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Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
Open accessAbstract
A retinal prosthesis was permanently implanted in the eye of a completely blind test subject. This report details the results from the first 10 weeks of testing with the implant subject. The implanted device included an extraocular case to hold electronics, an intraocular electrode array (platinum disks, 4 x 4 arrangement) designed to interface with the retina, and a cable to connect the electronics case to the electrode array. The subject was able to see perceptions of light (spots) on all 16 electrodes of the array. In addition, the subject was able to use a camera to detect the presence or absence of ambient light, to detect motion, and to recognize simple shapes.
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“Due to axonal activation, phosphenes often appear with an elongated shape distorting the image perceived by the patient [46].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [46]
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Cites
Prevalence of age-related maculopathy
Klein, R., Klein, B. E. K., & Linton, K. L. P. (1992) · Ophthalmology · doi:10.1016/s0161-6420(92)31871-8 · Cited by 1,845
The Five-year Incidence and Progression of Age-related Maculopathy
Klein, R., Klein, R., Jensen, S. C., & Meuer, S. M. (1997) · Ophthalmology · doi:10.1016/s0161-6420(97)30368-6 · Cited by 1,154
Will Retinal Implants Restore Vision?
Zrenner, E. (2002) · Science · doi:10.1126/science.1067996 · Cited by 736
Preservation of the Inner Retina in Retinitis Pigmentosa
Santos, A. (1997) · Archives of Ophthalmology · doi:10.1001/archopht.1997.01100150513011 · Cited by 651
Visual Perception Elicited by Electrical Stimulation of Retina in Blind Humans
Humayun, M. S. (1996) · Archives of Ophthalmology · doi:10.1001/archopht.1996.01100130038006 · Cited by 602
Self-citationPattern electrical stimulation of the human retina
Humayun, M. S., de Juan, E., Weiland, J. D., Dagnelie, G., Katona, S., Greenberg, R. J., & Suzuki, S. (1999) · Vision Research · doi:10.1016/s0042-6989(99)00052-8 · Cited by 598
Self-citationMorphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa.
Humayun, M. S., Prince, M. R., de Juan, E., Barrón, Y., Moskowitz, M., Klock, I. B., & Milam, A. H. (1999) · PubMed · Cited by 366
Self-citationNeural prostheses : fundamental studies
Agnew, W. F., & McCreery, D. B. (1990) · Medical Entomology and Zoology · Cited by 316
Learning Retina Implants with Epiretinal Contacts
Eckmiller, R. (2009) · Ophthalmic Research · doi:10.1159/000268026 · Cited by 257
Subretinal electrical stimulation of the rabbit retina
Chow, A. Y., & Chow, V. Y. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00185-7 · Cited by 242
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Hornig, R., & Velikay‐Parel, M. (2013) · Elsevier eBooks · doi:10.1533/9780857096289.3.469
Dagnelie, G. (2007) · Elsevier eBooks · doi:10.1016/b978-012370615-7/50073-1
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Villarreal, D. L., Zevallos, E. J. C., Perea, A. M., & Krautschneider, W. H. (2021) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc46164.2021.9629768
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Lawrence, D. S., & O’Banion, C. P. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.717952695.793458351
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Osakada, F., & Takahashi, M. (2013) · Springer eBooks · doi:10.1007/978-94-007-5690-8_5
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Self-citation刘, 易., 牛, 帅., 周, 业., 周, 阳., 任, 秋., & 牛, 金. (2007) · Science in China Series F-Information Sciences (in Chinese) · doi:10.1360/zf2007-37-10-1354
Seelman, K. D., Brabyn, J. A., Ortmann, A. J., & Palmer, C. V. (2006) · Wiley Encyclopedia of Biomedical Engineering · doi:10.1002/9780471740360.ebs1070
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Djilas, M., & Picaud, S. A. (2014) · Advances in bioinformatics and biomedical engineering book series · doi:10.4018/978-1-4666-6094-6.ch002
Thoreson, W. B., & Margalit, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.05181-3
