Cited by 655Receptor Mechanisms and SignalingCardiovascular, Neuropeptides, and Oxidative Stress ResearchNitric Oxide and Endothelin Effects

The DOI matches its Crossref record.

REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS

Furchgott, Robert F., Bhadrakom, Suchin·1953·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)05163-8

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/s0022-3565(25)05163-8

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Self-citation
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
A MODIFICATION OF RECEPTOR THEORY
STEPHENSON, R. P. (1956) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1956.tb00006.x · Cited by 1,167
Novel dihydropyridines with positive inotropic action through activation of Ca2+ channels
Schramm, M., Thomas, G., Towart, R., & Franckowiak, G. (1983) · Nature · doi:10.1038/303535a0 · Cited by 1,003
The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor Theory
Furchgott, R. F. (1972) · Springer eBooks · doi:10.1007/978-3-642-65249-3_9 · Cited by 814
Self-citation
The role of calcium in the secretory response of the adrenal medulla to acetylcholine
Douglas, W. W., & Rubin, R. N. (1961) · The Journal of Physiology · doi:10.1113/jphysiol.1961.sp006791 · Cited by 789
Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation
Rapoport, R. M., Draznin, M. B., & Murad, F. (1983) · Nature · doi:10.1038/306174a0 · Cited by 631
The emerging biology of the nitrite anion
Gladwin, M. T., Schechter, A. N., Kim-Shapiro, D. B., Patel, R. P., Hogg, N., Shiva, S., Cannon, R. O., Kelm, M., Wink, D. A., Espey, M. G., et al. (2005) · Nature Chemical Biology · doi:10.1038/nchembio1105-308 · Cited by 609
Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
Huang, Z. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24650 · Cited by 520
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
Crawford, J. H. (2006) · Blood · doi:10.1182/blood-2005-07-2668 · Cited by 497
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435
Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway
Lidder, S., & Webb, A. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04420.x · Cited by 360
COMPARISON OF THE ACTIONS OF U‐46619, A PROSTAGLANDIN H2‐ANALOGUE, WITH THOSE OF PROSTAGLANDIN H2 AND THROMBOXANE A2 ON SOME ISOLATED SMOOTH MUSCLE PREPARATIONS
Coleman, R. A., Humphrey, P. P. A., Kennedy, I., Levy, G., & LUMLEY, P. (1981) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1981.tb16814.x · Cited by 357
Circulating Nitrite Contributes to Cardioprotection by Remote Ischemic Preconditioning
Rassaf, T., Totzeck, M., Hendgen-Cotta, U. B., Shiva, S., Heusch, G., & Kelm, M. (2014) · Circulation Research · doi:10.1161/circresaha.114.303822 · Cited by 342
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341
Nitrite Infusion in Humans and Nonhuman Primates: Endocrine Effects, Pharmacokinetics, and Tolerance Formation
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334
Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats
Ferguson, S. K., Hirai, D. M., Copp, S. W., Holdsworth, C. T., Allen, J. D., Jones, A. M., Musch, T. I., & Poole, D. C. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.243121 · Cited by 333
Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., & Patel, R. P. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2006 · Cited by 329
“Indeed, nitrite at concentrations of 100 M was shown to vasodilate aortic ring bioassays by Furchgott as far back as 1953 and shown by Murad and Ignarro to activate guanylate cyclase in the mid-1970s and early 1980s (21, 46, 47, 63).”
Background
Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics
Kim-Shapiro, D. B., Schechter, A. N., & Gladwin, M. T. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000204350.44226.9a · Cited by 308
Studies of the characterisation of prostanoid receptors: A proposed classification
Kennedy, I., Coleman, R. A., Humphrey, P. P. A., et al. (1982) · Prostaglandins · doi:10.1016/0090-6980(82)90036-3 · Cited by 305
Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identification as Nitric Oxide
Furchgott, R. F. (1999) · Bioscience Reports · doi:10.1023/a:1020537506008 · Cited by 302
Self-citation
The functional nitrite reductase activity of the heme-globins
Gladwin, M. T., & Kim-Shapiro, D. B. (2008) · Blood · doi:10.1182/blood-2008-01-115261 · Cited by 293
Vascular Smooth Muscle: Dual Effect of Calcium
Bohr, D. F. (1963) · Science · doi:10.1126/science.139.3555.597 · Cited by 285
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281
Nitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260
“As early as 1880, nitrite was described in terms of its vasodilatory abilities [18] and much later, Furchgott and Bhadrakom in 1953 used acidified sodium nitrite to relax precontracted aortic strips [81].”
