating cholesteryl ester synthesis and accumulation in macrophages. In the present study, we demonstrated that beta-VLDL obtained from cholesterol-fed dogs fasted for 16 hr were heterogeneous and that two subpopulations of particles, referred to as Fractions I and II, could be isolated from the whole beta-VLDL fraction using gel filtration chromatography. These fractions of beta-VLDL were similar in that both were cholesteryl ester rich, had beta-electrophoretic mobility on Geon-Pevikon electrophoresis, and possessed the B and E apoproteins as major constituents. However, Fractions I and II differed in size, shape, electrophoretic mobility, chemical composition, and apoprotein B type. (Fraction I vs. Fraction II: size: 90 to 300 nm vs. 20 to 70 nm; shape: irregular with redundant surface vs. spherical; electrophoretic mobility on paper: origin vs. beta; chemical composition: rich in phospholipid and poor in protein vs. rich in protein and poor in triglycerides; apoprotein B types: equal amounts of the high and low molecular weight forms vs. predominant…

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Authors: Fainaru, M., Mahley, R. W., Hamilton, R. L., & Innerarity, T. L.
Affiliations: Gladstone Institutes (US)
ORCID: Mahley, R W
Hamilton, R L
Venue: Journal of Lipid Research
Publisher: Elsevier BV
Published: 1982-07
Volume: 23
Issue: 5
Pages: 702-714
ISSN: 0022-2275 (ISSN-L)
DOI: 10.1016/s0022-2275(20)38102-5
OpenAlex: W2336112818
Cited by: 156
References: 29
Citations by year: 2023: 1 · 2020: 1
FWCI: 34.22
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 13965 d)
Locations: Journal of Lipid Research (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: beta-VLDL, chylomicron remnants, type III hyperlipoproteinemia, apolipoprotein B, lipoprotein heterogeneity, cholesteryl ester synthesis, macrophages, retinol transport, lipoprotein clearance, fasting, lipoprotein metabolism, size exclusion chromatography
MeSH terms: Animals, Cells, Cultured, Cholesterol, Dietary, Chromatography, Gel, Dogs, Electrophoresis, Polyacrylamide Gel, Fasting, Female, Humans, Hyperlipoproteinemia Type III, Lipoproteins, VLDL, Male, Microscopy, Electron, Vitamin A, Mice

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Structural and metabolic heterogeneity of beta-very low density lipoproteins from cholesterol-fed dogs and from humans with type III hyperlipoproteinemia.

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