Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of down syndrome.
Abstract
Down syndrome (DS) is the most common genetically defined cause of intellectual disabilities. Both hippocampal function and volume seem to be disproportionally reduced in individuals with DS and in at least one aneuploid murine model of DS, the Ts65Dn mouse. Two previous studies by one research group have reported deficits in long-term potentiation (LTP) induced by in vitro high-frequency stimulation (HFS) of hippocampal CA1 synapses of adult Ts65Dn mice. Here, we report on the results of our own investigation on LTP in Ts65Dn mice. This study was designed to confirm the previous findings and possibly shed some light onto potential mechanisms underlying the reported deficit in this important form of long-term synaptic plasticity in a mouse model of DS. LTP was induced in area CA1 with either theta burst stimulation (TBS) or HFS. Contrary to the previous reports, our results showed no significant difference in HFS-induced LTP between Ts65Dn and euploid littermate mice. We have found, however, a significant reduction of the amount of TBS-induced LTP in Ts65Dn mice compared to euploid controls. Because this specific LTP deficit can be rescued by bath application of picrotoxin (10 microM), we hypothesize that an increase in GABA(A)-mediated inhibition or in plasticity of the inhibitory circuitry in Ts65Dn mice may underlie the observed deficits. However, future experiments to examine the state of hippocampus CA1 GABAergic inhibition in Ts65Dn mice will be necessary to further exp…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Ts65Dn hippocampus, long-term potentiation (LTP) induction fails due to excessive GABA-mediated inhibition.
“A seminal study in the field found failure of induction of long-term potentiation (LTP) in the Ts65Dn hippocampus due to excessive GABA-mediated inhibition and a wide array of following studies have confirmed this finding (Siarey et al., 1997, 1999; Kleschevnikov et al., 2004; Costa and Grybko, 2005; Fernandez et al., 2007).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Costa and Grybko, 2005
Cites
A mouse model for Down syndrome exhibits learning and behaviour deficits
Reeves, R. H., Irving, N. G., Moran, T. H., Wohn, A., Kitt, C., Sisodia, S. S., Schmidt, C., Bronson, R. T., & Davisson, M. T. (1995) · Nature Genetics · doi:10.1038/ng1095-177 · Cited by 913 · see citing works
Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1
Costa, R. M., Federov, N. B., Kogan, J. H., Murphy, G. G., Stern, J. N. H., Ohno, M., Kucherlapati, R., Jacks, T., & Silva, A. J. (2002) · Nature · doi:10.1038/nature711 · Cited by 586 · see citing works
The neuropsychology of down syndrome: evidence for hippocampal dysfunction.
Pennington, B. F., Moon, J., Edgin, J., Stedron, J., & Nadel, L. (2003) · Child Development · doi:10.1111/1467-8624.00522 · Cited by 514 · see citing works
Kleschevnikov, A. M., Belichenko, P. V., Villar, A. J., Epstein, C. J., Malenka, R. C., & Mobley, W. C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1766-04.2004 · Cited by 459 · see citing works
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome
Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13333 · Cited by 448 · see citing works
Strain-dependent Differences in LTP and Hippocampus-dependent Memory in Inbred MicePreprint
Nguyen, P., Abel, T. G., Kandel, E. R., & Bourtchouladze, R. (2000) · Learning & Memory · doi:10.1101/lm.7.3.170 · Cited by 237 · see citing works
A behavioral assessment of Ts65Dn mice: a putative Down syndrome model
Escorihuela, R. M., Fernández‐Teruel, A., Vallina, I. F., Baamonde, C., Lumbreras, M., Dierssen, M., Tobeña, A., & Flórez, J. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12052-6 · Cited by 234 · see citing works
Granholm, A., Sanders, L., & Crnic, L. S. (2000) · Experimental Neurology · doi:10.1006/exnr.1999.7289 · Cited by 229 · see citing works
