Cited by 959Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

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Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies

Ambati, Jayakrishna, Ambati, Balamurali K, Yoo, Sonia H, Ianchulev, Sean, Adamis, Anthony P·2003·Survey of Ophthalmology

DOI 10.1016/s0039-6257(03)00030-4

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Abstract

Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the United States, western Europe, Australia, and Japan. Despite intensive research, the precise etiology of molecular events that underlie age-related macular degeneration is poorly understood. However, investigations on parallel fronts are addressing this prevalent public health problem. Sophisticated biochemical and biophysical techniques have refined our understanding of the pathobiology of drusen, geographic atrophy, and retinal pigment epithelial detachments. Epidemiological identification of risk factors has facilitated an intelligent search for underlying mechanisms and fueled clinical investigation of behavior modification. Gene searches have not only brought us to the cusp of identifying the culpable gene loci in age-related macular degeneration, but also localized genes responsible for other macular dystrophies. Recent and ongoing investigations, often cued by tumor biology, have revealed an important role for various growth factors, particularly in the neovascular form of the condition. Transgenic and knockout studies have provided important mechanistic insights into the development of choroidal neovascularization, the principal cause of vision loss in age-related macular degeneration. This in turn has culminated in preclinical and clinical trials of directed molecular interventions.

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Angiotensin AT 1 and AT 2 Receptors Differentially Regulate Angiopoietin-2 and Vascular Endothelial Growth Factor Expression and Angiogenesis by Modulating Heparin Binding–Epidermal Growth Factor (EGF)–Mediated EGF Receptor Transactivation
Fujiyama, S., Matsubara, H., Nozawa, Y., Maruyama, K., Mori, Y., Tsutsumi, Y., Masaki, H., Uchiyama, Y., Koyama, Y., Nose, A., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.1.22 · Cited by 203
Retracted
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 5,000
The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Carmeliet, P., Ferreira, V., Breier, G., Pollefeyt, S., Kieckens, L., Gertsenstein, M., Fahrig, M., Vandenhoeck, A., Harpal, K., Eberhardt, C., et al. (1996) · Nature · doi:10.1038/380435a0 · Cited by 4,162
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285
Requirement of Vascular Integrin α v β 3 for Angiogenesis
Brooks, P. C., Clark, R. A. F., & Cheresh, D. A. (1994) · Science · doi:10.1126/science.7512751 · Cited by 3,020

Show all 550 references

Research works printed but not linked: 16

Age-Related Eye Disease Study Research Group, 2000, Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3, Ophthalmology, 107, 2224
Applegate, 2001, A treatment trial for geographic atrophy from AMD: The GAARD Study, Invest Ophthalmol Vis Sci, 42, S230
Baffi, 2001, The recruitment of inflammatory cells into vascular endothelial growth factor (VEGF) induced choroidal neovascularization (CNV) in rat, Invest Ophthalmol Vis Sci, 42, S227
Becerra, 2001, Pigment epithelium-derived factor (PEDF) in the monkey eye: apical secretion from the retinal pigment epithelium, Invest Ophthalmol Vis Sci, 42, S772
Blodi, 2001, Effects of prinomastat (AG3340), an angiogenesis inhibitor, in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration, Invest Ophthalmol Vis Sci, 41, S311
Hanssen, 1930, Zur anatomie der scheibenformigen degeneration der netzhaumitte, Z Augenh, 72, 360
Hegner, 1916, Retinitis exsudativa bei Lymphogranulomatosis, Klin Monatsbl Augenheil, 57, 27
Holz, 1994, Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors, Ophthalmology, 101, 1522, 10.1016/S0161-6420(94)31139-0 · DOI
Luna, 1996, Antagonists of integrin αvβ3 inhibit retinal neovascularization in a murine model, Lab Invest, 75, 563
Maguire, 2001, Results of the age-related macular degeneration and thalidomide study (AMDATS), Invest Ophthalmol Vis Sci, 42, S233
McFarlane, 2001, Advanced glycation endproducts (AGEs) modulate cathepsin D expression in retinal pigment epithelium (RPE): implications for age-related dysfunction, Invest Ophthalmol Vis Sci, 42, S414
Nozaki, 2001, Immunolocalization of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in choroidal neovascularization of human, Invest Ophthalmol Vis Sci, 42, S228
Paul, 1927, Choroiditis exsudativa under dem bilde der scheibenformigen entartung der netzhautmitte, Z Augenh, 63, 205
Razavi, 2001, Expression of integrins avb3 and avb5 in human choroidal neovascular membranes, Invest Ophthalmol Vis Sci, 42, S773
Spandau, 2000, High expression of angiogenic chemokines in choroidal neovascularization membranes, Invest Ophthalmol Vis Sci, 41, S836
Tanemura, 2001, Estrogen may enhance VEGFR-2 expression in the process of laser-induced CNV formation, Invest Ophthalmol Vis Sci, 42, S96

