Cited by 464DNA Repair MechanismsCarcinogens and Genotoxicity AssessmentDNA and Nucleic Acid Chemistry

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Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

Wang, David, Kreutzer, Deborah A., Essigmann, John M.·1998·Mutation research. Fundamental and molecular mechanisms of mutagenesis

DOI 10.1016/s0027-5107(98)00066-9

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Abstract

Vinyl chloride monomer (VCM) is a human carcinogen. However, the exact mechanism of carcinogenesis remains unclear. VCM may be metabolized by cytochrome P450 2E1 (CYP2E1), aldehyde dehydrogenase 2 (ALDH2) and glutathione S-transferases (GSTs). Thus workers with inherited variant metabolic enzyme activities may have an altered risk of genotoxicity. This study was designed to investigate which risk factors might affect sister chromatid exchange (SCE) frequency in polyvinyl chloride (PVC) workers. Study subjects were 44 male workers from three PVC factories. Questionnaires were administered to obtain detailed histories of cigarette smoking, alcohol consumption, occupations, and medications. SCE frequency in peripheral lymphocytes was determined using a standardized method, and CYP2E1, GSTM1, GSTT1 and ALDH2 genotypes were identified by the polymerase chain reaction (PCR). Analysis revealed that smoking status and exposure to VCM were significantly associated with increased SCE frequency. The presence of ALDH2 1-2/2-2 genotypes was also significantly associated with an elevation of SCE frequency (9. 5 vs. 8.1, p<0.01). However, CYP2E1, GSTM1 or GSTT1 genotypes were not significantly associated with SCE frequency. When various genotypes were considered together, combination of CYP2E1 c1c2/c2c2 with ALDH2 1-2/2-2 showed an additive effect on SCE frequency. Similar results were also found for the combination of smoking with CYP2E1, or smoking with ALDH2. These results suggest that VCM workers with ALDH2 1-2/2-2 genotypes, who also smoke, may have increased risk of DNA damage.

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Authors: Wang, D., Kreutzer, D. A., & Essigmann, J. M.
Affiliations: Massachusetts Institute of Technology (US)
Corresponding author: Essigmann, John M.
ORCID: Wang, David
Essigmann, John M.
Venue: Mutation research. Fundamental and molecular mechanisms of mutagenesis
Publisher: Elsevier BV
Published: 1998-05
Volume: 400
Issue: 1-2
Pages: 99-115
ISSN: 0027-5107 (ISSN-L)
1386-1964
DOI: 10.1016/s0027-5107(98)00066-9
OpenAlex: W2009187135
Cited by: 464
References: 179
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 15 · 2016: 14 · 2015: 19 · 2014: 21 · 2013: 21 · 2012: 22
FWCI: 6.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: oxidative DNA damage, mutagenicity, DNA repair, reactive oxygen species, mutational spectra, G:C to T:A transversions, G:C to A:T transitions, DNA adducts, mutational specificity, carcinogenesis, aging
MeSH terms: Animals, DNA Damage, DNA Mutational Analysis, DNA Repair, Humans, Oxidation-Reduction, Mutagenesis, Site-Directed, Reactive Oxygen Species, DNA Adducts

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Mutagenicity and repair of oxidative DNA damage: insights from studies using defined lesions

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