Cited by 464DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentDNA and Nucleic Acid Chemistry

The DOI matches its Crossref record; 169 of the 179 references it cites were found in a registry or an index.

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

Wang, David, Kreutzer, Deborah A., Essigmann, John M.·1998·Mutation research. Fundamental and molecular mechanisms of mutagenesis

DOI 10.1016/s0027-5107(98)00066-9

Open this paper in CoChat — free account

Abstract

Vinyl chloride monomer (VCM) is a human carcinogen. However, the exact mechanism of carcinogenesis remains unclear. VCM may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferases (GSTs). Thus workers with inherited variant metabolic enzyme activities may have an altered risk of genotoxicity. This study was designed to investigate which risk factors might affect sister chromatid exchange (SCE) frequency in polyvinyl chloride (PVC) workers. Study subjects were 44 male workers from three PVC factories. Questionnaires were administered to obtain detailed histories of cigarette smoking, alcohol consumption, occupations, and medications. SCE frequency in peripheral lymphocytes was determined using a standardized method, and CYP2E1, GSTM1, GSTT1 and ALDH2 genotypes were identified by the polymerase chain reaction (PCR). Analysis revealed that smoking status and exposure to VCM were significantly associated with increased SCE frequency. The presence of ALDH2 1-2/2-2 genotypes was also significantly associated with an elevation of SCE frequency (9. 5 vs. 8.1, p<0.01). However, CYP2E1, GSTM1 or GSTT1 genotypes were not significantly associated with SCE frequency. When various genotypes were considered together, combination of CYP2E1 c1c2/c2c2 with ALDH2 1-2/2-2 showed an additive effect on SCE frequency. Similar results were also found for the combination of smoking with CYP2E1, or smoking with ALDH2. These results suggest that VCM workers with ALDH2 1-2/2-2 genotypes, who also smoke, may have increased risk of DNA damage.

Integrity signals

Registry

Crossref · 10.1016/s0027-5107(98)00066-9

Cites

169 of 169 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Defective Transcription-Coupled Repair of Oxidative Base Damage in Cockayne Syndrome Patients from XP Group G
Cooper, P. K., Nouspikel, T. P., Clarkson, S. G., & Leadon, S. A. (1997) · Science · doi:10.1126/science.275.5302.990 · Cited by 306
Retracted
Free radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
DNA Repair and Mutagenesis
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Free Radicals in Biology and Medicine
Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871
DNA repair and mutagenesis
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
The Chemical Basis of Radiation Biology
O'Neill, P. (1987) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008714552571 · Cited by 1,849
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.
Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., & Loeb, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48474-8 · Cited by 1,844
The chemical basis of radiation biology
von Sonntag, C. (1987) · Medical Entomology and Zoology · Cited by 1,748