Altered long-term potentiation in the young and old Ts65Dn mouse, a model for down syndrome
Siarey, R. J., Stoll, J., Rapoport, S. I., & Galdzicki, Z. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00157-3 · Cited by 222 · see citing works
MRI volumes of the hippocampus and amygdala in adults with Down’s syndrome with and without dementia
Aylward, E. H., Li, Q., Honeycutt, N. A., Warren, A. C., Pulsifer, M. B., Barta, P. E., Chan, M. D., Smith, P. D., Jerram, M., & Pearlson, G. D. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.4.564 · Cited by 217 · see citing works
Down syndrome and genetics — a case of linked histories
Patterson, D., & Costa, A. C. S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1525 · Cited by 208 · see citing works
Self-citationGardiner, K., Fortna, A., Bechtel, L. J., & Davisson, M. T. (2003) · Gene · doi:10.1016/s0378-1119(03)00769-8 · Cited by 203 · see citing works
Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study
Pinter, J. D., Brown, W. E., D, S. E. M., Schmitt, J. E., Capone, G. T., & Reiss, A. L. (2001) · Neurology · doi:10.1212/wnl.56.7.972 · Cited by 197 · see citing works
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
Siarey, R. J., Carlson, E. J., Epstein, C. J., Balbo, A., Rapoport, S. I., & Galdzicki, Z. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00083-0 · Cited by 184 · see citing works
Hippocampal volume and neuronal number in Ts65Dn mice: a murine model of down syndrome.
Insausti, A. M., Megı́as, M., Crespo, D., Cruz-Orive, L. M., Dierssen, M., Vallina, T. F., Insausti, R., & Flórez, J. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00641-7 · Cited by 149 · see citing works
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome
Richtsmeier, J. T., Zumwalt, A., Carlson, E. J., Epstein, C. J., & Reeves, R. H. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.10175 · Cited by 142 · see citing works
Behavioral comparison of 4 and 6 month-old Ts65Dn mice:
Hunter, C. L., Bimonte, H. A., & Granholm, A. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00275-9 · Cited by 112 · see citing works
Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome
Hampton, T. G., Stasko, M. R., Kale, A., Amende, I., & Costa, A. C. S. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.006 · Cited by 108 · see citing works
Self-citationImpaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice
Demas, G. E., Nelson, R. J., Krueger, B. K., & Yarowsky, P. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(97)00116-2 · Cited by 98 · see citing works
Stasko, M. R., & Costa, A. C. S. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.01.012 · Cited by 79 · see citing works
Self-citationHyde, L. A., & Crnic, L. S. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.6.1239 · Cited by 77 · see citing works
Matsuyama, S., Namgung, U., & Routtenberg, A. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00444-7 · Cited by 65 · see citing works
Vaillend, C., & Billard, J. (2002) · Hippocampus · doi:10.1002/hipo.10068 · Cited by 63 · see citing works
Perez, Y., Chapman, C. A., Woodhall, G. L., Robitaille, R., & Lacaille, J. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00531-4 · Cited by 42 · see citing works
Mechanisms of presynaptic inhibition studied using paired-pulse facilitation
Stuart, G. J., & Redman, S. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90548-8 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome
Fernandez, F., Morishita, W., Zuniga, E., Nguyen, J., Blank, M., Malenka, R. C., & Garner, C. C. (2007) · Nature Neuroscience · doi:10.1038/nn1860 · Cited by 509 · see citing works
Deidda, G., Parrini, M., Naskar, S., Bozarth, I. F., Contestabile, A., & Cancedda, L. (2015) · Nature Medicine · doi:10.1038/nm.3827 · Cited by 268 · see citing works
Olig1 and Olig2 triplication causes developmental brain defects in down syndrome.
