The DOI matches its Crossref record; 169 of the 179 references it cites were found in a registry or an index.
Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions
Abstract
Vinyl chloride monomer (VCM) is a human carcinogen. However, the exact mechanism of carcinogenesis remains unclear. VCM may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferases (GSTs). Thus workers with inherited variant metabolic enzyme activities may have an altered risk of genotoxicity. This study was designed to investigate which risk factors might affect sister chromatid exchange (SCE) frequency in polyvinyl chloride (PVC) workers. Study subjects were 44 male workers from three PVC factories. Questionnaires were administered to obtain detailed histories of cigarette smoking, alcohol consumption, occupations, and medications. SCE frequency in peripheral lymphocytes was determined using a standardized method, and CYP2E1, GSTM1, GSTT1 and ALDH2 genotypes were identified by the polymerase chain reaction (PCR). Analysis revealed that smoking status and exposure to VCM were significantly associated with increased SCE frequency. The presence of ALDH2 1-2/2-2 genotypes was also significantly associated with an elevation of SCE frequency (9. 5 vs. 8.1, p<0.01). However, CYP2E1, GSTM1 or GSTT1 genotypes were not significantly associated with SCE frequency. When various genotypes were considered together, combination of CYP2E1 c1c2/c2c2 with ALDH2 1-2/2-2 showed an additive effect on SCE frequency. Similar results were also found for the combination of smoking with CYP2E1, or smoking with ALDH2. These results suggest that VCM workers with ALDH2 1-2/2-2 genotypes, who also smoke, may have increased risk of DNA damage.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The most common oxidative lesions in mtDNA are the G:C to T:A transversion mutations caused by adenine pairing with the guanine adduct 7,8-dihydro-8-oxo-deoxyguanosine (8-oxo-dG) (Wang et al., 1998).”
From Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases (2017) · cites this paper as Wang et al., 1998
Citations
Cites
1 retracted
Cooper, P. K., Nouspikel, T. P., Clarkson, S. G., & Leadon, S. A. (1997) · Science · doi:10.1126/science.275.5302.990 · Cited by 306
RetractedFree radicals in biology and medicine
Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178
Oxidants, antioxidants, and the degenerative diseases of aging.
Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Free Radicals in Biology and Medicine
Land, E. J. (1990) · International Journal of Radiation Biology · doi:10.1080/09553009014552071 · Cited by 4,871
Bootsma, D., & Hoeijmakers, J. H. J. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)81408-9 · Cited by 2,285
Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG
Shibutani, S., Takeshita, M., & Grollman, A. P. (1991) · Nature · doi:10.1038/349431a0 · Cited by 2,224
The Chemical Basis of Radiation Biology
O'Neill, P. (1987) · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · doi:10.1080/09553008714552571 · Cited by 1,849
8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions.
Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., & Loeb, L. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)48474-8 · Cited by 1,844
The chemical basis of radiation biology
von Sonntag, C. (1987) · Medical Entomology and Zoology · Cited by 1,748
Cited by
Sorted by citations
Items 401–463 of 463
Patlán, A. G., Ayala‐García, V. M., Vallin, C., Cortés, J., Vásquez-Morales, S. G., Robleto, E. A., Nudler, E., & Pedraza‐Reyes, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.866089 · Cited by 2
Diadema setosum Chemical Compounds with GC-MS Analysis as a Triple Inhibitor Antiviral Covid-19
Nugroho, E. D., Sururi, A. M., Rahayu, D. A., Ardiansyah, R., Kurniwawan, N., & Widodo, W. (2024) · Thalassas An International Journal of Marine Sciences · doi:10.1007/s41208-024-00732-z · Cited by 2
DNA Damage Responses in Atherosclerosis
Shimada, K., Crother, T. R., & Arditi, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-404732-7.00010-1 · Cited by 2
Emmanouil, C. (2011) · InTech eBooks · doi:10.5772/22171 · Cited by 2
Sonntag, D. M., de Boer, J., Medvedovic, M., Baxter, C. S., LeMasters, G. K., & Talaska, G. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.02.004 · Cited by 2
