Cited by 146Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentMemory and Neural Mechanisms

Differential involvement of the shell and core subterritories of the nucleus accumbens in latent inhibition and amphetamine-induced activity

Weiner, I., Gal, G., Rawlins, J.N.P., Feldon, J.·1996·Behavioural Brain Research

Abstract

Latent inhibition (LI) consists of retardation in conditioning to a stimulus as a consequence of its prior non-reinforced pre-exposure. In view of findings that LI is disrupted in acute schizophrenic patients and evidence from animal experiments pointing to the involvement of the mesolimbic dopamine (DA) system in this phenomenon, the present study investigated the effects of electrolytic lesions to the shell and core subterritories of the nucleus accumbens on LI in rats (Expt. 1). LI was indexed by the amount of suppression of drinking in the presence of a tone that was either pre-exposed or not prior to its pairing with reinforcement (a foot shock). Expt.2 tested the effects of the DA antagonist, haloperidol, on LI in shell- and core-lesioned animals. Expt. 3 tested the effects of shell and core lesions on spontaneous and amphetamine-induced locomotion. In Expt. 1, LI, i.e., lower suppression of drinking in the pre-exposed as compared to the non-pre-exposed animals, was obtained in the sham-operated condition. Core and shell lesions produced distinct effects on LI. Animals with core lesions developed LI, but exhibited an overall lower suppression of drinking in comparison to the sham-operated animals. In contrast, shell lesions led to a disappearance of LI. Expt. 2 replicated the differential effects of shell and core lesions on LI, although in this experiment, core lesion did not attenuate suppression of drinking. Haloperidol prevented shell-induced abolition of LI. In Exp…

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Crossref · 10.1016/s0166-4328(96)00051-4

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Authors
Weiner, I., Gal, G., Rawlins, J. N. P., & Feldon, J.
Affiliations
  • Tel Aviv University (IL)
  • University of Oxford (GB)
Corresponding author
Weiner, I.
ORCID
Gal, G.
Venue
Behavioural Brain Research
Publisher
Elsevier BV
Published
1996-11
Volume
81
Issue
1-2
Pages
123-133
ISSN
0166-4328 (ISSN-L)
OpenAlex
W2056093189
Cited by
146
References
85
Citations by year
2026: 1 · 2024: 2 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 4
FWCI
2.88
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioural Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Tel Aviv University
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
latent inhibition, nucleus accumbens shell, nucleus accumbens core, mesolimbic dopamine system, dopamine antagonism, haloperidol, amphetamine-induced locomotion, schizophrenia, electrolytic lesions, pre-exposure
MeSH terms
Amphetamine, Animals, Conditioning, Operant, Drinking, Emotions, Haloperidol, Handling, Psychological, Male, Motor Activity, Nucleus Accumbens, Stimulation, Chemical, Rats, Wistar, Dopamine Antagonists, Dopamine Uptake Inhibitors, Rats

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