Chakrabarti, L., Best, T. K., Cramer, N. P., Carney, R. S. E., Isaac, J. T. R., Galdzicki, Z., & Haydar, T. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2600 · Cited by 258 · see citing works
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions
Yu, T., Li, Z., Jia, Z., Clapcote, S. J., Liu, C., Li, S., Asrar, S., Pao, A., Chen, R., Fan, N., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq179 · Cited by 238 · see citing works
Duchon, A., Raveau, M., Chevalier, C., Nalesso, V., Sharp, A. J., & Herault, Y. (2011) · Mammalian Genome · doi:10.1007/s00335-011-9356-0 · Cited by 224 · see citing works
DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects
Ahn, K.-J., Jeong, H. K., Choi, H.-S., Ryoo, S.-R., Kim, Y. J., Goo, J.-S., Choi, S.-Y., Han, J.-S., Ha, I., & Song, W.-J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.006 · Cited by 220 · see citing works
The role of GABAergic signalling in neurodevelopmental disorders
Tang, X., Jaenisch, R., & Sur, M. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00443-x · Cited by 206 · see citing works
Belichenko, P. V., Kleschevnikov, A. M., Salehi, A., Epstein, C. J., & Mobley, W. C. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21433 · Cited by 202 · see citing works
Belichenko, N. P., Belichenko, P. V., Kleschevnikov, A. M., Salehi, A., Reeves, R. H., & Mobley, W. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1547-09.2009 · Cited by 201 · see citing works
Rodent models in Down syndrome research: impact and future opportunities
Hérault, Y., Delabar, J. M., Fisher, E., Tybulewicz, V. L. J., Yu, E. Y., & Brault, V. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.029728 · Cited by 191 · see citing works
Xu, R., Brawner, A. T., Li, S., Liu, J.-J., Kim, H., Xue, H., Pang, Z. P., Kim, W.-Y., Hart, R. P., Liu, Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.014 · Cited by 193 · see citing works
Deidda, G., Bozarth, I. F., & Cancedda, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00119 · Cited by 192 · see citing works
Duchon, A., & Herault, Y. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00104 · Cited by 181 · see citing works
Olson, L. E., Roper, R. J., Sengstaken, C. L., Peterson, E. A., Aquino, V. N., Galdzicki, Z., Siarey, R. J., Pletnikov, M. V., Moran, T. H., & Reeves, R. H. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm022 · Cited by 178 · see citing works
Kleschevnikov, A. M., Belichenko, P. V., Faizi, M., Jacobs, L. F., Htun, K. E., Shamloo, M., & Mobley, W. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1673-12.2012 · Cited by 174 · see citing works
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities
Rueda, N., Flórez, J., & Martínez-Cué, C. (2012) · Neural Plasticity · doi:10.1155/2012/584071 · Cited by 171 · see citing works
Kumar, A. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00007 · Cited by 169 · see citing works
Costa, A. C. S., Scott-McKean, J. J., & Stasko, M. R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301535 · Cited by 163 · see citing works
Self-citationMartínez‐Cué, C., Martinez, P. M., Rueda, N., Vidal, R., García-Cerro, S., Vidal, V., Corrales, A., Montero, J. A., Pazos, Á., Flórez, J., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1203-12.2013 · Cited by 154 · see citing works
Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
Clark, S. M., Schwalbe, J., Stasko, M. R., Yarowsky, P., & Costa, A. C. S. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.02.005 · Cited by 142 · see citing works
Self-citationThe GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome
Contestabile, A., Magara, S., & Cancedda, L. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00054 · Cited by 141 · see citing works
Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome
Contestabile, A., Benfenati, F., & Gasparini, L. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.01.003 · Cited by 134 · see citing works
Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model
Das, I., Park, J. M., Shin, J. H., Jeon, S. K., Lorenzi, H., Linden, D. J., Worley, P. F., & Reeves, R. H. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005983 · Cited by 134 · see citing works
Yu, T., Liu, C., Belichenko, P., Clapcote, S. J., Li, S., Pao, A., Kleschevnikov, A., Bechard, A. R., Asrar, S., Chen, R., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.107 · Cited by 127 · see citing works
