RAD51 is Involved in Repair of Damage Associated with DNA Replication in Mammalian Cells

Genome maintenance mechanisms for preventing cancer

Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824

Cancer Susceptibility and the Functions of BRCA1 and BRCA2

Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis

Sakahira, H., Enari, M., & Nagata, S. (1998) · Nature · doi:10.1038/34214 · Cited by 1,666

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

Waga, S., Hannon, G. J., Beach, D., & Stillman, B. (1994) · Nature · doi:10.1038/369574a0 · Cited by 1,655

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

Scully, R., Chen, J., Plug, A., Xiao, Y., Weaver, D., Feunteun, J., Ashley, T., & Livingston, D. M. (1997) · Cell · doi:10.1016/s0092-8674(00)81847-4 · Cited by 1,459

XRCC3 promotes homology-directed repair of DNA damage in mammalian cellsPreprint

Pierce, A. J., Johnson, R. D., Thompson, L. H., & Jasin, M. (1999) · Genes & Development · doi:10.1101/gad.13.20.2633 · Cited by 1,384

Chromosomal stability and the DNA double-stranded break connection

van Gent, D. C., Hoeijmakers, J. H. J., & Kanaar, R. (2001) · Nature Reviews Genetics · doi:10.1038/35056049 · Cited by 1,219

Reduction of Ribonucleotides

Thelander, L., & Reichard, P. A. (1979) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.48.070179.001025 · Cited by 1,160

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

Sharan, S. K., Morimatsu, M., Albrecht, U., Lim, D., Regel, E., Dinh, C. Q., Sands, A., Gregor Eichele, C., Hasty, P., & Bradley, A. (1997) · Nature · doi:10.1038/386804a0 · Cited by 1,087

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Petermann, E., Orta, M. L., Issaeva, N., Schultz, N., & Helleday, T. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.021 · Cited by 815

DNA double-strand break repair: From mechanistic understanding to cancer treatment

HELLEDAY, T., LO, J., VANGENT, D., & ENGELWARD, B. (2007) · DNA Repair · doi:10.1016/j.dnarep.2007.02.006 · Cited by 640

Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

Lundin, C. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki681 · Cited by 367

The consequences of Rad51 overexpression for normal and tumor cells

Klein, H. L. (2008) · DNA repair · doi:10.1016/j.dnarep.2007.12.008 · Cited by 357

Spontaneous Homologous Recombination Is Induced by Collapsed Replication Forks That Are Caused by Endogenous DNA Single-Strand Breaks

Saleh-Gohari, N., Bryant, H. E., Schultz, N., Parker, K. M., Cassel, T. N., & Helleday, T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7158-7169.2005 · Cited by 339

Pathways for mitotic homologous recombination in mammalian cells

Helleday, T. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.013 · Cited by 314

Homologous recombination in cancer development, treatment and development of drug resistance

Helleday, T. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq064 · Cited by 296

Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo

Koturbash, I., Rugo, R. E., Hendricks, C. A., Loree, J. M., Thibault, B. J., Kutanzi, K. R., Pogribny, I. P., Yanch, J. C., Engelward, B. P., & Kovalchuk, O. (2006) · Oncogene · doi:10.1038/sj.onc.1209467 · Cited by 217

p53 modulates homologous recombination by transcriptional regulation of the RAD51 gene

Arias, C., Lazaro‐Trueba, I., Kerr, P., Lord, C. J., Dexter, T., Iravani, M., Ashworth, A., & Silva, A. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400587 · Cited by 206

RAD51 interconnects between DNA replication, DNA repair and immunity

Bhattacharya, S., Kalayarasan, S., Abdisalaam, S., Su, F., Raj, P., Dozmorov, I. M., Mishra, R., Wakeland, E. K., Ghose, S., Mukherjee, S., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx126 · Cited by 185

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

Rasouli‐Nia, A., Karimi‐Busheri, F., & Weinfeld, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400099101 · Cited by 151

Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

Birkenkamp, K. U., Geugien, M., Schepers, H., Westra, J. M., Lemmink, H. H., & Vellenga, E. (2003) · Leukemia · doi:10.1038/sj.leu.2403145 · Cited by 143

Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart

Somyajit, K., Saxena, S., Babu, S., Mishra, A., & Nagaraju, G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv880 · Cited by 132

RAD51, genomic stability, and tumorigenesis

Richardson, C. A. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.08.009 · Cited by 118

FLT3-ITD-TKD dual mutants associated with AML confer resistance to FLT3 PTK inhibitors and cytotoxic agents by overexpression of Bcl-x(L)

Bagrintseva, K., Geisenhof, S., Kern, R., Eichenlaub, S., Reindl, C., Ellwart, J. W., Hiddemann, W., & Spiekermann, K. (2004) · Blood · doi:10.1182/blood-2004-06-2459 · Cited by 112

The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells

Zeidler, M. G., Varambally, S., Cao, Q., Chinnaiyan, A. M., Ferguson, D. O., Merajver, S. D., & Kleer, C. G. (2005) · Neoplasia · doi:10.1593/neo.05472 · Cited by 105

DNA damage responses and their many interactions with the replication fork

Andreassen, P. R., Ho, G. P. H., & D’Andrea, A. D. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi319 · Cited by 99

NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites

Ray, A., Milum, K., Battu, A., Wani, G., & Wani, A. A. (2013) · DNA Repair · doi:10.1016/j.dnarep.2013.01.003 · Cited by 85

A Molecular Portrait of Arabidopsis Meiosis

Mā, H. (2006) · The Arabidopsis Book · doi:10.1199/tab.0095 · Cited by 88

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest

Otterlei, M., Bruheim, P., Ahn, B., Bussen, W., Karmakar, P., Baynton, K., & Bohr, V. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03291 · Cited by 88

Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination

Ferrara, L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh822 · Cited by 82

A Surveillance Mechanism Ensures Repair of DNA Lesions during Zygotic Reprogramming

Ladstätter, S., & Tachibana-Konwalski, K. (2016) · Cell · doi:10.1016/j.cell.2016.11.009 · Cited by 77

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation

Groth, P., Orta, M. L., Elvers, I., Majumder, M. M., Lagerqvist, A., & Helleday, T. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks315 · Cited by 75

p53 Mediates Senescence-Like Arrest Induced by Chronic Replicational Stress

Marusyk, A., Wheeler, L. J., Mathews, C. K., & DeGregori, J. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01316-06 · Cited by 74

5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

Orta, M. L., Calderón‐Montaño, J. M., Domı́nguez, I., Pastor, N., Burgos‐Morón, E., López‐Lázaro, M., Cortés, F., Mateos, S., & Helleday, T. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt270 · Cited by 73

Homologous Recombination Is Required for Genome Stability in the Absence of DOG-1 inCaenorhabditis elegans

Youds, J. L., O’Neil, N. J., & Rose, A. M. (2006) · Genetics · doi:10.1534/genetics.106.056879 · Cited by 70

Homologous Recombination Conserves DNA Sequence Integrity Throughout the Cell Cycle in Embryonic Stem Cells

Serrano, L., Liang, L., Chang, Y., Deng, L., Maulion, C., Nguyen, S. C., & Tischfield, J. A. (2010) · Stem Cells and Development · doi:10.1089/scd.2010.0159 · Cited by 65

Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy

Chen, G., Magis, A. T., Xu, K., Park, D., Yu, D. S., Owonikoko, T. K., Sica, G., Satola, S. W., Ramalingam, S. S., Curran, W. J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92742 · Cited by 63

Clinical relevance of the homologous recombination machinery in cancer therapy

Miyagawa, K. (2007) · Cancer Science · doi:10.1111/j.1349-7006.2007.00644.x · Cited by 58

PC4 promotes genome stability and DNA repair through binding of ssDNA at DNA damage sites

Mortusewicz, O., Evers, B., & Helleday, T. (2015) · Oncogene · doi:10.1038/onc.2015.135 · Cited by 52

Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells

Akerman, G. S., Rosenzweig, B. A., Domon, O. E., Tsai, C., Bishop, M. E., McGarrity, L. J., MacGregor, J. T., Sistare, F. D., Chen, J. J., & Morris, S. M. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20091 · Cited by 52

The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates the Effects of Topoisomerase I Poisons by Suppressing Rad51 Expression in a p53-Dependent Manner

Ambrosini, G., Seelman, S. L., Qin, L., & Schwartz, G. K. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2395 · Cited by 49

p53 protects from replication-associated DNA double-strand breaks in mammalian cells

Kumari, A. R., Schultz, N., & Helleday, T. (2004) · Oncogene · doi:10.1038/sj.onc.1207379 · Cited by 48

Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents

Ferrara, L., Parekh‐Olmedo, H., & Kmiec, E. B. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.06.021 · Cited by 47

DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells

Brachman, E. E., & Kmiec, E. B. (2004) · Journal of Cell Science · doi:10.1242/jcs.01250 · Cited by 46

Genotoxicity of alcohol is linked to DNA replication-associated damage and homologous recombination repair

Kotova, N., Vare, D., Schultz, N. D., Gradecka-Meesters, D., Stepnik, M., Grawé, J., Helleday, T., & Jenssen, D. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs340 · Cited by 45

Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer

Li, Y., Kong, R., Chen, H., Zhao, Z., Li, L., Li, J., Hu, J., Zhang, G., Pan, S., Wang, Y., et al. (2019) · Aging · doi:10.18632/aging.102096 · Cited by 44

A role for SSRP1 in recombination‐mediated DNA damage response

Kumari, A. R., Mazina, O. M., Shinde, U. P., Mazin, A. V., & Lu, H. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22280 · Cited by 44

Regulation of targeted gene repair by intrinsic cellular processes

Engstrom, J. U., Suzuki, T., & Kmiec, E. B. (2009) · BioEssays · doi:10.1002/bies.200800119 · Cited by 42

Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

Hawtin, R. E., Stockett, D. E., Wong, O. K., Lundin, C., Helleday, T., & Fox, J. A. (2010) · Oncotarget · doi:10.18632/oncotarget.195 · Cited by 39

Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells

Xu, L., Wu, T., Lu, S., Hao, X., Qin, J., Wang, J., Zhang, X., Liu, Q., Kong, B., Gong, Y., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101604 · Cited by 39

The phosphatase and tensin homologue deleted on chromosome 10 mediates radiosensitivity in head and neck cancer

Pattje, W. J., Schuuring, E. M. D., Mastik, M. F., Slagter‐Menkema, L., Schrijvers, M. L., Alessi, S., van der Laan, B. F. A. M., Roodenburg, J. L. N., Langendijk, J. A., & van der Wal, J. E. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605707 · Cited by 39

Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling

Mukherjee, S., Abdisalaam, S., Bhattacharya, S., Kalayarasan, S., Sinha, D., & Asaithamby, A. (2019) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2018.11.004 · Cited by 39

Human Rad51 promotes mitochondrial DNA synthesis under conditions of increased replication stress

Sage, J. M., & Knight, K. L. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.04.004 · Cited by 38

High levels of RAD51 perturb DNA replication elongation and cause unscheduled origin firing due to impaired CHK1 activation

Parplys, A. C., Seelbach, J. I., Becker, S., Behr, M., Wrona, A., Jend, C., Mansour, W. Y., Joosse, S. A., Stuerzbecher, H.-W., Pospiech, H., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1055996 · Cited by 36

Modeled microgravity affects cell survival and HPRT mutant frequency, but not the expression of DNA repair genes in human lymphocytes irradiated with ionising radiation

Mognato, M., & Celotti, L. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.06.011 · Cited by 35

Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

Sy, S. M.-H., Jiang, J., Dong, S.-S., Lok, G. T.-M., Wu, J., Cai, H. “., Yeung, E. S. L., Huang, J., Chen, J., Deng, Y., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.232041 · Cited by 35

