Cardioprotective effects of acidified sodium nitrite in myocardial ischemia with reperfusion
Abstract
The effects of acidified sodium nitrite (NaNO2) which releases nitric oxide, a substance which is thought to be indistinguishable from endothelium-derived relaxing factor, were investigated in a 6-h model of myocardial ischemia (MI) with reperfusion in open-chest, anesthetized cats. Acidified NaNO2 (12.5-50 mmol/kg/hr) was infused i.v., starting 30 min postocclusion followed by reperfusion 1 hr later, in cats subjected to MI by occlusion of the left anterior descending coronary artery. Acidified NaNO2 infusion (25 and 50 mmol/kg/hr) resulted in significantly lower plasma creatine kinase activities at every time beyond 1 hr for the MI + vehicle group, and was not significantly different when compared to sham MI + NaNO2 controls. The areas at risk expressed as percentage of the total left ventricular weights were not significantly different between the MI + vehicle and MI + acidified NaNO2 groups. However, the necrotic area expressed as a percentage of the myocardial area at risk was significantly lower in the 25 and 50 mmol/kg/hr NaNO2-treated cats. Cardiac myeloperoxidase activities indicated that significantly fewer neutrophils were attracted to the ischemic zone of the NaNO2-treated MI cats when compared to the vehicle-infused MI cats. Acidified NaNO2 significantly inhibited platelet aggregation in a dose-dependent manner in cat platelet-rich plasma. Thus, acidified NaNO2 exerts a significant protective action during ischemia and reperfusion injury, which suggests that endothelium-derived relaxing factor has a cardioprotective effect in MI.
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Jones, D. A., Rathod, K. S., & Ahluwalia, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00015-6
Freeman, P. M. (2018) · ORCA Online Research @Cardiff (Cardiff University)
- Authors
- Johnson, G., Tsao, P. S., Mulloy, D., & Lefer, A. M.
- Affiliations
- Thomas Jefferson University (US)
- ORCID
- Tsao, P S
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 252
- Issue
- 1
- Pages
- 35-41
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2286008140
- Cited by
- 104
- References
- 0
- Citations by year
- 2023: 2 · 2021: 1 · 2020: 2 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 3 · 2012: 2
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- myocardial ischemia-reperfusion injury, cardioprotection, nitric oxide, endothelium-derived relaxing factor, myocardial necrosis, neutrophil infiltration, myeloperoxidase, platelet aggregation inhibition, coronary artery occlusion, creatine kinase
- MeSH terms
- Animals, Blood Pressure, Cats, Coronary Disease, Creatine Kinase, Heart, Heart Rate, Male, Peroxidase, Nitrites, Platelet Aggregation, Platelet Aggregation Inhibitors, Sodium Nitrite, Myocardial Reperfusion Injury
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