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Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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History and progress of hypotheses and clinical trials for Alzheimer’s disease

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Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

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Metalloenzyme-like Activity of Alzheimer's Disease β-Amyloid

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Therapeutics for Alzheimer's Disease Based on the Metal Hypothesis

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Metal Binding and Oxidation of Amyloid-β within Isolated Senile Plaque Cores: Raman Microscopic Evidence

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Copper in the brain and Alzheimer’s disease

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Biological metals and metal-targeting compounds in major neurodegenerative diseases

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Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

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Aqueous Dissolution of Alzheimer's Disease Aβ Amyloid Deposits by Biometal Depletion

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Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models

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Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation

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Amyloid Precursor Protein, Presenilins, and α-Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer’s Disease

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Copper Binding to the Amyloid-β (Aβ) Peptide Associated with Alzheimer's Disease

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Small heat shock proteins: Role in cellular functions and pathology

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Trace amounts of copper in water induce β-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease

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Targeting cuproplasia and cuproptosis in cancer

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Alzheimer Disease and Oxidative Stress

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Metal Binding Modes of Alzheimer's Amyloid β-Peptide in Insoluble Aggregates and Soluble Complexes

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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease

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A delicate balance: Iron metabolism and diseases of the brain

Hare, D. J., Ayton, S., Bush, A. I., & Lei, P. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00034 · Cited by 459

Metal dyshomeostasis and oxidative stress in Alzheimer’s disease

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Copper, zinc and iron in neurodegenerative diseases (Alzheimer's, Parkinson's and prion diseases)

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

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Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology

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Understanding the human health effects of chemical mixtures.

Carpenter, D. O., Arcaro, K. F., & Spink, D. C. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s125 · Cited by 437

Particulate Matter in Polluted Air May Increase Biomarkers of Inflammation in Mouse Brain

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Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

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Ratiometric Displacement Approach to Cu(II) Sensing by Fluorescence

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The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

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Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

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Targeted nanoparticles for drug delivery through the blood–brain barrier for Alzheimer's disease

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Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

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Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment

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Environmental-induced oxidative stress in neurodegenerative disorders and aging

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Evidence that the β-Amyloid Plaques of Alzheimer's Disease Represent the Redox-silencing and Entombment of Aβ by Zinc

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Copper Binding in the Prion Protein

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Roles of the metallothionein family of proteins in the central nervous system

Hidalgo, J., Aschner, M., Zatta, P. F., & Vašák, M. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00452-x · Cited by 389

Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies

Foster, E. M., Dangla-Valls, A., Lovestone, S., Ribe, E. M., & Buckley, N. J. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00164 · Cited by 381

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

Adlard, P. A., Parncutt, J. M., Finkelstein, D. I., & Bush, A. I. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5255-09.2010 · Cited by 376

Redox-active iron mediates amyloid-β toxicity

Rottkamp, C. A., Raina, A. K., Zhu, X., Gaier, E., Bush, A. I., Atwood, C., Chevion, M., Perry, G. L., & Smith, M. A. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00494-9 · Cited by 379

Copper Mediates Dityrosine Cross-Linking of Alzheimer's Amyloid-β

Atwood, C., Perry, G. L., Zeng, H., Kato, Y., Jones, W. D., Ling, K.-Q., Huang, X., Moir, R. D., Wang, D., Sayre, L. M., et al. (2003) · Biochemistry · doi:10.1021/bi0358824 · Cited by 371

Alzheimer's disease, metal ions and metal homeostatic therapy

Zatta, P., Drago, D., Bolognin, S., & Sensi, S. L. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.05.002 · Cited by 369

The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer’s disease

Miranda, S., Opazo, C., Larrondo, L. F., Muñoz, F. J., Ruiz, F., Leighton, F., & Inestrosa, N. C. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00015-0 · Cited by 369

Synaptically released zinc: Physiological functions and pathological effects

Frederickson, C. J., & Bush, A. I. (2001) · BioMetals · doi:10.1023/a:1012934207456 · Cited by 360

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361

Role of Metal Ions in the Self-assembly of the Alzheimer’s Amyloid-β Peptide

Faller, P., Hureau, C., & Berthoumieu, O. (2013) · Inorganic Chemistry · doi:10.1021/ic4003059 · Cited by 360

Metallostasis in Alzheimer's disease

Ayton, S., Lei, P., & Bush, A. I. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.558 · Cited by 359

Metal Ions in Alzheimer’s Disease: A Key Role or Not?

Liu, Y., Nguyen, M., Robert, A., & Meunier, B. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00248 · Cited by 353

Metals and amyloid‐β in Alzheimer's disease

Maynard, C. J., Bush, A. I., Masters, C. L., Cappai, R., & Li, Q. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00434.x · Cited by 356

Zinc and Alzheimer's Disease: An Update

Cuajungco, M. P., Lees, G. J., Kydd, R. R., Tanzi, R. E., & Bush, A. I. (1999) · Nutritional Neuroscience · doi:10.1080/1028415x.1999.11747277 · Cited by 6

Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of Alzheimer’s Disease Correlates with Metal Levels in the Surrounding Neuropil

James, S., Churches, Q. I., de Jonge, M. D., Birchall, I. E., Streltsov, V. A., McColl, G., Adlard, P. A., & Hare, D. J. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00362 · Cited by 136

Elevated cortical zinc in Alzheimer disease

Religa, D., Strozyk, D., Cherny, R. A., Volitakis, I., Haroutunian, V., Winblad, B. G., Näslund, J., & Bush, A. I. (2006) · Neurology · doi:10.1212/01.wnl.0000223644.08653.b5 · Cited by 273

Association of trace elements Aluminum, Copper and Zinc in blood of Alzheimer's disease

Anwar, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz70860_107018

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress.

Deibel, M. A., Ehmann, W. D., & Markesbery, W. R. (1996) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)00203-1 · Cited by 540