Comparative analysis of the early transcriptome of Brucella abortus – Infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis

Rossetti, C., Galindo, C. L., Everts, R. E., Lewin, H. A., Garner, H. R., & Adams, L. G. (2010) · Research in Veterinary Science · doi:10.1016/j.rvsc.2010.09.002 · Cited by 29

Poly(ADP-ribose) polymerase inhibitors as cancer therapy

Hilton, J. F. (2013) · Frontiers in bioscience · doi:10.2741/4188 · Cited by 29

Modulation of Early Mitotic Inhibitor 1 (EMI1) depletion on the sensitivity of PARP inhibitors in BRCA1 mutated triple-negative breast cancer cells

Moustafa, D., Elwahed, M. R. A., Elsaid, H. H., & Parvin, J. D. (2021) · PLoS ONE · doi:10.1371/journal.pone.0235025 · Cited by 28

Functional dissection of proliferating-cell nuclear antigens (1 and 2) in human malarial parasitePlasmodium falciparum:possible involvement in DNA replication and DNA damage response

Mitra, P., Banu, K., Deshmukh, A. S., Subbarao, N., & Dhar, S. K. (2015) · Biochemical Journal · doi:10.1042/bj20150452 · Cited by 27

The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination

Eppink, B., Tafel, A. A., Hanada, K., van Drunen, E., Hickson, I. D., Essers, J., & Kanaar, R. (2011) · DNA repair · doi:10.1016/j.dnarep.2011.08.006 · Cited by 26

Mesenchymal stem cells exhibit resistance to topoisomerase inhibition

Nicolay, N. H., Rühle, A., Perez, R. L., Trinh, T., Sisombath, S., Weber, K.-J., Schmezer, P., Ho, A. D., Debus, J., Saffrich, R., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.02.007 · Cited by 26

Differential roles of XRCC2 in homologous recombinational repair of stalled replication forks

Liu, N., & Lim, C. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20457 · Cited by 26

Cancer Therapy and Replication Stress

Kotsantis, P., Jones, R. M., Higgs, M. R., & Petermann, E. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.12.003 · Cited by 24

Microarray-based target identification using drug hypersensitive fission yeast expressing ORFeome

Arita, Y., Nishimura, S., Matsuyama, A., Yashiroda, Y., Usui, T., Boone, C. M., & Yoshida, M. (2011) · Molecular BioSystems · doi:10.1039/c0mb00326c · Cited by 23

Antitumor effects and mechanisms of olaparib in combination with carboplatin and BKM120 on human triple‑negative breast cancer cells

Zhao, H., Yang, Q., Hu, Y., & Zhang, J. (2018) · Oncology Reports · doi:10.3892/or.2018.6716 · Cited by 23

Interaction of hRad51 and hRad52 with MCM complex: A cross-talk between recombination and replication proteins

Shukla, A., Navadgi, V. M., Mallikarjuna, K., & Rao, B. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.106 · Cited by 22

Lactobacillus sp. Facilitate the Repair of DNA Damage Caused by Bile-Induced Reactive Oxygen Species in Experimental Models of Gastroesophageal Reflux Disease

Bernard, J. N., Chinnaiyan, V., Almeda, J., Catala-Valentin, A., & Andl, C. D. (2023) · Antioxidants · doi:10.3390/antiox12071314 · Cited by 21

PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice

Mochizuki, A. L., Katanaya, A., Hayashi, E., Hosokawa, M., Moribe, E., Motegi, A., Ishiai, M., Takata, M., Kondoh, G., Watanabe, H., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00117-17 · Cited by 20

Treatment Failure in Acute Myeloid Leukemia: Focus on the Role of Extracellular Vesicles

Mirfakhraie, R., Noorazar, L., Mohammadian, M., Hajifathali, A., Gholizadeh, M., Salimi, M., Sankanian, G., Roshandel, E., & Mehdizadeh, M. (2021) · Leukemia Research · doi:10.1016/j.leukres.2021.106751 · Cited by 22

