Cited by 655Receptor Mechanisms and SignalingCardiovascular, Neuropeptides, and Oxidative Stress ResearchNitric Oxide and Endothelin Effects

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REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS

Furchgott, Robert F., Bhadrakom, Suchin·1953·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)05163-8

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[19] Kinin receptors
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“The fact that higher nitrite levels dilate isolated vessel preparations has been detected in the early 1950s by Furchgott et al [28].”
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Nitric oxide bioactivity of traditional Chinese medicines used for cardiovascular indications
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“either endothelium-intact or endothelium-denuded vessels (data not shown), consistent with previous reports [19] showing that only very high concentrations of nitrite are vasoactive .”
Result
Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat
Badejo, A. M., Hodnette, C., Dhaliwal, J. S., Casey, D. B., Pankey, E., Murthy, S. N., Nossaman, B. D., Hyman, A. L., & Kadowitz, P. J. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00959.2009 · Cited by 32
“The ability of sodium nitrite to relax isolated arteries was first reported by Furchgott and Bhadrakom (18) in 1953, and the effect of nitrite on soluble guanylyl cyclase activity and cGMP levels was documented by Ignarro et al.”
Background
Die Entdeckung einiger biologischer Wirkungen von Stickstoffmonoxid und seiner Rolle für die Zellkommunikation (Nobel-Vortrag)
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Self-citation
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Schildkraut, J. J., Klerman, G. L., Friend, D. G., et al. (1963) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1963.tb13344.x · Cited by 32
Critical closure reexamined.
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Chronic inhibition of angiotensin converting enzyme decreases Ca2+-dependent tone of aorta in hypertensive rats.
Sada, T., Koike, H., Nishino, H., et al. (1989) · Hypertension · doi:10.1161/01.hyp.13.6.582 · Cited by 31
“Helical muscle preparations 3 mm wide and 25 mm long were made as described by Furchgott and Bhadrakom.(19) Endothelial cells were removed by rubbing the inner surface of the aortic tissue with a cotton stick for 1 minute.”
Method
Raised nitric oxide levels may cause atonic postpartum hemorrhage in women with anemia during pregnancy
Soltan, M. H., Ibrahim, E. M., Tawfek, M., et al. (2011) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2011.09.017 · Cited by 30
“Anemia, particularly when due to iron deficiency, increases NO production; furthermore, in the presence of tissue hypoxia and low oxygen pressure (induced by anemia itself), NO can signal smooth muscle relaxation and possible uterine atony [3,14,15,22].”
Background
Sar1-p-Benzoylphenylalanine-angiotensin, a new photoaffinity probe for selective labeling of the type 2 angiotensin receptor
Bossé, R., Servant, G., Zhou, L., et al. (1993) · Regulatory Peptides · doi:10.1016/0167-0115(93)90245-4 · Cited by 30
Cardiovascular effects of cnidarian toxins: A comparison of toxins extracted from Chiropsalmus quadrigatus and Chironex fleckeri
Freeman, S. E., & Turner, R. J. (1972) · Toxicon · doi:10.1016/0041-0101(72)90087-6 · Cited by 30
Effect of cyanide on nitrovasodilator-induced relaxation, cyclic GMP accumulation and guanylate cyclase activation in rat aorta
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The effect of alteration in temperature on contractile responses in human airways in vitro
Black, J. L., Armour, C. L., & Shaw, J. (1984) · Respiration Physiology · doi:10.1016/0034-5687(84)90076-8 · Cited by 30
The role of cyclic AMP in mesenteric vasodilation
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Plasma Vasoconstrictor Activity in Patients with Renal, Malignant, and Primary Hypertension
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The evaluation of the α-adrenoceptor blocking action of indoramin, phentolamine and thymoxamine on the rat and guinea-pig isolated mesenteric vasculature and aortic spiral preparations
Collis, M. G., & Alps, B. J. (1973) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1973.tb10648.x · Cited by 30
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Autonomic receptors in isolated rainbow trout vasculature
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α Agonist and Local anaesthetic properties of Xylazine
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“Isolated coronary vessels either were cut in a helical fashion (Furchgott and Bhadrakom, 1953) or in rings (Hooker et al.”
Background
What is the relationship between the endothelium derived relaxant factor and nitric oxide?
Long, C. J., & Berkowitz, B. A. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90429-3 · Cited by 29
CONTRACTION OF VASCULAR SMOOTH MUSCLE.