Background
Supersensitivity of Atherosclerotic Rabbit Aorta to Ergonovine
Henry, P. D., & Yokoyama, M. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109858 · Cited by 259
The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248
Coronary Tone Modulation: Formation and Actions of Prostaglandins, Endoperoxides, and Thromboxanes
Needleman, P., Kulkarni, P. S., & Raz, A. (1977) · Science · doi:10.1126/science.831285 · Cited by 243
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal
Forman, H. J., Fukuto, J. M., Miller, T., Zhang, H., Rinna, A., & Levy, S. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.06.011 · Cited by 226
Hypoxic Modulation of Exogenous Nitrite-Induced Vasodilation in Humans
Maher, A. R., Milsom, A. B., Gunaruwan, P., Abozguia, K., Ahmed, I., Weaver, R. A., Thomas, P., Ashrafian, H., Born, G. V. R., James, P. E., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.719591 · Cited by 210
Induction of B1-receptors for kinins in the rabbit by a bacterial lipopolysaccharide
Regoli, D. C., Marceau, F., & Lavigne, J. (1981) · European Journal of Pharmacology · doi:10.1016/0014-2999(81)90391-5 · Cited by 204
CYCLIC AMP AND SMOOTH MUSCLE FUNCTION*
Triner, L., Nahas, G. G., Vulliemoz, Y., et al. (1971) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1971.tb45273.x · Cited by 205
Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
Totzeck, M., Hendgen-Cotta, U. B., Luedike, P., Berenbrink, M., Klare, J. P., Steinhoff, H.-J., Semmler, D., Shiva, S., Williams, D., Kipar, A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.087155 · Cited by 202
“High concentrations of the inorganic anion, nitrite, has been known to be vasoactive for many years.(17) Indeed, millimolar to high micromolar pharmacological concentrations of exogenous nitrite have been demonstrated to relax preconstricted isolated vessels.”
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198
“In the absence of red blood cells, the addition of nitrite to pre-constricted aortic rings caused vasodilation only at high (greater than 10 μM) concentrations, consistent with previous data [58].”
Result
RECEPTORS FOR 5‐HYDROXYTRYPTAMINE AND NORADRENALINE IN RABBIT ISOLATED EAR ARTERY AND AORTA
Apperley, E., Humphrey, P. P. A., & Levy, G. (1976) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1976.tb10398.x · Cited by 197
Analysis of the Motor Effects Of 13-Norleucine Motilin on the Rabbit, Guinea Pig, Rat, and Human Alimentary Tract in Vitro
Strunz, U. T., Domschke, W., Mitznegg, P., Domschke, S., Schubert, E., Wünsch, E., Jaeger, E., & Demling, L. (1975) · Gastroenterology · doi:10.1016/s0016-5085(75)80136-3 · Cited by 184
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184
Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases
Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175
The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation
Kim‐Shapiro, D. B., Gladwin, M. T., Patel, R. P., & Hogg, N. (2004) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.10.034 · Cited by 173
NO-synthase independent NO generation in mammals
Lundberg, J. O., & Weitzberg, E. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.136 · Cited by 175
“Sodium and potassium nitrite were used in the beginning of the 20th century as antihypertensives and Robert Furchgott used acidified sodium nitrite to relax preconstricted rabbit aortic rings as early as 1953 [53].”
Method
A Specific Competitive Antagonist of the Vascular Action of Angiotensin II
Pals, D. T., Masucci, F. D., Sipos, F., et al. (1971) · Circulation Research · doi:10.1161/01.res.29.6.664 · Cited by 165
“Aortic strips prepared according to the method of Furchgott and Bhadrakom (3) were mounted in 10-ml organ baths maintained at 36° C by a Haake constant temperature circulator.”