Reduced Level of Ribonucleotide Reductase R2 Subunits Increases Dependence on Homologous Recombination Repair of Cisplatin-Induced DNA Damage

Lin, Z. P., Lee, Y., Lin, F., Belcourt, M. F., Li, P., Cory, J. G., Glazer, P. M., & Sartorelli, A. C. (2011) · Molecular Pharmacology · doi:10.1124/mol.111.074708 · Cited by 19

Overexpression of Drosophila Rad51 protein (DmRad51) disrupts cell cycle progression and leads to apoptosis

Yoo, S., & McKee, B. D. (2004) · Chromosoma · doi:10.1007/s00412-004-0300-x · Cited by 20

Characterisation of cytotoxicity and DNA damage induced by the topoisomerase II-directed bisdioxopiperazine anti-cancer agent ICRF-187 (dexrazoxane) in yeast and mammalian cells

Jensen, L. H., Dejligbjerg, M., Hansen, L. T., Grauslund, M., Jensen, P. B., & Sehested, M. (2004) · BMC Pharmacology · doi:10.1186/1471-2210-4-31 · Cited by 19

Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells

de Campos‐Nebel, M., Larripa, I. B., & González‐Cid, M. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.08.013 · Cited by 18

Diepoxybutane induces the formation of DNA–DNA rather than DNA–protein cross-links, and single-strand breaks and alkali-labile sites in human hepatocyte L02 cells

Wen, Y., Zhang, P., An, J., Yu, Y., Wu, M., Sheng, G., Fu, J., & Zhang, X. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.08.007 · Cited by 19

Molecular mechanisms of radiation resistance in doxorubicin-resistant breast adenocarcinoma cells

Luzhna, L., Golubov, A., Ilnytskyy, S., Chekhun, V. F., & Kovalchuk, O. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1845 · Cited by 17

Programming of Cell Resistance to Genotoxic and Oxidative Stress

Velegzhaninov, I. O., Ievlev, V., Игоревна, П. Я., Шадрин, Д. М., & Vakhrusheva, O. (2018) · Biomedicines · doi:10.3390/biomedicines6010005 · Cited by 16

RAD51 can inhibit PDGF-B–induced gliomagenesis and genomic instability

Westermark, U., Lindberg, N., Roswall, P., Bråsäter, D., Helgadottir, H. R., Hede, S., Zetterberg, A., Jasin, M., Nistér, M., & Uhrbom, L. (2011) · Neuro-Oncology · doi:10.1093/neuonc/nor131 · Cited by 16

Fine tuning chemotherapy to match BRCA1 status

Price, M. L., & Monteiro, Á. N. A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.05.015 · Cited by 17

Spontaneous homologous recombination is decreased in Rad51C-deficient hamster cells

Drexler, G. A., Rogge, S., Beisker, W., Eckardt‐Schupp, F., Zdzienicka, M. Z., & Fritz, E. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.05.002 · Cited by 16

Prochlorperazine enhances radiosensitivity of non-small cell lung carcinoma by stabilizing GDP-bound mutant KRAS conformation

Sad, K., Parashar, P., Tripathi, P., Hungyo, H., Sistla, R. K., Soni, R., & Tandon, V. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.11.001 · Cited by 15

The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer

Ko, J., Hong, J.-H., Wang, L.-H., & Lin, Y. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.02.013 · Cited by 15

Homozygous T172T and Heterozygous G135C Variants of Homologous Recombination Repairing Protein RAD51 are Related to Sporadic Breast Cancer Susceptibility

Zoubi, M. S. A., Mazzanti, C. M., Zavaglia, K. M., Hamad, M. A., Armogida, I., Lisanti, M. P., & Bevilacqua, G. (2015) · Biochemical Genetics · doi:10.1007/s10528-015-9703-z · Cited by 15

Influence of GSTT1, mEH, CYP2E1 and RAD51 polymorphisms on diepoxybutane-induced SCE frequency in cultured human lymphocytes

