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Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome
Abstract
We investigated the phenomenon of long-term potentiation (LTP) in a genetic model of Down Syndrome, the segmental trisomy mouse (Ts65Dn). Ts65Dn mice survive to adulthood and have an extra chromosome that contains a segment of chromosome 16 homologous to human chromosome 21. In this study, field excitatory postsynaptic potentials (fEPSP) were recorded from the CA1 area of in vitro hippocampal slices from diploid and Ts65Dn mice, and LTP was induced by a single tetanizing pulse train (1 sec in duration) at 100 Hz. The hippocampus from both young (2 months) and older (9 months) Ts65Dn mice had a reduced LTP over a period of 60 min compared with LTP in age-matched controls. This finding may explain the reported behavioral and learning impairments in Ts65Dn mice; it suggests that this mouse model can be used to study the role of altered synaptic plasticity in mental retardation of Down Syndrome.
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“This suggestion is largely driven by findings from mouse models of DS, particularly the Ts65Dn model, in which patch clamp electrophysiology analyses reveal reduced long-term potentiation (LTP) and increased long-term depression (LTD), reflecting the relative strengthening and weakening, respectively, of individual synapses123–126.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [123]
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Metadata
- Authors
- Siarey, R. J., Stoll, J., Rapoport, S. I., & Galdzicki, Z.
- Affiliations
- National Institutes of Health (US)
- Texas Tech University (US)
- Corresponding author
- Siarey, R.J.
- Galdzicki, Z.
- ORCID
- Stoll, J.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 36
- Issue
- 11-12
- Pages
- 1549-1554
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2019373887
- Cited by
- 222
- References
- 37
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 20
- FWCI
- 6.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- long-term potentiation, Ts65Dn mouse model, Down syndrome, hippocampal CA1, field excitatory postsynaptic potentials, synaptic plasticity, age-related decline, learning disabilities, intellectual disability, chromosome 21
- MeSH terms
- Aging, Animals, Diploidy, Down Syndrome, Electric Stimulation, Electrophysiology, Female, Karyotyping, Male, Mice, Neurologic Mutants, Trisomy, Long-Term Potentiation, Mice, In Vitro Techniques
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