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Cited by 148Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimers disease

a, S·1999·Journal of Psychiatric Research
DOI 10.1016/s0022-3956(98)90048-6
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Abstract

We hypothesized that 20 patients with isolated memory impairment (IMI) would demonstrate [18F]-2-fluoro-2-deoxy-D-glucose utilization and a progression of neuropsychological symptoms consistent with Alzheimer's disease (AD). IMI subjects performed similarly to AD in recall and verbal fluency, but comparable to normal subjects in other areas of cognitive functioning. A positron emission tomography (PET) diagnostic index based on parietal Z-scores categorized IMI patients into normal and abnormal metabolic patterns. Ten of the original 20 IMI patients (50%) reflected PET AD abnormalities. Clinical information was available for IMI patients at three-year follow-up. Ten (50%) had converted to AD, three were found to have pseudodementia and the seven remained IMI. Of the 10 IMI patients with an originally normal PET index, three (30%) were diagnosed with AD at three years. Of the 10 with an abnormal index originally, seven (70%) converted to AD. The finding that memory deficit in IMI was as pronounced as that in AD patients is consistent with the notion that memory is an initial symptom of AD. A substantial number of the IMI patients reflected regional hypometabolism similar to AD, suggesting that IMI is likely an early stage in progressive dementia. A large percentage of IMI patients converted clinically to AD within three years of initial study, though we observed impaired memory functioning well before a clinical diagnosis of AD could be made. In addition to potential clinical utility, IMI and PET represent an opportunity to study dementia in relation to brain chemistry at a time when brain pathology is in the process of development.

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Crossref · 10.1016/s0022-3956(98)90048-6

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Metadata

Authors
a, S.
Venue
Journal of Psychiatric Research
Publisher
Elsevier BV
Published
1999-01-02
Volume
33
Issue
1
Pages
7-16
ISSN
0022-3956 (ISSN-L)
DOI
10.1016/s0022-3956(98)90048-6
OpenAlex
W1566965501
Cited by
148
References
31
Citations by year
2026: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 3
FWCI
2.86
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychiatric Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ns024896-15)
  • National Institute on Aging (5 P50 AG 08671-07, P50AG008671)
  • National Institute of Neurological Disorders and Stroke (5 RO1 NS 24896)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
Alzheimer's disease, brain glucose metabolism, 18F-FDG PET, conversion to Alzheimer's disease, pseudodementia, early-stage dementia, memory retrieval, verbal fluency, neuropsychological assessment
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Follow-Up Studies, Glucose, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Time Factors, Tomography, Emission-Computed, Disease Progression

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