Okumura, K., Nishihara, S., & Inoue, Y. H. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.02.013 · Cited by 3
Wagenknecht, H. (2006) · Angewandte Chemie · doi:10.1002/ange.200602387 · Cited by 2
Enterococcus faecalis virulence mechanisms associated with colorectal cancer
Freitas, L. D., Ramos, K. B., Frazzon, A. P. G., & Wayhs, C. A. Y. (2023) · RevSALUS - Revista Científica da Rede Académica das Ciências da Saúde da Lusofonia · doi:10.51126/revsalus.v5i2.496 · Cited by 1
Mahrouk, A., Mosbah, A., Chaouche, N. K., Hamdi, M., Slimani, A., Badaoui, M. Y. Z., Amrani, Y., & Akkal, S. (2025) · Folia Microbiologica · doi:10.1007/s12223-025-01386-x · Cited by 1
Mitochondrial Mutagenesis in Aging and Disease
Vermulst, M., Khrapko, K., & Wanagat, J. (2012) · InTech eBooks · doi:10.5772/51099 · Cited by 1
Nagira, K., Tamura, S., Kawano, S., & Ikeda, S. (2013) · Genes and Environment · doi:10.3123/jemsge.2013.009 · Cited by 1
Cao, S. (2012) · J. Willard Marriott Library · doi:10.26053/0h-5njj-m100 · Cited by 1
Contribution of Nucleic Acids in the Pathogenesis of Alzheimer’s Disease
Farooqui, A. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809937-7.00004-5 · Cited by 1
Zhou, S., Wang, Z., & Klaunig, J. E. (2015) · International Journal of Cancer Studies & Research · doi:10.19070/2167-9118-1500011 · Cited by 1
NEW MARKERS OF OXIDATIVE DAMAGE TO MACROMOLECULES
Oksidativnog, N. M., Makromolekula, O. E., & olak, E. (2008) · Cited by 1
Oxidative Deformylation of the Predominant DNA Lesion 5-Formyl-2′-deoxyuridine
Robert, G., Sabourin, C., & Wagner, J. R. (2024) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.4c00410 · Cited by 1
Comparative Analysis of Context-Dependent Mutagenesis in Humans and Fruit Flies
Medvedeva, S., Panchin, A. Y., Alexeevski, A. V., Spirin, S., & Panchin, Y. V. (2013) · International Journal of Genomics · doi:10.1155/2013/173616 · Cited by 1
Genomic consequences of DNA oxidation by peroxynitrite
Neeley, W. L. (2006) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 1
DNA base modifications in aging
Gaubatz, J. W. (2001) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(01)04027-5 · Cited by 1
Radical Intermediates during Reductive Electron Transfer through DNA
Varghese, R., & Wagenknecht, H. (2009) · doi:10.1002/9780470526279.ch8 · Cited by 1
Cáncer pulmonar (1ª. de 2 partes)
Enríquez, S. S., Franco‐Topete, R. A., Flores-Alvarado, L. J., & Zepeda‐Moreno, A. (2004) · Cited by 1
A new mutator phenotype in breast cancer?
de Boer, J. G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082095799 · Cited by 1
Mechanisms of Action of Carcinogenic Chemicals Including Occupational Carcinogens
Kobets, T., & Williams, G. M. (2023) · Patty's Toxicology · doi:10.1002/0471125474.tox126 · Cited by 1
The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease
Israel, D. A., & Peek, R. M. (2009) · Springer eBooks · doi:10.1007/978-0-387-69182-4_16 · Cited by 1
2prime-Deoxyribonolactone lesion produces GA transitions in Escherichia coli
Constant, J., & Faure, V. (2004) · Nucleic Acids Research
Nucleic Acid Base Complexes: Elucidation of the Physical Origins of Their Stability
Czyżnikowska, Ż., Zaleśny, R., & Παπαδόπουλος, Μ. Γ. (2009) · Springer eBooks · doi:10.1007/978-90-481-2687-3_20
The role of Transforming Growth Factor (TGF) - Beta 1 Activated Kinase 1 (TAK1) in wound repair
Lam, I. C. R. (2013) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/53511
Ultrafast Charge Transfer Dynamics of a Modified Double Helical DNA
Manoj, P., Min, C., Aravindakumar, C. T., & Joo, T. (2007) · Springer series in chemical physics · doi:10.1007/978-3-540-68781-8_175
Chen, Q., Yu, Q., Song, Y., Li, P., Chang, Y., Wang, Z., Liu, L., Wu, W., & Lin, J. (2009) · Frontiers of Medicine · doi:10.1007/s11684-009-0032-7
Detection and Analysis of Genetic Alterations in Normal Skin and Skin Tumours
Sivertsson, Å. (2002) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
Goosens, V. J. (2009) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)
Bírošová, L., & Mikulášová, M. (2008) · Folia Microbiologica · doi:10.1007/s12223-008-0057-3
Relationship Between Psychological Stress & Oxidative Stress in victims of Motor Vehicle Accidents
Forlenza, M. J. (2002) · D-Scholarship@Pitt (University of Pittsburgh)
