Cited by 114Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

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Clinical study and follow-up of 100 patients withthe antiphospholipid syndrome

Muñoz-Rodríguez, Francisco J., Font, Josep, Cervera, Richard, Reverter, Joan Carles, Tàssies, Dolors, Espinosa, Gerard, López-Soto, Alfonso, Carmona, Francisco, Balasch, Joan, Ordinas, Antoni, Ingelmo, Miguel·1999·Seminars in Arthritis and Rheumatism

DOI 10.1016/s0049-0172(99)80029-8

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Abstract

Objectives To study the clinical characteristics at diagnosis and during follow-up of patients with the antiphospholipid syndrome (APS) and to analyze the influence of treatment on their outcome.Patients One hundred patients with APS were included (86% female and 14% male; mean age, 36 years). Sixty-two percent had primary APS and 38% had APS associated with systemic lupus erythematosus (SLE). The median length of follow-up was 49 months.Results Fifty-three percent of the patients had thromboses, 52% had thrombocytopenia, and 60% of the women had pregnancy losses. Patients with APS associated with SLE had a higher prevalence of hemolytic anemia (P = .02), thrombocytopenia (platelet count lower than 100 x 10(9)/L) (P = .004), antinuclear antibodies (P = .0002), and low complement levels. Fifty-three percent of the patients with thrombosis had recurrent episodes (86% in the same site as the previous thrombotic event). Recurrences were observed in 19% of the episodes treated with long-term oral anticoagulation, in 42% treated prophylactically with aspirin, and in 91% in which anticoagulant/antiaggregant treatment was discontinued (P = .0007). Multivariate analysis showed that prophylactic treatment and older age had an independent predictive value for rethrombosis. Prophylactic treatment during pregnancy (usually with aspirin) increased the live birth rate from 38% to 72% (P = .0002).Conclusions Patients with APS have a high risk of recurrent thromboses. Long-term oral anticoagulation seems to be the best prophylactic treatment to prevent recurrences. Prophylactic treatment with aspirin during pregnancy reduced the rate of miscarriages remarkably.

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Authors: Muñoz-Rodríguez, F. J., Font, J., Cervera, R., Reverter, J. C., Tàssies, D., Espinosa, G., López-Soto, A., Carmona, F., Balasch, J., Ordinas, A., & Ingelmo, M.
Corresponding author: Cervera, Richard
ORCID: Reverter, Joan Carles
Tàssies, Dolors
Espinosa, Gerard
Carmona, Francisco
Venue: Seminars in Arthritis and Rheumatism
Publisher: Elsevier BV
Published: 1999-12
Volume: 29
Issue: 3
Pages: 182-190
ISSN: 0049-0172 (ISSN-L)
DOI: 10.1016/s0049-0172(99)80029-8
OpenAlex: W2014368662
Cited by: 114
References: 41
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 4
FWCI: 4.73
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Seminars in Arthritis and Rheumatism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords: antiphospholipid syndrome, systemic lupus erythematosus, thrombosis, recurrent thrombosis, thrombocytopenia, miscarriage, hemolytic anemia, oral anticoagulation, aspirin prophylaxis, live birth rate, antinuclear antibodies, complement levels
MeSH terms: Adolescent, Adult, Aged, Anticoagulants, Diagnosis, Differential, Drug Therapy, Combination, Female, Follow-Up Studies, Humans, Male, Middle Aged, Platelet Aggregation Inhibitors, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies, Thrombocytopenia, Thrombosis, Antiphospholipid Syndrome, Treatment Outcome, Secondary Prevention

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Clinical study and follow-up of 100 patients withthe antiphospholipid syndrome

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