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Cited by 390Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and CancerAdipose Tissue and Metabolism

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in nondiabetic subjects

Phillips, D.I.W., Caddy, S., Ilic, V., Fielding, B.A., Frayn, K.N., Borthwick, A.C., Taylor, R.·1996·Metabolism
DOI 10.1016/s0026-0495(96)90260-7
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Abstract

Intracellular triglyceride (TG) is an important energy source for skeletal muscle. However, recent evidence suggests that if muscle contains abnormally high TG stores its sensitivity to insulin may be reduced, and this could predispose to type II diabetes. To test this hypothesis, we measured muscle lipid content in 27 women aged 47 to 55 years (mean, 52) and related it to their glucose tolerance, insulin resistance, and muscle insulin sensitivity as measured by insulin activation of glycogen synthase, an insulin-regulated enzyme that is rate-limiting for insulin action in muscle. Both muscle TG content and intracellular lipid determined by Oil red O staining of muscle fibers were negatively associated with glycogen synthase activation (r = .43, P = .03 and r = -.47, P = .02, respectively). In addition, intracellular lipid correlated with features of the insulin resistance syndrome, including an increased waist to hip ratio (r = .47, P = .01) and fasting nonesterified fatty acids ([NEFA] r = .44, P = .04). These data demonstrate that increased muscle TG stores are associated with decreased insulin-stimulated glycogen synthase activity. Intracellular fat may underlie a major part of the insulin resistance in normal subjects, as well as type II diabetics.

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Crossref · 10.1016/s0026-0495(96)90260-7

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Research works printed but not linked: 1

  1. Lillie, 1943, Supersaturated solutions of fat stains in dilute isopropanyl for demonstration of acute fatty degenerations not shown by Herxheimer technique, Arch Pathol, 36, 432

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Metadata

Authors
Phillips, D. I. W., Caddy, S., Ilic, V., Fielding, B. A., Frayn, K. N., Borthwick, A. C., & Taylor, R.
Affiliations
Southampton General Hospital (GB)
Corresponding author
Phillips, D.I.W.
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
1996-08
Volume
45
Issue
8
Pages
947-950
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/s0026-0495(96)90260-7
OpenAlex
W2075703747
Cited by
390
References
24
Citations by year
2026: 1 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 13
FWCI
6.05
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
intramuscular triglycerides, skeletal muscle insulin sensitivity, insulin resistance, glycogen synthase activation, intracellular lipids, type 2 diabetes, free fatty acids, waist-to-hip ratio, glucose tolerance
MeSH terms
Body Constitution, Female, Humans, Insulin Resistance, Middle Aged, Muscles, Reference Values, Triglycerides, Lipid Metabolism

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