Schlade‐Bartusiak, K., Rozik, K., Łaczmańska, I., Ramsey, D., & Sasiadek, M. M. (2004) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2003.11.007 · Cited by 14

Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair

Abeykoon, J. P., Wu, X., Nowakowski, K. E., Dasari, S., Paludo, J., Weroha, S. J., Hu, C., Hou, X., Sarkaria, J. N., Mladek, A. C., et al. (2020) · Blood · doi:10.1182/blood.2020009013 · Cited by 14

The rate of extrachromosomal homologous recombination within a novel reporter plasmid is elevated in cells lacking functional ATM protein

Drexler, G. A., Wilde, S., Beisker, W., Ellwart, J. W., Eckardt‐Schupp, F., & Fritz, E. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.05.001 · Cited by 13

Time-resolved RNA signatures of CD4+ T cells in Parkinson’s disease

Diener, C., Hart, M., Kehl, T., Becker, A., Tänzer, T., Schub, D., Krammes, L., Sester, M., Keller, A., Unger, M. M., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01333-0 · Cited by 13

Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2 −/− Hematopoietic Stem and Progenitor Cells

Yoon, Y. M., Storm, K., Kamimae-Lanning, A. N., Goloviznina, N. A., & Kurre, P. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.09.005 · Cited by 15

The Neurodevelopmental Disorders Associated Gene Rnf113a Regulates Survival and Differentiation Properties of Neural Stem Cells

Tsampoula, M., Tarampoulous, I., Manolakou, T., Ninou, E., & Politis, P. K. (2022) · Stem Cells · doi:10.1093/stmcls/sxac030 · Cited by 10

Rad51-related changes in global gene expression

Orre, L. M., Fält, S., Szeles, A., Lewensohn, R., Wennborg, A., & Flygare, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.185 · Cited by 11

DNA replication restart and cellular dynamics of Hef helicase/nuclease protein in Haloferax volcanii

Lestini, R., Delpech, F., & Myllykallio, H. (2015) · Biochimie · doi:10.1016/j.biochi.2015.07.022 · Cited by 11

Repression of DNA Repair Mechanisms in IRF-4-Expressing and HTLV-I-Infected T Lymphocytes

Mamane, Y., Loignon, M., Palmer, J., Hernandez, E., Césaire, R., Alaoui‐Jamali, M. A., & Hiscott, J. B. (2005) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2005.25.43 · Cited by 10

DUX4-induced HSATII transcription causes KDM2A/B–PRC1 nuclear foci and impairs DNA damage response

Arends, T., Tsuchida, H., Adeyemi, R. O., & Tapscott, S. J. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202303141 · Cited by 8

The molecular crosstalk between innate immunity and DNA damage repair/response: Interactions and effects in cancers

Omidvar, S., Vahedian, V., Sourani, Z., Yari, D., Asadi, M., Jafari, N., Khodavirdilou, L., Bagherieh, M., Shirzad, M., & Hosseini, V. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155405 · Cited by 9

RAD51 G135C genetic polymorphism and their potential role in gastric cancer induced byHelicobacter pyloriinfection in Bhutan

Trang, T. T. H., Nagashima, H., UCHIDA, T., Mahachai, V., Vilaichone, R., Tshering, L., Bình, T. T., & Yamaoka, Y. (2015) · Epidemiology and Infection · doi:10.1017/s0950268815001430 · Cited by 8

Gene Targeting Without DSB Induction Is Inefficient in Barley

Horvath, M., Steinbiß, H., & Reiss, B. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01973 · Cited by 8

A Tolerance of DNA Heterology in the Mammalian Targeted Gene Repair Reaction

Drury, M. D., Skogen, M., & Kmiec, E. B. (2005) · Oligonucleotides · doi:10.1089/oli.2005.15.155 · Cited by 7

Identification of RAD51 foci in cancer-associated circulating cells of patients with high-grade serous ovarian cancer: association with treatment outcomes

