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Cited by 959Retinal Diseases and TreatmentsRetinal Development and DisordersRetinal Imaging and Analysis

The DOI matches its Crossref record; 531 of the 550 references it cites were found in a registry or an index.

Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies

Ambati, Jayakrishna, Ambati, Balamurali K, Yoo, Sonia H, Ianchulev, Sean, Adamis, Anthony P·2003·Survey of Ophthalmology
DOI 10.1016/s0039-6257(03)00030-4
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Abstract

Age-related macular degeneration is the principal cause of registered legal blindness among those aged over 65 in the United States, western Europe, Australia, and Japan. Despite intensive research, the precise etiology of molecular events that underlie age-related macular degeneration is poorly understood. However, investigations on parallel fronts are addressing this prevalent public health problem. Sophisticated biochemical and biophysical techniques have refined our understanding of the pathobiology of drusen, geographic atrophy, and retinal pigment epithelial detachments. Epidemiological identification of risk factors has facilitated an intelligent search for underlying mechanisms and fueled clinical investigation of behavior modification. Gene searches have not only brought us to the cusp of identifying the culpable gene loci in age-related macular degeneration, but also localized genes responsible for other macular dystrophies. Recent and ongoing investigations, often cued by tumor biology, have revealed an important role for various growth factors, particularly in the neovascular form of the condition. Transgenic and knockout studies have provided important mechanistic insights into the development of choroidal neovascularization, the principal cause of vision loss in age-related macular degeneration. This in turn has culminated in preclinical and clinical trials of directed molecular interventions.

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Crossref · 10.1016/s0039-6257(03)00030-4

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Research works printed but not linked: 16

  1. Age-Related Eye Disease Study Research Group, 2000, Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: age-related eye disease study report number 3, Ophthalmology, 107, 2224
  2. Applegate, 2001, A treatment trial for geographic atrophy from AMD: The GAARD Study, Invest Ophthalmol Vis Sci, 42, S230
  3. Baffi, 2001, The recruitment of inflammatory cells into vascular endothelial growth factor (VEGF) induced choroidal neovascularization (CNV) in rat, Invest Ophthalmol Vis Sci, 42, S227
  4. Becerra, 2001, Pigment epithelium-derived factor (PEDF) in the monkey eye: apical secretion from the retinal pigment epithelium, Invest Ophthalmol Vis Sci, 42, S772
  5. Blodi, 2001, Effects of prinomastat (AG3340), an angiogenesis inhibitor, in patients with subfoveal choroidal neovascularization associated with age-related macular degeneration, Invest Ophthalmol Vis Sci, 41, S311
  6. Hanssen, 1930, Zur anatomie der scheibenformigen degeneration der netzhaumitte, Z Augenh, 72, 360
  7. Hegner, 1916, Retinitis exsudativa bei Lymphogranulomatosis, Klin Monatsbl Augenheil, 57, 27
  8. Holz, 1994, Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors, Ophthalmology, 101, 1522, 10.1016/S0161-6420(94)31139-0 · DOI
  9. Luna, 1996, Antagonists of integrin αvβ3 inhibit retinal neovascularization in a murine model, Lab Invest, 75, 563
  10. Maguire, 2001, Results of the age-related macular degeneration and thalidomide study (AMDATS), Invest Ophthalmol Vis Sci, 42, S233
  11. McFarlane, 2001, Advanced glycation endproducts (AGEs) modulate cathepsin D expression in retinal pigment epithelium (RPE): implications for age-related dysfunction, Invest Ophthalmol Vis Sci, 42, S414
  12. Nozaki, 2001, Immunolocalization of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in choroidal neovascularization of human, Invest Ophthalmol Vis Sci, 42, S228
  13. Paul, 1927, Choroiditis exsudativa under dem bilde der scheibenformigen entartung der netzhautmitte, Z Augenh, 63, 205
  14. Razavi, 2001, Expression of integrins avb3 and avb5 in human choroidal neovascular membranes, Invest Ophthalmol Vis Sci, 42, S773
  15. Spandau, 2000, High expression of angiogenic chemokines in choroidal neovascularization membranes, Invest Ophthalmol Vis Sci, 41, S836
  16. Tanemura, 2001, Estrogen may enhance VEGFR-2 expression in the process of laser-induced CNV formation, Invest Ophthalmol Vis Sci, 42, S96

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Metadata

Authors
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P.
Affiliations
Massachusetts Eye and Ear Infirmary (US)
ORCID
Venue
Survey of Ophthalmology
Publisher
Elsevier BV
Published
2003-05
Volume
48
Issue
3
Pages
257-293
ISSN
0039-6257 (ISSN-L)
DOI
10.1016/s0039-6257(03)00030-4
OpenAlex
W2016584341
Semantic Scholar
966a19179595c3864062c4154d58b52e09b9a723
Cited by
959
References
550
Citations by year
2026: 15 · 2025: 21 · 2024: 22 · 2023: 37 · 2022: 31 · 2021: 42 · 2020: 35 · 2019: 38 · 2018: 42 · 2017: 56 · 2016: 46 · 2015: 57 · 2014: 49 · 2013: 46 · 2012: 48
FWCI
9.20
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Survey of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords
age-related macular degeneration, drusen, geographic atrophy, retinal pigment epithelium, choroidal neovascularization, genetic risk factors, macular dystrophy, growth factors, gene therapy, treatment options, legal blindness, risk factors
MeSH terms
Animals, Disease Models, Animal, Humans, Macular Degeneration, Mice, Transgenic, Risk Factors, Mice, Knockout, Mice

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