The Total synthesis of (+)-artemisinin and (+)-9-desmethyltemesinin
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Chemical synthesis of artemisinin is far too expensive for many in the Third World because of the structural complexity of the target and the large number of steps in published synthetic routes.
“Although artemisinin can be produced by chemical synthesis [171,228,229,230,231,232,233,234,235,236,237,238,239], the structural complexity of this target and the large number of steps involved in all published synthetic routes render this approach far too expensive for many in the Third World who are most affected by malaria.”
From The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao) (2010) · cites this paper as [235]
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Kane, J. M., & Peet, N. P. (1990) · Progress in heterocyclic chemistry · doi:10.1016/b978-0-08-037070-5.50020-5 · Cited by 3 · see citing works
(2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813133-6.00003-2 · Cited by 2 · see citing works
Casteel, D. A. (2003) · Wiley eBooks · doi:10.1002/0471266949.bmc091 · Cited by 2 · see citing works
- Authors
- Avery, M. A., Jennings-White, C., & Chong, W. K. M.
- Affiliations
- SRI International (US)
- Venue
- Tetrahedron Letters
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 28
- Issue
- 40
- Pages
- 4629-4632
- ISSN
- 0040-4039 (ISSN-L)
- OpenAlex
- W2036394277
- Cited by
- 114
- References
- 8
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2015: 1 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Tetrahedron Letters (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Organic Chemistry Synthesis Methods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biological Activity of Diterpenoids and Biflavonoids
- Keywords
- artemisinin, total synthesis, sesquiterpenes
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