Cited by 540Trace Elements in HealthAlzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer’s disease: possible relation to oxidative stress.

Deibel, M.A, Ehmann, W.D, Markesbery, W.R·1996·Journal of the Neurological Sciences

Abstract

Copper (Cu), iron (Fe), and zinc (Zn) levels in five different brain regions (amygdala, hippocampus, inferior parietal lobule, superior and middle temporal gyri, and cerebellum) were determined by instrumental neutron activation analysis (INAA) in samples from Alzheimer's disease (AD) patients and age-matched control subjects. A significant decrease in Cu, and significant increases in Zn and Fe were found in AD hippocampus and amygdala, areas showing severe histopathologic alterations in AD. None of these elements were significantly imbalanced in the cerebellum which is minimally affected in AD.

Integrity signals

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Crossref · 10.1016/s0022-510x(96)00203-1

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54 of 54 references verified0 citation errors · 0 not checkable

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Authors
Deibel, M. A., Ehmann, W. D., & Markesbery, W. R.
Affiliations
University of Kentucky (US)
Corresponding author
Markesbery, W.R
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
1996-11
Volume
143
Issue
1-2
Pages
137-142
ISSN
0022-510X (ISSN-L)
OpenAlex
W1970452111
Cited by
540
References
54
Citations by year
2026: 4 · 2025: 7 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 22 · 2020: 24 · 2019: 20 · 2018: 26 · 2017: 24 · 2016: 14 · 2015: 21 · 2014: 31 · 2013: 25 · 2012: 31
FWCI
10.13
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, copper, iron, zinc, trace element imbalance, oxidative stress, hippocampus, amygdala, cerebellum, temporal lobe
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Amygdala, Cerebellum, Copper, Data Interpretation, Statistical, Female, Hippocampus, Humans, Iron, Male, Nerve Degeneration, Parietal Lobe, Temporal Lobe, Zinc, Oxidative Stress, Metals, Heavy

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