Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress.
Abstract
Copper (Cu), iron (Fe), and zinc (Zn) levels in five different brain regions (amygdala, hippocampus, inferior parietal lobule, superior and middle temporal gyri, and cerebellum) were determined by instrumental neutron activation analysis (INAA) in samples from Alzheimer's disease (AD) patients and age-matched control subjects. A significant decrease in Cu, and significant increases in Zn and Fe were found in AD hippocampus and amygdala, areas showing severe histopathologic alterations in AD. None of these elements were significantly imbalanced in the cerebellum which is minimally affected in AD.
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Perineuronal net loss in AD may contribute to increased susceptibility to oxidative stress.
“and increased susceptibility to oxidative stress (Deibel et al., 1996; Varadarajan et al., 2000; Manczak et al., 2006; De Felice et al., 2007).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Deibel et al., 1996
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- Authors
- Deibel, M. A., Ehmann, W. D., & Markesbery, W. R.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Markesbery, W.R
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 143
- Issue
- 1-2
- Pages
- 137-142
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1970452111
- Cited by
- 540
- References
- 54
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 22 · 2020: 24 · 2019: 20 · 2018: 26 · 2017: 24 · 2016: 14 · 2015: 21 · 2014: 31 · 2013: 25 · 2012: 31
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, copper, iron, zinc, trace element imbalance, oxidative stress, hippocampus, amygdala, cerebellum, temporal lobe
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amygdala, Cerebellum, Copper, Data Interpretation, Statistical, Female, Hippocampus, Humans, Iron, Male, Nerve Degeneration, Parietal Lobe, Temporal Lobe, Zinc, Oxidative Stress, Metals, Heavy
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