Rueda, N., Flórez, J., & Martínez‐Cué, C. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.039 · Cited by 127 · see citing works
Pereira, P. L., Magnol, L., Sahún, I., Brault, V., Duchon, A., Prandini, P., Gruart, A., Bizot, J., Chadefaux, B., Deutsch, S., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp438 · Cited by 125 · see citing works
Timing of therapies for Down syndrome: the sooner, the better
Stagni, F., Giacomini, A., Guidi, S., Ciani, E., & Bartesaghi, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00265 · Cited by 122 · see citing works
Kleschevnikov, A. M., Belichenko, P. V., Gall, J., George, L., Nosheny, R., Maloney, M. T., Salehi, A., & Mobley, W. C. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.009 · Cited by 124 · see citing works
Ts65Dn, a Mouse Model of Down Syndrome, Exhibits Increased GABAB-Induced Potassium Current
Best, T. K., Siarey, R. J., & Galdzicki, Z. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00626.2006 · Cited by 117 · see citing works
Gardiner, K. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s51476 · Cited by 114 · see citing works
The use of mouse models to understand and improve cognitive deficits in Down syndrome
Das, I., & Reeves, R. H. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007716 · Cited by 99 · see citing works
Morice, É., Andreae, L. C., Cooke, S. F., Vanes, L., Fisher, E., Tybulewicz, V. L. J., & Bliss, T. (2008) · Learning & Memory · doi:10.1101/lm.969608 · Cited by 97 · see citing works
Hanson, J. E., Blank, M., Valenzuela, R. A., Garner, C. C., & Madison, D. V. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.114868 · Cited by 94 · see citing works
Galante, M., Jani, H., Vanes, L., Daniel, H., Fisher, E., Tybulewicz, V. L. J., Bliss, T. V. P., & Morice, É. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp055 · Cited by 89 · see citing works
Jeremic, D., Sanchez-Rodriguez, I., Jimenez-Diaz, L., & Navarro-Lopez, J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107808 · Cited by 89 · see citing works
Siarey, R. J., Kline‐Burgess, A., Cho, M., Balbo, A., Best, T. K., Harashima, C., Klann, E., & Galdzicki, Z. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03971.x · Cited by 86 · see citing works
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities
Zamboni, V., Jones, R., Umbach, A., Ammoni, A., Passafaro, M., Hirsch, E., & Merlo, G. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061821 · Cited by 83 · see citing works
Lott, I. T. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.12.010 · Cited by 82 · see citing works
Prospects for Improving Brain Function in Individuals with Down Syndrome
Costa, A. C. S., & Scott-McKean, J. J. (2013) · CNS Drugs · doi:10.1007/s40263-013-0089-3 · Cited by 81 · see citing works
Self-citationMolecular basis of pharmacotherapies for cognition in Down syndrome
Gardiner, K. (2009) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.10.010 · Cited by 113 · see citing works
Cooper, A., Grigoryan, G., Guy-David, L., Tsoory, M., Chen, A., & Reuveny, E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109099109 · Cited by 78 · see citing works
Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome
Best, T. K., Cramer, N., Chakrabarti, L., Haydar, T. F., & Galdzicki, Z. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.033 · Cited by 74 · see citing works
Parrini, M., Ghezzi, D., Deidda, G., Medrihan, L., Castroflorio, E., Alberti, M., Baldelli, P., Cancedda, L., & Contestabile, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-17201-8 · Cited by 73 · see citing works
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues
Belichenko, P. V., Kleschevnikov, A. M., Becker, A., Wagner, G. E., Lysenko, L. V., Yu, Y. E., & Mobley, W. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134861 · Cited by 70 · see citing works
Using mouse models to explore genotype–phenotype relationship in Down syndrome
Salehi, A., Faizi, M., Belichenko, P. V., & Mobley, W. C. (2007) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.20164 · Cited by 70 · see citing works
Begenisic, T., Baroncelli, L., Sansevero, G., Milanese, M., Bonifacino, T., Bonanno, G., Cioni, G., Maffei, L., & Sale, A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.010 · Cited by 66 · see citing works
Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice
Mans, R. A., Chowdhury, N., Cao, D., McMahon, L. L., & Li, L. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.062 · Cited by 67 · see citing works
Colas, D., Chuluun, B., Warrier, D. R., Blank, M., Wetmore, D. Z., Buckmaster, P. S., Garner, C. C., & Heller, H. C. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12169 · Cited by 63 · see citing works
GABAergic over-inhibition, a promising hypothesis for cognitive deficits in Down syndrome
Martín, J. Z. D. S., Delabar, J. M., Bacci, A., & Potier, M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.002 · Cited by 64 · see citing works
Souchet, B., Duchon, A., Gu, Y., Dairou, J., Chevalier, C., Daubigney, F., Nalesso, V., Créau, N., Yu, Y., Janel, N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40328-9 · Cited by 54 · see citing works
Treating enhanced GABAergic inhibition in Down syndrome: Use of GABA α5-selective inverse agonists
Martínez-Cué, C., Delatour, B., & Potier, M.-C. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.12.008 · Cited by 58 · see citing works
Hanson, J. E., Weber, M., Meilandt, W. J., Wu, T. Z., Luu, T., Deng, L., Shamloo, M., Sheng, M., Scearce-Levie, K. A., & Zhou, Q. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.19 · Cited by 55 · see citing works
Cramer, N., & Galdzicki, Z. (2012) · Neural Plasticity · doi:10.1155/2012/101542 · Cited by 54 · see citing works
Emerging Pharmacotherapies for Neurodevelopmental Disorders
Wetmore, D. Z., & Garner, C. C. (2010) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e3181ee3833 · Cited by 54 · see citing works
Promotion of Neuronal Plasticity by (−)-Epigallocatechin-3-Gallate
Xie, W. Q., Ramakrishna, N., Wieraszko, A., & Hwang, Y. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9494-7 · Cited by 50 · see citing works
The Down Syndrome Critical Region Regulates Retinogeniculate Refinement
Blank, M., Fuerst, P. G., Stevens, B., Nouri, N., Kirkby, L. A., Warrier, D. R., Barres, B. A., Feller, M. B., Huberman, A. D., Burgess, R. W., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6015-10.2011 · Cited by 51 · see citing works
Corrales, A., Vidal, R., García-Cerro, S., Vidal, V., Martinez, P. M., García, E., Flórez, J., Sánchez‐Barceló, E. J., Martínez‐Cué, C., & Rueda, N. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12097 · Cited by 51 · see citing works
Pathways to cognitive deficits in Down syndrome
Sturgeon, X., Le, T., Ahmed, M. M., & Gardiner, K. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00005-4 · Cited by 51 · see citing works
GABAB–GIRK2-Mediated Signaling in Down Syndrome
Cramer, N., Best, T. K., Stoffel, M., Siarey, R. J., & Galdzicki, Z. (2010) · Advances in pharmacology · doi:10.1016/s1054-3589(10)58015-3 · Cited by 49 · see citing works
In vivo MRI identifies cholinergic circuitry deficits in a Down syndrome model
Chen, Y., Dyakin, V. V., Branch, C. A., Ardekani, B. A., Yang, D., Guilfoyle, D. N., Peterson, J. N., Peterhoff, C. M., Ginsberg, S. D., Cataldo, A. M., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.11.026 · Cited by 49 · see citing works
Scott-McKean, J. J., Surewicz, K. A., Choi, J.-K., Ruffin, V. A., Salameh, A., Nieznański, K., Costa, A. C. S., & Surewicz, W. K. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.001 · Cited by 49 · see citing works
Self-citationRafii, M. S., Kleschevnikov, A. M., Sawa, M., & Mobley, W. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00017-0 · Cited by 52 · see citing works
Popov, V. I., Kleschevnikov, A. M., Klimenko, O. A., Stewart, M. G., & Belichenko, P. V. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22573 · Cited by 48 · see citing works
Neurodevelopment in Down syndrome: Concordance in humans and models
Klein, J. A., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.941855 · Cited by 47 · see citing works
“A seminal study in the field found failure of induction of long-term potentiation (LTP) in the Ts65Dn hippocampus due to excessive GABA-mediated inhibition and a wide array of following studies have confirmed this finding (Siarey et al., 1997, 1999; Kleschevnikov et al., 2004; Costa and Grybko, 2005; Fernandez et al.,…”
ResultChang, Q., & Gold, P. E. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.05.007 · Cited by 46 · see citing works
Scott-McKean, J. J., & Costa, A. C. S. (2011) · Learning & Memory · doi:10.1101/lm.024182.111 · Cited by 44 · see citing works
Self-citationCosta, A. C. S. (2011) · Developmental Neuroscience · doi:10.1159/000330861 · Cited by 44 · see citing works
Self-citationThe kinesin superfamily protein KIF17: one protein with many functions
Wong‐Riley, M. T. T., & Besharse, J. C. (2012) · BioMolecular Concepts · doi:10.1515/bmc-2011-0064 · Cited by 42 · see citing works
Enhanced Dendritic Inhibition and Impaired NMDAR Activation in a Mouse Model of Down Syndrome
Schulz, J. M., Knoflach, F., Hernandez, M., & Bischofberger, J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2723-18.2019 · Cited by 39 · see citing works
Rachidi, M., & Lopes, C. (2010) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/1944-7558-115.2.83 · Cited by 36 · see citing works
Rueda, N., Flórez, J., & Martínez‐Cué, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.11.020 · Cited by 39 · see citing works
Impact of the Olig Family on Neurodevelopmental Disorders
Szu, J., Wojcinski, A., Jiang, P., & Kesari, S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.659601 · Cited by 36 · see citing works
The α5-Containing GABAA Receptors—a Brief Summary
Mohamad, F. H., & Has, A. T. C. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1246-4 · Cited by 38 · see citing works
Modeling Down syndrome in animals from the early stage to the 4.0 models and next
Moreno, M. D. M. M., Brault, V., Birling, M., Pavlovic, G., & Hérault, Y. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2019.08.001 · Cited by 32 · see citing works
Freeburn, A., & Munn, R. G. K. (2021) · Neuronal Signaling · doi:10.1042/ns20200011 · Cited by 37 · see citing works
Perturbation of dendritic protrusions in intellectual disability
Levenga, J., & Willemsen, R. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00008-x · Cited by 37 · see citing works
Navarro-Romero, A., Vázquez‐Oliver, A., Gomis‐González, M., Garzón-Montesinos, C., Falcón‐Moya, R., Pastor, A., Martín‐García, E., Pizarro, N., Busquets-García, A., Revest, J., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.014 · Cited by 35 · see citing works
Wang, P., Wang, F., Ni, L., Wu, P., & Chen, J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.11.012 · Cited by 37 · see citing works
Alldred, M. J., Penikalapati, S. C., Lee, S. H., Heguy, A., Roussos, P., & Ginsberg, S. D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02453-3 · Cited by 36 · see citing works
Early environmental therapy rescues brain development in a mouse model of Down syndrome
Begenisic, T., Sansevero, G., Baroncelli, L., Cioni, G., & Sale, A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.07.014 · Cited by 34 · see citing works
Parrini, M., Naskar, S., Alberti, M., Colombi, I., Morelli, G., Rocchi, A., Nanni, M., Piccardi, F., Charles, S., Ronzitti, G., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.05.023 · Cited by 33 · see citing works
The in vivo Down syndrome genomic library in mouse
Hérault, Y., Duchon, A., Velot, É., Maréchal, D., & Brault, V. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00009-1 · Cited by 32 · see citing works
Synaptic Pathology of Down Syndrome
Garner, C. C., & Wetmore, D. Z. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-7091-0932-8_20 · Cited by 33 · see citing works
Valbuena, S., García, Á., Mazier, W., Paternain, A. V., & Lerma, J. (2019) · Nature Communications · doi:10.1038/s41467-019-13004-9 · Cited by 32 · see citing works
Paternò, R., Casalia, M. L., & Baraban, S. C. (2019) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2019.12.015 · Cited by 32 · see citing works
Scott-McKean, J. J., Chang, B., Hurd, R. E., Nusinowitz, S., Schmidt, C., Davisson, M. T., & Costa, A. C. S. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4465 · Cited by 31 · see citing works
Self-citationTranslational validity and implications of pharmacotherapies in preclinical models of Down syndrome
Rueda, N., Flórez, J., Dierssen, M., & Martínez‐Cué, C. (2019) · Progress in brain research · doi:10.1016/bs.pbr.2019.10.001 · Cited by 29 · see citing works
Roles for DSCAM and DSCAML1 in central nervous system development and disease.