Method
Endothelium‐dependent relaxation of the pig aorta: relationship to stimulation of 86Rb efflux from isolated endothelial cells
Gordon, J. L., & Martin, W. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb11028.x · Cited by 164
Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
Bryan, N. S., Calvert, J. W., Gundewar, S., & Lefer, D. J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.04.040 · Cited by 161
“As early as 1880, nitrite was described in terms of its vasodilatory abilities [50], and much later, Furchgott and Bhadrakom used acidified sodium nitrite to relax precontracted aortic strips in 1953 [51].”
Background
The Photoactivated Relaxation of Smooth Muscle of Rabbit Aorta
Furchgott, R. F., Ehrreich, S. J., & Greenblatt, E. (1961) · The Journal of General Physiology · doi:10.1085/jgp.44.3.499 · Cited by 159
Self-citation
Rat atrial natriuretic factor. Purification and vasorelaxant activity
Grammer, R. T., Fukumi, H., Inagami, T., et al. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)90581-8 · Cited by 159
Mechanisms of nitrite bioactivation
Kim-Shapiro, D. B., & Gladwin, M. T. (2014) · Nitric Oxide · doi:10.1016/j.niox.2013.11.002 · Cited by 157
“In 1952 Furchgott and Bhadrakhom demonstrated the ability of nitrite to effect relaxation of pre-constricted aortic vessels, but the concentrations used where substantially higher than that found in physiological conditions (100 μM compared to normal levels of tens to hundreds of nanomolar) [27].”
Background
Nitrite and nitrate chemical biology and signalling
DeMartino, A. W., Kim‐Shapiro, D. B., Patel, R. P., & Gladwin, M. T. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14484 · Cited by 162
“This thinking was based on the relatively low potency of nitrite as a vasodilator of preconstricted aortic rings; high concentrations of nitrite, in the micromolar to millimolar range, were required to observe significant vasodilation (Furchgott and Bhadrakom, 1953).”
Background
NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics
Lundberg, J. O., & Weitzberg, E. (2009) · Archives of Pharmacal Research · doi:10.1007/s12272-009-1803-z · Cited by 153
Studies on the induction of pharmacological responses to des‐Arg9‐bradykinin in vitro and in vivo
Bouthillier, J., deBlois, D., & Marceau, F. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11319.x · Cited by 153
GR32191, a highly potent and specific thromboxane A2receptor blocking drug on platelets and vascular and airways smooth musclein vitro
Lumley, P., White, B. P., & Humphrey, P. P. A. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb12017.x · Cited by 148
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits
Machha, A., & Schechter, A. N. (2011) · European Journal of Nutrition · doi:10.1007/s00394-011-0192-5 · Cited by 146
“Indeed, the vasodilatory properties of pharmacological doses of exogenous nitrite have been known for more than half a century [85, 86].”
Background
Artery Wall Electrolytes in Renal and Dca hypertension1
Tobian, L. J., & BINION, J. T. (1954) · Journal of Clinical Investigation · doi:10.1172/jci103018 · Cited by 144
“Moreover, the smooth muscle cells in the aorta are continuous with and have many of the pharmacological reactions of similar cells in the smaller arteries and arterioles (2).”
Background
Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure
Bryan, N. S., Tribble, G., & Angelov, N. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0725-2 · Cited by 137
Nitrite confers protection against myocardial infarction: Role of xanthine oxidoreductase, NADPH oxidase and KATP channels
Baker, J. E., Su, J., Fu, X., Hsu, A., Gross, G. J., Tweddell, J. S., & Hogg, N. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.07.057 · Cited by 137
“One hundred micromolar nitrite also vasodilates aortic ring preparations [21], with subsequent studies showing the effect is mediated by soluble guanylyl cyclase [22,23].”
Background
EVIDENCE FOR TWO TYPES OF EXCITATORY RECEPTOR FOR 5‐HYDROXYTRYPTAMINE IN DOG ISOLATED VASCULATURE
Apperley, E., Feniuk, W., Humphrey, P. P. A., et al. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb10410.x · Cited by 136
Beta-Receptor Activity in Aorta
Fleisch, J. H., MOLING, H. M., & Brodie, B. B. (1970) · Circulation Research · doi:10.1161/01.res.26.2.151 · Cited by 135
“The activity of beta receptors is demonstrated in a preparation that is made to contract (5).”