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Effects of an extract of Ginkgo biloba and diverse substances on the phasic and tonic components of the contraction of an isolated rabbit aorta
Auguet, M., & Clostre, F. (1983) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(83)90010-1 · Cited by 29
The termination of action of catecholamines in the isolated venous tissue of the dog
Osswald, W., Guimar�es, S., & Coimbra, A. (1971) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf01422013 · Cited by 29
Application of Drug–Receptor Theories to Angiotensin
Rioux, F., Park, W. K., & Regoli, D. C. (1973) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y73-100 · Cited by 29
Cerebral Arteriolar Spasm Inhibited by -Adrenergic Blocking Agents
Rosenblum, W. I. (1969) · Archives of Neurology · doi:10.1001/archneur.1969.00480150086011 · Cited by 29
Toxicology and pharmacology of some ruthenium compounds: Vascular smooth muscle relaxation by nitrosyl derivatives of ruthenium and iridium
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Definition of bradykinin and other kinins
Silva, M. R. E. (1962) · Biochemical Pharmacology · doi:10.1016/0006-2952(62)90209-5 · Cited by 28
Antihypertensive activity of himbacine in anesthetized cats
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“Bhadrakom proved sodium nitrite to be a direct vasodilator using rabbit aorta rings [22].”
Background
Pharmacokinetic and pharmacodynamic studies with two α‐adrenoceptor antagonists, doxazosin and prazosin in the rabbit
Hamilton, C. A., Reid, J. L., & Vincent, J. (1985) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1985.tb09437.x · Cited by 27
Interaction between calcium and hydrogen ionsin canine coronary arteries
Rinaldi, G. J., AMADOCATTANEO, E., & Cingolani, H. E. (1987) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(87)80388-7 · Cited by 27
Spontaneous rhythmic contractions in isolated human coronary arteries
Kawasaki, K., Seki, K., & Hosoda, S. (1981) · Cellular and Molecular Life Sciences · doi:10.1007/bf01948367 · Cited by 27
Sulpiride: A weak antagonist of norepinephrine and 5-hydroxytryptamine
Kohli, J. D., & Cripe, L. D. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90185-7 · Cited by 27
Comparison of tricyclic antidepressants in rabbits: Antinociception and potentiation of the noradrenaline pressor responses
Saarnivaara, L., & Mattila, M. J. (1974) · Psychopharmacology · doi:10.1007/bf00437751 · Cited by 27
“The preparations were dissected according to Furchgott and Bhadrakom (1953) and suspended to Krebs solution bubbled with 5~ carbon dioxide in oxygen.”
Method
Analysis of the effects of apomorphine and bulbocapnine in relation to the proposed dopamine receptor
Patil, P. N., Burkman, A. M., Yamauchi, D., et al. (1973) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1973.tb10628.x · Cited by 27
The role of prostaglandins in hypertension. I. The release of prostaglandins by aorta strips of renal, DOCA–salt, and spontaneously hypertensive rats
Rioux, F., Quirion, R., & Regoli, D. C. (1977) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y77-178 · Cited by 27
Myography of isolated blood vessels: Considerations for experimental design and combination with supplementary techniques
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“The basic principles of these methods (isometric and isobaric myography) have been described long ago (force measurement of large vessels (Furchgott and Bhadrakom, 1953), isometric tension measurement of small arterioles and arteries (Bevan and Osher, 1972; Mulvany and Halpern, 1976; Mulvany and Halpern, 1977; Mulvany…”
Method
Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate
Hughan, K. S., Wendell, S. G., Delmastro-Greenwood, M. M., Helbling, N. L., Corey, C. G., Bellavia, L., Potti, G. K., Grimes, G. J., Goodpaster, B. H., Kim‐Shapiro, D. B., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09016 · Cited by 26
Pharmacological Testing Methods for Drugs Acting on the Peripheral Nervous System
Long, J. P., & Chiou, C. Y. (1970) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600590202 · Cited by 26
Studies on the longitudinal muscle of the anterior mesenteric artery of the domestic fowl
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AN INVESTIGATION OF THE ADRENERGIC BLOCKING ACTION OF CHLORPROMAZINE
Sd, G., Gulati, O. D., & PARIKH, H. M. (1964) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1964.tb01606.x · Cited by 26
Release od smooth muscle-contracting substances from isolated perfused lungs
Alabaster, V. A., & Bakhle, Y. S. (1976) · European Journal of Pharmacology · doi:10.1016/0014-2999(76)90238-7 · Cited by 26
Selective β-adrenoceptor activities of tetrahydronaphthalene derivatives
Nishikawa, M., Kanno, M., Kuriki, H., et al. (1975) · Life Sciences · doi:10.1016/0024-3205(75)90029-6 · Cited by 26
Effects of isoprenaline and phenylephrine on energy‐rich phosphate compounds and glucose‐6‐phosphate in smooth and cardiac muscle
Weston, A. H. (1971) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1971.tb07189.x · Cited by 26
Long-term inhibition of angiotensin converting enzyme suppresses calcium channel agonist-induced contraction of aorta in hypertensive rats.
Sada, T., Koike, H., & Miyamoto, M. (1989) · Hypertension · doi:10.1161/01.hyp.14.6.652 · Cited by 26
“Two helically cut strips, approximately 3 mm wide and 25 mm long, were prepared from the adjoining portion of the same aorta, as described by Furchgott and Bhadrakom.(20) Endothelial cells were removed by rubbing the inner surface of aortic tissue with a cotton stick for 1 minute.”
Method
Sodium nitrite causes relaxation of the isolated rat aorta: By stimulating both endothelial NO synthase and activating soluble guanylyl cyclase in vascular smooth muscle
Ling, W. C., Lau, Y. S., Murugan, D. D., Vanhoutte, P. M., & Mustafa, M. R. (2015) · Vascular Pharmacology · doi:10.1016/j.vph.2015.05.014 · Cited by 25
Pharmacology of LR‐B/081, a new highly potent, selective and orally active, nonpeptide angiotensin II AT1 receptor antagonist
Cirillo, R., Renzetti, A. R., Cucchi, P., et al. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb13323.x · Cited by 25
Effects of an extract of Ginkgo biloba on rabbit isolated aorta
Auguet, M., DeFeudis, F. V., Clostre, F., et al. (1982) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(82)90093-3 · Cited by 25
Relationship between ?1-adrenoreceptor density and functional response of rat vas deferens
Minneman, K. P., & Abel, P. W. (1984) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00502456 · Cited by 25
Adrenergic blockade by iproniazid
Griesemer, E. C., Dragstedt, C. A., Wells, J. A., et al. (1955) · Cellular and Molecular Life Sciences · doi:10.1007/bf02161306 · Cited by 25
PROCEEDINGS OF THE British Pharmacological Society
Dawson, W., & Tomlinson, R. (1974) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1974.tb09695.x · Cited by 25
Aortic vascular and atrial responses to (±)‐1‐O‐octadecyl‐2‐acetyl‐glyceryl‐3‐phosphorylcholine
Cervoni, P., Herzlinger, H. E., Lai, F. M., et al. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb10003.x · Cited by 25
Differential calcium dependence of contractile responses and 86Rb efflux from the rabbit aorta induced by vasoactive stimuli
Martin, W., & Gordon, J. L. (1983) · Journal of Cellular Physiology · doi:10.1002/jcp.1041150108 · Cited by 25
Kininases and vascular responses to kinins
Babiuk, C., Marceau, F., St-Pierre, S. A., & Regoli, D. C. (1982) · European Journal of Pharmacology · doi:10.1016/0014-2999(82)90233-3 · Cited by 24
Development of Tolerance to Inhibitory Effect of Ethanol on Endothelium‐dependent Vascular Relaxation in Ethanol‐fed Rats
Hatake, K., Wakabayashi, I., Kakishita, E., et al. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00527.x · Cited by 24
Effects of chlorbutol on 45 Ca movements and contractile responses of rat aorta and its relevance to the actions of Syntocinon
Barrigón, S., Tejerina, T., Delgado, C., et al. (1984) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1984.tb04443.x · Cited by 24
Pharmacological properties of two analogues of angiotensin II containing carboranylalanine (car)
Escher, E., Guillemette, G., Leukart, O., et al. (1980) · European Journal of Pharmacology · doi:10.1016/0014-2999(80)90458-6 · Cited by 24
Vascular smooth muscle response to ouabain. Relation of tissue Na+ to the contractile response.
Stewart, L., Hamilton, C., Ingwall, J. S., et al. (1993) · Circulation Research · doi:10.1161/01.res.73.6.1113 · Cited by 24
THE β‐ADRENERGIC BLOCKING AND PRESSOR ACTIONS OF ISOPRENALINE IN THE CAT
Butterworth, K. R. (1963) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1963.tb01536.x · Cited by 24
The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals
Lundberg, J. O., Weitzberg, E., Shiva, S., & Gladwin, M. T. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_3 · Cited by 26
Nitric oxide-dependent vasorelaxation and endothelial cell damage caused by mercury chloride
Golpon, H. A., Püchner, A., Barth, P. J., et al. (2003) · Toxicology · doi:10.1016/s0300-483x(03)00303-2 · Cited by 23
“Under these conditions, also acetylcholine, a substance known to relax blood vessels in an endothelial cell-dependent fashion, constricts blood vessels (Furchgott and Bhadrakon, 1953).”
Background
Demonstration of different contractile mechanisms for angiotensin II and des-Asp1-angiotensin II in rabbit aortic strips.
