New synthetic strategies towards (+)-artemisinin
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Chemical synthesis of artemisinin is far too expensive for many in the Third World because of the structural complexity of the target and the large number of steps in published synthetic routes.
“Although artemisinin can be produced by chemical synthesis [171,228,229,230,231,232,233,234,235,236,237,238,239], the structural complexity of this target and the large number of steps involved in all published synthetic routes render this approach far too expensive for many in the Third World who are most affected by malaria.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [232]
Cites
Qinghaosu (Artemisinin): an Antimalarial Drug from China
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Total synthesis of arteannuin and deoxyarteannuin
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Artemisinin (qinghaosu): a new type of antimalarial drug
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Stereoselective synthesis of artemisinin
Ravindranathan, T., Anil Kumar, M., Menon, R. B., & Hiremath, S. V. (1990) · Tetrahedron Letters · doi:10.1016/s0040-4039(00)94621-5 · Cited by 103 · see citing works
An expeditious approach for the synthesis of optically active acetylenic alcohols
Yadav, J. S., Chander, M. C., & Joshi, B. V. (1988) · Tetrahedron Letters · doi:10.1016/0040-4039(88)85274-2 · Cited by 84 · see citing works
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A short and stereospecific synthesis of (+)-deoxoartemisinin and (−)-deoxodesoxyartemisinin
Jung, M., Li, X., Bustos, D. A., ElSohly, H. N., & McChesney, J. D. (1989) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)93831-6 · Cited by 56 · see citing works
An efficient synthesis of qinghaosu and deoxoginghaosu from arteannuic acid
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Structure of 1-hydroxy-10-isopropyl-7-methyl-cis-bicyclo[4.4.0]decan-3-one
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The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)
Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works
Advances in the Chemical Synthesis of Artemisinin
Wang, Z., Yang, L., Yang, X., & Zhang, X. (2014) · Synthetic Communications · doi:10.1080/00397911.2014.884225 · Cited by 35 · see citing works
Synthesis of 6,7-dehydroartemisinic acid
Sy, L.-K., & Brown, G. D. (2001) · Journal of the Chemical Society, Perkin Transactions 1 · doi:10.1039/b104471k · Cited by 19 · see citing works
- Authors
- Bhonsle, J. B., Pandey, B., Deshpande, V. H., & Ravindranathan, T.
- Affiliations
- National Chemical Laboratory (IN)
- Venue
- Tetrahedron Letters
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 35
- Issue
- 30
- Pages
- 5489-5492
- ISSN
- 0040-4039 (ISSN-L)
- OpenAlex
- W1978629042
- Cited by
- 23
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2014: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tetrahedron Letters (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- artemisinin, total synthesis, menthol, C–H functionalization
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