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Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimers disease
Abstract
We hypothesized that 20 patients with isolated memory impairment (IMI) would demonstrate [18F]-2-fluoro-2-deoxy-D-glucose utilization and a progression of neuropsychological symptoms consistent with Alzheimer's disease (AD). IMI subjects performed similarly to AD in recall and verbal fluency, but comparable to normal subjects in other areas of cognitive functioning. A positron emission tomography (PET) diagnostic index based on parietal Z-scores categorized IMI patients into normal and abnormal metabolic patterns. Ten of the original 20 IMI patients (50%) reflected PET AD abnormalities. Clinical information was available for IMI patients at three-year follow-up. Ten (50%) had converted to AD, three were found to have pseudodementia and the seven remained IMI. Of the 10 IMI patients with an originally normal PET index, three (30%) were diagnosed with AD at three years. Of the 10 with an abnormal index originally, seven (70%) converted to AD. The finding that memory deficit in IMI was as pronounced as that in AD patients is consistent with the notion that memory is an initial symptom of AD. A substantial number of the IMI patients reflected regional hypometabolism similar to AD, suggesting that IMI is likely an early stage in progressive dementia. A large percentage of IMI patients converted clinically to AD within three years of initial study, though we observed impaired memory functioning well before a clinical diagnosis of AD could be made. In addition to potential clinical utility, IMI and PET represent an opportunity to study dementia in relation to brain chemistry at a time when brain pathology is in the process of development.
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“Reduced size or glucose metabolism (METglu) in the EC (10), Hip (11–16), temporal neocortex (17–20), and posterior cingulate gyrus (16) have been shown to predict the MCI conversion to AD.”
From Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET) (2001) · cites this paper as [19]
In the citing paper
“Others have observed that temporo-parietal METglu deficits predict AD (18–20).”
From Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET) (2001) · cites this paper as [19]
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Metadata
- Authors
- a, S.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 1999-01-02
- Volume
- 33
- Issue
- 1
- Pages
- 7-16
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1566965501
- Cited by
- 148
- References
- 31
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns024896-15)
- National Institute on Aging (5 P50 AG 08671-07, P50AG008671)
- National Institute of Neurological Disorders and Stroke (5 RO1 NS 24896)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, brain glucose metabolism, 18F-FDG PET, conversion to Alzheimer's disease, pseudodementia, early-stage dementia, memory retrieval, verbal fluency, neuropsychological assessment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Follow-Up Studies, Glucose, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Time Factors, Tomography, Emission-Computed, Disease Progression
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