Cited by 148Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

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Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimers disease

a, S·1999·Journal of Psychiatric Research

DOI 10.1016/s0022-3956(98)90048-6

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Abstract

We hypothesized that 20 patients with isolated memory impairment (IMI) would demonstrate [18F]-2-fluoro-2-deoxy-D-glucose utilization and a progression of neuropsychological symptoms consistent with Alzheimer's disease (AD). IMI subjects performed similarly to AD in recall and verbal fluency, but comparable to normal subjects in other areas of cognitive functioning. A positron emission tomography (PET) diagnostic index based on parietal Z-scores categorized IMI patients into normal and abnormal metabolic patterns. Ten of the original 20 IMI patients (50%) reflected PET AD abnormalities. Clinical information was available for IMI patients at three-year follow-up. Ten (50%) had converted to AD, three were found to have pseudodementia and the seven remained IMI. Of the 10 IMI patients with an originally normal PET index, three (30%) were diagnosed with AD at three years. Of the 10 with an abnormal index originally, seven (70%) converted to AD. The finding that memory deficit in IMI was as pronounced as that in AD patients is consistent with the notion that memory is an initial symptom of AD. A substantial number of the IMI patients reflected regional hypometabolism similar to AD, suggesting that IMI is likely an early stage in progressive dementia. A large percentage of IMI patients converted clinically to AD within three years of initial study, though we observed impaired memory functioning well before a clinical diagnosis of AD could be made. In addition to potential clinical utility, IMI and PET represent an opportunity to study dementia in relation to brain chemistry at a time when brain pathology is in the process of development.

