The DOI matches its Crossref record; 531 of the 550 references it cites were found in a registry or an index.
Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies
Abstract
Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the United States, western Europe, Australia, and Japan. Despite intensive research, the precise etiology of molecular events that underlie age-related macular degeneration is poorly understood. However, investigations on parallel fronts are addressing this prevalent public health problem. Sophisticated biochemical and biophysical techniques have refined our understanding of the pathobiology of drusen, geographic atrophy, and retinal pigment epithelial detachments. Epidemiological identification of risk factors has facilitated an intelligent search for underlying mechanisms and fueled clinical investigation of behavior modification. Gene searches have not only brought us to the cusp of identifying the culpable gene loci in age-related macular degeneration, but also localized genes responsible for other macular dystrophies. Recent and ongoing investigations, often cued by tumor biology, have revealed an important role for various growth factors, particularly in the neovascular form of the condition. Transgenic and knockout studies have provided important mechanistic insights into the development of choroidal neovascularization, the principal cause of vision loss in age-related macular degeneration. This in turn has culminated in preclinical and clinical trials of directed molecular interventions.
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“The pathogenesis of age-related macular degeneration is not well known, although a number of theories have been put forward, including oxidative stress, mitochondrial dysfunction, and inflammatory processes.9–13”
From Age-related macular degeneration (2008) · cites this paper as [10]
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Metadata
- Authors
- Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P.
- Affiliations
- Massachusetts Eye and Ear Infirmary (US)
- Venue
- Survey of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2003-05
- Volume
- 48
- Issue
- 3
- Pages
- 257-293
- ISSN
- 0039-6257 (ISSN-L)
- OpenAlex
- W2016584341
- Semantic Scholar
- 966a19179595c3864062c4154d58b52e09b9a723
- Cited by
- 959
- References
- 550
- Citations by year
- 2026: 15 · 2025: 21 · 2024: 22 · 2023: 37 · 2022: 31 · 2021: 42 · 2020: 35 · 2019: 38 · 2018: 42 · 2017: 56 · 2016: 46 · 2015: 57 · 2014: 49 · 2013: 46 · 2012: 48
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Survey of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, drusen, geographic atrophy, retinal pigment epithelium, choroidal neovascularization, genetic risk factors, macular dystrophy, growth factors, gene therapy, treatment options, legal blindness, risk factors
- MeSH terms
- Animals, Disease Models, Animal, Humans, Macular Degeneration, Mice, Transgenic, Risk Factors, Mice, Knockout, Mice
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