The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimers disease
Abstract
We hypothesized that 20 patients with isolated memory impairment (IMI) would demonstrate [18F]-2-fluoro-2-deoxy-D-glucose utilization and a progression of neuropsychological symptoms consistent with Alzheimer's disease (AD). IMI subjects performed similarly to AD in recall and verbal fluency, but comparable to normal subjects in other areas of cognitive functioning. A positron emission tomography (PET) diagnostic index based on parietal Z-scores categorized IMI patients into normal and abnormal metabolic patterns. Ten of the original 20 IMI patients (50%) reflected PET AD abnormalities. Clinical information was available for IMI patients at three-year follow-up. Ten (50%) had converted to AD, three were found to have pseudodementia and the seven remained IMI. Of the 10 IMI patients with an originally normal PET index, three (30%) were diagnosed with AD at three years. Of the 10 with an abnormal index originally, seven (70%) converted to AD. The finding that memory deficit in IMI was as pronounced as that in AD patients is consistent with the notion that memory is an initial symptom of AD. A substantial number of the IMI patients reflected regional hypometabolism similar to AD, suggesting that IMI is likely an early stage in progressive dementia. A large percentage of IMI patients converted clinically to AD within three years of initial study, though we observed impaired memory functioning well before a clinical diagnosis of AD could be made. In addition to potential clinical utility, IMI and PET represent an opportunity to study dementia in relation to brain chemistry at a time when brain pathology is in the process of development.
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“Reduced size or glucose metabolism (METglu) in the EC (10), Hip (11–16), temporal neocortex (17–20), and posterior cingulate gyrus (16) have been shown to predict the MCI conversion to AD.”
From Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET) (2001) · cites this paper as [19]
In the citing paper
“Others have observed that temporo-parietal METglu deficits predict AD (18–20).”
From Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET) (2001) · cites this paper as [19]
Citations
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
A New Clinical Scale for the Staging of Dementia
Hughes, C. P., Berg, L., Danziger, W., Coben, L. A., & Martin, R. L. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.140.6.566 · Cited by 7,056
Kaplan, E., Goodglass, H., Weıntraub, S., & Segal, O. (2001) · Medical Entomology and Zoology · Cited by 4,378
A Standardized Memory Scale for Clinical Use
Wechsler, D. (1945) · The Journal of Psychology · doi:10.1080/00223980.1945.9917223 · Cited by 2,949
Clinical neuropsychology: Current status and applications
(1975) · Behavior Therapy · doi:10.1016/s0005-7894(75)80088-8 · Cited by 1,556
(1995) · PubMed Central · doi:10.2967/jnumed.120.252510a · Cited by 996
Crook, T. H., Bartus, R. T., Ferris, S. H., Whitehouse, P. J., Cohen, G. D., & Gershon, S. (1986) · Developmental Neuropsychology · doi:10.1080/87565648609540348 · Cited by 930
Hodges, J. R. (1995) · Neuropsychologia · doi:10.1016/0028-3932(94)00127-b · Cited by 644
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Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 4,094
Current concepts in mild cognitive impairment
Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781
“Functional neuroimaging may also aid in the detection of subjects with MCI.(48,49) In group studies using positron emission tomography, early metabolic deficits in the temporoparietal region have been demonstrated in those at risk for familial AD(48) based on family history and those with an apolipoprotein E4 genotype.”
BackgroundBrain glucose metabolism in the early and specific diagnosis of Alzheimer?s disease
Mosconi, L. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1762-7 · Cited by 938
Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 698
“Posterior cingulate hypometabolism was a brain area to be recognized as an early sign of progression in a small study of eight patients with severe memory deficits (Berent et al., 1999; Minoshima et al., 1997; Mosconi et al., 2009).”
Backgroundde Leon, M. J., Convit, A., Wolf, O. T., Tarshish, C. Y., DeSanti, S., Rusinek, H., Tsui, W., Kandil, E., Scherer, A. J., Roche, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191044198 · Cited by 629
Metadata
- Authors
- a, S.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 1999-01-02
- Volume
- 33
- Issue
- 1
- Pages
- 7-16
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W1566965501
- Cited by
- 148
- References
- 31
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns024896-15)
- National Institute on Aging (5 P50 AG 08671-07, P50AG008671)
- National Institute of Neurological Disorders and Stroke (5 RO1 NS 24896)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, brain glucose metabolism, 18F-FDG PET, conversion to Alzheimer's disease, pseudodementia, early-stage dementia, memory retrieval, verbal fluency, neuropsychological assessment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Follow-Up Studies, Glucose, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Time Factors, Tomography, Emission-Computed, Disease Progression
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