Show all 179 references

Sorted by citations

Items 101–200 of 463

Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses
Henkler, F., Stolpmann, K., & Luch, A. (2012) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-7643-8340-4_5 · Cited by 119
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis
HARRIS, K., Brabant, W. H., Styrchak, S. M., GALL, A., & Daifuku, R. (2005) · Antiviral Research · doi:10.1016/j.antiviral.2005.03.004 · Cited by 109
A Biological Network in Saccharomyces cerevisiae Prevents the Deleterious Effects of Endogenous Oxidative DNA Damage
Huang, M., & Kolodner, R. D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.008 · Cited by 111
Oxidative DNA Damage: Endogenous and Chemically Induced
Williams, G. M., & Jeffrey, A. M. (2000) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.2000.1433 · Cited by 110
Eat to live, not live to eat
Weisburger, J. H. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00400-7 · Cited by 109
Oxidative stress in carcinogenesis
Klaunig, J. E., & Wang, Z. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.11.014 · Cited by 108
C → T mutagenesis and γ‐radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases
An, Q., Robins, P., Lindahl, T. L., & Barnes, D. E. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600689 · Cited by 111
A Novel Role for Escherichia coli Endonuclease VIII in Prevention of Spontaneous G→T Transversions
Blaisdell, J. O., Hatahet, Z., & Wallace, S. S. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.20.6396-6402.1999 · Cited by 106
Cause or casualty: The role of mitochondrial DNA in aging and age-associated disease
Chocrón, E. S., Munkácsy, E., & Pickering, A. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.035 · Cited by 117
Effect of DNA damage on PCR amplification efficiency with the relative threshold cycle method
Sikorsky, J. A., Primerano, D. A., Fenger, T. W., & Denvir, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.08.168 · Cited by 111
DNA Repair in Mammalian Cells
Kunz, C., Saito, Y., & Schär, P. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-8739-9 · Cited by 104
Mismatch Repair of DNA Replication Errors Contributes to Microevolution in the Pathogenic Fungus Cryptococcus neoformans
Boyce, K. J., Wang, Y., Verma, S., Shakya, V. P. S., Xue, C., & Idnurm, A. (2017) · mBio · doi:10.1128/mbio.00595-17 · Cited by 101
Urinary excretion of dna repair products correlates with metabolic rates as well as with maximum life spans of different mammalian species
Foksiński, M., Różalski, R., Guz, J., Ruszkowska-Ciastek, B., Sztukowska, P., Piwowarski, M., Klungland, A., & Oliński, R. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.014 · Cited by 101
Synthesis and Characterization of Oligodeoxynucleotides Containing Formamidopyrimidine Lesions and Nonhydrolyzable Analogues
Haraguchi, K., Delaney, M. O., Wiederholt, C. J., Sambandam, A., Hantosi, Z., & Greenberg, M. M. (2002) · Journal of the American Chemical Society · doi:10.1021/ja012135q · Cited by 104
In vitro DNA synthesis opposite oxazolone and repair of this DNA damage using modified oligonucleotides
Duarte, V. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.7.1555 · Cited by 102
Reductive Electron Transfer in Phenothiazine‐Modified DNA Is Dependent on the Base Sequence
Wagner, C., & Wagenknecht, H. (2005) · Chemistry - A European Journal · doi:10.1002/chem.200401013 · Cited by 103
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions
Sabourin, M., & Osheroff, N. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.9.1947 · Cited by 100
Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics
Dizdaroğlu, M., Coşkun, E., & Jaruga, P. (2017) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2017.02.001 · Cited by 99
Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway
Daviet, S., Couvé, S., Gros, L., Shinozuka, K., Ide, H., Saparbaev, M. K., & Ishchenko, A. A. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.08.001 · Cited by 93