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Nakanishi, Y., Hattori, T., Sriitsaranusorn, W., Tso, K.-C., Shodo, K., Takehara, H., Sunaga, Y., Haruta, M., Tashiro, H., Terasawa, Y., et al. (2025) · Japanese Journal of Applied Physics · doi:10.35848/1347-4065/ad99e0
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Mokwa, W. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-95478-5.00051-0 · Cited by 1
Rezende, F., Ramirez, K. A., Drew-Bear, L. E., Vega-Garces, M. I., Belandria, H. B., Grané, N. V., & Arévalo, J. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-29358-0_23-1
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Kartha, A., & Dagnelie, G. (2025) · doi:10.1093/oso/9780192887221.003.0034
Self-citationAn update on human visual prosthesis: The Claes H. Dohlman lecture 2025
Arévalo, J. F., & Ramirez, K. A. (2025) · Taiwan Journal of Ophthalmology · doi:10.4103/tjo.tjo-d-25-00041
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Falinska-Krol, J. (2010) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
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Ohta, J., Tokuda, T., Hiyama, K., Sawamura, S., Sasagawa, K., Nishida, K., Kitaguchi, Y., Kamei, M., Fujikado, T., & Tano, Y. (2024) · IISS online library · doi:10.60928/7dyp-tk8x
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Renshaw, K. T., & Pezaris, J. S. (2026) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ae46fd · Cited by 1
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Kime, S. (2016) · theses.fr (ABES) · doi:10.70675/a5e5f10fzf01cz40d1za5f2z5067b3e0d7b1
Neurochip implants for sight recovery bridging neuroscience and engineering
Khanna, V., & Khanna, P. (2026) · i-manager’s Journal on Future Engineering and Technology · doi:10.26634/jfet.21.2.843
Vision restoration: From prostheses to genetic-based brain–machine interfaces
Alcala, I., DESAILLY, E., Arcizet, F., Marazova, K., Gauvain, G., & Picaud, S. A. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-22212-2.00017-3
Trends in neuroprosthetic technologies to restore sensations
Park, B., Butterworth, W., Lee, N., & Kim, S. (2026) · Biomedical Engineering Letters · doi:10.1007/s13534-026-00603-x
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Dindar, I. A., Shoichet, M. S., Labriola, J. M., Forman, A., & Devenyi, R. G. (2026) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2026.08.039
Li, X., Khalil, I., Rahman, F., & Khan, M. N. (2026) · Biomimetics · doi:10.3390/biomimetics11090649 · Cited by 6
Rezende, F., Ramirez, K. A., Drew-Bear, L. E., Vega-Garces, M. I., Belandria, H. B., Grané, N. V., & Arevalo, J. F. (2026) · Springer eBooks · doi:10.1007/978-3-032-23052-2_23
Barnes, N. M., Petoe, M. A., Kolic, M., Baglin, E. K., Titchener, S. A., Habili, N., Kentler, W. G., Abbott, C. J., Allen, P. J., & Walker, J. G. (2026) · Translational Vision Science & Technology · doi:10.1167/tvst.15.10.21
Metadata
- Authors
- Humayun, M. S., Weiland, J. D., Fujii, G. Y., Greenberg, R., Williamson, R., Little, J., Mech, B., Cimmarusti, V., Van Boemel, G., Dagnelie, G., & de Juan, E.
- Affiliations
- University of Southern California (US)
- Second Sight Medical Products (US)
- Johns Hopkins University (US)
- Corresponding author
- Humayun, Mark S.
- Venue
- Vision Research
- Publisher
- Elsevier BV
- Published
- 2003-11
- Volume
- 43
- Issue
- 24
- Pages
- 2573-2581
- ISSN
- 0042-6989 (ISSN-L)
- OpenAlex
- W2131773286
- Cited by
- 856
- References
- 21
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 15 · 2023: 13 · 2022: 26 · 2021: 23 · 2020: 20 · 2019: 26 · 2018: 22 · 2017: 32 · 2016: 36 · 2015: 31 · 2014: 46 · 2013: 62 · 2012: 52
- FWCI
- 15.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Vision Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- National Eye Institute (R01EY012843)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Keywords
- retinal prosthesis, visual perception, platinum electrode, light perception, motion detection, shape recognition, chronic implantation
- MeSH terms
- Aged, Blindness, Electrodes, Implanted, Humans, Male, Photoreceptor Cells, Retina, Retinitis Pigmentosa, Visual Perception, Treatment Outcome, Prostheses and Implants
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