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López, O. L., Becker, J. T., & Kuller, L. H. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-129015 · Cited by 20
“PET, SPECT, and MRI have demonstrated abnormal cerebral structure and metabolism in the mesial temporal lobes and other heteromodal association cortices in MCI subjects who progressed to AD [112–124], and in normal subjects at risk for AD [125–127], especially those who are homozygous for APOE4 allele with family hist…”
Lactate infusion fails to improve semantic categorization in Alzheimer's disease
Kalman, J. L., Palotás, A., Bódi, N., Kincses, Z. T., Benedek, G., Janka, Z., & Antal, A. (2005) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2005.03.009 · Cited by 19
“[5] S.”
Background
Vitamin D Mitigates Hyperglycemia-Induced Cognition Decline in Danio rerio (Zebrafish) through the Activation of Antioxidant Mechanisms
Uthaiah, C. A., Devaru, N. C., SHIVAKUMAR, N. H., Rajalakshmi, R., & Madhunapantula, S. V. (2022) · Antioxidants · doi:10.3390/antiox11112114 · Cited by 19
“Furthermore, studies have demonstrated decreased utilization of cerebral glucose in conditions, such as memory dysfunction [6].”
Background
Mild Cognitive Impairment
Visser, P. J. (2005) · doi:10.1002/047009057x.ch94 · Cited by 15
ACR–ASNR Practice Parameter for Brain PET/CT Imaging Dementia
Frey, K. A., Lodge, M. A., MELTZER, C. C., Peller, P. J., Wong, T. Z., Hess, C. P., Petrella, J. R., Sair, H. I., & Subramaniam, R. M. (2015) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000001037 · Cited by 14
A Metabolic Imaging Severity Rating Scale for the Assessment of Cognitive Impairment
Newberg, A. B., Cotter, A., Udeshi, M., Alavi, A. A., & Clark, C. (2003) · Clinical Nuclear Medicine · doi:10.1097/00003072-200307000-00006 · Cited by 13
Early-Onset Dementia: Diagnostic Considerations and Implications for Families
Liebson, E. S., Rauch, P. K., Graff, S., & Folstein, M. F. (2005) · Harvard Review of Psychiatry · doi:10.1080/10673220590956492 · Cited by 12
P300 Latency with Memory Performance: A Promising Biomarker for Preclinical Stages of Alzheimer’s Disease
Mohamed, M., Mohamed, N., & Kim, J. G. (2024) · Biosensors · doi:10.3390/bios14120616 · Cited by 12
Does synaptic hypometabolism or synaptic dysfunction, originate cognitive loss? Analysis of the evidence
Fessel, J. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12177 · Cited by 10
Regional cortical blood flow changes following sodium lactate infusion in Alzheimer's disease
Kalman, J. L., Palotás, A., Kis, G., Boda, K., Túri, P., Bari, F., Domoki, F., Dóda, I., Árgyelán, M., Vincze, G., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03924.x · Cited by 11
“, 1999) and defective glucose uptake and metabolism (Friedland et al., 1983; Desgranges et al., 1998; Berent et al., 1999) are well documented in AD.”
Background
Glucose enhances newborn memory for spoken words
Horne, P., Barr, R. G., Valiante, G., Zelazo, P. R., & Young, S. N. (2006) · Developmental Psychobiology · doi:10.1002/dev.20172 · Cited by 10
Age-related mild cognitive deficit: a ready-to-use concept?
Gilles, C. (2003) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2003.5.1/cgilles · Cited by 9
PET en neurología y psiquiatría I. PET con FDG en el estudio del SNC
Andrée, R. M., Jiménez-Vicioso, A., Jáuregui, J. C., Aliño, J. J. L.-I., & Delgado, J. L. C. (2002) · Revista Española de Medicina Nuclear · doi:10.1016/s0212-6982(02)72110-1 · Cited by 8
Sodium lactate differently alters relative EEG power and functional connectivity in Alzheimer’s disease patients’ brain regions
Járdánházy, A., Járdánházy, T., & Kalman, J. L. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02016.x · Cited by 8
Aux frontières de l’Alzheimer
Chételat, G., Desgranges, B., Sayette, V. D. L., Viader, F., & Eustache, F. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)70944-3 · Cited by 8
Deterioro cognitivo ligero, ¿una entidad necesaria?
Carrasco, M. M., & Bulbena, A. (2007) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 6
Cognitive distinctions between depression and early Alzheimer's disease in the elderly
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“…date, neuropsychological research has fixated on contrasting memory skills in depression and early AD, but has so far identified primarily overlaps (Berent et al., 1999; Emery, 1999; Gainotti & Marra, 1994; Gainotti et al., 1998; Hill, Stoudemire, Morris, Martino-Saltzman, & Markwalter, 1993;…”
Background
The Importance of Understanding Amylin Signaling Mechanisms for Therapeutic Development in the Treatment of Alzheimer’s Disease
Servizi, S., Corrigan, R. R., & Casadesús, G. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200318151146 · Cited by 6
FDG PET in the Evaluation of Mild Cognitive Impairment and Early Dementia
Mosconi, L., & Silverman, D. H. S. (2009) · Springer eBooks · doi:10.1007/978-0-387-76420-7_3 · Cited by 6
La neuroimagen en la enfermedad de Alzheimer: perspectiva actual
Puche, J. C. M. (2004) · Revista de Neurología · doi:10.33588/rn.3812.2004291 · Cited by 7
Mild Cognitive Impairment