The Cockayne Syndrome Group B Gene Product Is Involved in Cellular Repair of 8-Hydroxyadenine in DNA
Tuo, J., Jaruga, P., Rodriguez, H., Dizdaroğlu, M., & Bohr, V. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204814200 · Cited by 98
Mutation versus Repair: NEIL1 Removal of Hydantoin Lesions in Single-Stranded, Bulge, Bubble, and Duplex DNA Contexts
Zhao, X., Krishnamurthy, N., Burrows, C. J., & David, S. S. (2010) · Biochemistry · doi:10.1021/bi901852q · Cited by 94
Supplementation with antioxidant vitamins prevents oxidative modification of DNA in lymphocytes of HIV-infected patients
Jaruga, P., Jaruga, B., Gackowski, D., Olczak, A., Halota, W., Pawłowska, M., & Oliński, R. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00821-8 · Cited by 94
Aging: A mitochondrial DNA perspective, critical analysis and an update
Shokolenko, I. N. (2014) · World Journal of Experimental Medicine · doi:10.5493/wjem.v4.i4.46 · Cited by 101
Fapy·dG Instructs Klenow Exo- to Misincorporate Deoxyadenosine
Wiederholt, C. J., & Greenberg, M. M. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026522r · Cited by 93
DNA damage reduces Taq DNA polymerase fidelity and PCR amplification efficiency
Sikorsky, J. A., Primerano, D. A., Fenger, T. W., & Denvir, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.169 · Cited by 92
DNA Adducts, Mutations, and Cancer 2000
Hemminki, K., Koskinen, M., Rajaniemi, H., & Zhao, C. (2000) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.2000.1431 · Cited by 91
Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias
Thorslund, T., Sunesen, M., Bohr, V. A., & Stevnsner, T. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00003-4 · Cited by 88
Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer
Ericson, N. G., Kulawiec, M., Vermulst, M., Sheahan, K. D., O'Sullivan, J. N., Salk, J. J., & Bielas, J. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002689 · Cited by 87
8‐Oxoguanine in a quadruplex of the human telomere DNA sequence
Vorlíčková, M., Tomaško, M., Sagi, A. J., Bednářová, K., & Sági, J. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08396.x · Cited by 86
The effect of hOGG1 and glutathione peroxidase I genotypes and 3p chromosomal loss on 8-hydroxydeoxyguanosine levels in lung cancer
Hardie, L. J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.2.167 · Cited by 87
Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis
Þorsteinsdóttir, S., Guðjόnsson, Þ., Nielsen, O. H., Vainer, B., & Seidelin, J. B. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.96 · Cited by 83
Short-Sequence Tandem and Nontandem DNA Repeats and Endogenous Hydrogen Peroxide Production Contribute to Genetic Instability ofStreptococcus pneumoniae
Pericone, C. D., Bae, D., Shchepetov, M., McCool, T. L., & Weiser, J. N. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.16.4392-4399.2002 · Cited by 82
Activity of OGG1 variants in the repair of pro-oxidant-induced 8-oxo-2′-deoxyguanosine
Smart, D. J., Chipman, J. K., & Hodges, N. J. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.06.001 · Cited by 81
The mitochondrial genome in aging and senescence
Lauri, A., Pompilio, G., & Capogrossi, M. C. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.001 · Cited by 80
Accumulation of abasic sites induces genomic instability in normal human gastric epithelial cells during Helicobacter pylori infection
Kidane, D., Murphy, D. L., & Sweasy, J. B. (2014) · Oncogenesis · doi:10.1038/oncsis.2014.42 · Cited by 79
Oxidative Damage to DNA and Aging
Remmen, H. V., Hamilton, M. L., & Richardson, A. G. (2003) · Exercise and Sport Sciences Reviews · doi:10.1097/00003677-200307000-00009 · Cited by 76
p53 Mutation in Nonmelanoma Skin Cancers Occurring in Psoralen Ultraviolet A-Treated Patients: Evidence for Heterogeneity and Field Cancerization
Stern, R. S., Bolshakov, S. V., Nataraj, A. J., & Ananthaswamy, H. N. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01814.x · Cited by 77