BackgroundMethod
Direct Tension Recording From Smooth Muscle of Resistance Vessels From Various Organs
Bohr, D. F., Goulet, P. L., & Taquini, A. C. (1961) · Angiology · doi:10.1177/000331976101201009 · Cited by 133
“The modified jeweler’s lathe has the following special features designed to facilitate sectioning of the small vessels: (1) two synchronously gear-driven chucks; (2) a moving slide rest which allows cutting of a strip as small as 50 ju wide (this is equivalent to cutting 500 threads to the inch); (3) a reversible vari…”
BackgroundMethod
Lung Circulation
Suresh, K. S., & Shimoda, L. A. (2016) · Comprehensive physiology · doi:10.1002/cphy.c140049 · Cited by 174
“Experiments where exogenous nitrite was administered showed that nitrite had the ability to dilate the systemic vasculature (193,288,324,345) and the pulmonary circulation under conditions where tone was increased (281, 739).”
Pharmacological characterization of a new highly potent B2 receptor antagonist (HOE 140: D-Arg-[Hyp3, Thi5, D-Tic7, Oic8]bradykinin)
Rhaleb, N., Rouissi, N., Jukic, D., et al. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90661-m · Cited by 124
Atrial natriuretic prohormone peptides 1–30, 31–67, and 79–98 vasodilate the aorta
Vesely, D. L., Norris, J. S., Walters, J. M., et al. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(87)80307-8 · Cited by 122
Nitrite Reduction and Cardiovascular Protection
Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121
Similarities between the pharmacological actions of quipazine and serotonin
Hong, E., Sancilio, L. F., Vargas, R., et al. (1969) · European Journal of Pharmacology · doi:10.1016/0014-2999(69)90185-x · Cited by 118
Nitrates and Nitrites in the Treatment of Ischemic Cardiac Disease
Nossaman, V. E., Nossaman, B. D., & Kadowitz, P. J. (2010) · Cardiology in Review · doi:10.1097/crd.0b013e3181c8e14a · Cited by 120
The Quantitative Determination of Renin in the Plasma of Patients with Arterial Hypertension
Helmer, O. M., Judson, W. E., & Sanders, R. M. (1963) · Circulation · doi:10.1161/01.cir.27.6.1050 · Cited by 117
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
“It is important to note that though the metabolic connections between NO and nitrite has been known for many years [5,6] and the role of nitrite was confined to the belief that it was simply an inert metabolic by-product of NO.”
Background
Novel Aspects of Endothelium-Dependent Regulation of Vascular Tone
Villar, I. C., Francis, S., Webb, A., Hobbs, A. J., & Ahluwalia, A. (2006) · Kidney International · doi:10.1038/sj.ki.5001680 · Cited by 112
Nitrite-dependent vasodilation is facilitated by hypoxia and is independent of known NO-generating nitrite reductase activities
Dalsgaard, T., Simonsen, U., & Fago, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01298.2006 · Cited by 110
Nitrate Ingestion: A Review of the Health and Physical Performance Effects
Clements, W., Lee, S.-R., & Bloomer, R. J. (2014) · Nutrients · doi:10.3390/nu6115224 · Cited by 118
“Dating back to 1953, however, Furchgott and Bhadrakhom [50] demonstrated nitrite’s ability to vasodilate pre-constricted rabbit aortic vessels.”
Background
Receptors for bradykinin and related kinins: a critical analysis
Regoli, D. C., Jukic, D., Gobeil, F. J., et al. (1993) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y93-079 · Cited by 112
Angiotensin Tachyphylaxis and its Reversal
Khairallah, P. A., Page, I. H., Bumpus, F. M., & Türker, R. K. (1966) · Circulation Research · doi:10.1161/01.res.19.2.247 · Cited by 111
“These strips were discarded since they would not respond to any stimulus.(17)”
BackgroundMethodInfluential
Safety and Feasibility of Long-term Intravenous Sodium Nitrite Infusion in Healthy Volunteers
Pluta, R. M., Oldfield, E. H., Bakhtian, K. D., Fathi, A. R., Smith, R. K., DeVroom, H. L., Nahavandi, M., Woo, S., Figg, W. D., & Lonser, R. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014504 · Cited by 112
“Thus, an increasing body of evidence indicates that nitrite [16,18] is a major intravascular storage pool for NO [17,19,20,21] and can serve as an alternative to systemic delivery of NO or nitrates.”
