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REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS
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“In 1952 Furchgott and Bhadrakhom demonstrated the ability of nitrite to effect relaxation of pre-constricted aortic vessels, but the concentrations used where substantially higher than that found in physiological conditions (100 μM compared to normal levels of tens to hundreds of nanomolar) [27].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [27]
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Holl, J. E., Kolbeck, R. C., & Speir, W. A. (1980) · PubMed · doi:10.1164/arrd.1980.122.6.909 · Cited by 5
Fruits, Serotonin, And Catechol Amines
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Liver Ischemia Modifies the Concentration of Plasmatic Catecholamines after Reperfusion in the Rat
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Effect of 2,5-dimethoxy-4-methylamphetamine on heart and smooth muscle contraction
Huang, J., & Ho, B. T. (1974) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1974.tb12825.x · Cited by 4
Dhillon, D. S., Pong, S. F., & Moorehead, T. J. (1992) · Drug Development Research · doi:10.1002/ddr.430250208 · Cited by 4
Ercan, Z. S., Törker, R. K., & Torunoğlu, M. (1978) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813457809055925 · Cited by 4
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Vasoactive effects of methanol and sodium formate on isolated canine basilar artery
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Structure-activity studies of new imidazolines on adrenoceptors of rat aorta and human platelets
Venkataraman, B. V., Shams, G. E.-D. A. M., Hamada, A., et al. (1991) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00172586 · Cited by 4
“An aortic strip of 2 cm in length (Furchgott and Bhadrakom 1953) was suspended in a 10 ml organ bath with 1.”
MethodEffects of bunaphtide on contractions induced by different agonists in the rat isolated aorta
Tamargo, J. L., Aleixandre, A., Rodriguez, S. G., et al. (1978) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1978.tb13288.x · Cited by 4
Actions of the novel bronchodilator, trimetaquinol, on bovine pulmonary vein
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Barrigón, S., Díez, J. J., Tamargo, J. L., et al. (1985) · European Journal of Pharmacology · doi:10.1016/0014-2999(85)90760-5 · Cited by 4
Responses of rabbit aorta to tyramine in relation to the surface of drug entry
Iriarte, C. F., Pascual, R., Morcillo, E. J., et al. (1985) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00695187 · Cited by 4
The absence of a significant histamine receptor reserve in vascular smooth muscle
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Asano, M., & Hidaka, H. (1983) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.33.145 · Cited by 4
α-Adrenergic activity of N,N-dimethyldopamine (DMDA)
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β‐Adrenoceptor stimulating properties of para‐dimethylaminobenzaldehyde
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Effect of atrial natriuretic peptide on bronchial tone in anesthetized rabbits
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Ogunbiyi, P. O., & Eyre, P. (1984) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.1984.tb00892.x · Cited by 4
Change of Activity of Angiotensins I and II In the Isolated Perfused Guinea-Pig Lung
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A comparative study of two structurally related analogs of Asp1-Ile5-angiotensin II
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“Rat ascending colon (Regoli and Vane, 1964) and rabbit aortic strips (Furchgott and Bhadrakom, 1953) were isolated in 5 ml organ baths containing warmed (37~ and oxygenated (95% 02 and 50/0 CO2) Krebs' solution (NaC1 112, NaHCO 3 25, KC1 5, NaH~PO a 1, CaC12 2.”