The level of typical biomarker of oxidative stress 8-hydroxy-2′-deoxyguanosine is higher in uterine myomas than in control tissues and correlates with the size of the tumor
Foksiński, M., Kotzbach, R., Szymański, W., & Oliński, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00358-0 · Cited by 76
Quantification of oxidative single-base and intrastrand cross-link lesions in unmethylated and CpG-methylated DNA induced by Fenton-type reagents
Cao, H., & Wang, Y. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm497 · Cited by 76
Atm deficiency causes an increased frequency of intrachromosomal homologous recombination in mice.
Bishop, A. J. R., Barlow, C., Wynshaw-Boris, A. J., & Schiestl, R. H. (2000) · PubMed · Cited by 75
Structure and potential mutagenicity of new hydantoin products from guanosine and 8-oxo-7,8-dihydroguanine oxidation by transition metals.
Burrows, C. J., Muller, J. G., Kornyushyna, O., Luo, W., Duarte, V., Leipold, M. D., & David, S. S. (2002) · Environmental Health Perspectives · doi:10.1289/ehp.02110s5713 · Cited by 78
Gastrointestinal Microbiota and Colon Cancer
Hold, G. L. (2016) · Digestive Diseases · doi:10.1159/000443358 · Cited by 75
Induction of microsatellite mutations by oxidative agents in human lung cancer cell lines
Zienolddiny, S., Ryberg, D., & Haugen, A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.521 · Cited by 74
Dysplastic Lesions in Inflammatory Bowel Disease: Molecular Pathogenesis to Morphology
Matkowskyj, K. A., Chen, Z. E., Rao, M. S., & Yang, G. (2013) · Archives of Pathology & Laboratory Medicine · doi:10.5858/arpa.2012-0086-ra · Cited by 74
Oncogene homologue Sch9 promotes age-dependent mutations by a superoxide and Rev1/Polζ-dependent mechanism
Madia, F., Wei, M., Yuan, V., Hu, J. H., Gattazzo, C., Pham, P., Goodman, M. F., & Longo, V. D. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200906011 · Cited by 72
Oxidatively Induced DNA−Protein Cross-Linking between Single-Stranded Binding Protein and Oligodeoxynucleotides Containing 8-Oxo-7,8-dihydro-2‘-deoxyguanosine
Johansen, M. E., Muller, J. G., Xu, X., & Burrows, C. J. (2005) · Biochemistry · doi:10.1021/bi047580n · Cited by 76
Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels
Kong, B., Qia, C., Erkan, M., Kleeff, J. H., & Michalski, C. W. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00246 · Cited by 73
Effects of functional modules and bacterial clusters response on transmission performance of antibiotic resistance genes under antibiotic stress during anaerobic digestion of livestock wastewater
Tang, T., Chen, Y., Du, Y., Yao, B., & Liu, M. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129870 · Cited by 71
Repair and Mutagenic Potential of Oxaluric Acid, a Major Product of Singlet Oxygen-Mediated Oxidation of 8-Oxo-7,8-dihydroguanine
Duarte, V., Gasparutto, D., Jaquinod, M., Ravanat, J., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx0001629 · Cited by 73
Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides
Traube, F. R., Schiffers, S., Iwan, K., Kellner, S. M., Spada, F., Müller, M., & Carell, T. (2018) · Nature Protocols · doi:10.1038/s41596-018-0094-6 · Cited by 73
Role of Endogenous Oxidative DNA Damage in Carcinogenesis: What Can We Learn from Repair-Deficient Mice?
Epe, B. (2002) · Biological Chemistry · doi:10.1515/bc.2002.049 · Cited by 73
Mismatch repair, G 2 /M cell cycle arrest and lethality after DNA damage
Aquilina, G., Crescenzi, M., & Bignami, M. (1999) · Carcinogenesis · doi:10.1093/carcin/20.12.2317 · Cited by 69
Preparation of 1‐Ethynylpyrene‐Modified DNA via Sonogashira‐Type Solid‐Phase Couplings and Characterization of the Fluorescence Properties for Electron‐Transfer Studies
Rist, M. J., Amann, N., & Wagenknecht, H. (2003) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200300125 · Cited by 69
Mapping oxidative changes in breast cancer: understanding the basic to reach the clinics.
Mencalha, A. L., Victorino, V. J., Cecchini, R., & Panis, C. (2014) · PubMed · Cited by 68
Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression
Lee, H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i14.3950 · Cited by 70
A 32P-Postlabeling Assay for the Oxidative DNA Lesion 8,5′-Cyclo-2′-deoxyadenosine in Mammalian Tissues
Randerath, K., Zhou, G.-D., Somers, R. L., Robbins, J. H., & Brooks, P. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105472200 · Cited by 67
Toxic and genotoxic effects of Roundup on tadpoles of the Indian skittering frog (Euflictis cyanophlyctis) in the presence and absence of predator stress
Yadav, S. S., Giri, S., Singha, U., Boro, F., & Giri, A. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.01.016 · Cited by 65
Ultrafast Proton‐Coupled Electron‐Transfer Dynamics in Pyrene‐Modified Pyrimidine Nucleosides: Model Studies towards an Understanding of Reductive Electron Transport in DNA
Raytchev, M., Mayer, E., Amann, N., Wagenknecht, H., & Fiebig, T. (2004) · ChemPhysChem · doi:10.1002/cphc.200301205 · Cited by 65
Zinc inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in human hepatocytes (HepG2 cells)
Yang, X., Lv, Y., Huang, K., Luo, Y., & Xu, W. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.03.012 · Cited by 69
DNA repair in reduced genome: The Mycoplasma model
Carvalho, F. M., da Fonsêca, M. M., de Medeiros, S. R. B., Scortecci, K. C., Blaha, C. A. G., & Agnez‐Lima, L. F. (2005) · Gene · doi:10.1016/j.gene.2005.06.012 · Cited by 64
Major Oxidative and Antioxidant Mechanisms During Heat Stress-Induced Oxidative Stress in Chickens
Aryal, B., Kwakye, J., Ariyo, O. W., Ghareeb, A. F. A., Milfort, M. C., Fuller, A. L., Khatiwada, S., Rekaya, R., & Aggrey, S. E. (2025) · Antioxidants · doi:10.3390/antiox14040471 · Cited by 85
HSF1 Down-regulates XAF1 through Transcriptional Regulation
Wang, J., He, H., Yu, L., Xia, H. H., Lin, M. C. M., Gu, Q., Li, M., Zou, B., An, X., Jiang, B., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505890200 · Cited by 63
Induction and Excretion of Ultraviolet-Induced 8-Oxo-2′-deoxyguanosine and Thymine Dimers In Vivo: Implications for PUVA
Cooke, M. S., Evans, M. D., Patel, K., Barnard, A., Lunec, J., Burd, R. M., & Hutchinson, P. E. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2001.01251.x · Cited by 62
Mitochondrial DNA exhibits resistance to induced point and deletion mutations
Valente, W. J., Ericson, N. G., Long, A. S., White, P. A., Marchetti, F., & Bielas, J. H. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw716 · Cited by 63
2′-Deoxycytidine Glycols, a Missing Link in the Free Radical-mediated Oxidation of DNA
Tremblay, S., Douki, T., Cadet, J., & Wagner, J. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.30.20833 · Cited by 60
Selective advantages favour high genomic AT-contents in intracellular elements
Dietel, A., Merker, H., Kaltenpoth, M., & Kost, C. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007778 · Cited by 62
Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?
Zsurka, G., Peeva, V., Kotlyar, A. B., & Kunz, W. S. (2018) · Genes · doi:10.3390/genes9040175 · Cited by 60
Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study
Dianzani, I., Gibello, L., Biava, A., Giordano, M., Bertolotti, M., Betti, M., Ferrante, D., Guarrera, S., Betta, G. P., Mirabelli, D., et al. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.02.005 · Cited by 59
Conservation consequences of Chernobyl and other nuclear accidents
Møller, A. P., & Mousseau, T. A. (2011) · Biological Conservation · doi:10.1016/j.biocon.2011.08.009 · Cited by 56
Profiling Cytosine Oxidation in DNA by LC-MS/MS
Samson-Thibault, F., Madugundu, G. S., Gao, S., Cadet, J., & Wagner, J. R. (2012) · Chemical Research in Toxicology · doi:10.1021/tx300195f · Cited by 53
Embryonic development and skeletogenic gene expression affected by X-rays in the Mediterranean sea urchin Paracentrotus lividus
Matranga, V., Zito, F., Costa, C., Bonaventura, R., Giarrusso, S., & Celi, F. (2009) · Ecotoxicology · doi:10.1007/s10646-009-0444-9 · Cited by 52
