Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and d-amphetamine in rats

Boye, Sandra M; Grant, Rebecca J; Clarke, Paul B.S

doi:10.1016/s0028-3908(01)00003-x

Cited by 87Neurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors StudyNeuroscience and Neuropharmacology Research

Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and d-amphetamine in rats

Boye, Sandra M, Grant, Rebecca J, Clarke, Paul B.S·2001·Neuropharmacology

DOI 10.1016/s0028-3908(01)00003-x

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Abstract

The locomotor stimulant effects of nicotine and amphetamine appear to be dependent on dopamine transmission in the nucleus accumbens. The present aim was to elucidate the contributions of the accumbens core and medial shell to these effects. In the first experiment, rats received bilateral intra-accumbens infusion of the dopaminergic antagonist eticlopride (or saline) prior to saline or nicotine (0.2 mg/kg s.c.) challenge. Eticlopride inhibited basal and nicotine-induced locomotor activity more effectively when infused into the core (0.0625--0.5 microg/side) than into the medial shell (0.5--1 microg/side). In a second experiment, rats received 6-hydroxydopamine infused into the core or medial shell, and were subsequently tested with saline, nicotine (0.2 mg/kg s.c.) and D-amphetamine (0.75 mg/kg s.c.). Residual dopaminergic innervation was assessed by autoradiographic [(125)I]RTI-55 labelling of the dopamine transporter. [(125)I]RTI-55 labelling in the accumbens core was positively correlated with the locomotor stimulant effects of both nicotine and D-amphetamine. In contrast, [(125)I]RTI-55 labelling in the medial shell was associated negatively with amphetamine-induced activity. Recent evidence suggests that dopamine release in the medial shell may mediate the reinforcing effect of nicotine and D-amphetamine. In contrast, the present findings suggest that dopamine release in the core subregion contributes preferentially to the locomotor stimulant effects of nicotine and D-amphetamine.

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6-OHDA lesions of dopaminergic terminals in the core, but not the medial shell, disrupt locomotor activity induced by intravenous psychomotor stimulants.
“Interestingly, 6-OHDA lesions of dopaminergic terminals in the core, but not the medial shell, disrupt locomotor activity induced by intravenous psychomotor stimulants (Boye et al., 2001; Sellings and Clarke, 2003; Sellings et al., 2006a; 2006b).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Boye et al., 2001

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Authors: Boye, S. M., Grant, R. J., & Clarke, P. B. S.
Affiliations: McGill University (CA)
Corresponding author: Boye, Sandra M
ORCID: Clarke, Paul B.S
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2001-05
Volume: 40
Issue: 6
Pages: 792-805
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/s0028-3908(01)00003-x
OpenAlex: W2023509166
Cited by: 87
References: 67
Citations by year: 2024: 1 · 2023: 1 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 5 · 2012: 6
FWCI: 1.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: McGill University
Medical Research Council Canada
H. Lundbeck A/S
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: nucleus accumbens core, dopamine signaling, nicotine, d-amphetamine, locomotor stimulant effects, eticlopride, 6-hydroxydopamine, dopamine transporter, dopamine release
MeSH terms: Animals, Dextroamphetamine, Dopamine, Male, Motor Activity, Nicotine, Nucleus Accumbens, Oxidopamine, Rats, Sprague-Dawley, Adrenergic Agents, Nicotinic Agonists, Dopamine Uptake Inhibitors, Rats

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Disruption of dopaminergic neurotransmission in nucleus accumbens core inhibits the locomotor stimulant effects of nicotine and d-amphetamine in rats

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

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Record

About these checks