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Söğüt, E., Ortak, H., Aydoğan, L., & Benli, İ. (2013) · Retina · doi:10.1097/iae.0b013e318287da59 · Cited by 6
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Hao, X.-L., Cheng, J., & Zhang, Z. (2018) · Medicine · doi:10.1097/md.0000000000011981 · Cited by 5
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Malek, G., Dwyer, M. A., & McDonnell, D. P. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0631-0_8 · Cited by 6
Comparison of the Effects between Intravitreal and Periocular Injections of Adenoviral Vectored Pigment Epithelium-Derived Factor on Suppressing Choroidal Neovascularization in Rats
Yan, H., Cui, J. Z., Wang, Y., & Yu, Y. (2012) · Ophthalmic Research · doi:10.1159/000342979 · Cited by 6
MHC class II expression by β2 integrin (CD18)-positive microglia, macrophages and macrophage-like cells in rabbit retina
Huang, W., Chamberlain, C. G., Sarafian, R. Y., & Chan‐Ling, T. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x0999007x · Cited by 6
Potential role of uric acid in the molecular pathogenesis of age-related macular degeneration
Mehryar, M., Farvardin, M., Hosseini, H., & Aslani, M. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.10.014 · Cited by 6
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Wang, Y., Jiang, D., Wang, Q., Cao, Y., Guo, H., Lu, Y., & Tian, F. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70051 · Cited by 7
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Antal, R., Benyó, Z., Nagy, Z. Z., Kovács, I., Fekete, J. T., Győrffy, B., & Kovács, K. A. (2025) · GeroScience · doi:10.1007/s11357-025-01921-1 · Cited by 5
Increased intercellular adhesion molecule-1 immunoreactivity in the sclera-choroid complex in hypercholesterolemia experimental model
Torres, R. J. D. A., de Noronha, L., Torres, R. D. R. D. A., Nagashima, S., Torres, C. L. D. A., Luchini, A., Torres, R. A. D. A., Précoma, L. B., & Précoma, D. B. (2014) · Revista Brasileira de Oftalmologia · doi:10.5935/0034-7280.20140046 · Cited by 5
Contribution of Calpain and Caspases to Cell Death in Cultured Monkey RPE Cells
Nakajima, E., Hammond, K. B., Hirata, M., Shearer, T. R., & Azuma, M. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22325 · Cited by 5
Hypoxic and osmotic expression of Kir2.1 potassium channels in retinal pigment epithelial cells: Contribution to vascular endothelial growth factor expression
Klose, E., Kuhrt, H., Kohen, L., Wiedemann, P., Bringmann, A., & Hollborn, M. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108741 · Cited by 5
Osteoporosis, bisphosphonates, and ocular inflammation
Nouraeinejad, A. (2022) · European Journal of Ophthalmology · doi:10.1177/11206721221125022 · Cited by 6
Efficient Delivery of siRNA by Atelocollagen in a Murine Laser-Induced Choroidal Neovascularization Model
Ito, Y., Nozaki, M., Sugitani, K., Ashikari, M., Hirano, Y., & Ogura, Y. (2013) · Ophthalmologica · doi:10.1159/000354092 · Cited by 5
Pathophysiologie und Therapie der AMD: Therapeutischer Anti‐VEGF‐Einsatz in der Augenheilkunde
Finger, R. P., Fleckenstein, M., Scholl, H. P. N., & Holz, F. G. (2007) · Pharmazie in unserer Zeit · doi:10.1002/pauz.200700237 · Cited by 5
Dobesilate for dry age-related macular degeneration
Cuevas, P., Outeiriño, L. A., Azanza, C., Angulo, J. C., & Giménez‐Gallego, G. (2013) · Journal of Biomedical Science and Engineering · doi:10.4236/jbise.2013.610a2002 · Cited by 5
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Özkök, A., Sigford, D. K., & Tezel, T. H. (2016) · Retina · doi:10.1097/iae.0000000000001034 · Cited by 5
Genetic association with intravitreal ranibizumab response for neovascular age-related macular degeneration in Hispanic population
Rodriguez, F. J., Ríos, H. A., Aguilar, M. C., Rosenstiehl, S. M., Gelvez, N. Y., López, G., & Tamayo, M. L. (2019) · Taiwan Journal of Ophthalmology · doi:10.4103/tjo.tjo_72_19 · Cited by 5
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Zhu, J., Su, T., Wang, M., Li, M., Liu, L., & Wang, F. (2021) · Seminars in Ophthalmology · doi:10.1080/08820538.2021.1883679 · Cited by 5
Sensitivity and specificity of optical coherence tomography angiography in the diagnosis of active choroidal neovascularization: a systematic review and meta-analysis
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Vitamin D and Age-Related Macular Degeneration
Yao, J., Chen, X., Jiang, Q., Preedy, V. R., & Yong, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401717-7.00034-4 · Cited by 5
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Nagpal, M. P., & India, G. (2018) · touchREVIEWS in Ophthalmology · doi:10.17925/usor.2018.11.2.91 · Cited by 5
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Cheng, K. C., & Canfield, V. A. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00491.x · Cited by 5
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Novais, E. A., Badaró, E., Hirai, F. E., Jorge, F. A., Leal, P., Farah, M. E., & Rodrigues, E. B. (2016) · Journal of Ophthalmology · doi:10.1155/2016/6971831 · Cited by 5
Pharmacodynamic Evaluation: Ocular Pharmacology
Sharif, N. A. (2019) · Springer eBooks · doi:10.1007/978-3-319-56637-5_54-1 · Cited by 5
Xeno-free, chemically defined and scalable monolayer differentiation protocol for retinal pigment epithelial cellsPreprint
Reyes, Á. P., Petrus-Reurer, S., Sánchez, S. P., Kumar, P., Douagi, I., Bartuma, H., Aronsson, M., Westman, S., Lardner, E., Falk, A., et al. (2020) · Research Square · doi:10.21203/rs.3.pex-635/v1 · Cited by 5
Bone morphogenetic proteins (BMPs) at the forefront of ocular diseases and therapeutics
Shi, Y., Zhang, J., Duan, W., Gao, L., & Liu, Y. (2025) · Eye and Vision · doi:10.1186/s40662-025-00445-1 · Cited by 4
Sostdc1 is expressed in all major compartments of developing and adult mammalian eyes
Valensi, M., Goldman, G., Marchant, D., Berghe, L. V. D., Jonet, L., Daruich, A., Robert, M. P. A., Krejci, É., Klein, C., Mascarelli, F., et al. (2019) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-019-04462-4 · Cited by 4
Vitreous tumor necrosis factor-alpha level in patients with wet type of age-related macular degeneration
Zayed, M., Tawwab, H. A., ATTYA, M. S. I. M. E. A., & Essawy, R. E. (2019) · Egyptian Retina Journal · doi:10.4103/erj.erj_10_19 · Cited by 4
Comparison of the effects of anti-vascular endothelial growth factor treatments on pigment epithelial detachment in age-related macular degeneration
Ulusoy, M. O., Kal, A., & Yılmaz, G. (2021) · International Ophthalmology · doi:10.1007/s10792-021-01695-3 · Cited by 4
Chorioretinal thickness and retinal pigment epithelial degeneration of fellow eyes in patients with unilateral neovascular age-related macular degeneration with subretinal drusenoid deposits
Kang, D., Yoon, E. G., Nam, K. T., & Yun, C. (2022) · BMC Ophthalmology · doi:10.1186/s12886-022-02518-4 · Cited by 4
Clinically compliant cryopreservation of differentiated retinal pigment epithelial cells
Baqué-Vidal, L., Main, H., Petrus-Reurer, S., Lederer, A. R., Beri, N. E., Bär, F., Metzger, H., Zhao, C., Efstathopoulos, P., Saietz, S., et al. (2024) · Cytotherapy · doi:10.1016/j.jcyt.2024.01.014 · Cited by 4
Age-Related Macular Degeneration
Storey, P. P., Hark, L. A., & Haller, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-401717-7.00002-2 · Cited by 4
Full macular translocation following photodynamic therapy in neovascular age-related macular degeneration
Suesskind, D., Voelker, M., Bartz-Schmidt, K. U., & Gelişken, F. (2007) · Eye · doi:10.1038/sj.eye.6702738 · Cited by 4

