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Cited by 114Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Clinical study and follow-up of 100 patients withthe antiphospholipid syndrome

Muñoz-Rodríguez, Francisco J., Font, Josep, Cervera, Richard, Reverter, Joan Carles, Tàssies, Dolors, Espinosa, Gerard, López-Soto, Alfonso, Carmona, Francisco, Balasch, Joan, Ordinas, Antoni, Ingelmo, Miguel·1999·Seminars in Arthritis and Rheumatism
DOI 10.1016/s0049-0172(99)80029-8
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Abstract

Objectives To study the clinical characteristics at diagnosis and during follow-up of patients with the antiphospholipid syndrome (APS) and to analyze the influence of treatment on their outcome.Patients One hundred patients with APS were included (86% female and 14% male; mean age, 36 years). Sixty-two percent had primary APS and 38% had APS associated with systemic lupus erythematosus (SLE). The median length of follow-up was 49 months.Results Fifty-three percent of the patients had thromboses, 52% had thrombocytopenia, and 60% of the women had pregnancy losses. Patients with APS associated with SLE had a higher prevalence of hemolytic anemia (P = .02), thrombocytopenia (platelet count lower than 100 x 10(9)/L) (P = .004), antinuclear antibodies (P = .0002), and low complement levels. Fifty-three percent of the patients with thrombosis had recurrent episodes (86% in the same site as the previous thrombotic event). Recurrences were observed in 19% of the episodes treated with long-term oral anticoagulation, in 42% treated prophylactically with aspirin, and in 91% in which anticoagulant/antiaggregant treatment was discontinued (P = .0007). Multivariate analysis showed that prophylactic treatment and older age had an independent predictive value for rethrombosis. Prophylactic treatment during pregnancy (usually with aspirin) increased the live birth rate from 38% to 72% (P = .0002).Conclusions Patients with APS have a high risk of recurrent thromboses. Long-term oral anticoagulation seems to be the best prophylactic treatment to prevent recurrences. Prophylactic treatment with aspirin during pregnancy reduced the rate of miscarriages remarkably.

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Metadata

Authors
Muñoz-Rodríguez, F. J., Font, J., Cervera, R., Reverter, J. C., Tàssies, D., Espinosa, G., López-Soto, A., Carmona, F., Balasch, J., Ordinas, A., & Ingelmo, M.
Corresponding author
Cervera, Richard
ORCID
Venue
Seminars in Arthritis and Rheumatism
Publisher
Elsevier BV
Published
1999-12
Volume
29
Issue
3
Pages
182-190
ISSN
0049-0172 (ISSN-L)
DOI
10.1016/s0049-0172(99)80029-8
OpenAlex
W2014368662
Cited by
114
References
41
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 4
FWCI
4.73
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Seminars in Arthritis and Rheumatism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
  • Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords
antiphospholipid syndrome, systemic lupus erythematosus, thrombosis, recurrent thrombosis, thrombocytopenia, miscarriage, hemolytic anemia, oral anticoagulation, aspirin prophylaxis, live birth rate, antinuclear antibodies, complement levels
MeSH terms
Adolescent, Adult, Aged, Anticoagulants, Diagnosis, Differential, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies, Thrombocytopenia, Thrombosis, Antiphospholipid Syndrome, Treatment Outcome, Secondary Prevention

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