MethodHassan, H. M., Eldin, I. M. T., Ahmed, E. M., et al. (2013) · Health · doi:10.4236/health.2013.56135 · Cited by 3
Influence of reserpine pretreatment on cardiovascular effects of angiotensin II in rabbits
Pérez-Olea, J., & Quevedo, M. (1975) · European Journal of Pharmacology · doi:10.1016/0014-2999(75)90322-2 · Cited by 3
Responses of pulmonary vasculature of cattle to dopamine and apomorphine
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Effect of venom from Bitis nasicornis (rhinoceros horned viper) on isolated rabbit aortic strips
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P1-purinoceptors mediate relaxation of the bovine bronchial artery
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RELAXATION OF ISOLATED AORTA OF THE RABBIT BY PICOLINIC ACIDS
Asano, M., & Hidaka, H. (1977) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1977.tb08414.x · Cited by 3
The Role of the Cell Background in Biased Signaling
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Cholinergic Signaling and Muscle Contraction
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Hussain, M., Waqas, H. M., Raza, S. M., et al. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.09.028 · Cited by 3
Robert Furchgott (1916-2009): A scientist with a mission
Rubin, R. P. (2019) · Journal of Medical Biography · doi:10.1177/0967772018825365 · Cited by 3
“By 1953, Furchgott published a paper on responses of the aorta to various agents including acetylcholine (ACh), which produced a paradoxical effect in that it caused contraction, in contrast to its well-described vasodilatory effects in vivo.(5) While in St Louis, Furchgott also discovered the phenomenon of photorelax…”
ResultA regional difference in the in vitro response of the rabbit vena cava to norepinephrine
Hellegouarch, A., DeFeudis, F. V., & Clostre, F. (1982) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(82)90008-8 · Cited by 3
Regulation of alpha-1 Adrenergic Receptors
Hoffman, B. B. (1987) · The Receptors · doi:10.1007/978-1-4612-4582-7_11 · Cited by 3
Observations on the Chymotrypsin Peptide Releasing Activity on Plasmas
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Release of labile cyclo-oxygenase products of arachidonic acid from kidney by endotoxin
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Garcı́a-Sevilla, J. A., & Erill, S. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90013-2 · Cited by 3
Involvement of prostanoids in the pulmonary pressor effect of histamine
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The in vitro actions of clenbuterol (NAB‐365) on bovine pulmonary vein and artery
Mirbahar, K. B., & Eyre, P. (1985) · Journal of Veterinary Pharmacology and Therapeutics · doi:10.1111/j.1365-2885.1985.tb00945.x · Cited by 3
Recherches Sur Les Recepteurs ADRenoceptifs α ET β CHEZ L'AÏ(Bradypus tridactylus)(1)
Philippot, E. (1965) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813456509081851 · Cited by 3
NICOTINE AND THE EFFECT OF ANTISYMPATHOMIMETIC AGENTS ON THE AORTA OF THE RABBIT
Millson, D. R. (1959) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1959.tb01391.x · Cited by 3
THE ACTION OF TYRAMINE ON THE DOG ISOLATED ATRIUM
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Determination of muscarinic receptors on cultivated endothelial cells
Mundt, S., & Teuscher, E. (1986) · Acta Histochemica · doi:10.1016/s0065-1281(86)80057-5 · Cited by 3
Interaction of cocaine with angiotensin and tyramine on the isolated rabbit aortic strips
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Action of angiotensin on vascular and intestinal smooth muscle and its antagonism by saralasin
Coruzzi, G., Poli, E., Adami, M., et al. (1983) · Pharmacological Research Communications · doi:10.1016/s0031-6989(83)80002-2 · Cited by 3
RS-61756-007: a potent and selective thromboxane receptor (TP) agonist
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Sekine, K., Yamakawa, K., & Ogata, E. (1984) · Clinical and Experimental Hypertension · doi:10.3109/10641968409039596 · Cited by 3
New insight sheds light as to how nitrite might reduce blood pressure height: is this alright?
Beusecum, J. P. V., & Harrison, D. G. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz248 · Cited by 3
“At a physiological pH, the amount of NO2 - needed to produce vasodilatation of isolated vessels is 100 lMol/l, 10 000 times lower than the concentration of NO needed to evoke the same response.(2) Over the last 15 years, however, it has become apparent that much lower concentrations of NO2 , either generated in vivo o…”
BackgroundNew Approaches to the Study of Angiotensin Tachyphylaxis
Moore, A. F., Bumpus, F. M., & Khairallah, P. A. (1977) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)09864-7 · Cited by 3
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THE EVALUATION OF THE NOVEL PRESSOR ACTIVITY OF γ‐PIPERIDINOBUTYRAMIDE (WY 20051, DF480)
Alps, B. J., DEVOY, P. W., & Waterfall, J. F. (1976) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1976.tb07440.x · Cited by 2
Pharmacological activity of the new calcium antagonist, lacidipine, on isolated preparations
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Effects of tyramine on the human uterine artery In vitro
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Pruneau, D., Roy, F., & Nl, B. (1990) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1990.tb00490.x · Cited by 2
PROCEEDINGS OF THE British Pharmacological Society
Birch, P. J., Clough, D. P., Hatton, R., et al. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb10705.x · Cited by 2
Studies of the chemical nature of the α-adrenergic receptor—V
Termer, U. K., Cook, D., & Marks, G. S. (1971) · Biochemical Pharmacology · doi:10.1016/0006-2952(71)90146-8 · Cited by 2
PROCEEDINGS OF THE British Pharmacological Society
Al-Jeboory, A., & Marshall, R. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb08473.x · Cited by 2
Prolonged effects of reserpine administration on adrenoceptor activity in dogs
Cavero, I., Jandhyala, B. S., & Buckley, J. P. (1971) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1971.tb09915.x · Cited by 2
Wilson, V. G., Wilson, K., & Downing, O. A. (1987) · Journal of Autonomic Pharmacology · doi:10.1111/j.1474-8673.1987.tb00134.x · Cited by 2
deBlois, D., Bouthillier, J., & Marceau, F. (1990) · Life Sciences · doi:10.1016/0024-3205(90)90355-u · Cited by 2
Ehrenpreis, S., Munson, H. R., Bigo-Gullino, M., et al. (1964) · Life Sciences · doi:10.1016/0024-3205(64)90142-0 · Cited by 2
Cohen, M. L., & Wiley, K. S. (1979) · Clinical and Experimental Hypertension · doi:10.3109/10641967909068638 · Cited by 2
Vonderlage, M. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90096-x · Cited by 2
Organ selective angiotensin antagonists: Sarcosyl1-cysteinyl(s-methyl)8-angiotensin I
Freer, R. J., Sutherland, J. C., & Day, A. R. (1980) · European Journal of Pharmacology · doi:10.1016/0014-2999(80)90338-6 · Cited by 2
Scriabine, A., & McShane, W. K. (1965) · The Journal of New Drugs · doi:10.1002/j.1552-4604.1965.tb00239.x · Cited by 2
Further investigation of a potential calcium channel modulator isolated from rat erythrocytes
Huang, B. S., McCumbee, W. D., & Wright, G. L. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-199 · Cited by 2
THE CARDIOVASCULAR EFFECTS OF TRIMAZOSIN AND PRAZOSIN IN THE RABBIT
Vincent, J., Hamilton, C. A., & Reid, J. L. (1986) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1986.tb00944.x · Cited by 2
Assay of Catechol Amines in Urine by Means of a Strip of Rabbit Aorta
Helmer, O. M., Furchgott, R. F., & Jannetta, P. J. (1961) · Standard methods of clinical chemistry · doi:10.1016/b978-1-4831-9684-8.50011-9 · Cited by 2
Self-citationAuguet, M., Delaflotte, S., Garay, R. P., et al. (1985) · Regulatory Peptides · doi:10.1016/0167-0115(85)90230-7 · Cited by 2
Isolated Preparations: Dose—Response Data
Tallarida, R. J., & Jacob, L. S. (1979) · Springer eBooks · doi:10.1007/978-1-4684-6265-4_6 · Cited by 2
THE DISCOVERY OF THE PATHOPHYSIOLOGICAL ROLE OF NITRIC OXIDE IN BLOOD VESSELS
Channon, K. M. (2011) · IMPERIAL COLLEGE PRESS eBooks · doi:10.1142/9781848168275_0013 · Cited by 1
Role of Perindopril in Mitigating Doxorubicin’s Vascular Toxicity in a Rat Model
Marada, A., Stračina, T., Marhefka, F., Šůstková, L., Nádeníček, J., Smutná, J., Scheer, P., Hložková, J., Hendrych, M., Studenik, C. R., et al. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10092-0 · Cited by 1
“S6).”
Mangel, A. W., & Marion, S. B. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s60448 · Cited by 1
“Electrical activity of aortic smooth muscle In contrast to gastrointestinal smooth muscle, segments of aortic smooth muscle are generally quiescent both electrically and mechanically in organ baths or show spontaneous contractions at a frequency significantly slower than the cardiac cycle.(11,12) When aortic segments…”
Effects of nitrite and oxygen on angiogenesis in vascular networks of the chicken embryo
Connery, M. (2013) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/gsc8-e274 · Cited by 1
Effect of isoprenaline on dopamine receptors in the rabbit isolated renal artery
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Relaxation of rabbit aorta by chlordimeform
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Felodipine and Vasomotion Physiology
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Differential relaxing response of various arterial smooth muscles of dogs to nifedipine.
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Pulmonary and hemodynamic effects of histamine in the pig. In vitro and in vivo studies
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Actions of Calcium Agonists and Antagonists on Femoral Arteries of Spontaneously Hypertensive Rats
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Nitroglycerin on the carotid artery and femoral artery of the dog
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“Strips of aorta were prepared according to Furchgott and Bhadrakom (16) and suspended in 5-mL organ baths containing Krebs solution at 37◦C; they were aerated continuously with a mixture of 95% O2 and 5% CO2.”
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Characteristics of Apomorphine Tachyphylaxis
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Nitric Oxide and the Pulmonary Circulation in the Adult
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Metadata
- Authors
- Furchgott, R. F., & Bhadrakom, S.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1953-06
- Volume
- 108
- Issue
- 2
- Pages
- 129-143
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2302863210
- Cited by
- 655
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 9
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- rabbit aorta, epinephrine, isoproterenol, sodium nitrite, norepinephrine, histamine, acetylcholine, vascular smooth muscle contraction, drug sensitivity, drug antagonism
- MeSH terms
- Animals, Aorta, Epinephrine, Isoproterenol, Norepinephrine, Rabbits, Sodium Nitrite
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