In vivo treatment with aflatoxin B1 increases DNA oxidation, base excision repair activity and 8-oxoguanine DNA glycosylase 1 levels in mouse lung
Guindon, K. A., Mulder, J. E., & Massey, T. E. (2014) · Toxicology · doi:10.1016/j.tox.2014.03.004 · Cited by 51
Radioprotectors – the Evergreen Topic
Kuntić, V. S., Stanković, M., Vujić, Z. B., Brborić, J. S., & Uskoković‐Marković, S. (2013) · Chemistry & Biodiversity · doi:10.1002/cbdv.201300054 · Cited by 51
Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever
Kırkalı, G., Tunca, M., Genç, Ş., Jaruga, P., & Dizdaroğlu, M. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.09.020 · Cited by 51
The Pattern of p53 Mutations Caused by PAH o-Quinones is Driven by 8-oxo-dGuo Formation while the Spectrum of Mutations is Determined by Biological Selection for Dominance
Park, J., Gelhaus, S. L., Vedantam, S., Oliva, A. L., Batra, A., Blair, I. A., Troxel, A. B., Field, J. M., & Penning, T. M. (2008) · Chemical Research in Toxicology · doi:10.1021/tx700404a · Cited by 51
Review of the evidence for thresholds for DNA-Reactive and epigenetic experimental chemical carcinogens
Kobets, T., & Williams, G. M. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.11.011 · Cited by 52
Alterations in gene expression profiles and the DNA‐damage response in ionizing radiation‐exposed TK6 cells
Akerman, G. S., Rosenzweig, B. A., Domon, O. E., Tsai, C., Bishop, M. E., McGarrity, L. J., MacGregor, J. T., Sistare, F. D., Chen, J. J., & Morris, S. M. (2005) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20091 · Cited by 52
Ultraviolet Exposure as the Main Initiator of p53 Mutations in Basal Cell Carcinomas from Psoralen and Ultraviolet A-Treated Patients with Psoriasis
Seidl, H., Kreimer-Erlacher, H., Bäck, B., Soyer, H. P., Kerl, H., Wolf, P., & Höfler, G. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01413.x · Cited by 53
Induction of Hepatic 8-Oxo-deoxyguanosine Adducts by 2,3,7,8-Tetrachlorodibenzo- p -dioxin in Sprague−Dawley Rats Is Female-Specific and Estrogen-Dependent
Wyde, M. E., Wong, V. A., Kim, A. H., Lucier, G. W., & Walker, N. J. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000266j · Cited by 50
Quantification of Multiple DNA Adducts Formed through Oxidative Stress Using Liquid Chromatography and Electrospray Tandem Mass Spectrometry
Churchwell, M. I., Beland, F. A., & Doerge, D. R. (2002) · Chemical Research in Toxicology · doi:10.1021/tx0101595 · Cited by 50
Chronic Oxidative Stress Leads to Malignant Transformation Along With Acquisition of Stem Cell Characteristics, and Epithelial to Mesenchymal Transition in Human Renal Epithelial Cells
Mahalingaiah, P. K. S., Ponnusamy, L., & Singh, K. P. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24922 · Cited by 49
Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico
Poovathingal, S. K., Gruber, J., Halliwell, B. B., & Gunawan, R. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000572 · Cited by 47
Direct repeats in mitochondrial DNA and mammalian lifespan
Khaidakov, M., Siegel, E. R., & Reis, R. J. S. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.07.008 · Cited by 49
Mutation and Abnormal Expression of the p53 Gene in the Viral Skin Carcinogenesis of Epidermodysplasia Verruciformis
Padlewska, K., Ramoz, N., Cassonnet, P., RIOU, G. F., Barrois, M., Majewski, S., Croissant, O., Jabłońska, S., & Orth, G. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01515.x · Cited by 48
Aging-associated accumulation of mitochondrial DNA mutations in tumor origin
Kong, M., Guo, L., Xu, W., He, C., Jia, X., Zhao, Z., & Gu, Z. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac014 · Cited by 51
Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis
Krüger, M., Pabst, A. M., Al‐Nawas, B., Horke, S., & Moergel, M. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-1941-2 · Cited by 48
Induction and elimination of bulky benzo[a]pyrene-related DNA adducts and 8-oxodGuo in mussels Mytilus galloprovincialis exposed in vivo to B[a]P-contaminated feed
Akcha, F., Burgeot, T., Budzinski, H., Pfohl‐Leszkowicz, A., & Narbonne, J. (2000) · Marine Ecology Progress Series · doi:10.3354/meps205195 · Cited by 48
Measurement of 8-hydroxy-2′-deoxyadenosine in DNA by liquid chromatography/mass spectrometry
Jaruga, P., Rodriguez, H., & Dizdaroğlu, M. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00594-9 · Cited by 48
Oxidation of Thymine to 5-Formyluracil in DNA Promotes Misincorporation of dGMP and Subsequent Elongation of a Mismatched Primer Terminus by DNA Polymerase
Masaoka, A., Terato, H., Kobayashi, M., Ohyama, Y., & Ide, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008598200 · Cited by 47
New Markers of Oxidative Damage to Macromolecules
Čolak, E. (2008) · Journal of Medical Biochemistry · doi:10.2478/v10011-007-0049-x · Cited by 47
The Escherichia coli SOS Gene dinF Protects against Oxidative Stress and Bile Salts
Rodríguez-Beltrán, J., Rodríguez-Rojas, A., Guelfo, J. R., Couce, A., & Blázquez, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034791 · Cited by 45
Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery
Zhang, C., Yang, J., & Jennings, L. K. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00162.2004 · Cited by 46
Inflammatory Bowel Disease: A Model of Chronic Inflammation-Induced Cancer
Yang, G., Taboada, S., & Liao, J. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-447-6_9 · Cited by 46
High Mutation Frequency at Ha-ras Exons 1-4 in Squamous Cell Carcinomas from PUVA-treated Psoriasis Patients¶
Kreimer-Erlacher, H., Seidl, H., Bäck, B., Kerl, H., & Wolf, P. (2001) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2001)0740323hmfahr2.0.co2 · Cited by 46
RNA polymerase pausing, stalling and bypass during transcription of damaged DNA: from molecular basis to functional consequences
Agapov, A., Olina, A., & Kulbachinskiy, A. V. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac174 · Cited by 45
The evolution of bacterial DNA base composition
Agashe, D., & Shankar, N. (2014) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.22565 · Cited by 43
On‐Line Electrochemistry/Electrospray Ionization Mass Spectrometry (EC/ESI‐MS) for the Generation and Identification of Nucleotide Oxidation Products
Baumann, A., Lohmann, W., Jahn, S., & Kärst, U. (2009) · Electroanalysis · doi:10.1002/elan.200900358 · Cited by 46
Frequent mutations of lysophosphatidic acid receptor-1 gene in rat liver tumors
Obo, Y., Yamada, T., Furukawa, M., Hotta, M., Honoki, K., Fukushima, N., & Tsujiuchi, T. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.10.005 · Cited by 45
DNA repair in Mycoplasma gallisepticum
Gorbachev, A. Y., Fisunov, G. Y., Izraelson, M., Evsyutina, D. V., Mazin, P., Alexeev, D. G., Pobeguts, O. V., Gorshkova, T. N., Kovalchuk, S. I., Kamashev, D., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-726 · Cited by 45
Aldo-Keto Reductases and Formation of Polycyclic Aromatic Hydrocarbon o-Quinones
Penning, T. M. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78003-9 · Cited by 46

Authors: Wang, D., Kreutzer, D. A., & Essigmann, J. M.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Essigmann, John M.
ORCID: Wang, David
Essigmann, John M.
Venue: Mutation research. Fundamental and molecular mechanisms of mutagenesis
Publisher: Elsevier BV
Published: 1998-05
Volume: 400
Issue: 1-2
Pages: 99-115
ISSN: 0027-5107 (ISSN-L)
1386-1964
DOI: 10.1016/s0027-5107(98)00066-9
OpenAlex: W2009187135
Cited by: 464
References: 179
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 19 · 2014: 21 · 2013: 21 · 2012: 22
FWCI: 6.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: oxidative DNA damage, mutagenicity, DNA repair, reactive oxygen species, mutational spectra, G:C to T:A transversions, G:C to A:T transitions, DNA adducts, mutational specificity, carcinogenesis, aging
MeSH terms: Animals, DNA Damage, DNA Mutational Analysis, DNA Repair, Humans, Oxidation-Reduction, Mutagenesis, Site-Directed, Reactive Oxygen Species, DNA Adducts

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks