Brain FDG PET study of normal aging in Japanese: effect of atrophy correction
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Purpose The aim of this study was to investigate the effects of atrophy correction on the results of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) in the context of normal aging.Methods Before the human study was performed, a Hoffman 3D brain phantom experiment was carried out in order to validate a newly developed correction method for partial volume effects (PVEs). Brain FDG PET was then performed in 139 healthy Japanese volunteers (71 men, 68 women; age 24-81 years). PET images were corrected for PVEs using grey matter volume, which was segmented from co-registered magnetic resonance images and convoluted with the spatial resolution of the PET scanner. We investigated the correlation between advancing age and relative regional FDG activity, which was normalised to the global activity before and after PVE correction using Statistical Parametric Mapping 99.Results The PET image, when corrected for PVEs, provided more homogeneous tracer distribution in the whole phantom than in the original PET image. The human PET study of both sexes revealed significant negative correlations between age and relative FDG activity in the bilateral perisylvian and medial frontal areas before PVE correction. However, these negative correlations were largely resolved after PVE correction.Conclusion Correction for PVEs was effective in our FDG PET study. The reduction in FDG uptake with advancing age that was detected by FDG PET without PVE correction could be accounted for largely by an age-related cerebral volume loss in the bilateral perisylvian and medial frontal areas.
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Studies using ROI or VBM have yielded contradictory results regarding whether the hippocampus is preserved or deteriorates with aging.
“In spite of the objectivity of this method, studies led to somewhat contradictory results regarding the hippocampus: some authors have found this structure to be preserved with aging [29,31], whereas others have reported structural deterioration [38,81,84,87].”
From Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging (2009) · cites this paper as [87]
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Voxel-based mapping of brain gray matter volume and glucose metabolism profiles in normal aging
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- Authors
- Yanase, D., Matsunari, I., Yajima, K., Chen, W., Fujikawa, A., Nishimura, S., Matsuda, H., & Yamada, M.
- Affiliations
- Kanazawa University (JP)
- The Medical and Pharmacological Research Center Foundation (JP)
- Corresponding author
- Matsunari, Ichiro
- Venue
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2005-03-10
- Volume
- 32
- Issue
- 7
- Pages
- 794-805
- ISSN
- 1619-7070 (ISSN-L)
- 1619-7089
- OpenAlex
- W2033802724
- Cited by
- 104
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 9 · 2020: 3 · 2018: 6 · 2017: 4 · 2016: 8 · 2015: 7 · 2014: 7 · 2013: 8 · 2012: 4
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- normal brain aging, partial volume correction, FDG-PET, brain atrophy, gray matter volume, perisylvian cortex, medial frontal cortex, Japanese population
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Atrophy, Brain, Female, Glucose, Humans, Image Processing, Computer-Assisted, Japan, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, Emission-Computed, Single-Photon, Phantoms, Imaging, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography
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