Background
Adrenergic receptors in the veins of the dog
Guimarães, S., & Osswald, W. (1969) · European Journal of Pharmacology · doi:10.1016/0014-2999(69)90021-1 · Cited by 110
Mechanisms of cerebral vasospasm in subarachnoid haemorrhage
Cook, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(94)00080-m · Cited by 108
Diminution of contractile response of the aorta from endotoxin-injected rats
Wakabayashi, I., Hatake, K., Kakishita, E., & Nagai, K. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90417-1 · Cited by 109
Paradoxical endogenous synthesis of a coronary dilating substance from arachidonate
Kulkarni, P. S., Roberts, R., & Needleman, P. (1976) · Prostaglandins · doi:10.1016/0090-6980(76)90015-0 · Cited by 110
Role of cyclic AMP- and cyclic GMP-phosphodiesterases in the control of cyclic nucleotide levels and smooth muscle tone in rat isolated aorta
Schoeffter, P., Lugnier, C., Demesy-Waeldele, F., et al. (1987) · Biochemical Pharmacology · doi:10.1016/0006-2952(87)90465-5 · Cited by 106
THE α‐ AND β‐ADRENOCEPTOR BLOCKING POTENCIES OF LABETALOL AND ITS INDIVIDUAL STEREOISOMERS IN ANAESTHETIZED DOGS AND IN ISOLATED TISSUES
Brittain, R. T., Drew, G. M., & Levy, G. (1982) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1982.tb09275.x · Cited by 106
Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155)
Boissier, J. R., Giudicelli, J. F., Fichelle, J., et al. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90183-0 · Cited by 106
Hemoglobin-Mediated, Hypoxia-Induced Vasodilation via Nitric Oxide
Robinson, J. M., & Lancaster, J. R. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.f292 · Cited by 104
Thrombin, collagen and A23187 stimulated endogenous platelet arachidonate metabolism: Differential inhibition by PGE1, local anesthetics and a serine-protease inhibitor
Feinstein, M. B., Becker, E. L., & Fraser, C. A. (1977) · Prostaglandins · doi:10.1016/0090-6980(77)90286-6 · Cited by 102
Recent methodological advances in the analysis of nitrite in the human circulation: Nitrite as a biochemical parameter of the l-arginine/NO pathway
Grau, M., Hendgen-Cotta, U. B., Brouzos, P., Drexhage, C., Rassaf, T., Lauer, T., Dejam, A., Kelm, M., & Kleinbongard, P. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.002 · Cited by 100
Effects of human urotensin II in isolated vessels of various species; comparison with other vasoactive agents
Camarda, V., Rizzi, A., Calò, G., et al. (2002) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-001-0503-0 · Cited by 101
Analysis of the cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (Catapres)
Constantine, J. W., & McShane, W. K. (1968) · European Journal of Pharmacology · doi:10.1016/0014-2999(68)90167-2 · Cited by 101
More answers to the still unresolved question of nitrate tolerance
Münzel, T. F., Daiber, A., & Gori, T. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht249 · Cited by 99
Synthesis and Structure of New Pyrido[2,3-d]pyrimidine Derivatives with Calcium Channel Antagonist Activity
Pastor, A., Alajarı́n, R., Vaquero, J. J., et al. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)85291-1 · Cited by 100
Calcium leakage as a cause of the high resting tension in vascular smooth muscle from the spontaneously hypertensive rat.
Noon, J. P., Rice, P. J., & Baldessarini, R. J. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1605 · Cited by 100
Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling
Zuckerbraun, B. S., George, M. P., & Gladwin, M. T. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq370 · Cited by 99
Sensitization of isolated canine coronary arteries to calcium ions after exposure to cholesterol.
Yokoyama, M., & Henry, P. D. (1979) · Circulation Research · doi:10.1161/01.res.45.4.479 · Cited by 98
“To expose the artery to a selected cholesterol concentration, the organ bath was replaced by the overflow technique (Furchgott and Bhadrakom, 1953).”
