Codon—anticodon pairing: The wobble hypothesis
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The pairing between anticodons and codons often has flexibility, known as wobble, so the same anticodons can pair with more than one codon.
“The relative lack of criticality is related to the fact that the pairing between the anticodons and codons often enjoy a certain flexibility, so those same anticodons can pair with more than one codon, a phenomenon that is known as wobble [118].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [118]
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- Authors
- Crick, F. H. C.
- Affiliations
- MRC Laboratory of Molecular Biology (GB)
- Corresponding author
- Crick, F.H.C.
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 1966-08
- Volume
- 19
- Issue
- 2
- Pages
- 548-555
- ISSN
- 0022-2836 (ISSN-L)
- OpenAlex
- W2068694787
- Cited by
- 2,029
- References
- 0
- Citations by year
- 2026: 39 · 2025: 43 · 2024: 62 · 2023: 64 · 2022: 50 · 2021: 53 · 2020: 71 · 2019: 50 · 2018: 68 · 2017: 46 · 2016: 51 · 2015: 46 · 2014: 59 · 2013: 60 · 2012: 47
- FWCI
- 26.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Profiles in Science (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Keywords
- codon-anticodon pairing, genetic code degeneracy, codon, anticodon, triplet codons
- MeSH terms
- Adenine, Cytosine, Genetic Code, Guanine, Molecular Biology, Nucleosides, Uracil
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