Cited by 189Advanced MRI Techniques and ApplicationsDementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging

Bentourkia, M’hamed, Bol, Anne, Ivanoiu, Adrian, Labar, Daniel, Sibomana, Mérence, Coppens, Ann, Michel, Christian, Cosnard, Guy +1 more·2000·Journal of the Neurological Sciences

Abstract

The regional cerebral blood flow (rCBF) and metabolic rate for glucose (rCMRGlc) are associated with functional activity of the neural cells. The present work reports a comparison study between rCBF and rCMRGlc in a normal population as a function of age. 10 young (25.9+/-5.6 years) and 10 old (65.4+/-6.1 years) volunteers were similarly studied at rest. In each subject, rCBF and rCMRGlc were measured in sequence, during the same session. Both rCBF and rCMRGlc values were found to decrease from young (mean rCBF=43.7 ml/100 g per min; mean rCMRGlc=40.6 micromol/100 g per min) to old age (mean rCBF=37.3 ml/100 g per min; mean rCMRGlc=35.2 micromol/100 g per min), resulting in a drop over 40 years of 14.8% (0.37%/year) and 13.3% (0.34%/year), respectively. On a regional basis, the frontal and the visual cortices were observed to have, respectively, the highest and the lowest reduction in rCBF, while, for rCMRGlc, these extremes were observed in striatum and cerebellum. Despite these differences, the ratio of rCBF to rCMRGlc was found to have a similar behavior in all brain regions for young and old subjects as shown by a correlation coefficient of 88%. This comparative study indicates a decline in rCBF and rCMRGlc values and a coupling between CBF and CMRGlc as a function of age.

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Crossref · 10.1016/s0022-510x(00)00396-8

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Authors
Bentourkia, M., Bol, A., Ivanoiu, A., Labar, D., Sibomana, M., Coppens, A., Michel, C., Cosnard, G., & De Volder, A. G.
Affiliations
UCLouvain (BE)
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
2000-12
Volume
181
Issue
1-2
Pages
19-28
ISSN
0022-510X (ISSN-L)
OpenAlex
W1963947389
Cited by
189
References
57
Citations by year
2026: 2 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 11 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 4 · 2013: 11 · 2012: 9
FWCI
3.88
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • DIAL (Catholic University of Leuven) (submittedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
regional cerebral blood flow, brain glucose metabolism, aging, brain aging, frontal cortex, visual cortex, striatum, cerebellum, regional brain metabolism, normal brain
MeSH terms
Adult, Aged, Aging, Brain, Cerebrovascular Circulation, Female, Glucose, Humans, Male, Middle Aged, Tomography, Emission-Computed

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