Method
Increase in atrial pressure releases atrial natriuretic peptide from isolated perfused rat hearts
Ruskoaho, H. J., Th�lken, H., & Lang, R. E. (1986) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580671 · Cited by 96
Calcium-dependent resistance to stretch and stress relaxation in resting smooth muscles
Siegman, M., Tm, B., Mooers, S. U., et al. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.231.5.1501 · Cited by 94
“8 for rabbit taenia coli (16), where E = % strain and S = stress x lo6 dynes l cm*).”
BackgroundMethod
Characterization of postsynaptic α‐adrenoceptors in rat aortic strips and portal veins
Digges, K. G., & Summers, R. J. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb10002.x · Cited by 93
Assessments of the chemistry and vasodilatory activity of nitrite with hemoglobin under physiologically relevant conditions
Luchsinger, B. P., Rich, E. N., Yan, Y., Williams, E. M., Stamler, J. S., & Singel, D. J. (2005) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2004.12.010 · Cited by 89
Inorganic nitrate and the cardiovascular system
Kapil, V., Webb, A. J., & Ahluwalia, A. (2010) · Heart · doi:10.1136/hrt.2009.180372 · Cited by 90
“That NO2 (but not NO3 ) exerts functional effects in the cardiovascular system was shown more than half a century ago when Robert Furchgott demonstrated that very high supraphysiological concentrations (high mmol/l) exert relaxant effects on vascular smooth muscle.(61) Moreover, it was demonstrated by two separate gro…”
Background
The actions of kinin antagonists on B1 and B2 receptor systems
Regoli, D. C., Drapeau, G., Rovero, P., et al. (1986) · European Journal of Pharmacology · doi:10.1016/0014-2999(86)90687-4 · Cited by 91
Vascular Smooth Muscle Reactivity in Normotensive and Hypertensive Rats
Spector, S., Fleisch, J. H., Maling, H. M., et al. (1969) · Science · doi:10.1126/science.166.3910.1300 · Cited by 90
A Brief History of Great Discoveries in Pharmacology: In Celebration of the Centennial Anniversary of the Founding of the American Society of Pharmacology and Experimental Therapeutics
Rubin, R. P. (2007) · Pharmacological Reviews · doi:10.1124/pr.107.70102 · Cited by 88
“Aware that ACh was a potent dilator in vivo and in isolated perfused organs, he surprisingly observed that ACh elicited a contractile response of the aortic strip (Furchgott and Bhadrakom, 1953).”
Background
A New, Long-Lasting Competitive Inhibitor of Angiotensin
Türker, R. K., Hall, M. M., Yamamoto, M., et al. (1972) · Science · doi:10.1126/science.177.4055.1203 · Cited by 88
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate
Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 87
“This enzyme can produce both O 2 and hydrogen peroxide during its metabolism of purines.242–244 This enzyme, as discussed above, belongs to the major endogenous pathways contributing to the reduction in inorganic nitrate/nitrite to NO.”
BackgroundInfluential
Influence of papaverine, D 600, and nifedipine on the effects of noradrenaline and calcium on the isolated aorta and mesenteric artery of the rabbit
Sch�mann, H. J., G�rlitz, B. D., & Wagner, J. (1975) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00508414 · Cited by 85
“Thereafter the thoracic aorta and the mesenterie artery were prepared according to Furchgott and Bhadrakom (1953). After removing the connective tissue the vessels were cut into spiral strips and mounted in an organ bath of 40 ml of Tyrode solution.”
Method
Plasma Renin Activity in Acute Tubular Necrosis and Other Renal Diseases Associated with Hypertension
Tu, W.-H., & Dawson, M. (1965) · Circulation · doi:10.1161/01.cir.31.5.686 · Cited by 84

Authors: Furchgott, R. F., & Bhadrakom, S.
Affiliations: Washington University in St. Louis (US)
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1953-06
Volume: 108
Issue: 2
Pages: 129-143
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)05163-8
OpenAlex: W2302863210
Cited by: 655
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 9
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: rabbit aorta, epinephrine, isoproterenol, sodium nitrite, norepinephrine, histamine, acetylcholine, vascular smooth muscle contraction, drug sensitivity, drug antagonism
MeSH terms: Animals, Aorta, Epinephrine, Isoproterenol, Norepinephrine, Rabbits, Sodium Nitrite

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks