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REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS
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“In 1952 Furchgott and Bhadrakhom demonstrated the ability of nitrite to effect relaxation of pre-constricted aortic vessels, but the concentrations used where substantially higher than that found in physiological conditions (100 μM compared to normal levels of tens to hundreds of nanomolar) [27].”
From Mechanisms of nitrite bioactivation (2014) · cites this paper as [27]
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Items 601–654 of 654
Temporal integration of α1-adrenergic responses in BC3H-1 muscle cells
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The action of certain drugs on the respiration of the smooth muscle of blood vessels
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The Comparative Sensitivity of Isolated Coronary and Systemic Vessels To Vasomotor Agents
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A comparison of the central ear artery and aorta of the Jackrabbit and rabbit
Robinson, C. P., Blank, C. L., Haines, H., et al. (1978) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0306-4492(78)90134-x
Isolation of a protein-2-halogenoethylamine complex from rabbit aortic tissue
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Inhibition of transmitter release from isolated rabbit kidney by bradykinin
Türker, R. K., & Ercan, Z. S. (1977) · Inflammation Research · doi:10.1007/bf01966852
“The venous outflow was superfused continuously over a spirally cut rabbit aortic strip [11] prepared similar to the 'blood bathed organ technique' [12].”
BackgroundMethodZum Mechanismus der Adrenalindilatation der Skeletmuskelgef��e
Schmidt-Vanderheyden, W., & Koepchen, H. P. (1967) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00362630
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de Zwart, M., Vollinga, R. C., Beukers, M. W., et al. (1999) · Drug Development Research · doi:10.1002/(sici)1098-2299(199911)48:3 · Cited by 56
Effect of phosvitin on smooth muscle “in vitro”
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Phentolamine and propranolol on isoprenaline induced responses on rabbit aortic strips
Fernández, P. L., Martinez, A. M., & de Jalon, P. G. (1974) · Cellular and Molecular Life Sciences · doi:10.1007/bf01921607
Interaction catecholamines-pyrogallol on rabbit aortic strips
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Change of the Activities of Angiotensins I and II On the Vascular Smooth Muscle by Crude Kallikrein
Ercan, Z. S., & Törker, R. K. (1977) · Archives Internationales de Physiologie et de Biochimie · doi:10.3109/13813457709069875
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Pasos-Peniche, J. E., Miranda‐Díaz, A. G., Totsuka-Sutto, S. E., et al. (2007)
Rabbit Aorta to Ergonovine MEDIATION BY A SEROTONERGIC MECHANISM
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Hoose, P. M. V. (2015) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2293
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Inorganic nitrite and conduit artery function
Omar, S. A. (2015)
Ercan, Z. S., & Türker, R. K. (1977) · Cellular and Molecular Life Sciences · doi:10.1007/bf02002832
Pacher, P., Kecskeméti, V., Rónai, A. Z., et al. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006844012590
“Spirally cut strips from the thoracic aorta were prepared according to Furchgott and Bhadrakom [21].”
MethodDRUG INTERACTIONS ON THE SMOOTH MUSCLES OF THE ISOLATED SPIRALLY CUT STRIP OF RAT AORTA
Paradelis, A. G., Karachalios, D., & FIDANI, V. (1986) · Elsevier eBooks · doi:10.1016/b978-0-08-034190-3.50059-2
Vascular desensitisation--possible role of prostaglandins.
Js, P., Vg, D., D'Souza, R. S. D., et al. (1987) · PubMed
Chapter 1 Endothelium-Dependent Relaxation in Systemic Arteries
Furchgott, R. F. (1988)
Self-citationShort communication Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor
Constantine, J. W., Lebel, W. S., & Woody, H. A. (1990)
Nitrite and Nitrate as a Treatment for Hypertension
Kapil, V. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_17
Estudo da tolerância in vitro induzida pelo doador de NO cis-[Ru(bpy)2(py)NO2](PF6)(RuBPY)
Banin, T. M. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.60.2019.tde-02052016-144520
Carvalho, C. C. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2019.tde-12082019-115008
[On the mechanism of adrenaline dilatation of skeletal muscle blood vessels].
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Woessner, M. N. (2019) · Victoria University Research Repository (Victoria University)
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Assessment of Small Artery Structure and Function by Micromyography
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Stewart‐Lee, A. L. (1991) · UCL Discovery (University College London)
ARTERIAL AND ARTERIOLAR SYSTEMS
(1962) · Elsevier eBooks · doi:10.1016/b978-1-4832-3144-0.50007-2
(1982) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1982.tb17349.x
O’Gallagher, K., & Webb, A. J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91391-1.00051-0
Subhan, Z., Ali, N., Ullah, A., et al. (2025) · Biomolecules · doi:10.3390/biom15050611
“The experimental method employed was a modified version of the technique described by Furchgott and Bhadrakom (1953) [26,27].”
Valderrama, A. A., & Montufar‐Rueda, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21435-6.00006-9
Protection Against Diseases of the Nervous System
Pan, Y. L. (2025) · Springer eBooks · doi:10.1007/978-981-95-2824-0_9
Lim, P. O. (2025) · Springer eBooks · doi:10.1007/978-3-032-10734-3_7
Towards nitrite as a therapy in cardiovascular disease
Ormerod, J. O. M. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham)
Investigating the role of nitric oxide clones in cardiovascular conditions
Arif, S. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Furchgott, R. F., & Bhadrakom, S.
- Affiliations
- Washington University in St. Louis (US)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1953-06
- Volume
- 108
- Issue
- 2
- Pages
- 129-143
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2302863210
- Cited by
- 655
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 9
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- rabbit aorta, epinephrine, isoproterenol, sodium nitrite, norepinephrine, histamine, acetylcholine, vascular smooth muscle contraction, drug sensitivity, drug antagonism
- MeSH terms
- Animals, Aorta, Epinephrine, Isoproterenol, Norepinephrine, Rabbits, Sodium Nitrite
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