Alizzi, Z., Saravi, S., Khalique, S., Mcdonald, T., Karteris, E., & Hall, M. (2023) · International Journal of Gynecological Cancer · doi:10.1136/ijgc-2023-004483 · Cited by 6

The analysis of S. cerevisiae cells deleted for mitotic cyclin Clb2 reveals a novel requirement of Sgs1 DNA helicase and Exonuclease 1 when replication forks break in the presence of alkylation damage

Signon, L., & Simon, M. N. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.07.008 · Cited by 5

Minor structural modifications to alchemix influence mechanism of action and pharmacological activity

Abdallah, Q., Phillips, R. M., Johansson, F., Helleday, T., Cosentino, L., Abdel-Rahman, H. M., Etzad, J., Wheelhouse, R. T., Kiakos, K., Bingham, J. P., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.02.017 · Cited by 5

A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity

Uringa, E.-J., Baldeyron, C., Odijk, H., Wassenaar, E., van Cappellen, W. A., Maas, A., Hoeijmakers, J. H. J., Baarends, W. M., Kanaar, R., & Essers, J. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.11.002 · Cited by 6

Unravelling the molecular basis of PARP inhibitor resistance in prostate cancer with homologous recombination repair deficiency

Zaman, N., Kushwah, A. S., Badriprasad, A., & Chakraborty, G. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2024.03.004 · Cited by 5

DNA Damage Repair and Cancer: The Role of RAD51 Protein and Its Genetic Variants

Nogueira, A., Catarino, R., & Medeiros, R. (2011) · InTech eBooks · doi:10.5772/23137 · Cited by 4

DNA Repair in Normal Stem Cells

Momčilović, O., & Schatten, G. P. (2012) · Springer eBooks · doi:10.1007/978-94-007-4590-2_4 · Cited by 2

Ataxia Telangiectasia–Mutated and Rad3-Related Inhibition and Topoisomerase I Trapping Create a Synthetic Lethality in Cancer Cells

Zou, L. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.77.1857 · Cited by 2

Disruption of theRAD51 gene sensitizesS. cerevisiae cells to the toxic and mutagenic effects of hydrogen peroxide

Dudášová, Z., Dudáš, A., Alemayehu, A., Vlasáková, D., Markova, E. N., Chovanec, M., Vlčková, V., & Brozmanová, I. (2004) · Folia Microbiologica · doi:10.1007/bf02931040 · Cited by 2

The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

Marttila, P., Bonagas, N., Chalkiadaki, C., Stigsdotter, H., Schelzig, K., Shen, J., Farhat, C. M., Hondema, A., Albers, J. J., Wiita, E., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13645 · Cited by 2

5G RF-EMFs Mitigate UV-Induced Genotoxic Stress Through Redox Balance and p38 Pathway Regulation in Skin Cells

Kim, J. H., Jin, H., Jang, K. M., Lee, J. E., Na, S., Jeon, S., Choi, H., Moon, J., Kim, N., Lim, K., et al. (2026) · Antioxidants · doi:10.3390/antiox15010127 · Cited by 1

Investigating the Role of Rad51 in Mammalian Ectopic Homologous Recombination

Knapp, J. R. (2013) · The Atrium (University of Guelph)

ATP Hydrolysis by Mammalian RAD51 Has a Key Role during Homology-directed DNA Repair

Stark, J. M., Hu, P., Pierce, A. J., Moynahan, M. E., Ellis, N. A., & Jasin, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112132200 · Cited by 144

Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells

Osakabe, K., Abe, K., Yamanouchi, H., Takyuu, T., Yoshioka, T., Ito, Y., Kato, T., Tabata, S., Kurei, S., Yoshioka, Y., et al. (2005) · Plant Molecular Biology · doi:10.1007/s11103-005-2187-1 · Cited by 52

Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

Baumann, P., & West, S. C. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01232-8 · Cited by 570

RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans

Mazin, A. V., & Mazina, O. M. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4741-2_12 · Cited by 3