Ackerly, J. A., Moore, A. F., & Peach, M. J. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5725 · Cited by 23
Antagonism of the response of human isolated arteries to noradrenaline
Birmingham, A. T., Ernest, K., & Newcombe, J. F. (1969) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1969.tb07973.x · Cited by 23
Antihypertensive and adrenergic receptor blocking properties of the enantiomers of medroxalol
Cheng, H. C., Reavis, O. K., Grisar, J. M., et al. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90534-2 · Cited by 23
CARDIOVASCULAR EFFECTS OF NEUROTOXIC INDOLETHYLAMINES*
Göthert, M., & Klupp, N. (1978) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1978.tb31541.x · Cited by 23
Effect of epinephrine and potassium chloride on contraction and energy intermediates in rabbit thoracic aorta strips
Needleman, P., & Blehm, D. J. (1970) · Life Sciences · doi:10.1016/0024-3205(70)90151-7 · Cited by 23
EFFECT OF PROPRANOLOL ON ALPHA‐ADRENERGIC BLOCKADE IN THE DOG AND ISOLATED RABBIT AORTIC STRIP
OLIVARES, G. J., Smith, N. T., & Aronow, L. (1967) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1967.tb02130.x · Cited by 23
Kinins and peptide receptors
Regoli, D. C., & Gobeil, F. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0240 · Cited by 22
“Using the classical preparation described by Furchgott in 1953 (Furchgott and Bhadrakom, 1953) on rbA, they found that BK relaxed the aorta contracted with noradrenaline and those effects reflected the in vivo hypotensive effect of BK, administered intravenously, in the rabbit.”
MethodResultInfluential
Nitrite, NO and hypoxic vasodilation
Allen, J. D., & Gow, A. J. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00447.x · Cited by 23
“The vasodilatory properties of nitrite at supra-physiological levels have been recognized for decades (Furchgott and Bhadrakom, 1953); yet, the high micromolar concentrations required to elicit an effect limited its role in vascular physiology to that of an inactive product of NO oxidation.”
Background
Short-term exposure to homocysteine depresses rat aortic contractility by an endothelium-dependent mechanism
Wang, S., Wright, G. L., Harrah, J., et al. (2000) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-78-6-500 · Cited by 22
Epinephrine infusion induces hyporesponsiveness of vascular smooth muscle
Maze, M., Spiss, C. K., Tsujimoto, G., et al. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90475-8 · Cited by 22
Distribution Theory of Resistance of Neurogenic Vasoconstriction to Alpha-Receptor Blockade in the Rabbit
Bevan, J. A., & Su, C. (1971) · Circulation Research · doi:10.1161/01.res.28.2.179 · Cited by 20
“Experiments described in this paper were carried out with the standard helical strip preparation of the rabbit aorta (13), the isolated right recurrent cardiac nerve-pulmonary artery preparation (14), and the superfused, transmurally stimulated vessel strip (15).”
Method
Comparative Reactivities of Aortic Strips from Hypertensive and Normotensive Rats to Epinephrine and Levarterenol
Mallov, S. (1959) · Circulation Research · doi:10.1161/01.res.7.2.196 · Cited by 22
A potent competitive antagonist of angiotensin II
Yamamoto, M., Türker, R. K., Khairallah, P. A., & Bumpus, F. M. (1972) · European Journal of Pharmacology · doi:10.1016/0014-2999(72)90031-3 · Cited by 22
Absence of inhibitory effects of catecholamines on lower vertebrate arterial strip preparations
Burnstock, G., & Kirby, S. (1968) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1968.tb09773.x · Cited by 22
Role of converting enzyme in the responses of rabbit atria, aortas, and adrenal zona glomerulosa to [des-Asp1]angiotensin I.
Ackerly, J. A., Tsai, B. S., & Peach, M. J. (1977) · Circulation Research · doi:10.1161/01.res.41.2.231 · Cited by 22
“25 x 2 cm) were prepared according to the method of Furchgott and Bhadrakom.(8) Each strip was mounted in a 5-ml organ bath containing Krebs' buffer at 37°C, gassed with 95% O2-5% CO2- The strip was placed under an initial 2-g passive tension and allowed to equilibrate for approximately 2 hours.”
Method
Control of Vascular Contractility by the Cardiac Pacemaker
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Authors: Furchgott, R. F., & Bhadrakom, S.
Affiliations: Washington University in St. Louis (US)
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1953-06
Volume: 108
Issue: 2
Pages: 129-143
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)05163-8
OpenAlex: W2302863210
Cited by: 655
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 9
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: rabbit aorta, epinephrine, isoproterenol, sodium nitrite, norepinephrine, histamine, acetylcholine, vascular smooth muscle contraction, drug sensitivity, drug antagonism
MeSH terms: Animals, Aorta, Epinephrine, Isoproterenol, Norepinephrine, Rabbits, Sodium Nitrite

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REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS

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