INVESTIGATION OF THE ROLE OF OXIDATIVE DNA DAMAGE IN AFLATOXIN B1-INDUCED PULMONARY CARCINOGENESIS
Guindon, K. A. (2008) · QSpace (Queen's University Library)
Effec t of DNA Base Modific ation on Polymerase Chain Reaction Effic iency and Fidelity
Sikorsky, J. A. (2005)
Mendes, B. (2012) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Isolation and Characterization of Biologically Active Compounds from Selected Medicinal Plants
Haq, I. U. (2012) · HEC National Digital Library
Oliński, R., Lunec, J., Gackowski, D., & Cooke, M. S. (2005) · Chemical and functional properties of food components series · doi:10.1201/9781420039269.ch7
Mesalazine and the prevention of colorectal cancer in inflammatory bowel disease
Bos, C. L., Richel, D. J., & Peppelenbosch, M. P. (2008) · Springer eBooks · doi:10.1007/978-1-4020-6826-3_19
Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models
Yang, C. S., Chen, X. L., & Yang, G. (2013) · CRC Press eBooks · doi:10.1201/b15323-5
Melo, T. Q. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2017.tde-01032017-131637
Nemera, D. B., Jones, A. R., & Merino, E. J. (2013) · Wiley eBooks · doi:10.1002/9781118355886.ch4
Nachtergael, A., Lanterbecq, D., Spanoghe, M., Belayew, A., & Duez, P. (2021) · Planta Medica · doi:10.1055/a-1527-1435
Silva, L. N. L., Muniz, C. C., Oliveira, E. S., & Ignácio, Á. R. A. (2021) · Ambiente e Agua - An Interdisciplinary Journal of Applied Science · doi:10.4136/ambi-agua.2730
XRCC1, un élément clef de la réparation des dommages de l'ADN couplée à la réplication
Lévy, N. (2007) · OpenGrey (Institut de l'Information Scientifique et Technique)
Carbon tetrachloride [MAK Value Documentation, 2002]
tetrachloride, O. A. O. C., haloalkanes, A. O. O., & absorption., D. O. T. V. U. L. O. T. S. I. A. A. A. I. C. O. T. A. A. I. W. 1. %. E. S. D. N. A. T. (2012) · The MAK-Collection for Occupational Health and Safety · doi:10.1002/3527600418.mb5623e0018
Damage and Repair of Ion-Implanted Dna
(2007) · Springer eBooks · doi:10.1007/0-387-25586-9_6
Ultrafast Charge Transfer Dynamics of a Modified Double Helical DNA
Manoj, P., Min, C., Joo, T., & Aravindakumar, C. T. (2006) · International Conference on Ultrafast Phenomena · doi:10.1364/up.2006.thd6
Piña, B., Barata, C., & Portugal, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.11344-3
Tetrachlormethan [MAK Value Documentation in German language, 2000]
Arbeitsstoffe, D. F. S. S. Z. P. G., & Greim, H. (2012) · The MAK-Collection for Occupational Health and Safety · doi:10.1002/3527600418.mb5623d0031
Crystal structure of the nucleoside 2′-deoxyguanosine dimethyl sulfoxide disolvate
Spingler, B. (2023) · Acta Crystallographica Section E Crystallographic Communications · doi:10.1107/s2056989023007405
Suco de laranja e vitamina C : efeito sobre a estabilidade genômica
Franke, S. I. R. (2006) · Americanae (AECID Library)
Sauty, S. M., Shine, J., Bostan, H., Li, J.-L., Mieczkowski, P. A., Loeser, R. F., Diekman, B. O., & Gordenin, D. A. (2026) · PLOS Genetics · doi:10.1371/journal.pgen.1012156
Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics
Nikolovska, M., Stojchevski, R., Eftimov, A., Mladenov, M. I., Avtanski, D. B., & Hadzi‐Petrushev, N. (2026) · Cell Biochemistry and Function · doi:10.1002/cbf.70301
Oxidation of DNA at guanine by chromium: Products and mechanisms
Slade, P. G. (2006) · The Mathematics Enthusiast
Metadata
- Authors
- Wang, D., Kreutzer, D. A., & Essigmann, J. M.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Essigmann, John M.
- Venue
- Mutation research. Fundamental and molecular mechanisms of mutagenesis
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 400
- Issue
- 1-2
- Pages
- 99-115
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W2009187135
- Cited by
- 464
- References
- 179
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 19 · 2014: 21 · 2013: 21 · 2012: 22
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- oxidative DNA damage, mutagenicity, DNA repair, reactive oxygen species, mutational spectra, G:C to T:A transversions, G:C to A:T transitions, DNA adducts, mutational specificity, carcinogenesis, aging
- MeSH terms
- Animals, DNA Damage, DNA Mutational Analysis, DNA Repair, Humans, Oxidation-Reduction, Mutagenesis, Site-Directed, Reactive Oxygen Species, DNA Adducts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review