Montesinos, M. (2014) · Advances in neurobiology · doi:10.1007/978-1-4614-8090-7_11 · Cited by 32 · see citing works
Mechanism based approaches for rescuing and enhancing cognition
LYNCH, G. S. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00143 · Cited by 30 · see citing works
Kleschevnikov, A. M., Belichenko, P. V., Salehi, A., & Wu, C. (2012) · Progress in brain research · doi:10.1016/b978-0-444-54299-1.00010-8 · Cited by 29 · see citing works
Mouse models of cognitive disabilities in trisomy 21 (Down syndrome)
Roubertoux, P. L., & Carlier, M. (2010) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.30280 · Cited by 28 · see citing works
Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome
Fernandez, F., & Garner, C. C. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.04.075 · Cited by 28 · see citing works
Kazim, S. F., Blanchard, J., Bianchi, R., & Iqbal, K. (2017) · Scientific Reports · doi:10.1038/srep45561 · Cited by 28 · see citing works
Brain circuit pathology in Down syndrome: from neurons to neural networks
Bartesaghi, R. (2023) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0067 · Cited by 25 · see citing works
Liu, H., Caballero-Florán, R. N., Hergenreder, T., Yang, T., Hull, J. M., Pan, G., Li, R., Veling, M. W., Isom, L. L., Kwan, K. Y., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002078 · Cited by 25 · see citing works
Cunha‐Reis, D., Aidil-Carvalho, M. F., & Ribeiro, J. A. (2014) · Hippocampus · doi:10.1002/hipo.22316 · Cited by 24 · see citing works
Borralleras, C., Mato, S., Amédée, T., Matute, C., Mulle, C., Jurado, L. A. P., & Campuzano, V. (2016) · Molecular Brain · doi:10.1186/s13041-016-0258-7 · Cited by 24 · see citing works
Consorti, A., Marco, I. D., & Sansevero, G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.710303 · Cited by 25 · see citing works
Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome
Fernandez, F., Trinidad, J. C., Blank, M., Feng, D., Burlingame, A. L., & Garner, C. C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06110.x · Cited by 22 · see citing works
Stachowicz, K. (2018) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2018-019 · Cited by 23 · see citing works
- Authors
- Costa, A. C. S., & Grybko, M. J.
- Affiliations
- University of Denver (US)
- Corresponding author
- Costa, Alberto C.S.
- ORCID
- Costa, Alberto C.S.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 382
- Issue
- 3
- Pages
- 317-322
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2082869264
- Cited by
- 174
- References
- 25
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 13 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 9 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 12 · 2012: 14
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD037424, R01HD037113, HD-24605, HD37424, P01HD024605, HD37113)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Down syndrome, Ts65Dn mouse model, hippocampal CA1, long-term potentiation, theta burst stimulation, high-frequency stimulation, picrotoxin, GABAA inhibition, synaptic plasticity, intellectual disability, aneuploidy
- MeSH terms
- Animals, Disease Models, Animal, Down Syndrome, Electric Stimulation, Hippocampus, Male, Synaptic Transmission, Organ Culture Techniques, Picrotoxin, Long-Term Potentiation, GABA Antagonists, Excitatory Postsynaptic Potentials, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review