Authors: Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P.
Affiliations: Massachusetts Eye and Ear Infirmary (US)
ORCID: Ambati, Jayakrishna
Ambati, Balamurali K
Yoo, Sonia H
Venue: Survey of Ophthalmology
Publisher: Elsevier BV
Published: 2003-05
Volume: 48
Issue: 3
Pages: 257-293
ISSN: 0039-6257 (ISSN-L)
DOI: 10.1016/s0039-6257(03)00030-4
OpenAlex: W2016584341
Semantic Scholar: 966a19179595c3864062c4154d58b52e09b9a723
Cited by: 959
References: 550
Citations by year: 2026: 15 · 2025: 21 · 2024: 22 · 2023: 37 · 2022: 31 · 2021: 42 · 2020: 35 · 2019: 38 · 2018: 42 · 2017: 56 · 2016: 46 · 2015: 57 · 2014: 49 · 2013: 46 · 2012: 48
FWCI: 9.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Survey of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: age-related macular degeneration, drusen, geographic atrophy, retinal pigment epithelium, choroidal neovascularization, genetic risk factors, macular dystrophy, growth factors, gene therapy, treatment options, legal blindness, risk factors
MeSH terms: Animals, Disease Models, Animal, Humans, Macular Degeneration, Mice, Transgenic, Risk Factors, Mice, Knockout, Mice

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Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies

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