Cited by 655Receptor Mechanisms and SignalingCardiovascular, Neuropeptides, and Oxidative Stress ResearchNitric Oxide and Endothelin Effects

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REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS

Furchgott, Robert F., Bhadrakom, Suchin·1953·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)05163-8

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“Nitrite has been known to underlie vasodilatory effects since 1880 [21], an activity that was later suggested to involve the interaction of this anion with sGC [22, 23].”
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“5 g tension in a 20 ml organ bath at 37oc in Tyrode's solution oxygenated with 95% 02 and 5% CO 2 (Furchgott and Bhadrakom 1953).”
Method
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“The vascular strip preparation is widely used by physiologists and pharmacologists since it was introduced by Furchgott and Bhadrakom (1953).”
Background
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Method
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A human arterial preparation for studying the effects of vasoactive agents.
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Competitive antagonism of 8-ala-angiotensin II to angiotensins I and II on isolated rabbit aorta and rat ascending colon
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Effect of Prolonged Cold Storage on the Contractile Response of Strips of Rabbit Aorta to Various Agents
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“Spiral aortic strips were prepared after excessive fat and connective tissue had been removed (5).”
Background
Demonstration of specific vascular dopamine receptors mediating vasodilation on the isolated rabbit mesenteric artery
Brodde, O., Meyer, F.-J., Schemuth, W., et al. (1981) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00507222 · Cited by 41
Experimental Studies of Intracranial Arterial Spasm Using Aortic Strip Assays
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“In early in vitro studies, as reported by Furchgott and Bhadrakom (48), high NO2- concentrations (≈100 μM) were typically used to induce aortic ring relaxation or to activate purified sGC, the enzyme that catalyzes the conversion of guanosine triphosphate (GTP) to cGMP and that mediates NO vasorelaxation (49).”
Background
Antihypertensive action of indapamide and review of pharmacology and toxicology
Moore, R. A., Seki, T., Ohsumi, S., et al. (1977) · Current Medical Research and Opinion · doi:10.1185/03007997709110220 · Cited by 40
Analysis of bradykinin receptor mediating relaxation of cat cerebral arteries in vivo and in vitro
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“Strips of aortae from a single rabbit (2.2kg) were prepared according to the method of Furchgott and Bhadrakom (1953) and suspended in 10ml tissue baths containing Krebs-Henseleit solution as described above.”
Method
Cardiovascular effects of amitriptyline, nortriptyline, protriptyline and doxepin in conscious rabbits
Elonen, E., Mattila, M. J., & Saarnivaara, L. (1974) · European Journal of Pharmacology · doi:10.1016/0014-2999(74)90130-7 · Cited by 40
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Quantitative analysis on isolated organs of the autonomic blocking properties of indoramin hydrochloride (Wy 21901)
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Etiology of hypertension in toxemia of pregnancy
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Imidazo[1,5-a]pyrimidine and benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as calcium antagonists
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FR 173657: A New, Potent, Nonpeptide Kinin B2Receptor Antagonist
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“For instance, Furchgott [9] observed that Iso at concentrations 1–500 mM caused contraction of rabbit thoracic aorta, a tissue in which all three a1- AR subtypes are expressed (reviewed in [43].”
Background
A MODIFICATION OF RECEPTOR THEORY
STEPHENSON, R. P. (1997) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1997.tb06784.x · Cited by 37
The rabbit jugular vein is a contractile NK-1 receptor system
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Role of the thyroid gland in the development and maintenance of spontaneous hypertension in rats.
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Evidence Mounts That Nitrite Contributes to Hypoxic Vasodilation in the Human Circulation
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Moderate‐intensity endurance training improves endothelial glycocalyx layer integrity in healthy young men
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Authors: Furchgott, R. F., & Bhadrakom, S.
Affiliations: Washington University in St. Louis (US)
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1953-06
Volume: 108
Issue: 2
Pages: 129-143
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)05163-8
OpenAlex: W2302863210
Cited by: 655
References: 0
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 6 · 2016: 9 · 2015: 9 · 2014: 13 · 2013: 7 · 2012: 9
FWCI: 2.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: rabbit aorta, epinephrine, isoproterenol, sodium nitrite, norepinephrine, histamine, acetylcholine, vascular smooth muscle contraction, drug sensitivity, drug antagonism
MeSH terms: Animals, Aorta, Epinephrine, Isoproterenol, Norepinephrine, Rabbits, Sodium Nitrite

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REACTIONS OF STRIPS OF RABBIT AORTA TO EPINEPHRINE, ISOPROPYLARTERENOL, SODIUM NITRITE AND OTHER DRUGS

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