Kluger, A., Golomb, J. B., & Ferris, S. H. (2003) · Wiley eBooks · doi:10.1002/9780470752340.ch25 · Cited by 6
Evaluation of Early Dementia (Mild Cognitive Impairment)
Osorio, R. S., Berti, V., Mosconi, L., Li, Y., Glodzik, L., Santi, S. D., & de Leon, M. J. (2010) · PET Clinics · doi:10.1016/j.cpet.2009.12.003 · Cited by 5
Neuroimaging of Alzheimer’s Disease, Mild Cognitive Impairment, and Other Dementias
Risacher, S. L., & Saykin, A. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_19 · Cited by 5
Model Systems for Assessing Cognitive Function: Implications for HIV-1 Infection and Drugs of Abuse
Zink, W. E., Boyle, J., Persidsky, Y., Xiong, H., & Gendelman, H. E. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-47611-8_2 · Cited by 5
ACR–ACNM–ASNR–SNMMI Practice Parameter for the Performance of Brain PET/CT Imaging in Dementia
Tu, R. K., Esposito, G., Agarwal, A., Akin, E. A., Catana, C., Chiang, G. C.-Y., Colletti, P. M., Dhingra, J., Kuo, P. H., Franceschi, A. M., et al. (2026) · American Journal of Neuroradiology · doi:10.3174/ajnr.a9105 · Cited by 3
Neurologie und Psychiatrie
Pientka, L., Wiltfang, J., Becker, G., & Christiansen, K. (2004) · Springer eBooks · doi:10.1007/978-3-642-18705-6_7 · Cited by 3
Diagnosis of Predementia AD in a Clinical Setting
Visser, P. J. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-661-4_17 · Cited by 3
Diagnosis of mild cognitive impairment
Ciesielska, N., Sokołowski, R., Stemplowski, W., Łakomski, M., Żukow, W., & Kędziora–Kornatowska, K. (2014) · Cited by 2
Curriculum Vitae Personal Data
Selmeczi, D. (2008) · Cited by 2
Advancements in quantitative perfusion magnetic resonance imaging (mri) of dementia
Chang, S.-K., & Dai, W. (2006) · Cited by 1
Early cognitive screening for individuals on the dementia continuum: A novel approach amid current trends
Urian, D. M., Gupta, G., Battista, M. E., Wild, C. J., & Owen, A. M. (2026) · Journal of Alzheimer s Disease · doi:10.1177/13872877261424289 · Cited by 2
Diagnosis of Dementia Using Nuclear Medicine Imaging Modalities
Merissa, N., Garrett, M., & Scott, P. J. H. (2011) · InTech eBooks · doi:10.5772/25283 · Cited by 2
“For example, Berent and colleagues reported 70% progression of disease in 3 years following an abnormal PET scan, but only 30% progression after a normal PET scan (Berent, et al., 1999).”
Positron Emission Tomography in Alzheimer‘s Disease: Early Prediction and Differentiation
Mistur, R. L., Mosconi, L., Santi, S. D., Li, Y., Tsui, W., & de Leon, M. J. (2008) · Future Neurology · doi:10.2217/14796708.4.1.23 · Cited by 1
11 The Early Detection of Alzheimer's Disease with Positron Emission Tomography
Mistur, R. L., Mosconi, L., Switalski, R., Santi, S. D., Li, Y., Glodzik, L., Bryś, M., Tsui, W., Rusinek, H., & de Leon, M. J. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328875.003.0011 · Cited by 1
[18F]Fluorodeoxyglucose Positron Emission Tomography in Alzheimer Disease and Related Disorders
MIYAZAWA, N., & Shinohar, T. (2012) · InTech eBooks · doi:10.5772/30326
“Investigation of the prediction of progression from MCI to AD in a small number of cases examined (17 to 20 cases) found progression occurred in 41% to 50% of cases during 18 months to 3 years, associated with glucose metabolism reduction in the association cortex, bilateral temporoparietal cortices, and left temporal…”
Background
Oscillatory brain activity in memory disorders
Osipova, D. V. (2007)
MRI and CSF studies in the early diagnosis of Alzheimer's
Eon, L., Lark, C. C., DeSanti, S., Zinkowski, R. P., Segal, S., Clark, C. N., DeBernardis, J. F., Lair, L. L., & Reisberg, ‌. (2004)
Neuronal dysfunction in aging and Alzheimer´s disease
Hatanpaa, K. J. (1999) · Tampere University Institutional Repository (Tampere University)
13 Functional Imaging with FDG-PET in Mild Cognitive Impairment
Herholz, K. (2009) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195328875.003.0013 · Cited by 1

Authors: a, S.
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 1999-01-02
Volume: 33
Issue: 1
Pages: 7-16
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/s0022-3956(98)90048-6
OpenAlex: W1566965501
Cited by: 148
References: 31
Citations by year: 2026: 2 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 1 · 2012: 3
FWCI: 2.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ns024896-15)
National Institute on Aging (5 P50 AG 08671-07, P50AG008671)
National Institute of Neurological Disorders and Stroke (5 RO1 NS 24896)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: Alzheimer's disease, brain glucose metabolism, 18F-FDG PET, conversion to Alzheimer's disease, pseudodementia, early-stage dementia, memory retrieval, verbal fluency, neuropsychological assessment
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Follow-Up Studies, Glucose, Humans, Male, Memory Disorders, Middle Aged, Neuropsychological Tests, Time Factors, Tomography, Emission-Computed, Disease Progression

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Neuropsychological function and cerebral glucose utilization in isolated memory impairment and Alzheimers disease

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