Outcome of patients with anticardiolipin antibodies: a 10 year follow-up of 52 patients
Abstract
We report a 10-year follow-up on 52 patients with raised levels of anticardiolipin antibodies (aCL) who were first seen at our tertiary referral centre in 1986. The clinical and serological features of these 52 patients are described. Thirty-one patients had the antiphospholipid syndrome (APS) in 1986. Nine of these patients (29%) had further thrombotic events during the follow-up period. Of the other 21 aCL positive patients without clinical manifestations of APS, 11 (52%) developed the syndrome over this period. Five patients (10%) died during the follow-up. Close monitoring of patients with connective tissue diseases and aCL is essential as the likelihood of developing antiphospholipid syndrome is high.
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Retrospective, case-control and cross-sectional studies with different designs, patient selection criteria, aPL profiles and risk factors have produced contradictory results.
“Retrospective, [1][2][3][4] case-control [5][6][7][8][9][10][11][12] and cross-sectional 13,14 studies with different designs, patient selection criteria, aPL profiles and risk factors have produced contradictory results.”
From Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. (2011) · cites this paper as [2]
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- Authors
- Shah, N. M., Khamashta, M. A., Atsumi, T., & Hughes, G. R.
- Affiliations
- St Thomas' Hospital (GB)
- Venue
- Lupus
- Publisher
- SAGE Publications
- Published
- 1998-01
- Volume
- 7
- Issue
- 1
- Pages
- 3-6
- ISSN
- 0961-2033 (ISSN-L)
- 1477-0962
- OpenAlex
- W1975218766
- Cited by
- 204
- References
- 1
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 6
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lupus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- anticardiolipin antibodies, antiphospholipid syndrome, thrombosis, connective tissue diseases, long-term follow-up, serological properties, clinical features
- MeSH terms
- Adolescent, Adult, Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Antiphospholipid Syndrome, Antibodies, Anticardiolipin
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