The DOI matches its Crossref record; 71 of the 72 references it cites were found in a registry or an index.
Copper, iron and zinc in Alzheimer's disease senile plaques
Abstract
Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P<0.05). Copper was significantly elevated (P<0.05) in the rim of SP compared with AD neuropil. Comparison of AD and control neuropil revealed a significant (P<0.05) elevation of Zn in AD subjects. The elevation of these elements in SP in AD is of interest in light of the observation that Cu, Fe and particularly Zn, can accelerate aggregation of amyloid beta peptide.
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In the citing paper
“Post-mortem examination of the brain suggested that bio-available metals (i.e., copper, zinc, and iron) are found in high concentration in the amyloid plaques.”
From The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity (2013) · cites this paper as [12]
In the citing paper
“Thus, these metal ions have been shown to promote Aβ40 aggregation,23–27,29–32”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [23]
In the citing paper
“Remarkably high concentrations of Zn, Cu, and Fe have been found within the amyloid deposits in AD-affected brains,23,24”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [23]
In the citing paper
“This is in contrast with a large number of reports showing the aggregation-promoting effect of metal ions on the Aβ peptide.23–27,29–32,37,38”
From Bifunctional Compounds for Controlling Metal-Mediated Aggregation of the Aβ42Peptide (2012) · cites this paper as [23]
In the citing paper
“unusually high concentrations of copper, iron, and zinc have been found within the amyloid deposits in AD-affected brains.11”
From Small Bifunctional Chelators That Do Not Disaggregate Amyloid β Fibrils Exhibit Reduced Cellular Toxicity (2014) · cites this paper as [11]
Citations
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Cited by
Sorted by citations
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Neurodegenerative diseases and oxidative stress
Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683
Reactive Oxygen Species (ROS)-Based Nanomedicine
Yang, B., Chen, Y., & Shi, J. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00626 · Cited by 2,477
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Cheignon, C., Tomas, M., Bonnefont-Rousselot, D., Faller, P., Hureau, C., & Collin, F. (2018) · Redox Biology · doi:10.1016/j.redox.2017.10.014 · Cited by 2,185
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
Que, E. L., Domaille, D. W., & Chang, C. J. (2008) · Chemical Reviews · doi:10.1021/cr078203u · Cited by 2,077
Metadata
- Authors
- Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L., & Markesbery, W. R.
- Affiliations
- University of Kentucky (US)
- University of Guelph (CA)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1998-06
- Volume
- 158
- Issue
- 1
- Pages
- 47-52
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W2083500052
- Cited by
- 2,120
- References
- 72
- Citations by year
- 2026: 38 · 2025: 52 · 2024: 69 · 2023: 82 · 2022: 100 · 2021: 92 · 2020: 95 · 2019: 103 · 2018: 80 · 2017: 94 · 2016: 87 · 2015: 82 · 2014: 89 · 2013: 96 · 2012: 116
- FWCI
- 18.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (2-PO1-AG05119, P01AG005119, 5-P50 AG0514)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, amyloid plaques, copper, iron, zinc, trace elements, amygdala, amyloid-beta aggregation, neuropil
- MeSH terms
- Alzheimer Disease, Amygdala, Copper, Humans, Iron, Spectrometry, X-Ray Emission, Zinc, Neuropil, Biotinylation, Plaque, Amyloid
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