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Cited by 162Cardiovascular and exercise physiologyNeuroscience of respiration and sleepHeart Rate Variability and Autonomic Control

Respiratory influences on sympathetic vasomotor outflow in humans

Dempsey, Jerome A, Sheel, A.William, St. Croix, Claudette M, Morgan, Barbara J·2002·Respiratory Physiology & Neurobiology
DOI 10.1016/s0034-5687(01)00327-9
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Abstract

We have attempted to synthesize findings dealing with four types of respiratory system influences on sympathetic outflow in the human. First, a powerful lung volume-dependent modulation of muscle sympathetic nerve activity (MSNA) occurs within each respiratory cycle showing late-inspiratory inhibition and late-expiratory excitation. Secondly, in the intact human, neither reductions in spontaneous respiratory motor output nor voluntary near-maximum increases in central respiratory motor output and inspiratory effort, per sec, influence MSNA modulation within a breath, MSNA total activity or limb vascular conductance. Thirdly, carotid chemoreceptor stimuli markedly increase total MSNA; but most of the MSNA response to chemoreceptor activation appears to be mediated independently of increased central respiratory motor output. Fourthly, repeated fatiguing contractions of the diaphragm or expiratory muscles in the human show a metaboreflex mediated time-dependent increase in MSNA and reduced vascular conductance and blood flow in the resting limb. Recent evidence suggests that these respiratory influences contribute significantly to sympathetic vasomotor outflow and to the distribution of systemic vascular conductances and blood flow in the exercising human.

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Crossref · 10.1016/s0034-5687(01)00327-9

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  • Studies in healthy subjects suggest that high levels of respiratory muscle work may result in a sympathetically mediated metaboreflex which causes redistribution of blood flow from the locomotor muscles to the respiratory muscles.

    “Studies in healthy subjects suggest that high levels of respiratory muscle work may result in a sympathetically mediated metaboreflex which causes redistribution of blood flow from the locomotor muscles to the respiratory muscles.70–72”

    From Pathogenesis of hyperinflation in chronic obstructive pulmonary disease (2014) · cites this paper as [72]

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Authors
Dempsey, J. A., Sheel, A. W., St. Croix, C. M., & Morgan, B. J.
Affiliations
  • University of Wisconsin–Madison (US)
  • University of British Columbia (CA)
Corresponding author
Dempsey, Jerome A
ORCID
Venue
Respiratory Physiology & Neurobiology
Publisher
Elsevier BV
Published
2002-03
Volume
130
Issue
1
Pages
3-20
ISSN
1569-9048 (ISSN-L)
DOI
10.1016/s0034-5687(01)00327-9
OpenAlex
W1977351645
Cited by
162
References
90
Citations by year
2026: 4 · 2025: 6 · 2024: 8 · 2023: 6 · 2022: 8 · 2021: 5 · 2020: 6 · 2019: 12 · 2018: 4 · 2017: 11 · 2016: 6 · 2015: 4 · 2014: 12 · 2013: 8 · 2012: 5
FWCI
0.83
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Respiratory Physiology & Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29hl057401-04)
  • National Heart, Lung, and Blood Institute (HL 15469, HL 57401)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
muscle sympathetic nerve activity, carotid chemoreceptors, muscle metaboreflex, diaphragm fatigue, limb blood flow, inspiratory effort
MeSH terms
Feedback, Humans, Respiratory Physiological Phenomena, Sympathetic Nervous System, Vasoconstriction, Vasomotor System, Exercise

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